Pre-Treatment Lymphocyte Count Influences ATLG Transplantation Outcomes
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  • Release Date: 2023-08-10
  • GVHD
  • ALC
  • ATLG
  • HSCT
Video Introduction

This video is adapted from 10.3390/cells12141831

In allogeneic hematopoietic stem cell transplantation (HSCT), Anti-T-Lymphocyte Globulin (ATLG) may be used for the prevention of severe graft-versus-host disease (GVHD). ATLG targets both the recipient’s lymphocytes and those transferred with the graft. Assuming an inverse relation between the recipient’s absolute lymphocyte count (ALC) and exposure of remaining ATLG to the graft, the aim is to evaluate the impact of the recipient’s ALC before the first ATLG administration on the benefits (prevention of GVHD and GVHD-associated mortality) and potential risks (increased relapse incidence) associated with ATLG.

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Nikoloudis, A.; Buxhofer-Ausch, V.; Aichinger, C.; Binder, M.; Hasengruber, P.; Kaynak, E.; Wipplinger, D.; Milanov, R.; Strassl, I.; Stiefel, O.; et al. Pre-Treatment Lymphocyte Count Influences ATLG Transplantation Outcomes. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/853 (accessed on 15 November 2024).
Nikoloudis A, Buxhofer-Ausch V, Aichinger C, Binder M, Hasengruber P, Kaynak E, et al. Pre-Treatment Lymphocyte Count Influences ATLG Transplantation Outcomes. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/853. Accessed November 15, 2024.
Nikoloudis, Alexander, Veronika Buxhofer-Ausch, Christoph Aichinger, Michaela Binder, Petra Hasengruber, Emine Kaynak, Dagmar Wipplinger, Robert Milanov, Irene Strassl, Olga Stiefel, et al. "Pre-Treatment Lymphocyte Count Influences ATLG Transplantation Outcomes" Encyclopedia, https://encyclopedia.pub/video/video_detail/853 (accessed November 15, 2024).
Nikoloudis, A., Buxhofer-Ausch, V., Aichinger, C., Binder, M., Hasengruber, P., Kaynak, E., Wipplinger, D., Milanov, R., Strassl, I., Stiefel, O., Machherndl-Spandl, S., Petzer, A., Weltermann, A., & Clausen, J. (2023, August 10). Pre-Treatment Lymphocyte Count Influences ATLG Transplantation Outcomes. In Encyclopedia. https://encyclopedia.pub/video/video_detail/853
Nikoloudis, Alexander, et al. "Pre-Treatment Lymphocyte Count Influences ATLG Transplantation Outcomes." Encyclopedia. Web. 10 August, 2023.
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