Nipah Virus Disease: History
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Luigi Bruno
,
Maria Anna Nappo
,
Luca Ferrari
,
Rosanna Di Lecce
,
Chiara Guarnieri
,
Anna Maria Cantoni
,
Attilio Corradi

Nipah virus (NiV) infection is a viral disease caused by a Henipavirus, belonging to the Paramyxoviridae family, responsible for a zoonosis. The course of the disease can be very serious and lead to death. NiV natural hosts are fruit bats (also known as megabats) belonging to the Pteropodidae family, especially those of the Pteropus genus. Natural infection in domestic animals has been described in farming pigs, horses, domestic and feral dogs and cats. Natural NiV transmission is possible intra-species (pig-to-pig, human-to-human) and inter-species (flying bat-to-human, pig-to-human, horse-to-human).

  • Nipah virus
  • pathology
  • vaccines
  • epidemiology
  • diagnostics
  • legislation
  • pathogenesis
  • immune response
  • geographic information system
  • spillover events

1. Introduction

Nipah virus (NiV) infection is a viral disease caused by a virus belonging to the Henipavirus genus, in the Paramyxoviridae family, responsible for a zoonosis whose main clinical manifestations in humans are respiratory and neurological. It can be defined as an emerging zoonosis. Zoonotic pathogens account for 60% of emerging infectious diseases, of which about 70% originate from wildlife [1]. The novel RNA paramyxovirus (genus Henipavirus), closely related to the Hendra virus, was named after the outbreak in the village of Sungai Nipah in the State of Negeri Sembilan (close to the Federal Territory of Kuala Lumpur), Malaysia, in which the virus was first isolated from a human patient in 1998 [2]. The course of the disease can be very serious and lead to death. The disease is also widely described in pigs, with clinical signs involving the respiratory and nervous systems [3]. The natural reservoir of the virus is represented by frugivorous bats called “flying foxes” belonging to the Pteropus genus. The main outbreaks of NiV infection have so far occurred in the geographical area of the carrier bats, i.e., in Malaysia, Singapore, Bangladesh and India, but cases were also described in the Philippines. The emergence of the virus and the zoonotic potential of transmission to animals and humans seem to be related to losses in the bats’ habitat [4]. The modes of transmission are different: Pteropus-swine-man, human contagion through the consumption of contaminated food, and inter-human contagion; direct bat-human contagion is also hypothesized. When outbreaks occur in pigs, the only possible measures are isolation, blocking of movements and killing of infected animals [5][6]. A definitive diagnosis can be performed by using molecular techniques, but serological tests are also available. NiV infection is an emerging and potentially dangerous disease whose spread must be curbed; currently, the main strategy is prevention via limiting contacts with reservoir species, using proper pig farming practices and improving the hygiene and feeding habits of some populations living in areas where the disease occurs [5]. Nowadays, drugs and vaccines and/or vaccine candidates in various species are scarcely employed or under investigation, therefore further studies are necessary to improve the knowledge about the interaction between NiV and the immune response, apply prevention methods, and develop effective prophylactic and curative therapies. In particular, due to the high risk in manipulating the virus itself in challenge animal studies, several experimental vaccines based on the main NiV immunogenic proteins or peptides have been developed mainly to investigate their immunogenicity, that is their ability to elicit a neutralizing antibody response potentially able to rapidly counteract the infection and induce a cell-mediated response to mediate viral clearance [7][8][9]. However, some experimental vaccines also elicited a response to varying degrees of clinical protection in model animals [3][10][11][12][13].
Furthermore, a better understanding of the spatial habitat preferences and diffusion of reservoir bats would be a useful contribution to their conservation and would help better prevent potential disease transmission [4]. Remote sensing (RS) and geographic information system (GIS) technologies have proven to be useful tools in investigating animal distribution in relation to environment/human settlements and diseases in wildlife [14][15], including the characteristics of the flying fox colonies potentially carrying NiV and their neighborhoods [4][16].
However, climate change, bringing an extreme increase in air temperature in tropical monsoon areas, has an adverse effect on the adaptive capacity of flying foxes to new environmental conditions, especially in relation to demography and species survival and thus NiV diffusion [17][18][19].
In Europe, the relative legislation refers to the generic management of communicable diseases, and specifically to the articles listed in the Regulation 2016/429 [20] about emerging diseases. In Malaysia, following the NiV outbreaks in pigs, a series of provisions aimed at containing the spread of the infection were planned, such as the strict isolation of the potential disease transmitters, the prohibition of the pig and meat trade, the establishment of an infected area and a protection area around the outbreaks, and the killing of infected pigs [2][21]. In India, following the recent cases in humans, the Indian National Centre for Disease Control (NCDC) established guidelines for the definition of suspected, probable and confirmed cases of NiV infection in order to detect and control the outbreaks early and subsequently regulate several public health activities aimed at containing the spread of the infection [3][22].
Therefore, a “One Health” approach, considering humans, domestic and peridomestic animals as well as the environment, is required to effectively control the disease.

2. Biological Features of the Nipah Virus (NiV)

NiV is a virus belonging to the Henipavirus genus, in the Paramyxoviridae family and Orthoparamyxovirinae subfamily [23][24]. The only other member of the genus endowed with pathogenicity and zoonotic potential is the Hendravirus (HeV) [25][26][27] identified in the 1990s following the death of several people after contact with infected equines in Australia [28]. At present, reports of spillover phenomena of the Henipavirus disease in humans are limited to Southeast Asia, although the widening of surveillance has allowed to identify these viruses in chiroptera sera in sub-Saharan Africa and Brazil [29][30][31][32][33][34]. Furthermore, in a recent study on sera from humans and bats in Cameroon, about 3–4% of human samples were found to be seropositive. Particularly, they were individuals who were involved in the butchering of bat meat [35]. Antibodies produced against NiV also cross-react with the HeV but not with other members of this family [36]. One of the most important biological characteristics of henipaviruses is the broad host spectrum both in vivo and in vitro [37]. Bats can be the main reservoir for some henipaviruses, which can cause a spontaneous disease in humans, pigs, horses, dogs and cats.
Paramyxoviruses are enveloped pleomorphic viruses with an unsegmented single-stranded negative-sense RNA genome, encoding six structural and three accessory proteins [24][38][39]. These include the genome codes for nucleoprotein (N), phosphoprotein (P), matrix protein (M), fusion protein (F), adhesion glycoprotein (G) and for large protein (L) or RNA polymerase in the order 3′-N-P-M-F-G-L-5′ [40][41][42]. The genome of some viruses of the Paramyxoviridae family codes for cell attachment proteins which can exert hemagglutination (H) and neuraminidase (N) functions. Specifically, the NiV G protein is involved in the adsorption phase but does not display H functions. In addition, the P gene also provides the three non-structural proteins V, W and C by means of mRNA editing mechanisms and alternative open reading frames (ORF) (Figure 1) [5][43].
Animals 13 00159 g001
Figure 1. Schematic representation of the NiV structure and viral genome organization. N, P and L proteins interact with the unsegmented single-stranded negative-sense viral RNA genome forming the ribonucleoprotein (RNP) complex. The matrix M protein, used for viral assembly and budding, is associated with the inner side of the envelope which contains the G and F glycoproteins for adhesion to ephrin-B2 and -B3 receptors and fusion, respectively. The P gene products (V, W and C proteins) derive from mRNA editing and alternative open reading frames (ORF). The six coded genes are flanked by a 3′ leader and a 5′ trailer region.
Non-structural proteins play a crucial role in virulence by indirectly inhibiting the action of immune interferons [44][45]. The virus is classified as a BSL-4 (biosafety level-4) pathogen, due to its high pathogenicity and the absence of effective treatments or vaccines [46][47][48].
The exact length of the NiV genomic sequence is described in multiple isolations [44][45][49]. The complete viral genome consists of approximately 18 kilobases (kb) [39][50] and, like the HeV genome, is significantly longer than that of other members of Paramyxoviridae (about 155 kb on average) [51].
The P gene of HeV and NiV contains an mRNA editing site that is identical to that of the measles virus [44]. A single G insertion allows the expression of the V protein, while two G insertions allow the expression of a protein comparable with the Sendai virus W protein [44][52][53][54].
Both NiV and HeV do not show hemagglutinin and neuraminidase activities, which are a common feature of many paramyxoviruses. Furthermore, they share a broad host spectrum unlike that of the other viruses of the family they belong to [43][55].
Several variants have been observed in human NiVs sampled from various outbreaks in Malaysia, India and Bangladesh. Similarly, NiVs isolated from chiroptera samples collected in different geographic areas revealed different genomic variations [45][56][57].
The interaction of paramyxoviruses with target cells is mediated via adsorption using the G, H or HN proteins and the transmembrane fusion F protein. Specifically, NiV uses glycoprotein G, which exploits the ephrin-B2 or, to a lesser extent, ephrin-B3 receptors [58][59][60]. The ephrin-B2 receptors are mainly expressed in endothelium, smooth muscle and the brain, followed by the lungs, placenta and prostate [61]. The distribution of these receptors explains the clinical-pathological characteristics observed during the clinical signs of the disease.
The ephrin-B2 and -B3 receptors play a fundamental role in the migration of neuron precursors during embryogenesis [62] and for this reason they are highly conserved in the different classes of animals, sharing about 96% homology with proteins [63].
NiV can survive up to 3 days in some fruit juices or mangoes and at least 7 days in date sap kept at 22 °C. The virus resists for approximately 18 h in the urine of reservoir bats. The pathogen is relatively stable in the environment and remains viable at 70 °C for 1 h and is completely inactivated by heat at 100 °C for longer than 15 min [46][47]. NiV is inactivated by common disinfectants such as sodium hypochlorite [64].

3. Host Range

Natural hosts of NiV are fruit bats (also known as megabats) belonging to the Pteropodidae family, especially those of the Pteropus genus. Flying foxes are the fruit bats mostly involved in NiV spread, with direct shedding to receptive animals, human beings included, or through NiV-contaminated palm fruits (or palm sap) or biological bat matrixes (e.g., urine, faeces). Megabats represent NiV reservoirs in endemic geographical areas of Southeast Asia and sub-Saharan Africa.
Natural infection in domestic animals has been described in farming pigs, horses, and domestic and feral cats. Natural NiV transmission can be intra-specific (pig-to-pig, human-to-human) and inter-specific (flying bat-to-human; pig-to-human and horse-to-human). Ruminants are spillover hosts in which NiV infection in the ovi-caprine is ascertained, while bovine is a species considered as NiV-permissive. Dogs are also susceptible to NiV infection, but dogs and cats do not seem to play a zoonotic role [65]. A study on NiV infection in peridomestic and feral cats in the Tioman island (Malaysia) pointed out that natural NiV infection is rare in cats and the zoonotic risk is classified as low [66].
To date, no data are available on the susceptibility and infection of wildlife, except for the different members of the Pteropodidae bat family. It is reported by the members of the World Organization for Animal Health (WOAH), through the voluntary annual report, that NiV infection is a non-WOAH-listed disease in wildlife [67][68].
During a Malaysian NiV outbreak, indirect evidence of non-susceptibility to NiV infection was observed in rodents and birds living in the outbreak area, proven using NiV-seronegative blood immunoglobulin testing [69].
In experimental infection animal models, a permissive NiV transmission was recognized in ferrets, guinea pigs, golden hamsters and mice, as well as in non-human primates (e.g., squirrel monkeys and African green monkeys) [70].
NiV zoonotic infection, flying fox-to-human, is possible via the inhalation of aerosol NiV virions or ingestion of NiV-contaminated palm fruits or palm sap. NiV-contaminated palm fruits are also a cause of infection in pigs and horses fed with or upon accidental food ingestion of contaminated fruit or palm sap. NiV zoonotic transmission, pig-to-human, is well recognized in pig farms and pig slaughterhouse workers, respectively during piglet and pork handling. A zoonotic NiV outbreak in the Philippines was associated with handling horse meat or horse NiV-contaminated biological fluids at slaughterhouses. Human consumers were infected by ingestion of undercooked horse NiV-contaminated meat, but also human-to-human transmission was identified [3][71].

4. Climate and Anthropogenic Influence on Pteropus Bats and NiV Spillover Events

Habitat loss is the greatest threat to wildlife and biodiversity. The loss and fragmentation of wildlife habitats can lead to increased contact among wildlife, domestic animals and humans, potentially leading to the emergence and spread of zoonotic diseases.
Useful tools to understand spatial patterns and relationships among different variables, even apparently unrelated, are geographic information system (GIS) and remote sensing (RS) technologies. These geospatial technologies have been applied to gather information describing phenomena also in the veterinary field, such as the distribution of pathogen outbreaks and diseases in wildlife related to human behaviors and settlements as well as environmental factors and changes in climate in order to monitor and predict future pathogen spread and potential zoonotic outbreaks. These technologies help different categories of professionals and institutions to implement better management policies in a “One Health” perspective [4][14][15][16][72][73].
A better understanding of the Pteropus flying fox habitat preferences and diffusion would be a useful contribution to its conservation and would help better prevent potential disease transmission. In this regard, a study focused on the spatial characterization of colonies of flying foxes in Thailand using field observations, RS and GIS, showed that flying fox colonies are found particularly in locations surrounded by water, vegetation and controlled/protected religious areas. This aimed at mapping potential contact zones for bats, pigs and humans. High-risk areas for NiV zoonosis in pigs were proven to include the agricultural area around Bangkok where pig farms are numerous [4].
A recent GIS-based study on NiV-carrying bats in India and Bangladesh investigated the likely change in the distribution of Pteropus medius (based on data from 2015 onwards) under different future socioeconomic and environmental scenarios and the concurrent risk increase in NiV spillover events. It was predicted that the risk of NiV spillover events in India and Bangladesh will likely increase due to population growth and persistent environmental degradation. The adoption of rigorous public health measures in the areas predicted to be at major risk of NiV spillover from Pteropus medius to humans could reduce potential future spillovers and control future outbreaks [16].
Climate and anthropogenic changes can have important roles in the spread of viral infections to animals and humans [74]. Regarding NiV infection, it is thought that the emergence of the virus and the zoonotic transmission to susceptible animals and humans is related to losses in the reservoir bat’s habit.
Fruit bats Pteropus populate the climate area of tropical monsoons, category Am, of the Köppen climate classification [75]. The tropical monsoon has a characteristic yearly constant temperature of 18 °C, as a minimum climate degree, and high rainfall. Tropical monsoon climate areas favor the maintenance of the tropical forest including fruit bats’ feed reserve and bats play a role (i.e., pollinators and seed dispersers) in maintaining vital tropical forest eco-systems [19][76].
Bats manage a wide range of body thermal regulation as homeotherms or poikilotherms. Flying fox bats are able to control body temperatures adapting to environment temperatures above 30 °C by decreasing the basal metabolic rate and entering a state of “torpor”.
The bat, a nocturnal mammal, enters a state of controlled torpor during the hottest hours of the day, reducing basal metabolic activities to a minimum to overcome heat stress. The extreme environmental thermal events were studied in Australia and a significant rate of mortality was recorded in flying fox bats when the air temperature was ≥42.0 °C [17][18][19].
However, flying fox bat geographical distribution is highly dependent on food sources, a combination of nectar, pollen and fruit, especially those produced by Eucalyptus trees in woodlands and open forests [77][78][79]; therefore, a lack of food resources due to deforestation and climate change may disperse flying foxes outside their typical habitats with consequent increased levels of stress. Studies using urine cortisol concentrations to measure the physiological stress in Pteropid bats have pointed out that lower winter temperatures increase cortisol concentrations, which are associated with HeV excretion in flying foxes [80][81]. A similar condition may occur with NiV. Another aspect is the body condition score (BCS) that is related to the nutritional status. Poor body condition is associated with increased seroconversion and HeV infection risk in flying foxes. This increases the urinary excretion of viable virus, with an increased risk of transmission to horses, the main host of the HeV disease [82][83].
Specific weather patterns have been associated with spillover events. A number of studies have consistently demonstrated associations between dry conditions and spillover events of HeV [1][79][84][85][86][87]. El Niño cycles (warmer and drier conditions) in spring/summer correlates with spillover events in autumn/winter [79][84]. El Niño and drought events are predicted to occur more frequently in the future due to climate change [88][89]. Therefore, these extreme weather conditions coupled with the cascading effects on flying foxes may increase the risk and frequency of HeV spillover events/outbreaks and expansion into new areas.
Field studies carried out in Malaysia have suggested a complex interaction of several factors that might have triggered the 1997–1998 outbreak: the reduction of the inhabitants of the reservoirs that are linked to deforestation for commercial and agricultural purposes, prolonged drought driven by the strong El Niño Southern Oscillation (ENSO) phenomenon, forest fires caused by man, intense promiscuity of crops and pig farms and overcrowding of pigsties. All this led to a greater probability of virus spillover from its natural reservoir to the pig and consequently to humans [90].
Regarding human behaviors and NiV infection, in a qualitative study in two districts of Bangladesh, interviews were conducted with 30 bat hunters who hunted bats primarily for consumption, to understand the process and reasons for hunting bats and their perception about bats and bat-borne disease. It was reported that bat meat is prepared for personal consumption and to be sold in neighboring communities. Live bats are also sold to traditional healers. Many informants (53%) reported being bitten by bats. Some informants reported hearing about a disease from bat-contaminated date palm sap, and NiV was mentioned, but they did not believe that bats could spread a disease to humans because of the absence of disease in their community that have been hunting and consuming bats for generations. However, the close bat–human interaction highlights a risk of pathogen spillover [91].
Also, the trade of flying bat meat in markets in Southeast Asia may represent a source of potential infection. For instance, north and southeast areas of the Sulawesi Island in Indonesia are dynamic sites for the wildlife trade of hunted species in wild meat markets, including large amounts of flying foxes that roost are under hunting pressure. However, the current rates of flying fox harvests are significantly unstainable and the impact of this trade on local ecosystems remains mostly unknown [92].

This entry is adapted from the peer-reviewed paper 10.3390/ani13010159

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