Chromosome 10

Version	Summary	Created by	Modification	Content Size	Created at	Operation
1		Peter Tang	+ 598 word(s)	598	2020-12-15 08:15:01

This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/chromosome/10

Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Two copies of chromosome 10, one copy inherited from each parent, form one of the pairs.

chromosomes & mtDNA

1. Introduction

Chromosome 10 spans more than 133 million DNA building blocks (base pairs) and represents between 4 and 4.5 percent of the total DNA in cells.

Identifying genes on each chromosome is an active area of genetic research. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Chromosome 10 likely contains 700 to 800 genes that provide instructions for making proteins. These proteins perform a variety of different roles in the body.

2. Health Conditions Related to Chromosomal Changes

2.1. 10q26 deletion syndrome

10q26 deletion syndrome is a condition that results from the loss (deletion) of a small piece of chromosome 10 in each cell. The deletion occurs on the long (q) arm of the chromosome at a position designated 10q26.

The signs and symptoms of 10q26 deletion syndrome vary widely, even among affected members of the same family. Affected individuals may have distinctive facial features, growth problems, mild to moderate intellectual disability, developmental delay, genital abnormalities in males, or skeletal or heart defects.

People with 10q26 deletion syndrome are missing between 3.5 million and 17 million DNA building blocks (base pairs), also written as 3.5 and 17 megabases (Mb), at position q26 on chromosome 10. The exact size of the deletion varies, and it is unclear what exact region needs to be deleted to cause the condition. In many affected individuals, the 10q26 deletions include the tip of the q arm of chromosome 10; however, some smaller deletions occur within the arm of the chromosome.

The signs and symptoms of 10q26 deletion syndrome are probably related to the loss of one or more genes in the deleted region. However, it is unclear which missing genes contribute to the specific features of the disorder.

2.2. Cancers

Changes in the number and structure of chromosome 10 are associated with several types of cancer. For example, a loss of all or part of chromosome 10 is often found in brain tumors called gliomas, particularly in aggressive, fast-growing gliomas. The association of cancerous tumors with a loss of chromosome 10 suggests that some genes on this chromosome play critical roles in controlling the growth and division of cells. Without these genes, cells could grow and divide too quickly or in an uncontrolled way, resulting in cancer. Researchers are working to identify the specific genes on chromosome 10 that may be involved in the development and progression of gliomas.

A complex rearrangement (translocation) of genetic material between chromosomes 10 and 11 is associated with several types of blood cancer known as leukemias. This chromosomal abnormality is found only in cancer cells. It fuses part of a specific gene from chromosome 11 (the KMT2A gene) with part of another gene from chromosome 10 (the MLLT10 gene). The abnormal protein produced from this fused gene signals cells to divide without control or order, leading to the development of cancer.

2.3. Other chromosomal conditions

Other changes in the number or structure of chromosome 10 can have a variety of effects. Intellectual disability, delayed growth and development, distinctive facial features, and heart defects are common features. Changes to chromosome 10 include an extra piece of the chromosome in each cell (partial trisomy), a missing segment of the chromosome in each cell (partial monosomy), and an abnormal structure called a ring chromosome 10. Ring chromosomes occur when a chromosome breaks in two places and the ends of the chromosome arms fuse together to form a circular structure. Translocations or inversions (breakage of a chromosome in two places) can also lead to extra or missing material from chromosome 10.

References

Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, SimsSK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG,Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP,Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K,Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J,Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, FranklandJA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E,Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, KokkinakiM, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM,Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M,Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, PearceAV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT,Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N,Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J,Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J. The DNA sequence andcomparative analysis of human chromosome 10. Nature. 2004 May27;429(6990):375-81.
Deloukas P, French L, Meitinger T, Moschonas NK. Report of the thirdinternational workshop on human chromosome 10 mapping and sequencing 1999.Cytogenet Cell Genet. 2000;90(1-2):1-12.
Ensembl Human Map View: Chromosome 10
Gilbert F. Chromosome 10. Genet Test. 2001 Spring;5(1):69-82.
Lin S, Zhou Y, Fang Q, Wu J, Zhang Z, Ji Y, Luo Y. Chromosome 10q26 deletionsyndrome: Two new cases and a review of the literature. Mol Med Rep. 2016Dec;14(6):5134-5140. doi: 10.3892/mmr.2016.5864.
Meyer C, Schneider B, Jakob S, Strehl S, Attarbaschi A, Schnittger S, SchochC, Jansen MW, van Dongen JJ, den Boer ML, Pieters R, Ennas MG, Angelucci E, KoehlU, Greil J, Griesinger F, Zur Stadt U, Eckert C, Szczepański T, Niggli FK,Schäfer BW, Kempski H, Brady HJ, Zuna J, Trka J, Nigro LL, Biondi A, Delabesse E,Macintyre E, Stanulla M, Schrappe M, Haas OA, Burmeister T, Dingermann T,Klingebiel T, Marschalek R. The MLL recombinome of acute leukemias. Leukemia.2006 May;20(5):777-84.
Ohgaki H, Kleihues P. Genetic pathways to primary and secondary glioblastoma. Am J Pathol. 2007 May;170(5):1445-53. Review.
Rasheed BK, Wiltshire RN, Bigner SH, Bigner DD. Molecular pathogenesis ofmalignant gliomas. Curr Opin Oncol. 1999 May;11(3):162-7. Review.
Scigliano S, Grégoire MJ, Schmitt M, Jonveaux PH, LeHeup B. Terminal deletion of the long arm of chromosome 10. Clin Genet. 2004 Apr;65(4):294-8. Review.
UCSC Genome Browser: Statistics
Van Limbergen H, Poppe B, Janssens A, De Bock R, De Paepe A, Noens L, SpelemanF. Molecular cytogenetic analysis of 10;11 rearrangements in acute myeloidleukemia. Leukemia. 2002 Mar;16(3):344-51. Review.
Vera-Carbonell A, López-González V, Bafalliu JA, Ballesta-Martínez MJ,Fernández A, Guillén-Navarro E, López-Expósito I. Clinical comparison of 10q26overlapping deletions: delineating the critical region for urogenital anomalies. Am J Med Genet A. 2015 Apr;167A(4):786-90. doi: 10.1002/ajmg.a.36949.

©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.

Upload a video for this entry

Information

Subjects: Genetics & Heredity

Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :

Peter Tang

View Times: 351

Entry Collection: MedlinePlus

Update Date: 24 Dec 2020

Table of Contents

Video Upload Options

Confirm