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Topic Review
Delusional Disorder
The Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) defines delusional disorder (DD) as the presence of one or more delusions, lasting for at least one month or longer, in the absence of affective symptoms, prominent hallucinations or other symptoms of schizophrenia. The prevalence of DD is estimated to be approximately 0.2%. Subtypes of DD have been categorized according to the content of the primary delusion: persecutory, jealous, erotomanic, somatic, grandiose, mixed and unspecified.
  • 675
  • 08 Dec 2020
Topic Review
Physician Burnout in COVID-19 Period
The main aim of this study was to analyse and summarise the current knowledge on factors/potential factors contributing to burnout amongst healthcare professionals amidst the pandemic . This study also makes a few recommendations on how best to prepare intervention programmes for physicians. Results from our systematic review generally showed that the introduction of COVID-19 has heightened existing challenges that physicians face such as increasing workload, which is directly correlated with increased burnout. However, exposure to COVID-19 does not necessarily correlate with increased burnout and is an area for more research. There is some evidence showing that techniques such as mindfulness may help relieve burnout. However, given the small number of studies focusing on physician burnout amidst a pandemic, conclusions should be taken with caution. More studies are needed to support these findings.
  • 652
  • 09 Nov 2020
Topic Review
COVID-19 Pandemic for People with Pre-Existing Psychiatric Disorders
It seems that the impact of the first stage of the COVID-19 pandemic on psychiatric disorders was two-fold: (1) an overall effect, in which people suffering from psychiatric disorders in general experienced more psychological distress and anxiety when compared to people who had no psychiatric diagnosis, and (2) a condition-specific effect, namely in people suffering from eating disorders and obsessive compulsive disorders. Moreover, the current work highlights that there were also some external factors that were related to worsening symptoms. For instance, unemployment or experiencing work and financial difficulties can be a trigger for greater distress during the pandemic for people with mood disorders, and being alone and in social isolation during the COVID-19 pandemic may actually increase substance use and relapse rates. Further studies are needed to prospectively investigate the long-term effects of the current COVID-19 pandemic on people with (pre)-existing psychiatric conditions and on the onset or deterioration of psychiatric-related symptoms in a larger number of participants, as well as exploring the long-term effects of the current pandemic on mental health. 
  • 649
  • 29 Apr 2022
Topic Review
Psychological First Aid
Psychological First Aid (PFA) focuses on providing humane, supportive, and practical help to individuals who are suffering and in need of support in the immediate aftermath of a disaster [20]. The three main principles of PFA are to look (for safety, for who needs help), listen (to the person in distress) and link (to further support) [20,24].
  • 642
  • 26 Feb 2021
Topic Review
Mental Health Disturbances
The presence of mental health problems in the population of medical students in Italy has been evaluated in several cross-sectional studies, which have used different methodologies and study designs. However, a global overview of the prevalence of mental health problems in Italian medical students is not available, although this would be essential for promoting preventive strategies and supportive treatments.
  • 634
  • 05 Jan 2021
Topic Review
Trauma in Rapes and Assaults
This entry describes that psychological trauma in rapes and assaults is a serious public health issue. 
  • 616
  • 14 Dec 2021
Topic Review
Chromatin Remodeler CHD8
Chromodomain Helicase DNA-binding 8 (CHD8) is a high confidence risk factor for autism spectrum disorders (ASDs) and the genetic cause of a distinct neurodevelopmental syndrome with the core symptoms of autism, macrocephaly, and facial dysmorphism. The role of CHD8 is well-characterized at the structural, biochemical, and transcriptional level. By contrast, much less is understood regarding how mutations in CHD8 underpin altered brain function and mental disease. Studies on various model organisms have been proven critical to tackle this challenge.
  • 615
  • 12 Feb 2021
Topic Review
Higher Blood Pressure & Neurodegeneration
High Blood Pressure (Hypertension) is a major risk factor for cerebral health. Midlife hypertension is associated with a two- to five-fold increased risk of stroke, and up to 50% greater risk of developing vascular dementia. Moreover, hypertension is also linked to the development of amyloid angiopathy, the progression of white matter lesions (WMLs), and neurodegeneration. This recent meta-analysis demonstrates that higher blood pressure, even within the normal range, is associated with a reduction in global and regional brain volumes.
  • 601
  • 06 Mar 2021
Topic Review
Late Life Depression and Dementia
The number of people living with dementia and Alzheimer’s disease is growing rapidly, making dementia one of the biggest challenges for this century. Many studies have indicated that depression plays an important role in development of dementia, including Alzheimer’s disease; depression, especially, during the late life may either increase the risk of dementia or even being its prodromal stage. Despite a notably large number of carried observational studies and/or clinical trials, the association between the late life depression and dementia remains, due to the complexity of their relationship, still unclear. Moreover, during past two decades multiple other (non-)modifiable risk and possibly protective factors such as the hypertension, social engagement, obesity, level of education or physical (in)activity have been identified and their relationship with the risk for development of dementia and Alzheimer’s disease has been extensively studied. It has been proposedthat to understand mechanisms of dementia and Alzheimer’s disease pathogeneses require their multifactorial nature represented by these multiple factors to be considered. In this work, we summarize the recent literature findings on roles of the late life depression and the other known (non-)modifiable risk and possibly protective factors in development of dementia and Alzheimer’s disease. Then, we provide evidences supporting hypotheses that (i) depressive syndromes in latelife may indicate the prodromal stage of dementia (Alzheimer’s disease) and, (ii) the interplay among the multiple (non-)modifiable risk and protective factors should be considered to gain a better understanding of dementia and Alzheimer’s disease pathogeneses. We also discuss the evidences of recently established interventions considered to prevent or delay the prodromes of dementia and provide the prospective future directions in prevention and treatment of dementia and Alzheimer’s disease using both the single-domain and multidomain interventions.
  • 553
  • 05 Feb 2021
Topic Review
Depressive and Alcohol Use Disorders
Depressive disorders and alcohol use disorders are widespread among the general population and are significant public health and economic burdens. Alcohol use disorders often co-occur with other psychiatric conditions and this dual diagnosis is called comorbidity. Depressive disorders invariably contribute to the development and worsening of alcohol use disorders, and vice versa. The mechanisms underlying these disorders and their comorbidities remain unclear. Recently, interest in the lateral habenula, a small epithalamic brain structure, has increased because it becomes hyperactive in depression and alcohol use disorders, and can inhibit dopamine and serotonin neurons in the midbrain reward center, the hypofunction of which is believed to be a critical contributor to the etiology of depressive disorders and alcohol use disorders as well as their comorbidities. Additionally, calcium/calmodulin-dependent protein kinase II (CaMKII) in the lateral habenula has emerged as a critical player in the etiology of these comorbidities.
  • 545
  • 03 Dec 2020
Topic Review
Lifetrack Therapy
Lifetrack Therapy, founded by the Japanese Keio educated and Harvard trained psychiatrist Dr. Yukio Ishizuka, is a new personality model and therapy based on universal spheres of psychological health. Ishizuka's willingness to learn from his patients, as well as his exposure to the East, He draws from the principles of both Zen Buddhism and quantum mechanics in his method of treatment. Ishizuka developed Lifetrack therapy, an approach and methodology to help his patients experience psychological health.
  • 450
  • 25 Oct 2022
Topic Review
Suicide Behaviors
Suicides and suicidal behaviors are very important causes of mortality and morbidity and have become a serious global problem. More than 800,000 people die from suicide every year. Previous researches have established that lipids play an important role in the pathogenesis of suicide.
  • 433
  • 24 Feb 2021
Topic Review
Hyperactivity and Impulsivity in Children with ADHD
Treatment of the ADHD types (hyperactive-impulsive, inattentive, and combined) in children has rarely been studied separately, although their prognostic courses differ widely. In addition, data show that improvements in hyperactivity/impulsivity are hard to achieve.
  • 369
  • 11 Oct 2023
Topic Review
Mechanisms of Epigenetic Inheritance in Post-Traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a psychiatric disorder that causes debilitating functional impairment in patients. Observations from survivors of traumatic historical events solidify that this disease is not only associated with personal experiences but can also be inherited from familial traumas. Over the past decades, researchers have focused on epigenetic inheritance to understand how responses to adverse experiences can be passed down to future generations.
  • 363
  • 30 Jan 2024
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