Bacterial Cellulose-Based Polymer Nanocomposites: History
View Latest Version
Please note this is an old version of this entry, which may differ significantly from the current revision.
Contributor:
Viktor V. Revin
,
Elena V. Liyaskina
,
Marina V. Parchaykina
,
Tatyana P. Kuzmenko
,
Irina V. Kurgaeva
,
Vadim D. Revin
,
Muhammad Wajid Ullah

Bacterial cellulose (BC) is currently one of the most popular environmentally friendly materials with unique structural and physicochemical properties for obtaining various functional materials for a wide range of applications. In this regard, the literature reporting on bacterial nanocellulose has increased exponentially. Extensive investigations aim at promoting the manufacturing of BC-based nanocomposites with other components such as nanoparticles, polymers, and biomolecules, and that will enable to develop of a wide range of materials with advanced and novel functionalities.

  • bacterial cellulose
  • nanocomposites
  • biopolymers

1. Introduction

Bacterial nanocellulose (BNC) has received remarkable attention and has been widely studied due to its excellent structural and physical properties such as high surface area and special surface chemistry, high crystallinity and mechanical strength, hydrophilicity, and excellent biological features (biocompatibility, biodegradability, and non-toxicity). Although BNC exhibits unique features, it lacks the ones like antimicrobial activity, antioxidant activity, electromagnetic properties, and catalytic activity, which are required for its specialized applications [1]. The problem can be solved by modifying the BC surface and creating BNC-based biocomposite materials [1][2][3][4][5]. The cellulose surface modification significantly increased its potential due to its OH group. There are various types of surface modification described with detail in a recent review by Aziz et al. [2]. A recent review by Aditya provides the information on Bacterial Cellulose (BC) functionalization via chemical and physical means to yield nanocomposites and fabricate materials with improved functionalities for the biomedical application, primarily, for vascular and neural applications, wound healing, and bactericidal interfaces [3]. Generally, composites consist of two types of individual materials, namely: the matrix and the reinforcement material, and have a defined interface between them [4][5]. The matrix acts as a scaffold supporting the reinforcement material, while the reinforcements impart the physico-chemical and biological properties to the matrix.
BC composites have been synthesized using numerous materials ranging from natural and synthetic polymers to inorganic nanoparticles and nanomaterials. Shah et al. classified BC composites by the nature of the reinforcement material into organic materials and inorganic materials [5]. These two main classes they further subdivided into BC composites with polymers, NPs, metals, metal oxides, clays and macro-sized solid particles. Until now, many nanomaterials, such as metal nanoparticles (Ag, Au, Pd, Pt, Ni) and metal oxides nanoparticles (ZnO, CuO, MgO, FeO, TiO2, Al2O3, CeO), mineral nanomaterials (SiO2, CaCO3, montmorillonite) and carbonaceous nanomaterials (grapheme, carbon nanotube) have been placed into nanocellulose matrices to prepare BC nanocomposites. There have also been obtained BC biocomposites with biopolymers such as chitosan (Ch), alginate (ALG), hyaluronic acid (HA), starch, gelatin (GT), collagen, keratin, polylactic acid (PLA), polyhydroxyalkanoate (PHA) and synthetic polymers such as polyvinyl alcohol (PVA), polyaniline (PANI), poly-2-aminoethyl-methacrylate (PAEM) [6]. A series of novel polysaccharide-based biocomposites was obtained by impregnation of BC produced by K. rhaeticus with the solutions of negatively charged polysaccharides such as hyaluronan, sodium alginate, or carrageenan, and subsequently with positively charged chitosan [7]. In addition, BC composites with biomolecules such as antibiotics, enzymes, hormones, peptides, amino acids and cells were obtained [1][2][3][8][9][10][11].
There are four main methods compounds can be loaded in the cellulose matrix, they can be loaded during BC synthesis; in post-synthesis via saturation; chemical modification once the cellulose has been processed and purified; and finally, through the genetic manipulation of the cellulose-producing organism [12]. A review by Shah et al. and Mbituyimana et al. summarized the strategies for BC-based composites with improved properties [5][13]. The synthesis of BC-based composites has adopted different strategies depending on application purposes. The most common methods used for BC composite preparation are: in situ approach, ex situ approach, and the synthesis of a BC composite from a BC solution [5]. The in situ approach involves reinforcement substances added into the culture medium during BC synthesis, which finally becomes a part of the produced BC hydrogel. In the ex-situ method, composites are produced by adding or impregnating reinforcement materials into a synthesized polymer. In the first case, a reinforcing element is introduced into the cultivation medium of the producer, and the composite is obtained in the process of BC biosynthesis. Thus, Saibuatong and Phisalaphong synthesized BC-Aloe vera composites in the form of films under static conditions of producer cultivation by adding different amounts of Aloe vera gel to the synthetic medium [14]. Park et al. obtained a 3D BC-based scaffold by cultivating G. xylinus in a culture medium containing carbon nanotubes [15]. The synthesized scaffolds were implanted into the mouse skull for bone tissue regeneration. Gao et al. used 6-carboxyfluorescein-modified glucose (6CF-Glc) as a carbon source to modify BC by fermentation of the bacterium K. sucrofermentans [16]. In another recent study, Wan et al. [17] prepared a composite of BC and silver nanowires (AgNW) using in situ biosynthesis. The synthesized BC/AgNW dressings showed better release of Ag+ and a high ability to improve cell proliferation, skin regeneration and the formation of epithelial tissue according to the in vivo wound healing test. Thus, in situ BC-based composites have significantly improved mechanical properties, crystallinity, and thermal stability [18]. However, the use of static cultivation conditions is not always possible to obtain biocomposites using the in situ method, since the particles are in suspension for a short period of time, and a film is formed on the medium surface. Therefore, the cultivation of the producer under dynamic conditions is often used to obtain. The in situ method limitation are also the toxicity and an antibacterial effect of some metals and metal oxides, such as Ag, ZnO, TiO2, and antibiotics, which inhibit the growth of microorganisms.When using the ex situ method, reinforcing materials are introduced into BC after its biosynthesis. Soluble substances and solid nanoparticles easily penetrate a porous cellulose matrix. The interaction can be physical as a result of absorption and due to the formation of hydrogen bonds. A large number of composites with polymers, inorganic materials, metals, and metal oxides have been obtained using this method [19][20][21][22]. The method is often used for the production of medical biocomposites. Thus, Fatima et al. obtained an ex situ BC-based composite with antimicrobial activity by introducing bactericidal plant extracts into its three-dimensional matrix [23]. Ul-Islam et al. using an ex situ method developed a high tensile strength BC-Aloe vera gel composite for potential environmental and medical applications [24].

2. BC-Based Nanocomposites for Biomedical Applications

Recently, BC-based nanocomposites have greatly advanced in biomedical applications, such as wound healing dressings, tissue engineering, drug delivery, and cancer treatment. However, most of these materials have restrictions, for example, a lack of antibacterial activity and low mechanical properties [13]. Recently, several reviews on BC materials for biomedical applications have been reported [12][21][22][25][26][27][28][29][30][31].

2.1. Wound Dressings

At present, there are various wound dressings that can protect a wound from further injuries, or isolate the external environment in wound treatment [32][33][34][35][36][37][38][39][40][41]. An ideal wound dressing should facilitate healing, maintain moist environment, absorb exudates, support angiogenesis, allow gaseous exchange, prevent microbial infections, be comfortable, and cost-effective. It should be non-toxic, non-allergenic, non-adherent, and should be easy to remove without trauma [33][36]. BC has attractive features in wound healing, including its good flexibility, strong water holding capacity, biocompatibility, vapor permeability, elasticity, and non-toxicity [41][42][43]. The microfibrillar structure of BC serves as a flexible 3D scaffold that can serve as a physical barrier against pathogens contributing to cell attachment and tissue granulation. In addition, BC can be modified to meet all the necessary functional requirements as a wound dressing [38].
Recently, a series of commercial medical materials based on BC has been obtained such as Biofill® (Curitiba, Brazil) and Bioprocess® (Curitiba, Brazil) for the therapy of burns and ulcers, Gengiflex® (Curitiba, Brazil) to treat periodontal diseases, Dermafill® (Londrina, Brazil) for effective wound-healing burns and ulcers, Membracel® (Curitiba, Brazil) for venous leg ulcers and lacerations, xCell® (New York, NY, USA) to treat chronic wounds, EpiProtect® (Royal Wootton Bassett, UK) for burn wounds, and Nanoskin® (São Carlos, Brazil) (the antimicrobial BC product incorporated with silver ions) [25][44]. By the product form and a method of administration, wound dressings are divided into: films, hydrogels, sponges, foams, fiber scaffolds, bandages [36].
BC has many excellent properties for wound healing, and acts as an effective physical barrier for a bacterial infection, but the lack of antibacterial activity limits its application in wound dressings. The BC functionalization by adding antimicrobial agents can solve the problem. A review by Zheng et al. considered several wound dressings of nanocellulose with inorganic nanomaterials (metal/metal oxides, carbon-based nanomaterials, nanosilicates), organic antimicrobials (natural polymers, bioactive materials, synthetic materials), and antibiotics [39]. The most acceptable form of new wound dressings is BC nanomaterials with nanoscale inorganic particles. For this purpose, silver nanoparticles are included [45][46][47][48], and they have antimicrobial, anti-inflammatory and healing. Silver nanoparticles (AgNP) incorporated into the BC matrix imparts antibacterial properties to the composite through the release of silver ions affecting DNA replication, the breakdown of the cell membrane, and the release of reactive oxygen species [48]. Pal et al. developed the Ag/BC nanocomposite for wound healing with antibacterial activity against E. coli using a UV photochemical reduction process [46]. Wan et al. developed a novel composite for wound-dressing by dispersing silver nanowires in BC [17]. Metal oxides such as TiO2, CuO, CeO2, ZnO, etc. also exhibit antibacterial activity and promote wound healing [49][50][51][52][53][54][55][56]. Therefore, the combination of BC composites with TiO2 and ZnO also displayed excellent antibacterial properties and had cellular adhesion and proliferation of fibroblast cells, thereby improving the wound-healing capability [49][51]. Similarly, Khalid et al. developed a BC–ZnO nanocomposite for healing burn wounds. The composite succeeded in killing about 90%, 87.4%, 94.3%, and 90.9% of E. coli, Pseudomonas aeruginosa, Staphylococcus aureus, and Citrobacterfreundii, respectively [55]. A design of new nanocomposites of BC and betulin diphosphate (BDP) pre-impregnated into the surface of zinc oxide nanoparticles (ZnO NPs) to produce wound dressings was suggested [56]. The effective wound healing with BC-ZnO NPs-BDP nanocomposites can be explained by the synergistic effect of all nanocomposite components, which regulate oxygenation and microcirculation reducing hypoxia and an oxidative stress in a burn wound. Another direction of BC functionalization is the creation of composites with other biopolymers, such as chitosan, alginate, hyaluronic acid, collagen, etc. Chitosan (CS) is one of the most important biopolymers for wound dressings [57][58][59][60][61][62]. CS in a biocomposite has an antibacterial effect against E. coli and S. aureus, exhibits a wound healing effect and accelerates epithelialization. CS molecules easily penetrate into the BC matrix resulting in the formation of hydrogen bonds between the OH groups of BC and the NH groups of CS. In this case, the mechanical strength of the composite increases. Cacicedo et al. developed a ciprofloxacin-loaded CS-BC patch showing cytocompatibility with human fibroblasts and high antibacterial activity against P. aeruginosa and S. aureus for potential wound healing [61]. Cazón et al. developed BC films combined with CS and polyvinyl alcohol [62]. Volova et al. developed a hybrid wound dressings using two biomaterials: BC and copolymer of 3-hydroxybutyric and 4-hydroxybutyric acids—a biodegradable polymer of microbial origin [63]. Mohamad et al. developed a hydrogel for burn wounds based on BC and acrylic acid with fibroblasts and keratinocytes added [64].
The antibacterial activity of BC-based wound dressings is often achieved by adding antibiotics. The most commonly used antibiotics are tetracycline hydrochloride, amoxicillin, ciprofloxacin, ceftriaxone, etc. [65][66][67][68]. Junka et al. have shown BC saturated with gentamycin significantly to reduces the level of biofilm-forming bone pathogens, namely S. aureus and P. aeruginosa [65]. BC composite materials containing amikacin and ceftriaxone were prepared by immersing dried BC films in antibiotic solutions of various concentrations. Moreover, the composites have obvious antibacterial activity against E. coli, P. aeruginosa, S. pneumoniae and S. aureus, so they are supposed to be used as wound dressings [47]. The composites of BC with tetracycline hydrochloride were obtained and characterized by other authors [66]. The composites exhibited excellent antibacterial activity and good biocompatibility as well as controlled the antibiotic release. Vancomycin and ciprofloxacin can be incorporated into BNC or modified BNC to confer biological activity in wound dressings and tissue engineering scaffolds [68]. Volova et al. obtained BC composites with silver nanoparticles (BC/AgNPs) and antibacterial drugs (chlorhexidine, baneocin, cefotaxime, and doripenem) with antibacterial activity against E. coli and S. aureus, and investigated the structure, physicochemical, and mechanical properties of the composites [69]. Revin et al. developed the biocomposite materials for medical purposes with antibacterial, regenerative, and hemostatic properties based on BC in the form of aerogels, hydrogels, film forms, and fusidic acid (FA) [70][71]. FA is an antibiotic, with high antibacterial activity against S. aureus, including the MRSA strains [72]. The inhibitory effect of FA on the biofilm formation and the expression of α-toxin was reported [73][74]. BNC- FA biocomposite films with excellent antibacterial activity against S. aureus were obtained by immersing dried BNC films in a solution of the antibiotics of various concentrations for 1–24 h [70].
The use of aerogels for the production of biomaterials has started relatively recently [75]. In the past decade, aerogels have attracted great interest due to their special properties (large porosity, high internal surface, controlled pore diameter, and three-dimensional interconnected structure). Biopolymer-based aerogels additionally provide excellent cytocompatibility, biocompatibility, and biodegradability, and can be successfully used in biomedicine for targeted drug delivery, tissue engineering, and antibacterial materials [75][76]. Revin et al. for the first time obtained new biocomposites with antibacterial properties based on native BC and sodium fusidate (NBC/SF) and TEMPO oxidized BC and sodium fusidate (OBC/SF) in the form of aerogels by incorporating sodium fusidate (SF) into hydrogel native BC and oxidized BC [71]. The antibacterial activity of the resulting aerogels was studied by the disk diffusion method. The biocomposites with sodium fusidate BC/SF and OBC/SF show high antibacterial activity, their S. aureus inhibition zone diameters are 28 and 27 mm, respectively. The present entry clearly illustrates that the resulting aerogels exhibit excellent antibacterial activity against S. aureus. Despite the small difference in antibacterial activity, OBC/SF aerogels had greater mechanical strength than BC/SF aerogels.
Malheiros et al. immobilized antimicrobial peptides of Lactobacillus sakei on BC [77]. Bayazidi et al. obtained a material with antibacterial activity by immobilizing lysozyme on BC [78]. Gupta et al. obtained BC nanocomposite wound dressings with curcumin, which has antimicrobial, antioxidant, antitumor, and wound healing effects [79].

2.2. Tissue Engineering

Recently, BC has attracted much attention in tissue engineering due to their unique properties for tissue regeneration as scaffolds [26][80]. 3D BC scaffolds provide an almost ideal environment for cell growth and tissue development, unlike 2D materials, where only superficial growth occurs. Therefore, BC 3D scaffolds become potential candidates for being used in tissue engineering and regenerative medicine. The porous structure of BC enables massive transfer of nutrients and oxygen, supporting cell survival. It can support the growth of endothelial, smooth muscle cells, chondrocytes, and cause no toxic effects. From the cellular point of view, an important feature of BC is the structure of its nanofibrils, which resembles the structure of extracellular matrix components, namely collagen [81]. BC and collagen have the same diameter (less than 0.1 µm), both are polymers functioning, primarily, as mechanical support structures.

Cartilage Tissue Engineering

The regeneration problem of articular cartilage damage is important because of the limited ability of self-repair. The cartilage repair requires biomaterials with good porosity and a certain pore size, where chondrocytes can penetrate and proliferate to produce their extracellular matrix. BC is a suitable scaffold for cartilage tissue engineering due to mechanical strength and biocompatibility [82]. Svenson et al. reported BC potential to proliferate cartilage chondrocyte cells [83]. However, native BC has a small pore size (~0.02–10 µm) and therefore cannot provide the penetration of cartilage cells. Therefore, the porosity of the BC scaffold requires improvement. Several methods were implemented to enhance the pore size and interconnectivity of BC scaffolds. To increase the pore size of BC scaffolds, some authors developed BC scaffolds based on agarose particles with a pore size 300–500 µm [84][85] and 150–300 µm [82] followed by removal of progen particles (agarose), for example, by autoclaving [84] or extrusion [82]. Xun et al. developed a macroporous scaffold with a pore size of 200 µm by using the freeze-drying technique for BC suspension followed by crosslinking [86]. Methacrylate gelatin–BC hydrogels with the pores 200–10 µm in size were developed using photo polymerization [87]. Horbert et al. developed a novel technique for 3D-laser perforation of BC seeded with chondrocyte cells [88]. Yang et al. suggested preparing 3D structures simulating intervertebral discs [89]. In conclusion, the improvement of BC scaffold porosity makes it appropriate for cartilage regeneration.

Bone Tissue Engineering

Attention to the creation of artificial composite materials similar to natural bone tissue is growing rapidly, and a major problem is to obtain a composite that would be as close as possible in structure and properties to its natural counterpart. It is known that bones are composed of bone tissue cells such as osteoblasts, osteocytes, and osteoclasts. And the matrix of bone tissue mainly consists of collagen and hydroxyapatite.
Recently, a number of BC-based composites have been developed for bone tissue regeneration [26][90][91][92][93]. Due to its strength characteristics (the tensile strength of the BC gel film is ~10 GPa), BC can serve as a promising basis for a bone precursor. BC can serve as a scaffold for proliferation and potential differentiation of mesenchymal stem cells into osteocytes and chondrocytes [94]. Sundberg et al. developed macroporous mineralized BNC scaffolds coated with calcium phosphate. [95]. A number of scientists have also used osteogenic growth peptide for bone tissue engineering [91][96][97]. A composite based on BC and hydroxyapatite (HA) nanocrystals, biocompatible with living organisms, is considered promising as a bone tissue precursor. The BC composite with hydroxyapatite mimics the intercellular substance of normal bone tissue. It plays the role of a barrier preventing loose connective tissue from replacing the lost or destroyed fragment of the skeleton. At the same time, bone tissue cells—osteocytes—can be grafted on it, and they will multiply there. Tazi et al. developed BC-HA scaffolds to improve osteoblast adhesion and growth [90]. Ran et al. developed an organic–inorganic multicomponent composite using BC, gelatin, and HA combination to provide better mechanical properties [98].
Moreover, 3D printing is a promising method for bone tissue engineering. It is used to synthesize composite scaffolds with controlled porosity, mechanical strength, and shape to facilitate cell growth and regeneration [99][100]. For example, Cakmak et al. developed a 3D printed BC/polycaprolactone/gelatin/hydroxyapatite composite scaffold for bone tissue engineering [101]. A review by Khan et al. demonstrated that nanocellulose does not only serve as the matrix for the deposition of different materials to develop bone substitutes but also functions as a drug carrier to treat bone diseases [26]. Hernández et al. have recently developed a BC-based composite scaffold with carbon nanotubes to improve its mechanical properties [92].

Soft Tissue Engineering

According to the literature data, BC-based composites have great potential as biomaterials for soft tissues, such as blood vessels, adipose tissue, nerves, the liver, and skin [26][80][102][103][104][105][106][107]. Recent studies have shown BC to be a promising material for vascular tissue engineering with attractive properties such as biocompatibility, high burst pressure, and ultrafine fibrous collagen-like structure [29][107][108]. By taking the advantage of producing BC of different shapes, Schumann et al. and Leitao et al. developed small-caliber vascular grafts [103][109]. So, to replace small arterial, Schumann et al. developed a small-caliber vascular graft, 1.0–3.7 mm in diameter, 5.0–10.0 mm long, and its wall-thickness being 0.7 mm [103]. Leitao et al. developed a simple, cost-effective method for producing small-caliber BC graft vascular prostheses using the capillary drying, shaping, and freeze-drying [109]. Recently, BC-based composites have been shown to be promising scaffold candidates with good biocompatibility and high transmission properties for the corneal stroma [110][111][112]. Moreover, BC-based composites are considered an attractive material for creating neuronal implants due to their high biocompatibility, flexibility, and ability to register nerve signals [113]. So, Yang et al. developed Au–BC microarrays for neural interfaces [114]. Hou et al. developed a biodegradable, biocompatible scaffold with good mechanical properties based on oxidized BC [115]. The current preclinical and clinical studies have confirmed the prospects for studying BNC in neurosurgery as implants for closing the defects in the dura mater in the spinal cord and its meninges pathologies [116].

2.3. Drug Delivery System

Drug delivery systems refer to the advanced technologies used for targeted delivery and/or controlled release of therapeutic drugs [117]. In the past few decades, drug delivery systems received much attention, since they offer potential benefits, such as reducing side effects, improving therapeutic effects, and possible reduction of drug doses [118][119]. There are three key factors required in an effective drug delivery system, including drug carriers, drug-loading ratio, and controlled release rate [120].
In recent years, natural polysaccharides have been considered as the ideal candidates for novel drug delivery systems due to their good biocompatibility, biodegradation, low immunogenicity, renewable source and easy modification [121]. These natural polymers are widely used in designing nanocarriers, which find a wide application in therapeutics, diagnostics, delivery and protection of bioactive compounds or drugs. Recently, interesting reviews were published in the Journal ‘Polymers’ characterizing the composite materials used in drug delivery systems [9][121][122]. The review by Qiu et al. introduced a series of polysaccharide-based nanodrug delivery systems such as nanoparticles, nanoliposomes, nanomicelles, nanoemulsions and nanohydrogels for diabetes treatment [121]. The review Huo et al. represented the typical drug release behaviors and the drug release mechanisms of nanocellulose-based composite materials, and considered the potential application of these composites [122]. Due to its adaptable surface chemistry, high surface area, biocompatibility, and biodegradability, nanocellulose-based composite materials can be further transformed into drug delivery carriers [122]. The review by Lunardi et al. reported various methods for modifying and functionalizing nanocellulose to obtain nanocarriers in drug delivery systems [9].
Generally, the most common method of loading drugs in BC membranes is via immersion in a drug solution, usually following lyophilisation to provide maximum drug absorption [12]. The most common drugs to be incorporated into BC are anti-inflammatory drugs, such as ibuprofen and diclofenac [123], and antimicrobial drugs [66]. Due to its unique characteristics, BC has been shown to be a promising biomaterial for cancer treatment [124][125][126][127]. For example, Cacicedo et al. combined a BC hydrogel and nanostructured lipid carriers to use as an implant for local drug delivery in cancer therapy using doxorubicin as a model drug [126]. Zhang et al. developed BC-based composites with Fe3O4 magnetic nanoparticles coated with doxorubicin and hematoporphyrin monomethyl ether, and additionally conjugated with folic acid for breast cancer therapy [127]. Nanocellulose-based scaffolds are also being used as useful tools for cancer diagnosis. BC can be used as a drug delivery system to treat diseases. For example, it has been used to control curcumin delivery to improve tissue granulation in addition to its antifungal, antitumor, antibacterial, and antioxidant properties [128]. BC has been used to deliver lidocaine to promote tissue repair in third-degree burns in rats [129]. Moreover, BC has been used to deliver antibacterial and antiseptic agents [130]. Luo et al. developed a BC composite with graphene oxide with controlled release of ibuprofen [131]. Ahmad et al. developed a polyacrylic acid hydrogel grafted with BC for oral protein delivery [132].

3. Biosensors

Biosensors are small devices with a biologically active element. They quantify (or semi-quantify) a biological or chemical analyte by generating a measurable signal proportional to its concentration [133]. Biosensors have provoked great interest in recent years. They are considered as powerful emerging tools for detecting various biomarkers for both healthcare and environmental monitoring [134][135]. Biosensors are generally applied in different fields: biomedical, environmental, and allow to monitor specific disease biomarkers in body fluids (blood, urine, saliva, and sweat) [136], and detect microorganisms [134] and pollutants [137] in the environment.
A biosensor is mainly made up of three elements including a biologically active element immobilized on a convenient substrate such as cellulose, a transducer, and a signal processor. A biologically active element could be an enzyme, antibody, protein, whole cell, or DNA. Biosensors can be classified based on a type of transducers and operating principles into optical, acoustic, electrochemical, and piezoelectric. Optical biosensors take the advantage of optical characteristics such as absorbance, fluorescence and chemiluminescence. For instance, a fluorescence biosensor based on BC and nitrogen-doped carbon quantum dots (N-CDs) was fabricated for the first time by Lv et al. to determine Fe+3 ions in a liquid medium [138]. Acoustic biosensors based on piezoelectric crystals operate by detecting the binding of the analyte (target) by its modulation of the crystal oscillation frequency. In electrochemical biosensors, the changes in the electrical properties are used as a measuring parameter. For instance, Zhang et al. prepared a BC biosensor for H2O2 detection [139].
When developing biosensors, it is of primary importance to ensure high biocatalytic activity, sensitivity, selectivity, environmental friendliness, and low cost. BC is a promising material for creating biosensors, since it is an environmentally friendly natural three-dimensional nanostructure and characterized by high absorption capacity, large surface area, high crystallinity, mechanical strength, and can be easily modified and functionalized with nanoparticles, carbon nanotubes, metal oxides, conductive materials, and biomolecules [140]. BC has a great potential for developing cytosensors due to its various unique properties including biocompatibility. The review by Kamel and Khattab presents the current techniques for the preparation and modification of cellulose substrates as biosensors [133] The review by Torres considered the recent advances regarding the development, production and applications of new BC-based biosensors [140]. To increase the sensitivity of the cellulose surface, novel modifications can be made using conductive materials such as gold nanoparticles (AuNP), carbon nanotubes, graphene oxide (GO), and conductive polymers. Different materials have been used to prepare BC-based biosensors. Gold (Au), palladium (Pd) and platinum (Pt) nanoparticles, and titanium dioxide (TiO2), ferrous oxide (FeO) and Zinc oxide (ZnO) have been used to increase the electric and magnetic conductivity of native BC [139][141][142][143][144][145][146]. Polystyrene sulphonate and polyaniline have also been used to increase BC conductivity to fabricate biosensors [147][148][149][150]. Enzymes such as laccase and haem proteins including glucose oxidase and horseradish were immobilized in BC-based networks to prepare electrochemical biosensors to detect H2O2, hydroquinone, dopamine and glucose, among others [139][142][143][145][146]. BC-based biosensors are prepared by adding a second phase into the BC network [141][151][152], either by modifying the culture medium during cellulose synthesis [138][153] or by incorporating the second phase after obtaining the BC network [154][155]. A different approach is used when the BC network is first destroyed and then combined with another material to prepare BC-based biosensors [139][156]. Future investigations should place special emphasis on overcoming the current limitations related to the immobilization of enzymes on the BC surface in order to expand the potential application of BC biosensors. The applications will include the development of biosensors for detecting biomarkers produced from cells or tissues resulted from diseases and disorders.

4. Adsorbents

In recent years, adsorption has been used as an effective strategy for separating contaminants due to the fact that an adsorbent can be recovered, reused and recycled, and the method is considered the best, however, the high cost of sorbents limits their use [157]. The use of adsorbates of natural origin is promising, since they are harmless to the environment and human health. Among them, natural fibers such as cellulose have been extensively studied. Shi et al. published a review article summarized the recent progress of adsorbents produced by modification and functionalization of cellulose and cellulose-based nanocomposites to remove heavy metals ions and organic pollutants [158]. An exciting review by Salama et al. presents the latest research results on nanocellulose-based materials for wastewater treatment including adsorption, absorption, flocculation, photocatalytic decomposition, disinfection, etc., and discusses various approaches to their chemical modification [159].
BNC attracts special attention due to the following characteristics: a large surface area, high adsorption capacity, nanoscale structure, high reactivity due to the presence of hydroxyl groups on the surface, which allows it to be chemically modified to interact with various pollutants depending on its nature [160]. Other important BNC properties are biodegradability, high mechanical properties, and low density [161]. BC has many advantages to be used as an adsorbent, including high surface area and density of functional groups [162]. Numerous hydroxyl groups (or others if chemically modified) on nanocellulose result in higher adsorption capacity [163][164][165][166][167]. In addition, nanocellulose-based materials are completely biodegradable, which ensures their biological application without side effects [168][169]. BC serves as a matrix for immobilizing catalysts, enzymes, and other sensory materials, both to detect environmental pollutants, and also for the decomposition of various wastes, for example, waste from the textile industry, which can later be used as a carbon source and biotransformed into valuable products.
BC has the ability to function as a matrix for incorporating various molecules or inorganic particles. Therefore, BC composites can be used for wastewater treatment from heavy metals [170][171][172][173]. A number of BNC-based adsorbents have been obtained for removing hazardous metals. For example, Shoukat et al. developed a nanocomposite based on BC and titanium oxide (TiO2) [171]. The nanocomposite was evaluated as an adsorbent to remove lead (Pb) from an aqueous solution. The TiO2-BC nanocomposite removes Pb at a concentration of 100 mg/L with a removal efficiency of more than 90% in 120 min at pH 7 and at a room temperature. The adsorbent proved to be effective, stable and reusable for removing lead from environmental water samples. Biocomposite aerogels based on BC and polyaniline can be used to remove hexavalent chromium [172]. A comparative study on the efficiency of mercury removal from wastewater using BC membranes and their oxidized analogue was carried out [174]. The results obtained showed the modification of BC by oxidation to improve the mercury removal capacity, making the modified membranes an excellent material for mercury removal from wastewater. Mensah et al. developed a composite based on BC and graphene oxide as an efficient and environmentally friendly adsorbent for removing metal ions, especially Pb2+, from an aqueous system [173].
Another important problem is the purification of water from fluorine. The high content of fluorine in water is an urgent issue all over the world. But despite the growing concern about water pollution, effective technologies for removing fluoride have not yet been developed. Among various physical and chemical methods for removing fluorine from water, adsorption is a preferable one due to its simplicity, relatively low cost, and industrial scalability. Recently, a number of inorganic [175][176][177][178][179] and organic [180][181][182] adsorbents have been obtained to remove fluorine from water. Revin et al. developed a new biocomposite material with a high sorption capacity for fluorine ions (80.1 mg/g) based on BC and nanosized aluminum oxide films chemically immobilized on its surface using ALD technology [183].
Nanocellulose-based materials can also be used to treat wastewater contaminated with hazardous organic pollutants, including dyes, pharmaceutical compounds, and petroleum products [157][184][185][186][187][188]. For example, Wang et al. reported a new superabsorbent aerogel based on BC and graphene oxide, which showed excellent absorption property of organic liquids [184]. Cellulose composite aerogels can be used for oil sorption [186][187]. The development and synthesis of new materials is vital to the removal of new contaminants, such as pharmaceuticals, from polluted water. Ieamviteevanich et al. developed a magnetic carbon nanofiber derived from BC to remove diclofenac from water [188]. Diclofenac is one of the non-steroidal anti-inflammatory drugs widely used to treat acute and chronic pain in humans and animals. Conventional processes used in wastewater treatment are not sufficient to remove diclofenac from water. The efficiency of these processes is less than 20%. Therefore, alternative methods for removing diclofenac from water have been explored. The maximum adsorption capacity of magnetic carbon nanofiber is 67 mg/g. The results of the study showed it can effectively adsorb diclofenac from water with further removal by magnetic separation. Photocalysis can be considered as another promising method for the degradation of organic pollutants and dyes in wastewater [159]. Although nanocellulose alone exhibits the limited photocatalytic activity in the visible and UV spectra, photocatalysts such as metal oxides ZnO [189] and TiO2 [190] can be added to enhance the photocatalytic activity. Nanocellulose can also be used for antimicrobial filtration. So BC membranes were examined for removal of E. coli from a sanitary effluent [191].

This entry is adapted from the peer-reviewed paper 10.3390/polym14214670

References

  1. Ullah, M.W.; Rojas, O.J.; McCarthy, R.R.; Yang, G. Editorial: Nanocellulose: A Multipurpose Advanced Functional Material. Front. Bioeng. Biotechnol. 2021, 9, 738779.
  2. Aziz, T.; Farid, A.; Haq, F.; Kiran, M.; Ullah, A.; Zhang, K.; Li, C.; Ghazanfar, S.; Sun, H.; Ullah, R.; et al. A Review on the Modification of Cellulose and Its Applications. Polymers 2022, 14, 3206.
  3. Aditya, T.; Allain, J.P.; Jaramillo, C.; Restrepo, A.M. Surface Modification of Bacterial Cellulose for Biomedical Applications. Int. J. Mol. Sci. 2022, 23, 610.
  4. Moniri, M.; Boroumand, M.A.; Azizi, S.; Abdul Rahim, R.; Bin Ariff, A.; Zuhainis Saad, W.; Navaderi, M.; Mohamad, R. Production and Status of Bacterial Cellulose in Biomedical Engineering. Nanomaterials 2017, 7, 257.
  5. Shah, N.; Ul-Islam, M.; Khattak, W.A.; Park, J.K. Overview of bacterial cellulose composites: A multipurpose advanced material. Carbohydr. Polym. 2013, 98, 1585–1598.
  6. Nunes, S.B.; Hodel, K.V.S.; Sacramento, G.d.C.; Melo, P.d.S.; Pessoa, F.L.P.; Barbosa, J.D.V.; Badaró, R.; Machado, B.A.S. Development of Bacterial Cellulose Biocomposites Combined with Starch and Collagen and Evaluation of Their Properties. Materials 2021, 14, 458.
  7. Petrova, V.A.; Khripunov, A.K.; Golovkin, A.S.; Mishanin, A.I.; Gofman, I.V.; Romanov, D.P.; Migunova, A.V.; Arkharova, N.A.; Klechkovskaya, V.V.; Skorik, Y.A. Bacterial Cellulose (Komagataeibacter rhaeticus) biocomposites and their cytocompatibility. Materials 2020, 13, 4558.
  8. Randhawa, A.; Dutta, S.D.; Ganguly, K.; Patil, T.V.; Patel, D.K.; Lim, K.-T. A Review of Properties of Nanocellulose, Its Synthesis, and Potential in Biomedical Applications. Appl. Sci. 2022, 12, 7090.
  9. Lunardi, V.B.; Soetaredjo, F.E.; Putro, J.N.; Santoso, S.P.; Yuliana, M.; Sunarso, J.; Ju, Y.-H.; Ismadji, S. Nanocelluloses: Sources, Pretreatment, Isolations, Modification, and Its Application as the Drug Carriers. Polymers 2021, 13, 2052.
  10. Rol, F.; Belgacem, M.N.; Gandini, A.; Bras, J. Recent advances in surface-modified cellulose nanofibrils. Prog. Polym. Sci. 2019, 88, 241–264.
  11. Chen, P.; Cho, S.Y.; Jin, H. Modification and applications of bacterial celluloses in polymer science. Macromol. Res. 2010, 18, 309–320.
  12. Swingler, S.; Gupta, A.; Gibson, H.; Kowalczuk, M.; Heaselgrave, W.; Radecka, I. Recent advances and applications of bacterial cellulose in biomedicine. Polymers 2021, 13, 412.
  13. Mbituyimana, B.; Liu, L.; Ye, W.; Boni, O.; Zhang, K.; Chen, J.; Sabu, T.; Revin, V.V.; Zhijun, S.; Yang, G. Bacterial cellulose-based composites for biomedical and cosmetic applications: Research progress and existing products. Carbohydr. Polym. 2021, 273, 118565.
  14. Saibuatong, O.; Phisalaphong, M. Novo aloe vera–bacterial cellulose composite film from biosynthesis. Carbohydr. Polym. 2010, 79, 455–460.
  15. Park, S.; Park, J.; Jo, I.; Cho, S.P.; Sung, D.; Ryu, S.; Kim, B.S. In situ hybridization of carbon nanotubes with bacterial cellulose for three-dimensional hybrid bioscaffolds. Biomaterials 2015, 58, 93–102.
  16. Gao, J.; Li, Z.; Bao, M.; Hu, R.; Nian, D.; Feng, D.; An, X.; Li, M.; Xian, H. A natural in situ fabrication method of functional bacterial cellulose using a microorganism. Nat. Commun. 2019, 10, 437.
  17. Wan, Y.; Yang, S.; Wang, J.; Gan, D.; Gama, M.; Yang, Z.; Zhu, Y.; Yao, F.; Luo, H. Scalable synthesis of robust and stretchable composite wound dressings by dispersing silver nanowires in continuous bacterial cellulose. Compos. Part B Eng. 2020, 199, 108259.
  18. Gao, G.; Cao, Y.; Zhang, Y.; Wu, M.; Ma, T.; Li, G. In situ production of bacterial cellulose/xanthan gum nanocomposites with enhanced productivity and properties using Enterobacter sp. FY-07. Carbohydr. Polym. 2020, 248, 116788.
  19. Gorgieva, S.; Trček, J. Bacterial cellulose: Production, modification and perspectives in biomedical applications. Nanomaterials 2019, 9, 1352.
  20. Choi, S.M.; Shin, E.J. The Nanofication and Functionalization of Bacterial Cellulose and Its Applications. Nanomaterials 2020, 10, 406.
  21. Popa, L.; Ghica, M.V.; Tudoroiu, E.E.; Ionescu, D.G.; Dinu-Pirvu, C.E. Bacterial cellulose-A remarkable polymer as a source for biomaterials tailoring. Materials 2022, 15, 1054.
  22. Wahid, F.; Huang, L.-H.; Zhao, X.-Q.; Li, W.-C.; Wang, Y.-Y.; Jia, S.-R.; Zhong, C. Bacterial cellulose and its potential for biomedical applications. Biotechnol. Adv. 2021, 53, 107856.
  23. Fatima, A.; Yasir, S.; Ul-Islam, M.; Kamal, T.; Ahmad, M.W.; Abbas, Y.; Manan, S.; Ullah, M.W.; Yang, G. Ex situ development and characterization of green antibacterial bacterial cellulose-based composites for potential biomedical applications. Adv. Compos. Hybrid Mater. 2020, 5, 307–321.
  24. Ul-Islam, M.; Ahmad, F.; Fatima, A.; Shah, N.; Yasir, S.; Ahmad, M.W.; Manan, S.; Ullah, M.W. Ex situ Synthesis and Characterization of High Strength Multipurpose Bacterial Cellulose-Aloe vera Hydrogels. Front. Bioeng. Biotechnol. 2021, 9, 601988.
  25. Choi, S.M.; Rao, K.M.; Zo, S.M.; Shin, E.J.; Han, S.S. Bacterial Cellulose and Its Applications. Polymers 2022, 14, 1080.
  26. Khan, S.; Ul-Islam, M.; Ullah, M.W.; Zhu, Y.; Narayanan, K.B.; Han, S.S.; Park, J.K. Fabrication strategies and biomedical applications of three-dimensional bacterial cellulose-based scaffolds: A review. Int. J. Biol. Macromol. 2022, 209, 9–30.
  27. Nicu, R.; Ciolacu, F.; Ciolacu, D.E. Advanced Functional Materials Based on Nanocellulose for Pharmaceutical/Medical Applications. Pharmaceutics 2021, 13, 1125.
  28. Pandit, A.; Kumar, R. A Review on Production, Characterization and Application of Bacterial Cellulose and Its Biocomposites. J. Polym. Environ. 2021, 29, 2738–2755.
  29. Gorgieva, S. Bacterial Cellulose as a Versatile Platform for Research and Development of Biomedical Materials. Processes 2020, 8, 624.
  30. Sionkowska, A.; Mezykowska, O.; Piatek, J. Bacterial nanocelullose in biomedical applications: A review. Polym. Int. 2019, 68, 1841–1847.
  31. Abdelhamid, H.N.; Mathew, A.P. Cellulose-Based Nanomaterials Advance Biomedicine: A Review. Int. J. Mol. Sci. 2022, 23, 5405.
  32. Kushwaha, A.; Goswami, L.; Kim, B.S. Nanomaterial-based therapy for wound healing. Nanomaterials 2022, 12, 618.
  33. Niculescu, A.G.; Grumezescu, A.M. An up-to-date review of biomaterials application in wound management. Polymers 2022, 14, 421.
  34. Moradpoor, H.; Mohammadi, H.; Safaei, M.; Mozaffari, H.R.; Sharifi, R.; Gorji, P.; Sulong, A.B.; Muhamad, N.; Ebadi, M. Recent Advances on Bacterial Cellulose-Based Wound Management: Promises and Challenges. Int. J. Polym. Sci. 2022, 1, 1214734.
  35. Jankau, J.; Błażyńska-Spychalska, A.; Kubiak, K.; Jędrzejczak-Krzepkowska, M.; Pankiewicz, T.; Ludwicka, K.; Dettlaff, A.; Pęksa, R. Bacterial Cellulose Properties Fulfilling Requirements for a Biomaterial of Choice in Reconstructive Surgery and Wound Healing. Front. Bioeng. Biotechnol. 2022, 9, 805053.
  36. Teixeira, M.A.; Paiva, M.C.; Amorim, M.T.P.; Felgueiras, H.P. Electrospun nanocomposites containing cellulose and its derivatives modified with specialized biomolecules for an enhanced wound healing. Nanomaterials 2020, 10, 557.
  37. Ahmed, J.; Gultekinoglu, M.; Edirisinghe, M. Bacterial cellulose micro-nano fibres for wound healing applications. Biotechnol. Adv. 2020, 41, 107549.
  38. Sulaeva, I.; Henniges, U.; Rosenau, T.; Potthast, A. Bacterial cellulose as a material for wound treatment: Properties and modifications. A review. Biotechnol. Adv. 2015, 33, 1547–1571.
  39. Zheng, L.; Li, S.; Luo, J.; Wang, X. Latest Advances on Bacterial Cellulose-Based Antibacterial Materials as Wound Dressings. Front. Bioeng. Biotechnol. 2020, 8, 593768.
  40. de Amorim, J.D.P.; da Silva Junior, C.J.G.; de Medeiros, A.D.M.; do Nascimento, H.A.; Sarubbo, M.; de Medeiros, T.P.M.; Costa, A.F.d.S.; Sarubbo, L.A. Bacterial Cellulose as a Versatile Biomaterial for Wound Dressing Application. Molecules 2022, 27, 5580.
  41. Portela, R.; Leal, C.R.; Almeida, P.L.; Sobral, R.G. Bacterial cellulose: A versatile biopolymer for wound dressing applications. Microb. Biotechnol. 2019, 12, 586–610.
  42. Pang, M.; Huang, Y.; Meng, F.; Zhuang, Y.; Liu, H.; Du, M.; Ma, Q.; Wang, Q.; Chen, Z.; Chen, L.; et al. Application of bacterial cellulose in skin and bone tissue engineering. Eur. Polym. J. 2020, 122, 109365.
  43. Picheth, G.F.; Pirich, C.L.; Sierakowski, M.R.; Woehl, M.A.; Sakakibara, C.N.; de Souza, C.F.; Martin, A.A.; da Silva, R.; de Freitas, R.A. Bacterial cellulose in biomedical applications: A review. Int. J. Biol. Macromol. 2017, 104, 97–106.
  44. Cielecka, I.; Szustak, M.; Kalinowska, H.; Gendaszewska-Darmach, E.; Ryngajłło, M.; Maniukiewicz, W.; Bielecki, S. Glycerolplasticized bacterial nanocellulose-based composites with enhanced flexibility and liquid sorption capacity. Cellulose 2019, 26, 5409–5426.
  45. Massironi, A.; Franco, A.R.; Babo, P.S.; Puppi, D.; Chiellini, F.; Reis, R.L.; Gomes, M.E. Development and Characterization of Highly Stable Silver NanoParticles as Novel Potential Antimicrobial Agents for Wound Healing Hydrogels. Int. J. Mol. Sci. 2022, 23, 2161.
  46. Pal, S.; Nisi, R.; Stoppa, M.; Licciulli, A. Silver-functionalized bacterial cellulose as antibacterial membrane for wound-healing applications. ACS Omega 2017, 2, 3632–3639.
  47. Volova, T.G.; Shumilova, A.; Shidlovskiy, I.P.; Nikolaeva, E.D.; Sukovatiy, A.G.; Vasiliev, A.D.; Shishatskaya, E.I. Antibacterial properties of films of cellulose composites with silver nanoparticles and antibiotics. Polym. Test. 2018, 65, 54–68.
  48. Le Ouay, B.; Stellacci, F. Antibacterial activity of silver nanoparticles: A surface science insight. Nano Today 2015, 10, 339–354.
  49. Ul-Islam, M.; Khattak, W.A.; Ullah, M.W.; Khan, S.; Park, J.K. Synthesis of regenerated bacterial cellulose-zinc oxide nanocomposite films for biomedical applications. Cellulose 2014, 21, 433–447.
  50. Janpetch, N.; Saito, N.; Rujiravanit, R. Fabrication of bacterial cellulose-ZnO composite via solution plasma process for antibacterial applications. Carbohydr. Polym. 2016, 148, 335–344.
  51. Khan, S.; Ul-Islam, M.; Khattak, W.A.; Ullah, M.W.; Park, J.K. Bacterial cellulose-titanium dioxide nanocomposites: Nanostructural characteristics, antibacterial mechanism, and biocompatibility. Cellulose 2015, 22, 565–579.
  52. Ullah, M.W.; Ul-Islam, M.; Khan, S.; Kim, Y.; Jang, J.H.; Park, J.K. In situ synthesis of a bio-cellulose/titanium dioxide nanocomposite by using a cell-free system. RSC Adv. 2016, 6, 22424–22435.
  53. Oprea, M.; Panaitescu, D.M. Nanocellulose Hybrids with Metal Oxides Nanoparticles for Biomedical Applications. Molecules 2020, 25, 4045.
  54. Gofman, I.V.; Nikolaeva, A.L.; Khripunov, A.K.; Ivan’kova, E.M.; Shabunin, A.S.; Yakimansky, A.V.; Romanov, D.P.; Popov, A.L.; Ermakov, A.M.; Solomevich, S.O.; et al. Bacterial Cellulose-Based Nanocomposites Containing Ceria and Their Use in the Process of Stem Cell Proliferation. Polymers 2021, 13, 1999.
  55. Khalid, A.; Khan, R.; Ul-Islam, M.; Khan, T.; Wahid, F. Bacterial cellulose-zinc oxide nanocomposites as a novel dressing system for burn wounds. Carbohydr. Polym. 2017, 164, 214–221.
  56. Melnikova, N.; Knyazev, A.; Nikolskiy, V.; Peretyagin, P.; Belyaeva, K.; Nazarova, N.; Liyaskina, E.; Malygina, D.; Revin, V. Wound Healing Composite Materials of Bacterial Cellulose and Zinc Oxide Nanoparticles with Immobilized Betulin Diphosphate. Nanomaterials 2021, 11, 713.
  57. Ao, H.; Jiang, W.; Nie, Y.; Zhou, C.; Zong, J.; Liu, M.; Liu, X.; Wan, Y. Engineering quaternized chitosan in the 3D bacterial cellulose structure for antibacterial wound dressings. Polym. Test. 2020, 86, 106490.
  58. Ostadhossein, F.; Mahmoudi, N.; Morales-Cid, G.; Tamjid, E.; Navas-Martos, F.J.; Soriano-Cuadrado, B.; Paniza, J.M.L.; Simchi, A. Development of chitosan/bacterial cellulose composite films containing nanodiamonds as a potential flexible platform for wound dressing. Materials 2015, 8, 5309.
  59. Zhao, H.; Zhang, L.; Zheng, S.; Chai, S.; Wei, J.; Zhong, L.; He, Y.; Xue, J. Bacteriostatic activity and cytotoxicity of bacterial cellulose-chitosan film loaded with in-situ synthesized silver nanoparticles. Carbohydr. Polym. 2021, 281, 119017.
  60. Ressler, A. Chitosan-Based Biomaterials for Bone Tissue Engineering Applications: A Short Review. Polymers 2022, 14, 3430.
  61. Cacicedo, M.L.; Pacheco, G.; Islan, G.A.; Alvarez, V.A.; Barud, H.S.; Castro, G.R. Chitosan-bacterial cellulose patch of ciprofloxacin for wound dressing: Preparation and characterization studies. Int. J. Biol. Macromol. 2020, 147, 1136–1145.
  62. Cazón, P.; Velazquez, G.; Vázquez, M. Characterization of bacterial cellulose films combined with chitosan and polyvinyl alcohol: Evaluation of mechanical and barrier properties. Carbohydr. Polym. 2019, 216, 72–85.
  63. Volova, T.; Shumilova, A.; Nikolaeva, E.; Kirichenko, A.; Shishatskaya, E. Biotechnological wound dressings based on bacterial cellulose and degradable copolymer P(3HB/4HB). Int. J. Biol. Macromol. 2019, 131, 230–240.
  64. Mohamad, N.; Loh, E.Y.X.; Fauzi, M.B.; Ng, M.H.; Amin, M.C.I.M. In vivo evaluation of bacterial cellulose/acrylic acid wound dressing hydrogel containing keratinocytes and fibroblasts for burn wounds. Drug Deliv. Transl. Res. 2018, 9, 444–452.
  65. Junka, A.; Bartoszewicz, M.; Dziadas, M.; Szymczyk, P.; Dydak, K.; Zywicka, A.; Owczarek, A.; Bil-Lula, I.; Czajkowska, J.; Fijałkowski, K. Application of Bacterial Cellulose Experimental Dressings Saturated with Gentamycin for Management of Bone Biofilm In Vitro And Ex Vivo. J. Biomed. Mater. Res. Part B Appl. Biomater. 2019, 108, 30–37.
  66. Shao, W.; Liu, H.; Wang, S.; Wu, J.; Huang, M.; Min, H.; Liu, X. Controlled release and antibacterial activity of tetracycline hydrochloride-loaded bacterial cellulose composite membranes. Carbohydr. Polym. 2016, 145, 114–120.
  67. Ye, S.; Jiang, L.; Wu, J. Flexible Amoxicillin-Grafted Bacterial Cellulose Sponges for Wound Dressing: In Vitro and in Vivo Evaluation. ACS Appl. Mater. Interfaces 2018, 10, 5862–5870.
  68. Vismara, E.; Bernardi, A.; Bongio, C.; Farè, S.; Pappalardo, S.; Serafini, A.; Pollegioni, L.; Rosini, E.; Torri, G. Bacterial nanocellulose and its surface modification by glycidyl methacrylate and ethylene glycol dimethacrylate. incorporation of vancomycin and ciprofloxacin. Nanomaterials 2019, 9, 1668.
  69. Volova, T.G.; Prudnikova, S.V.; Kiselev, E.G.; Nemtsev, I.V.; Vasiliev, A.D.; Kuzmin, A.P.; Shishatskaya, E.I. Bacterial Cellulose (BC) and BC Composites: Production and Properties. Nanomaterials 2022, 12, 192.
  70. Liyaskina, E.; Revin, V.; Paramonova, E.; Nazarkina, M.; Pestov, N.; Revina, N.; Kolesnikova, S. Nanomaterials from bacterial cellulose for antimicrobial wound dressing. J. Phys. 2017, 784, 012034.
  71. Revin, V.V.; Nazarova, N.B.; Tsareva, E.E.; Liyaskina, E.V.; Revin, V.D.; Pestov, N.A. Production of Bacterial Cellulose Aerogels With Improved Physico-Mechanical Properties and Antibacterial Effect. Front. Bioeng. Biotechnol. 2020, 8, 603407.
  72. Fernandes, P. Fusidic acid: A bacterial elongation factor inhibitor for the oral treatment of acute and chronic staphylococcal infections. Cold Spring Harb. Perspect. Med. 2016, 6, a025437.
  73. Liu, L.; Shen, X.; Yu, J.; Cao, X.; Zhan, Q.; Guo, Y.; Yu, F. Subinhibitory Concentrations of Fusidic AcidMay Reduce the Virulence of S. aureus by downregulating sara and saers to reduce biofilm formation and α-toxin expression. Front. Microbiol. 2020, 11, 25.
  74. Siala, W.; Rodriguez-Villalobos, H.; Fernandes, P.; Tulkens, P.M.; Van Bambeke, F. Activities of combinations of antistaphylococcal antibiotics with fusidic acid against staphylococcal biofilms in in vitro static and dynamic models. Antimicrob. Agents Chemother. 2018, 62, e00598-18.
  75. Nita, L.E.; Ghilan, A.; Rusu, A.G.; Neamtu, I.; Chiriac, A.P. New trends in bio-based aerogels. Pharmaceutics 2020, 12, 449.
  76. Gopakumar, D.; Malaysia, U.; Thomas, M.; Thomas, M.; Khalil, A.; Folahan Abdul-Wahab Taiwo, O. Nanocellulose Based Aerogels for Varying Engineering Applications. Renew. Sustain. Mater. 2020, 2, 155–165.
  77. Malheiros, P.S.; Jozala, A.F.; Pessoa, A., Jr.; Vila, M.M.D.C.; Balcão, V.M.; Franco, B.D.G.M. Immobilization of Antimicrobial Peptides from Lactobacillus Sakei Subsp. Sakei 2a in Bacterial Cellulose: Structural and Functional Stabilization. Food Packag. Shelf Life 2018, 17, 25–29.
  78. Bayazidi, P.; Almasi, H.; Asl, A.K. Immobilization of lysozyme on bacterial cellulose nanofibers: Characteristics, antimicrobial activity and morphological properties. Int. J. Biol. Macromol. 2018, 107, 2544–2551.
  79. Gupta, A.; Keddie, D.; Kannappan, V.; Gibson, H.; Khalil, I.; Kowalczuk, M.; Martin, C.; Shuai, X.; Radecka, I. Production and characterisation of bacterial cellulose hydrogels loaded with curcumin encapsulated in cyclodextrins as wound dressings. Eur. Polym. J. 2019, 118, 437–450.
  80. Chen, C.; Xi, Y.; Weng, Y. Recent Advances in Cellulose-Based Hydrogels for Tissue Engineering Applications. Polymers 2022, 14, 3335.
  81. Petersen, N.; Gatenholm, P. Bacterial cellulose-based materials and medical devices: Current state and perspectives. Appl. Microbiol. Biotechnol. 2011, 91, 1277–1286.
  82. Andersson, J.; Stenhamre, H.; Bäckdahl, H.; Gatenholm, P. Behavior of human chondrocytes in engineered porous bacterial cellulose scaffolds. J. Biomed. Mater. Res. A 2010, 94, 1124–1132.
  83. Svensson, A.; Nicklasson, E.; Harrah, T.; Panilaitis, B.; Kaplan, D.L.; Brittberg, M.; Gatenholm, P. Bacterial cellulose as a potential scaffold for tissue engineering of cartilage. Biomaterials 2005, 26, 419–431.
  84. Yin, N.; Stilwell, M.D.; Santos, T.M.; Wang, H.; Weibel, D.B. Agarose particle-templated porous bacterial cellulose and its application in cartilage growth in vitro. Acta Biomater. 2015, 12, 129–138.
  85. Wu, J.; Yin, N.; Chen, S.; Weibel, D.B.; Wang, H. Simultaneous 3D cell distribution and bioactivity enhancement of bacterial cellulose (BC) scaffold for articular cartilage tissue engineering. Cellulose 2019, 26, 2513–2528.
  86. Xun, X.; Li, Y.; Zhu, X.; Zhang, Q.; Lu, Y.; Yang, Z.; Wan, Y.; Yao, F.; Deng, X.; Luo, H. Fabrication of Robust, Shape Recoverable, Macroporous Bacterial Cellulose Scaffolds for Cartilage Tissue Engineering. Macromol. Biosci. 2021, 2021, 2100167.
  87. Gu, L.; Li, T.; Song, X.; Yang, X.; Li, S.; Chen, L.; Liu, P.; Gong, X.; Chen, C.; Sun, L. Preparation and characterization of methacrylated gelatin/bacterial cellulose composite hydrogels for cartilage tissue engineering. Regen. Biomater. 2020, 7, 195–202.
  88. Horbert, V.; Boettcher, J.; Foehr, P.; Kramer, F.; Udhardt, U.; Bungartz, M.; Brinkmann, O.; Burgkart, R.H.; Klemm, D.O.; Kinne, R.W. Laser perforation and cell seeding improve bacterial nanocellulose as a potential cartilage implant in the in vitro cartilage punch model. Cellulose 2019, 26, 647–664.
  89. Yang, J.; Wang, L.; Zhang, W.; Sun, Z.; Li, Y.; Yang, M.; Zeng, D.; Peng, B.; Zheng, W.; Jiang, X.; et al. Reverse reconstruction and bioprinting of bacterial cellulose-based functional total intervertebral disc for therapeutic implantation. Small 2018, 14, 1702582.
  90. Tazi, N.; Zhang, Z.; Messaddeq, Y.; Almeida-Lopes, L.; Zanardi, L.M.; Levinson, D.; Rouabhia, M. Hydroxyapatite bioactivated bacterial cellulose promotes osteoblast growth and the formation of bone nodules. AMB Express 2012, 2, 61.
  91. Dubey, S.; Mishra, R.; Roy, P.; Singh, R.P. 3-D macro/microporous-nanofibrous bacterial cellulose scaffolds seeded with BMP-2 preconditioned mesenchymal stem cells exhibit remarkable potential for bone tissue engineering. Int. J. Biol. Macromol. 2021, 167, 934–946.
  92. Gutiérrez-Hernández, J.M.; Escobar-García, D.M.; Escalante, A.; Flores, H.; González, F.J.; Gatenholm, P.; Toriz, G. In vitro evaluation of osteoblastic cells on bacterial cellulose modified with multi-walled carbon nanotubes as scaffold for bone regeneration. Mater. Sci. Eng. C. 2017, 75, 445–453.
  93. Klinthoopthamrong, N.; Chaikiawkeaw, D.; Phoolcharoen, W.; Rattanapisit, K.; Kaewpungsup, P.; Pavasant, P.; Hoven, V.P. Bacterial cellulose membrane conjugated with plant-derived osteopontin: Preparation and its potential for bone tissue regeneration. Int. J. Bio. Macromol. 2020, 149, 51–59.
  94. Favi, P.M.; Benson, R.S.; Neilsen, N.R.; Hammonds, R.L.; Bates, C.C.; Stephens, C.P.; Dhar, M.S. Cell proliferation, viability, and in vitro differentiation of equine mesenchymal stem cells seeded on bacterial cellulose hydrogel scaffolds. Mater. Sci. Eng. C Mater. Biol. Appl. 2013, 33, 1935–1944.
  95. Sundberg, J.; Götherström, C.; Gatenholm, P. Biosynthesis and in vitro evaluation of macroporous mineralized bacterial nanocellulose scaffolds for bone tissue engineering. Biomed. Mater. Eng. 2015, 25, 39–52.
  96. Saska, S.; Scarel-Caminaga, R.M.; Teixeira, L.N.; Franchi, L.P.; Dos Santos, R.A.; Gaspar, A.M.M.; de Oliveira, P.T.; Rosa, A.L.; Takahashi, C.S.; Messaddeq, Y.; et al. Characterization and in vitro evaluation of bacterial cellulose membranes functionalized with osteogenic growth peptide for bone tissue engineering. J. Mater. Sci. Mater. Med. 2012, 23, 2253–2266.
  97. Shi, Q.; Li, Y.; Sun, J.; Zhang, H.; Chen, L.; Chen, B.; Yang, H.; Wang, Z. The osteogenesis of bacterial cellulose scaffold loaded with bone morphogenetic protein-2. Biomaterials 2012, 33, 6644–6649.
  98. Ran, J.; Jiang, P.; Liu, S.; Sun, G.; Yan, P.; Shen, X.; Tong, H. Constructing multi-component organic/inorganic composite bacterial cellulose-gelatin/hydroxyapatite double-network scaffold platform for stem cell-mediated bone tissue engineering. Mater. Sci. Eng. C 2017, 78, 130–140.
  99. Shao, H.; He, J.; Lin, T.; Zhang, Z.; Zhang, Y.; Liu, S. 3D gel-printing of hydroxyapatite scaffold for bone tissue engineering. Ceram. Int. 2019, 45, 1163–1170.
  100. Aki, D.; Ulag, S.; Unal, S.; Sengor, M.; Ekren, N.; Lin, C.C.; Gunduz, O. 3D printing of PVA/hexagonal boron nitride/bacterial cellulose composite scaffolds for bone tissue engineering. Mater. Des. 2020, 196, 109094.
  101. Cakmak, A.M.; Unal, S.; Sahin, A.; Oktar, F.N.; Sengor, M.; Ekren, N.; Gunduz, O.; Kalaskar, D.M. 3D printed polycaprolactone/gelatin/bacterial cellulose/hydroxyapatite composite scaffold for bone tissue engineering. Polymers 2020, 12, 1962.
  102. Zhang, C.; Cao, J.; Zhao, S.; Luo, H.; Yang, Z.; Gama, M.; Zhang, Q.; Su, D.; Wan, Y. Biocompatibility evaluation of bacterial cellulose as a scaffold material for tissue-engineered corneal stroma. Cellulose 2020, 27, 2775–2784.
  103. Schumann, D.A.; Wippermann, J.; Klemm, D.O.; Kramer, F.; Koth, D.; Kosmehl, H.; Wahlers, T.; Salehi-Gelani, S. Artificial vascular implants from bacterial cellulose: Preliminary results of small arterial substitutes. Cellulose 2009, 16, 877–885.
  104. Pértile, R.; Moreira, S.; Andrade, F.; Domingues, L.; Gama, M. Bacterial cellulose modified using recombinant proteins to improve neuronal and mesenchymal cell adhesion. Biotechnol. Prog. 2012, 28, 526–532.
  105. Kim, D.Y.; Park, S.E.; Jo, I.S.; Kim, S.M.; Kang, D.H.; Cho, S.P.; Park, J.B.; Hong, B.H.; Yoon, M.H. Multiscale modulation of nanocrystalline cellulose hydrogel via nanocarbon hybridization for 3D neuronal bilayer formation. Small 2017, 13, 1700331.
  106. Hosseini, H.; Zirakjou, A.; Goodarzi, V.; Mousavi, S.M.; Khonakdar, H.A.; Zamanlui, S. Lightweight aerogels based on bacterial cellulose/silver nanoparticles/ polyaniline with tuning morphology of polyaniline and application in soft tissue engineering. Int. J. Biol. Macromol. 2020, 152, 57–67.
  107. Sämfors, S.; Karlsson, K.; Sundberg, J.; Markstedt, K.; Gatenholm, P. Biofabrication of bacterial nanocellulose scaffolds with complex vascular structure. Biofabrication 2019, 11, 045010.
  108. da Silva, I.G.R.; dos Santos Pantoja, B.T.; Almeida, G.H.D.R.; Carreira, A.C.O.; Miglino, M.A. Bacterial Cellulose and ECM Hydrogels: An Innovative Approach for Cardiovascular Regenerative Medicine. Int. J. Mol. Sci. 2022, 23, 3955.
  109. Leitao, A.F.; Faria, M.A.; Faustino, A.M.; Moreira, R.; Mela, P.; Loureiro, L.; Silva, I.; Gama, M. A novel small-caliber bacterial cellulose vascular prosthesis: Production, characterization, and preliminary In vivo testing. Macromol. Biosci. 2016, 16, 139–150.
  110. Han, Y.; Li, C.; Cai, Q.; Bao, X.; Tang, L.; Ao, H.; Liu, J.; Jin, M.; Zhou, Y.; Wan, Y.; et al. Studies on Bacterial Cellulose/Poly (Vinyl Alcohol) Hydrogel Composites as Tissue-Engineered Corneal Stroma. Biomed. Mater. 2020, 15, 035022.
  111. Sepúlveda, R.V.; Valente, F.L.; Reis, E.C.C.; Araújo, F.R.; Eleotério, R.B.; Queiroz, P.V.S.; Borges, A.P.B. Bacterial cellulose and bacterial cellulose/polycaprolactone composite as tissue substitutes in rabbits’ cornea. Pesqui. Vet. Bras. 2016, 36, 986–992.
  112. Anton-Sales, I.; D’Antin, J.C.; Fernández-Engroba, J.; Charoenrook, V.; Laromaine, A.; Roig, A.; Michael, R. Bacterial nanocellulose as a corneal bandage material: A comparison with amniotic membrane. Biomater. Sci. 2020, 8, 2921–2930.
  113. Heo, D.N.; Kim, H.J.; Lee, Y.J.; Heo, M.; Lee, S.J.; Lee, D.H.; Do, S.H.; Lee, S.H.; Kwon, I.K. Flexible and highly biocompatible nanofiber-based electrodes for neural surface interfacing. ACS Nano 2017, 11, 2961–2971.
  114. Yang, J.; Du, M.; Wang, L.; Li, S.; Wang, G.; Yang, X.; Zhang, L.; Fang, Y.; Zheng, W.; Yang, G.; et al. Bacterial cellulose as a supersoft neural interfacing substrate. ACS Appl. Mater. Interfaces 2018, 10, 33049–33059.
  115. Hou, Y.; Wang, X.; Yang, J.; Zhu, R.; Zhang, Z.; Li, Y. Development and biocompatibility evaluation of biodegradable bacterial cellulose as a novel peripheral nerve scaffold. J. Biomed. Mater. Res. Part A 2018, 106, 1288–1298.
  116. Kharchenko, A.V.; Stupak, V.V. Bacterial nanocellulose as a plastic material for closure of defects of the dura mater: Literature review. Hir. Pozvonoc. 2019, 16, 62–73, In Russian.
  117. Das, S.; Ghosh, B.; Sarkar, K. Nanocellulose as sustainable biomaterials for drug delivery. Sens. Int. 2022, 3, 100135.
  118. Mensah, A.; Chen, Y.; Christopher, N.; Wei, Q. Membrane Technological Pathways and Inherent Structure of Bacterial Cellulose Composites for Drug Delivery Bioengineering. Bioengineering 2022, 9, 3.
  119. Hasan, N.; Rahman, L.; Kim, S.-H.; Cao, J.; Arjuna, A.; Lallo, S.; Jhun, B.H.; Yoo, J.-W. Recent advances of nanocellulose in drug delivery systems. J. Pharm. Investig. 2020, 50, 553–572.
  120. Li, X.; Liu, Y.; Yu, Y.; Chen, W.; Liu, Y.; Yu, H. Nanoformulations of quercetin and cellulose nanofibers as healthcare supplements with sustained antioxidant activity. Carbohydr. Polym. 2019, 207, 106–168.
  121. Qiu, A.; Wang, Y.; Zhang, G.; Wang, H. Natural Polysaccharide-Based Nanodrug Delivery Systems for Treatment of Diabetes. Polymers 2022, 14, 3217.
  122. Huo, Y.; Liu, Y.; Xia, M.; Du, H.; Lin, Z.; Li, B.; Liu, H. Nanocellulose-Based Composite Materials Used in Drug Delivery Systems. Polymers 2022, 14, 2648.
  123. Silva, N.H.; Rodrigues, A.F.; Almeida, I.F.; Costa, P.; Rosado, C.F.; Neto, C.P.; Silvestre, A.J.D.; Freire, C.S.R. Bacterial cellulose membranes as transdermal delivery systems for diclofenac: In vitro dissolution and permeation studies. Carbohydr. Polym. 2014, 106, 264–269.
  124. Liu, W.; Du, H.; Zhang, M.; Liu, K.; Liu, H.; Xie, H.; Zhang, X.; Si, C. Bacterial cellulose-based composite scaffolds for biomedical applications: A review. ACS Sustain. Chem. Eng. 2020, 8, 7536–7562.
  125. Ul, S.; Ul-islam, M.; Ahsan, H.; Bilal, M.; Shehzad, A.; Fatima, A.; Kyung, J.; Sup, Y. Potential applications of bacterial cellulose and its composites for cancer treatment. Int. J. Biol. Macromol. 2020, 168, 301–309.
  126. Cacicedo, M.L.; Islan, G.A.; León, I.E.; Álvarez, V.A.; Chourpa, I.; Allard-Vannier, E.; Castro, G.R. Bacterial cellulose hydrogel loaded with lipid nanoparticles for localized cancer treatment. Colloids Surf. B Biointerfaces 2018, 170, 596–608.
  127. Zhang, L.K.; Du, S.; Wang, X.; Jiao, Y.; Yin, L.; Zhang, Y.; Guan, Y.Q. Bacterial cellulose based composites enhanced transdermal drug targeting for breast cancer treatment. Chem. Eng. J. 2019, 370, 749–759.
  128. Sajjad, W.; He, F.; Ullah, M.W.; Ikram, M.; Shah, S.M.; Khan, R.; Khan, T.; Khalid, A.; Yang, G.; Wahid, F. Fabrication of Bacterial Cellulose-Curcumin Nanocomposite as a Novel Dressing for Partial Thickness Skin Burn. Front. Bioeng. Biotechnol. 2020, 8, 553037.
  129. Brassolatti, P.; Kido, H.W.; Bossini, P.S.; Gabbai-Armelin, P.R.; Otterço, A.N.; Almeida-Lopes, L.; Zanardi, L.M.; Napolitano, M.A.; Avó, L.R.D.S.D.; Forato, L.A.; et al. Bacterial cellulose membrane used as biological dressings on third-degree burns in rats. Bio-Med. Mater.Eng. 2017, 29, 29–42.
  130. Inoue, B.S.; Streit, S.; Schneider, A.L.D.S.; Meier, M.M. Bioactive bacterial cellulose membrane with prolonged release of chlorhexidine for dental medical application. Int. J. Biol. Macromol. 2020, 148, 1098–1108.
  131. Luo, H.; Ao, H.; Li, G.; Li, W.; Xiong, G.; Zhu, Y.; Wan, Y. Bacterial cellulose/graphene oxide nanocomposite as a novel drug delivery system. Curr. Appl. Phys. 2017, 17, 249–254.
  132. Ahmad, N.; Amin, M.C.I.M.; Mahali, S.M.; Ismail, I.; Chuang, V.T.G. Biocompatible and mucoadhesive bacterial cellulose-g-poly (acrylic acid) hydrogels for oral protein delivery. Mol. Pharm. 2014, 11, 4130–4142.
  133. Kamel, S.; Khattab, T.A. Recent Advances in Cellulose-Based Biosensors for Medical Diagnosis. Biosensors 2020, 10, 67.
  134. Kotsiri, Z.; Vidic, J.; Vantarakis, A. Applications of Biosensors for Bacteria and Virus Detection in Food and Water–A Systematic Review. J. Environ. Sci. 2022, 111, 367–379.
  135. Vidic, J.; Manzano, M.; Chang, C.M.; Jaffrezic-Renault, N. Advanced biosensors for detection of pathogens related to livestock and poultry. Vet. Res. 2017, 48, 11.
  136. Senf, B.; Yeo, W.-H.; Kim, J.-H. Recent Advances in Portable Biosensors for Biomarker Detection in Body Fluids. Biosensors 2020, 10, 127.
  137. Ray, S.; Panjikar, S.; Anand, R. Design of Protein-Based Biosensors for Selective Detection of Benzene Groups of Pollutants. ACS Sens. 2018, 3, 1632–1638.
  138. Lv, P.; Yao, Y.; Li, D.; Zhou, H.; Naeem, M.A.; Feng, Q.; Huang, J.; Cai, Y.; Wei, Q. Self-assembly of nitrogen-doped carbon dots anchored on bacterial cellulose and their application in iron ion detection. Carbohydr.Polym. 2017, 172, 93–101.
  139. Zhang, T.; Wang, W.; Zhang, D.; Zhang, X.; Ma, Y.; Zhou, Y.; Qi, L. Biotemplated synthesis of gold nanoparticle–bacteria cellulose nanofiber nanocomposites and their application in biosensing. Adv. Funct. Mater. 2010, 20, 1152–1160.
  140. Torres, F.G.; Troncoso, O.P.; Gonzales, K.N.; Sari, R.M.; Gea, S. Bacterial cellulose based biosensors. Med. Devices Sens. 2020, 3, e10102.
  141. Gutierrez, J.; Tercjak, A.; Algar, I.; Retegi, A.; Mondragon, I. Conductive properties of TiO2/bacterial cellulose hybrid fibres. J.Colloid Interface Sci. 2012, 377, 88–93.
  142. Li, D.; Ao, K.; Wang, Q.; Lv, P.; Wei, Q. Preparation of Pd/bacterial cellulose hybrid nanofibers for dopamine detection. Molecules 2016, 21, 618.
  143. Li, G.; Sun, K.; Li, D.; Lv, P.; Wang, Q.; Huang, F.; Wei, Q. Biosensor based on bacterial cellulose-Au nanoparticles electrode modified with laccase for hydroquinone detection. Colloids Surf. A Physicochem. Eng. Asp. 2016, 509, 408–414.
  144. Núñez-Carmona, E.; Bertuna, A.; Abbatangelo, M.; Sberveglieri, V.; Comini, E.; Sberveglieri, G. BC-MOS: The novel bacterial cellulose based MOS gas sensors. Mater. Lett. 2019, 237, 69–71.
  145. Wang, W.; Li, H.-Y.; Zhang, D.-W.; Jiang, J.; Cui, Y.-R.; Qiu, S.; Zhou, Y.-L.; Zhang, X.-X. Fabrication of bienzymatic glucose biosensor based on novel gold nanoparticles-bacteria cellulose nanofibers nanocomposite. Electroanalysis 2010, 22, 2543–2550.
  146. Wang, W.; Zhang, T.-J.; Zhang, D.-W.; Li, H.-Y.; Ma, Y.-R.; Qi, L.-M.; Zhou, Y.-L.; Zhang, X.-X. Amperometric hydrogen peroxide biosensor based on the immobilization of heme proteins on gold nanoparticles–bacteria cellulose nanofibers nanocomposite. Talanta 2011, 84, 71–77.
  147. Jasim, A.; Ullah, M.W.; Shi, Z.; Lin, X.; Yang, G. Fabrication of bacterial cellulose/polyaniline/single-walled carbon nanotubes membrane for potential application as biosensor. Carbohydr. Polym. 2017, 163, 62–69.
  148. Hu, W.; Chen, S.; Liu, L.; Ding, B.; Wang, H. Formaldehyde sensors based on nanofibrous polyethyleneimine/bacterial cellulose membranes coated quartz crystal microbalance. Sens. Actuators B Chem. 2011, 157, 554–559.
  149. Hu, W.; Chen, S.; Yang, Z.; Liu, L.; Wang, H. Flexible electrically conductive nanocomposite membrane based on bacterial cellulose and polyaniline. J. Phys. Chem. B 2011, 115, 8453–8457.
  150. Yue, L.; Xie, Y.; Zheng, Y.; He, W.; Guo, S.; Sun, Y.; Zhang, T.; Liu, S. Sulfonated bacterial cellulose/polyaniline composite membrane for use as gel polymer electrolyte. Compos. Sci.Technol. 2017, 145, 122–131.
  151. Evans, B.R.; O’Neill, H.M.; Malyvanh, V.P.; Lee, I.; Woodward, J. Palladium-bacterial cellulose membranes for fuel cells. Biosens. Bioelectron. 2003, 18, 917–923.
  152. Li, X.; Li, D.; Zhang, Y.; Lv, P.; Feng, Q.; Wei, Q. Encapsulation of enzyme by metal-organic framework for single-enzymatic biofuel cell-based self-powered biosensor. Nano Energy 2019, 68, 104308.
  153. Sanchis, M.J.; Carsí, M.; Gómez, C.M.; Culebras, M.; Gonzales, K.N.; Torres, F.G. Monitoring molecular dynamics of bacterial cellulose composites reinforced with graphene xide by carboxymethyl cellulose addition. Carbohyd. Polym. 2017, 157, 353–360.
  154. Cummins, D.; Boschloo, G.; Ryan, M.; Corr, D.; Rao, S.N.; Fitzmaurice, D. Ultrafast electrochromic windows based on redox-chromophore modified nanostructured semiconducting and conducting films. J. Phys. Chem. B 2020, 104, 11449–11459.
  155. Torres, F.G.; Arroyo, J.J.; Troncoso, O.P. Bacterial cellulose nanocomposites: An all-nano type of material. Mater. Sci. Eng. C Mater. Biol. Appl. 2019, 98, 1277–1293.
  156. Rana, A.; Scarpa, F.; Vijay, K. Cellulose/polyaniline hybrid nanocomposites: Design, fabrication, and emerging multidimensional applications Thakur. Ind. Crops Prod. 2022, 187, 115356.
  157. Varsha, M.; Senthil Kumar, P.; Senthil Rathi, B. A Review on Recent Trends in the Removal of Emerging Contaminants from Aquatic Environment Using Low-Cost Adsorbents. Chemosphere 2022, 287, 132270.
  158. Shi, R.-J.; Wang, T.; Lang, J.-Q.; Zhou, N.; Ma, M.-G. Multifunctional Cellulose and Cellulose-Based (Nano) Composite Adsorbents. Front. Bioeng. Biotechnol. 2022, 10, 891034.
  159. Salama, A.; Abouzeid, R.; Leong, W.S.; Jeevanandam, J.; Samyn, P.; Dufresne, A.; Bechelany, M.; Barhoum, A. Nanocellulose-Based Materials for Water Treatment: Adsorption, Photocatalytic Degradation, Disinfection, Antifouling, and Nanofiltration. Nanomaterials 2021, 11, 3008.
  160. Voisin, H.; Bergström, L.; Liu, P.; and Mathew, A. Nanocellulose-based Materials for Water Purification. Nanomaterials 2017, 7, 57.
  161. Madivoli, E.S.; Kareru, P.G.; Gachanja, A.N.; Mugo, S.; Murigi, M.K.; Kairigo, P.K.; Kipyegon, C.; Mutembei, J.K.; Njonge, F. Adsorption of Selected Heavy Metals on Modified Nano Cellulose. Irjpac 2016, 12, 1–9.
  162. Köse, K.; Mavlan, M.; Youngblood, J.P. Applications and impact of nanocellulose based adsorbents. Cellulose 2020, 27, 2967–2990.
  163. Anirudhan, T.S.; Deepa, J.R. Synthesis and characterization of multi-carboxyl-functionalized nanocellulose/nanobentonite composite for the adsorption of uranium (VI) from aqueous solutions: Kinetic and equilibrium profiles. Chem. Eng. J. 2015, 273, 390–440.
  164. Olivera, S.; Muralidhara, H.B.; Venkatesh, K.; Guna, V.K.; Gopalakrishna, K.; Kumar, K.Y. Potential applications of cellulose and chitosan nanoparticles/composites in wastewater treatment: A review. Carbohydr. Polym. 2016, 153, 600–618.
  165. Putro, J.N.; Kurniawan, A.; Ismadji, S.; Ju, Y.-H. Nanocellulose based biosorbents for wastewater treatment: Study of isotherm, kinetic, thermodynamic and reusability. Environ. Nanotechnol. Monit. Manag. 2017, 8, 134–149.
  166. Shak, K.P.Y.; Pang, Y.L.; Mah, S.K. Nanocellulose: Recent advances and its prospects in environmental remediation. Beilstein J. Nanotechnol. 2018, 9, 2479–2498.
  167. Taleb, K.; Markovski, J.; Velickovic, Z.C.; Rusmirovic, J.; Rancic, M.; Pavlovic, V.; Marinkovic, A. Arsenic removal by magnetiteloaded amino modified nano/microcellulose adsorbents: Effect of functionalization and media size. Arab. J. Chem. 2019, 8, 4675–4693.
  168. Bhatnagar, A.; Sillanpää, M.; Witek-Krowiak, A. Agricultural waste peels as versatile biomass for water purification—A review. Chem. Eng. J. 2015, 270, 244–271.
  169. Vartiainen, J.; Pöhler, T.; Sirola, K.; Pylkkänen, L.; Alenius, H.; Hokkinen, J.; Tapper, U.; Lahtinen, P.; Kapanen, A.; Putkisto, K.; et al. A Health and environmental safety aspects of friction grinding and spray drying of microfibrillated cellulose. Cellulose 2011, 18, 775–786.
  170. Stoica-Guzun, A.; Stroescu, M.; Jinga, S.I.; Mihalache, N.; Botez, A.; Matei, C.; Berger, D.; Damian, C.M.; Ionita, V. Box-Behnken experimental design for chromium (VI) ions removal by bacterial cellulose-magnetite composites. Int. J. Biol. Macromol. 2016, 91, 1062–1072.
  171. Shoukat, A.; Wahid, F.; Khan, T.; Siddique, M.; Nasreen, S.; Yang, G.; Ullah, M.W.; Khan, R. Titanium oxide-bacterial cellulose bioadsorbent for the removal of lead ions from aqueous solution. Int. J. Biol. Macromol. 2019, 129, 965–971.
  172. Hosseini, H.; Mousavi, S.M. Bacterial cellulose/polyaniline nanocomposite aerogels as novel bioadsorbents for removal of hexavalent chromium: Experimental and simulation study. J. Clean. Prod. 2021, 278, 123817.
  173. Mensah, A.; Lv, P.; Narh, C.; Huang, J.; Wang, D.; Wei, Q. Sequestration of Pb (II) Ions from Aqueous Systems with Novel Green Bacterial Cellulose Graphene Oxide Composite. Materials 2019, 12, 218.
  174. Suárez-Avendaño, D.; Martínez-Correa, E.; Cañas-Gutierrez, A.; Castro-Riascos, M.; Zuluaga-Gallego, R.; Gañán-Rojo, P.; Peresin, M.; Pereira, M.; Castro-Herazo, C. Comparative Study on the Efficiency of Mercury Removal From Wastewater Using Bacterial Cellulose Membranes and Their Oxidized Analogue. Front. Bioeng. Biotechnol. 2022, 10, 815892.
  175. Nigussie, W.; Zewge, F.; Chandravanshi, B.S. Removal of excess fluoride from water using waste residue from alum manufacturing process. J. Hazard. Mat. 2007, 147, 954–963.
  176. Shimelis, B.; Zewge, F.; Chandravanshi, B.S. Removal of excess fluoride from water by aluminum hydroxide. Bull. Chem. Soc. Ethiop. 2006, 20, 17–34.
  177. Alemu, S.; Mulugeta, E.; Zewge, F.; Chandravanshi, B.S. Water defluoridation by aluminium oxide-manganese oxide composite material. Environ. Technol. 2014, 35, 1893–1903.
  178. Gómez-Hortigüela, L.; Pérez-Pariente, J.; García, R.; Chebude, Y.; Díaz, I. Natural zeolites from Ethiopia for elimination of fluoride from drinking water. Sep. Purif. Technol. 2013, 120, 224–229.
  179. Alhassan, S.I.; He, Y.; Huang, L.; Wu, B.; Yan, L.; Deng, H.; Wang, H. A review on fluoride adsorption using modified bauxite: Surface modification and sorption mechanisms perspectives. J. Environ. Chem. Eng. 2020, 8, 104532.
  180. Wendimu, G.; Zewge, F.; Mulugeta, E. Aluminium-iron-amended activated bamboo charcoal (AIAABC) for fluoride removal from aqueous solutions. J. Water Proc. Eng. 2017, 16, 123–131.
  181. Mondal, N.K.; Bhaumik, R.; Datta, J.K. Removal of fluoride by aluminum impregnated coconut fiber from synthetic fluoride solution and natural water. Alexandria Eng. J. 2015, 54, 1273–1284.
  182. Vázquez-Guerrero, A.; Alfaro-Cuevas-Villanueva, R.; Rutiaga-Quiñones, J.G.; Cortés-Martínez, R. Fluoride removal by aluminummodified pine sawdust: Effect of competitive ions. Ecol. Eng. 2016, 94, 365–379.
  183. Revin, V.V.; Dolganov, A.V.; Liyaskina, E.V.; Nazarova, N.B.; Balandina, A.V.; Devyataeva, A.A.; Revin, V.D. Characterizing Bacterial Cellulose Produced by Komagataeibacter sucrofermentans H-110 on Molasses Medium and Obtaining a Biocomposite Based on It for the Adsorption of Fluoride. Polymers 2021, 13, 1422.
  184. Wang, Y.; Yadav, S.; Heinlein, T.; Konjik, V.; Breitzke, H.; Buntkowsky, G.; Schneider, J.J.; Zhang, K. Ultra-light nanocomposite aerogels of bacterial cellulose and reduced graphene oxide for specific absorption and separation of organic liquids. RSC Adv. 2014, 4, 21553–21558.
  185. Zhu, H.-Y.; Fu, Y.-Q.; Jiang, R.; Jiang, J.-H.; Xiao, L.; Zeng, G.-M.; Zhao, G.-M.; Wang, Y. Adsorption Removal of congo Red onto Magnetic cellulose/Fe3O4/activated Carbon Composite: Equilibrium, Kinetic and Thermodynamic Studies. Chem. Eng. J. 2011, 173, 494–502.
  186. Galdino, C.J.S.; Maia, A.D.; Meira, H.M.; Souza, T.C.; Amorim, J.D.; Almeida, F.C.; Costa, A.F.; Sarubbo, L.A. Use of a bacterial cellulose filter for the removal of oil from wastewater. Process. Biochem. 2020, 91, 288–296.
  187. Paulauskiene, T.; Uebe, J.; Ziogas, M. Cellulose aerogel composites as oil sorbents and their regeneration. Peer J. 2021, 9, e11795.
  188. Ieamviteevanich, P.; Daneshvar, E.; Eshaq, G.; Puro, L.; Mongkolthanaruk, W.; Pinitsoontorn, S.; Bhatnagar, A. Synthesis and Characterization of a Magnetic Carbon Nanofiber Derived from Bacterial Cellulose for the Removal of Diclofenac from Water. ACS Omega 2022, 7, 7572–7584.
  189. Zheng, W.-L.; Hu, W.-L.; Chen, S.-Y.; Zheng, Y.; Zhou, B.-H.; Wang, H.-P. High photocatalytic properties of zinc oxide nanoparticles with amidoximated bacterial cellulose nanofibers as templates. Chin. J. Polym. Sci. 2014, 32, 169–176.
  190. Wang, S.-D.; Ma, Q.; Liu, H.; Wang, K.; Ling, L.-Z.; Zhang, K.-Q. Robust electrospinning cellulose 2 ultrafine fibers for dyeing water treatment by photocatalytic reactions. RSC Adv. 2015, 5, 40521–40530.
  191. Alves, A.A.; Silva, W.E.; Belian, M.F.; Lins, L.S.G.; Galembeck, A. Bacterial Cellulose Membranes for Environmental Water Remediation and Industrial Wastewater Treatment. Int. J. Environ. Sci. Technol. 2020, 17, 3997–4008.
More
© Text is available under the terms and conditions of the Creative Commons Attribution (CC BY) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
This entry is offline, you can click here to edit this entry!
Video Production Service
Feedback