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Topic Review
The Psychological Impact of Living with End-Stage Disease
End-Stage Renal Disease (ESRD) represents the final stage of chronic kidney disease, where the kidneys can no longer function adequately to meet the body's needs. At this point, individuals require either dialysis or a kidney transplant to survive. While ESRD has significant physical health implications, its psychological impact can be just as profound, affecting emotional well-being, mental health, and quality of life. The challenges faced by individuals with ESRD go beyond managing their physical symptoms—they must also cope with the mental and emotional burdens that accompany living with a life-threatening, chronic illness. In this article, we explore the psychological effects of living with ESRD, including anxiety, depression, and cognitive difficulties, and discuss strategies to address these issues and improve mental health outcomes for patients.
  • 269
  • 06 May 2025
Topic Review
Translation in Proteinogenesis Based on Genetic Code Symmetry
The genetic code symmetry is additional proofreading mechanism to prevent tRNA misreading in process of proteinogenesis. tRNA is a bridging molecule which leads to the identification of enzymes responsible for establishing a link between the nucleotides of mRNA and aminoacyl-tRNA synthetases (aaRSs).
  • 260
  • 04 Feb 2025
Topic Review
Gene Regulation in the Context of Male Infertility
This study investigates the regulatory features of 26 genes linked to nonsyndromic male infertility using computational analysis. Researchers identified the number and placement of gene promoters, finding that most genes have between 1 and 6 promoters, primarily within 1 kb upstream of the transcription start site. Notably, 41% of promoters are located more than 500 bp upstream. While a common TATA box sequence is found across all genes, it is unusually positioned in the EFCAB9 gene. The C2H2 zinc finger transcription factor appears most frequently across gene promoters, while the bZIP family shows specific binding to the JUNB promoter. Additionally, two genes, NANOS1 and ZMYND15, may be less affected by DNA methylation due to high CpG content in their promoters.
  • 129
  • 24 Jun 2025
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