Submitted Successfully!
To reward your contribution, here is a gift for you: A free trial for our video production service.
Thank you for your contribution! You can also upload a video entry or images related to this topic.
Version Summary Created by Modification Content Size Created at Operation
1
Peter Tang
 + 320 word(s) 320 2020-12-15 08:14:58

Video Upload Options

Do you have a full video?
Send video materials Upload full video

Confirm

Are you sure to Delete?
Yes No
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Tang, P. ZMYM2 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4662 (accessed on 26 April 2024).
Tang P. ZMYM2 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4662. Accessed April 26, 2024.
Tang, Peter. "ZMYM2 Gene" Encyclopedia, https://encyclopedia.pub/entry/4662 (accessed April 26, 2024).
Tang, P. (2020, December 24). ZMYM2 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4662
Tang, Peter. "ZMYM2 Gene." Encyclopedia. Web. 24 December, 2020.
ZMYM2 Gene
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/zmym2

Zinc finger MYM-type containing 2

genes

1. Normal Function

The ZMYM2 gene (previously known as ZNF198) provides instructions for making a protein whose function is not clearly understood. It is a member of a family of zinc finger proteins, which contain one or more short regions called zinc finger domains. The zinc finger domains in the ZMYM2 protein are thought to allow it to regulate interactions between other proteins. ZMYM2 is found in the nucleus of the cell, where it likely associates with other proteins. Through these associations, the ZMYM2 protein may be involved in repairing DNA errors, controlling gene activity, or forming structures in the nucleus called PML nuclear bodies that block the growth and division of cells and promote their self-destruction (apoptosis).

2. Health Conditions Related to Genetic Changes

2.1. 8p11 myeloproliferative syndrome

A genetic change involving the ZMYM2 gene causes most cases of 8p11 myeloproliferative syndrome. This condition is characterized by an increased number of white blood cells (myeloproliferative disorder) and the development of lymphoma, a blood-related cancer that causes tumor formation in the lymph nodes. The myeloproliferative disorder usually develops into another form of blood cancer called acute myeloid leukemia. 8p11 myeloproliferative syndrome most commonly results from a rearrangement (translocation) of genetic material between chromosome 13 and chromosome 8. This genetic change fuses part of the ZMYM2 gene on chromosome 13 with part of the FGFR1 gene on chromosome 8. The translocation is found only in cancer cells.

The protein produced from the normal FGFR1 gene can turn on cellular signaling that helps the cell respond to its environment, for example by stimulating cell growth. The protein produced from the fused ZMYM2-FGFR1 gene leads to constant FGFR1 signaling. The uncontrolled signaling promotes continuous cell growth and division, leading to cancer.

3. Other Names for This Gene

  • FIM

  • fused in myeloproliferative disorders protein

  • MYM

  • RAMP

  • rearranged in an atypical myeloproliferative disorder

  • SCLL

  • zinc finger MYM-type protein 2

  • zinc finger protein 198

  • zinc finger, MYM-type 2

  • ZMYM2_HUMAN

  • ZNF198

References

  1. Gocke CB, Yu H. ZNF198 stabilizes the LSD1-CoREST-HDAC1 complex on chromatinthrough its MYM-type zinc fingers. PLoS One. 2008 Sep 22;3(9):e3255. doi:10.1371/journal.pone.0003255.
  2. Jackson CC, Medeiros LJ, Miranda RN. 8p11 myeloproliferative syndrome: areview. Hum Pathol. 2010 Apr;41(4):461-76. doi: 10.1016/j.humpath.2009.11.003.Review.
  3. Kunapuli P, Kasyapa CS, Chin SF, Caldas C, Cowell JK. ZNF198, a zinc fingerprotein rearranged in myeloproliferative disease, localizes to the PML nuclearbodies and interacts with SUMO-1 and PML. Exp Cell Res. 2006 Nov15;312(19):3739-51.
  4. Kunapuli P, Somerville R, Still IH, Cowell JK. ZNF198 protein, involved inrearrangement in myeloproliferative disease, forms complexes with the DNArepair-associated HHR6A/6B and RAD18 proteins. Oncogene. 2003 May29;22(22):3417-23.
  5. Xiao S, McCarthy JG, Aster JC, Fletcher JA. ZNF198-FGFR1 transforming activitydepends on a novel proline-rich ZNF198 oligomerization domain. Blood. 2000 Jul15;96(2):699-704.
  6. Xiao S, Nalabolu SR, Aster JC, Ma J, Abruzzo L, Jaffe ES, Stone R, WeissmanSM, Hudson TJ, Fletcher JA. FGFR1 is fused with a novel zinc-finger gene, ZNF198,in the t(8;13) leukaemia/lymphoma syndrome. Nat Genet. 1998 Jan;18(1):84-7.
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Peter Tang
View Times: 593
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
Table of Contents
    1000/1000
    Hot Most Recent
    Feedback