Microneedles (MNs) are minimally invasive, tiny needle devices that can be fabricated from a variety of materials, such as biomaterials, metals, polymers, ceramics, and composites [39,40,41], which are designed to penetrate the skin’s stratum corneum layer for various applications. The aim of microneedles is the delivery of bioactive materials, vaccines, and pharmaceutical agents, and the collection of bio-signals and substances from the body with minimal invasiveness. The administration of drugs through the gastrointestinal passage has not been the most efficient due to the poor absorption of orally ingested drugs and the pharmacokinetic activities of the body, which leaves only a fraction of the drug to achieve its intended therapeutic effect. Patients’ compliance with the conventional use of hypodermic needles has dropped significantly over the years due to the pain, anxiety, and discomfort that accompany their usage. A more appealing approach that offers the possibility of controlled release at the expense of the time of administration is transdermal drug delivery (TDD) using a microneedle patch. However, TDD is severely limited by the inability of most single drug particles to cross the skin at therapeutic rates due to the great barrier that is imposed by the skin’s stratum corneum layer [42]. In order to increase the skin’s permeability, different approaches have been investigated, including, but not limited to, chemical lipid enhancers, electric field employing iontophoresis, and electroporation to pressure waves that are generated by ultrasound or photoacoustic effects [43]. An alternative approach involves creating a pathway of micron-scale needles that serves to create microscopic holes on the outermost layer, called the stratum corneum, by inserting microneedles that are made of silicon, metal, or polymeric material. Microneedle arrays are promising devices in transdermal drug delivery applications.

Microneedles are designed to be able to create an easier passage to the rich blood supply in the lower dermal layers, allowing an easy, pain-free delivery of a wide range of medicines across the skin [44]. The advantages of microneedles include painless administration, faster healing, ease of administration, and more control over the rate of drug delivery. Microneedle patches are categorized into five types, as shown in Figure 1, which include the following: solid microneedles, coated microneedles, dissolvable microneedles, hollow microneedles, and hydrogel-based microneedles. Each microneedle type has particular fabrication procedures and application areas. The first report of the term “microneedle” dates back to 1921 (Chambers, 1921), as a means of the micro-dissection of echinoderm eggs [45].

The microneedle concept started with using large needles, until it evolved over the years to the current micro-sized needles. In 1905, a German dermatologist used a motor-powered dental brush to treat skin ailments [47]. In the 1970s, Gerstel et al. introduced the microneedle concept, however, this concept was not demonstrated experimentally until the 1990s [48]. In 1998, Henry et al. were the first to propose a microneedle to be used for transdermal drug delivery [49]. The microneedle array in their study was fabricated using silicon as the material, with etching and photolithography as the manufacturing techniques. Initially, the purpose of the microneedle was to increase the skin’s permeability by using a solid microneedle. Another purpose was to fabricate hollow microneedles with advanced functionality compared to the ordinary hypodermic needles [50]. Eventually, this concept was extended to different applications, such as drug delivery, vaccine delivery, therapeutics, diagnostics, and cosmetic applications. A variety of materials, such as silicon, stainless steel, sugar, and polymers, have been used in order to fabricate solid microneedles, coated microneedles, hollow microneedles, or dissolvable microneedles [51]. Silicon was the first proposed material for fabricating a solid microneedle [49]; however, many other materials were studied in order to manufacture microneedles, such as stainless steel [52], ceramic [53], glass [54], and polymer [55]. Various types of manufacturing methods and techniques have been utilized over the years to fabricate specific and customized microneedle arrays. These manufacturing methods include, but are not limited to, lithography [56,57], micro milling, mold-based techniques, injection molding [58], laser ablation [59,60], an elasto-capillarity-driven self-assembly mechanism, and additive manufacturing [27,61]. Many of these conventional fabrication methods have some limitations, such as cost-efficiency, requiring manual steps, requiring sophisticated equipment, and being labor-intensive. Hence, accessible and cost-efficient technologies, such as additive manufacturing, are needed in order to produce microneedles. A summary of the fabrication techniques for the different types of microneedles is illustrated in Table 2.