Summary

On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Caused by SARS-CoV-2, COVID-19 continues nearly 18 months later to present significant challenges to health systems and public health in both hemispheres, as well as the economies of every country. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed many hospitals and clinics and continue to do so in many countries. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This entry collection aims to gather diverse fields about COVID-19, including in epidemiology, public health, medicine, genetics, systems biology, informatics, data science, engineering, sociology, anthropology, nursing, environmental studies, statistics, and psychology.

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Entries
Topic Review
Infectious Diseases Associated with and Causing Disaster
In 2019, 396 natural disasters were recorded in the Emergency Events Database (EM-DAT), with 11,755 deaths, 95 million people affected, and USD 103 billion in economic losses worldwide. This burden was not shared equally since Asia suffered the highest impact, accounting for 40% of disaster events, 45% of deaths and 74% of the total affected. During disasters, a lack of safe water access and inadequate sanitation facilities allow the transmission of water-borne and food-borne pathogens. Diarrheal diseases such as cholera, typhoid fever, and shigellosis cause epidemics with high mortality rates. Malaria and other vector-borne diseases in risk areas include arboviruses, such as dengue, yellow fever, Japanese encephalitis, Rift Valley fever, and tick-borne illnesses, including Crimean–Congo hemorrhagic fever and typhus. Diseases associated with overcrowding, such as measles in unvaccinated areas and tuberculosis, can occur after natural disasters.
  • 1.9K
  • 09 Mar 2022
Topic Review
Psychological Effects of Digital Companies’ Employees during COVID-19
The ways people use words online can furnish psychological processes about their beliefs, fears, thinking patterns, and so on. Extracting from online employees’ reviews on the workplace community websites, the psychological effects of employees during the phase of the COVID-19 pandemic can be quantified. Affected by the pandemic after 2020, although the overall evaluation of digital companies employees was tending to be better, were work–life balance, culture and values, senior management, career opportunities, and salary and benefits, which were still getting worse. 
  • 1.2K
  • 07 Mar 2022
Topic Review
Ensuring Sustainability during a Crisis Using Flexible Methodologies
The COVID-19 pandemic forced national governments and administrations to seek flexible solutions to deal with the emergency. Thus, it is necessary to design a model of a flexible methodology based on detailed flexible methodologies to make decisions and measures connected to COVID-19 pandemic to be effectively applied without the loss of meaning and within a short time. As a result, an expandable set of relevant methodologies for crisis management and flexible methodologies was identified, modeled, and formalized using a broad literature review and an innovative model of a flexible methodology for crisis management was created in accordance with standardized concepts, transforming them into secondary use models.
  • 1.1K
  • 07 Mar 2022
Topic Review
Adrenomedullin and COVID-19
The COVID-19 pandemic is still in progress, and a significant number of patients have presented with severe illness. Recently introduced vaccines, antiviral medicines, and antibody formulations can suppress COVID-19 symptoms and decrease the number of patients exhibiting severe disease. However, complete avoidance of severe COVID-19 has not been achieved and there are insufficient methods to treat it. Adrenomedullin (AM) is an endogenous peptide that maintains vascular tone and endothelial barrier function. The AM plasma level is markedly increased during severe inflammatory disorders, such as sepsis, pneumonia, and COVID-19, and associated with its prognosis. Exogenous AM administration reduced inflammation and related organ damage in rodent models. The results strongly suggest that AM could be an alternative therapy for COVID-19. Researchers are currently conducting an investigator-initiated phase 2a trial for moderate to severe COVID-19 using AM.
  • 1.1K
  • 07 Mar 2022
Topic Review
Predictors of COVID-19 Vaccine Hesitancy
Modifiable predictors of vaccine hesitancy at the start of South Africa’s COVID-19 vaccination rollout have been identified here. These factors should be addressed by different stakeholders involved in the national immunization program through tailored communication and other effective strategies that increase vaccine literacy, reach low-income households, and engender confidence in government. 
  • 907
  • 04 Mar 2022
Topic Review
The Role of Immunity in Combating SARS-CoV-2
The coronavirus disease 2019 (COVID-19) is an epidemic caused by SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2). Populations at risk as well as those who can develop serious complications are people with chronic diseases such as diabetes, hypertension, and the elderly. Severe symptoms of SARS-CoV-2 infection are associated with immune failure and dysfunction. The approach of strengthening immunity may be the right choice in order to save lives.
  • 774
  • 03 Mar 2022
Topic Review
Omicron vs. Delta Variant
Coronavirus disease 2019 (COVID-19) first emerged in Wuhan city in December 2019, and became a grave global concern due to its highly infectious nature. The Severe Acute Respiratory Coronavirus-2, with its predecessors (i.e., MERS-CoV and SARS-CoV) belong to the family of Coronaviridae. Reportedly, COVID-19 has infected 344,710,576 people around the globe and killed nearly 5,598,511 persons in the short span of two years. On November 24, 2021, B.1.1.529 strain, later named Omicron, was classified as a Variant of Concern (VOC). SARS-CoV-2 has continuously undergone a series of unprecedented mutations and evolved to exhibit varying characteristics.
  • 1.2K
  • 04 Mar 2022
Topic Review
The Corona Dashboard in Context (‘Dutchboard’)
The core corona dashboard depicts quantitative data—systemically decomposed—on key facts of the space and time spread of COVID-19 cases. There are three context-specific factors that determine the trajectory of the spread of the corona virus: (i) the degree of vaccination intensity in a given country; (ii) the policy stringency in coping with the virus; (iii) the degree of intensity of social contacts. 
  • 996
  • 04 Mar 2022
Topic Review
Motor and Cognitive Functions with Home-Confinement COVID-19
Distancing and confinement at home during the Coronavirus Disease 2019 (COVID-19) outbreak has led to worsening of motor and cognitive functions, both for healthy adults and for patients with neurodegenerative diseases. The decrease in physical activity, the cessation of the intervention of the recovery and the social distance imposed by the lockdown, has had a negative impact on the physical and mental health, quality of life, daily activities, as well as on the behavioral attitudes of the diet.
  • 691
  • 28 Feb 2022
Topic Review
Antivirals on the Cardiovascular Conditions
The COVID-19 pandemic has resulted in a complex clinical challenge, caused by a novel coronavirus, partially similar to previously known coronaviruses but with a different pattern of contagiousness, complications, and mortality. Safety profiles of antivirals are largely questioned and addressed by health agencies, in consideration of COVID-19 cardiac and pro-thrombotic complications generally experienced by predisposed subjects.
  • 1.1K
  • 25 Feb 2022
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