Your browser does not fully support modern features. Please upgrade for a smoother experience.
Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery
Academic Video Service
All videos are free for registered users. Please login to proceed.
Sign Up Log In
  • View Times: 27
  • |
  • Update Date: 06 Apr 2023
  • hibernating myocardium
  • diastolic dysfunction
  • mesenchymal stem cell
  • ischemic heart disease
  • cardiac MRI
  • CABG
  • PGC1α
Video Introduction

This video is adapted from 10.3390/ijms24065475

Diastolic dysfunction persists despite coronary artery bypass graft surgery (CABG) in patients with hibernating myocardium (HIB). Researchers studied whether the adjunctive use of a mesenchymal stem cells (MSCs) patch during CABG improves diastolic function by reducing inflammation and fibrosis. HIB was induced in juvenile swine by placing a constrictor on the left anterior descending (LAD) artery, causing myocardial ischemia without infarction. At 12 weeks, CABG was performed using the left-internal-mammary-artery (LIMA)-to-LAD graft with or without placement of an epicardial vicryl patch embedded with MSCs, followed by four weeks of recovery. The animals underwent cardiac magnetic resonance imaging (MRI) prior to sacrifice, and tissue from septal and LAD regions were collected to assess for fibrosis and analyze mitochondrial and nuclear isolates. During low-dose dobutamine infusion, diastolic function was significantly reduced in HIB compared to the control, with significant improvement after CABG + MSC treatment.

Full Transcript
${ textCharacter }/${ maxCharacter }
Submit
Cancel
There is no comment~
${ textCharacter }/${ maxCharacter }
Submit
Cancel
${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
Submit
Cancel
Confirm
Are you sure to Delete?
Yes No
Content is available under the terms and conditions of the Creative Commons Attribution (CC BY) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Aggarwal, R.; Potel, K.N.; Shao, A.; So, S.W.; Swingen, C.; Reyes, C.P.; Rose, R.; Wright, C.; Stone, L.L.H.; Mcfalls, E.O.; et al. Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery. Encyclopedia. Available online: https://encyclopedia.pub/video/video_detail/686 (accessed on 17 January 2026).
Aggarwal R, Potel KN, Shao A, So SW, Swingen C, Reyes CP, et al. Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery. Encyclopedia. Available at: https://encyclopedia.pub/video/video_detail/686. Accessed January 17, 2026.
Aggarwal, Rishav, Koray N. Potel, Annie Shao, Simon W. So, Cory Swingen, Christina P. Reyes, Rebecca Rose, Christin Wright, Laura L. Hocum Stone, Edward O. Mcfalls, et al. "Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery" Encyclopedia, https://encyclopedia.pub/video/video_detail/686 (accessed January 17, 2026).
Aggarwal, R., Potel, K.N., Shao, A., So, S.W., Swingen, C., Reyes, C.P., Rose, R., Wright, C., Stone, L.L.H., Mcfalls, E.O., Butterick, T.A., & Kelly, R.F. (2023, April 06). Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery. In Encyclopedia. https://encyclopedia.pub/video/video_detail/686
Aggarwal, Rishav, et al. "Coronary Artery Bypass Graft Surgery Improves Diastolic Recovery." Encyclopedia. Web. 06 April, 2023.
Academic Video Service
Feedback