Timeline of Chagas Disease: History
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This is a timeline of Chagas disease, describing major events such as scientific and medical developments, as well as major organizations and campaigns aimed at combating the disease.

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1. Full Timeline

First and last reported presence of Chagas disease vector rhodnius prolixus in Central America and Mexico [1]. https://handwiki.org/wiki/index.php?curid=1437642
Estimated Nuber of immigrants infected with trypanosoma cruzi in European countries [2]. https://handwiki.org/wiki/index.php?curid=1252769
Year/period Type of event Event Geographical location
7–10 million BP   The ancestor of Chagas disease parasite trypanosoma cruzi is probably introduced to South America via bats.[3] South America
~15000 BP Infection Chagas parasite trypanosoma cruzi starts to affect human beings upon their arrival in the Americas.[3] Americas
~9000 BP Infection The earliest detection of a chagas parasite trypanosoma cruzi infection in a human comes from a Chinchorro mummy. Chagas disease causative parasite trypanosoma cruzi infections would also be found in mummies of subsequent cultures that succeeded the Chinchorros and were living in the same area up to the time of the Spanish conquest in the 16th century.[3] South America
1707 Medical development Portuguese physician Miguel Diaz Pimenta publishes book first suggesting clinical report relating to possible intestinal symptoms of Chagas disease. Pimenta describes a condition, which is known as “bicho”, “that causes the humours to be retained, causing the patient to have little desire to eat”.[3]  
1735 Medical development Portuguese physician, Luís Gomes Ferreira describes account on the megavisceral syndrome of Chagas disease.[3]  
1835 Report During The Voyage of the Beagle, British naturalist Charles Darwin writes account of blood sucking process of a triatomine bug (known as benchuca or the great black bug of the Pampas) attacking on him. Based on this encounter and Darwin's prolonged gastric and nervous symptoms, it would be hypothesised that Darwin was suffering from Chagas disease later in his life. Despite all this, the critical role of triatomine bugs in transmitting Chagas disease would remain undiscovered until 1909.[3] Argentina
1873 Medical development Danish physician Theodoro Langgaard describes Chagas disease as “mal de engasgo” probably referring to dysphagia.[3][4] Brazil
1909 Scientific development Brazilian scientist Carlos Chagas, after years of researching trypanosomes, finds the relation between these pathogenes and a feverish two-year-old girl with enlarged spleen and liver and swollen lymph nodes. Chagas discovers a new human disease which soon would bear his name.[3][5][6] Brazil
1913 Scientific development Nattan-Larrier reports finding Chagas disease causing parasite trypanosoma cruzi in the milk of laboratory animals.[7]  
1915 Scientific development Rhodnius prolixus, one of the main vectors of trypanosoma cruzi (causative agent of Chagas disease) in Central America, is discovered in El Salvador.[1] El Salvador
1930–1939 Scientific development Argentine epidemiologist Salvador Mazza describes more than a thousand Chagas disease cases in the Argentine Chaco province. Mazza is the first to raise the possibility that Chagas disease could be transmitted by blood transfusion.[3] Argentina
1934   Chagas disease vector Rhodnius prolixus, is first reported in Guatemala.[1] Guatemala
1936 Scientific development Study reports having found trypomastigotes in the milk of mothers in the acute phase of Chagas disease.[7]  
1939 Scientific development Swiss chemist discovers Organochloride DDT's insecticidal properties.[8] This would allow vector control in the 1940s when the first organochlorine insecticides are developed.[3]  
1947 Prevention development Gamma-hexachlorocyclohexane (BHC) insecticide is released and recommended for its use as first control alternative against Chagas disease vectors. For many years ahead, BHC would remain the mainstay of Chagas disease vector control trials and campaigns.  
1949   Chagas disease vector Rhodnius prolixus, is first reported in Nicaragua.[1] Nicaragua
1953 Medical development Dye crystal violet is found to kill Chagas disease parasite trypanosoma cruzi in blood preservations. Since then the dye would be widely employed in blood banks in endemic areas to eliminate the parasite from blood used for transfusion.[3]  
1953   Chagas disease vector Rhodnius prolixus, is first reported in Costa Rica.[1] Costa Rica
1956–1959   Chagas disease vector Rhodnius prolixus, is first reported in Honduras.[1] Honduras
1966 Medical development Swiss multinational health-care company Hoffmann-La Roche introduces benznidazole for treatment of Chagas disease.[3] Switzerland
1970 Medical development German multinational company Bayer introduces Nifurtimox for treatment of Chagas disease. Germany
1972 Scientific development M. A. Miles detects trypomastigotes and antibodies against Chagas disease parasite trypanosoma cruzi, after examining the milk of mice in the acute phase of the disease. Finally, Miles would conclude that, experimentally, even in the acute phase of the disease, Chagas transmission through breast-feeding is rare.[7]  
1975 Program launch Brazil starts operating Chagas disease control program. At the time, 711 out of over 5000 municipalities have triatomine-infested houses targeted by the program. Brazil
1975–1978 Program launch The Ministry of Health of Brazil conducts a seroprevalence survey in its Chagas disease endemic areas and finds 4.1% individuals positive, equivalent to about 800,000 cases of the disease. Brazil
1983 Program launch Brazil launches national campaign of Chagas disease vector control. By 1986 75% of the initial objectives would be attained. Brazil
1986 Report Brazil reports 186 municipalities infested with triatomines (potential Chagas disease vectors). Brazil
1991 Program launch A Southern Cone Initiative (INCOSUR), a regional intergovernmental control program agreed between the governments of Argentina, Bolivia, Brazil, Chile, Paraguay, Uruguay and Peru, is launched with the original objectives of eliminating all domestic and peridomestic populations of the main vector triatoma infestans and transmission of trypanosoma cruzi via blood transfusion in the Southern Cone countries by the year 2000.[5][9][10] Argentina , Bolivia, Brazil , Chile , Paraguay, Uruguay, Peru
1993 Report Brazil reports 83 municipalities infested with triatomines (potential Chagas disease vectors). Brazil
1997 Eradication Control over the transmission of Chagas disease infection by vector triatoma infestans is certified in Uruguay by the Pan American Health Organization.[5][10] Uruguay
1997 Program launch The Initiative of the Andean Countries (IAC) is launched by Colombia, Ecuador, Peru and Venezuela with the purpose of interrupting transmission via vector and transfusion of Chagas disease in the region.[5][11] Colombia, Ecuador, Peru, Venezuela
1997 Program launch The Initiative of Central America and Mexico is launched with the objectives of interrupting the transmission of Chagas disease by vector rhodnius prolixus, reducing domestic infestation by vector triatoma dimidiata and interrupting parasite trypanosoma cruzi transmission through blood transfusion.[1][5]  
1998 Program launch The World Health Assembly and others set target for interruprion of transmission of Chagas disease by 2005 (not achieved).[9]  
1999 Eradication Control over the transmission of Chagas disease infection by vector triatoma infestans is certified in Chile by the Pan American Health Organization.[5][10] Chile
2002 Report The burden of Chagas disease in Latin America is calculated to amount to as much as 2.7 times the joint burden of malaria, schistosomiasis, leishmaniasis and leprosy, and accounts for 670 000 disability-adjusted life years through its impact on worker productivity, premature disability and death.[9] Latin America
2002 Organization The Initiative of the Amazon Countries (AMCHA) is organized by the Pan American Health Organization with the objectives of evaluating the risks of Chagas endemicity becoming established in the Amazon Region, identifying the research required for monitoring and prevention of Chagas disease in the region, proposing monitoring and prevention, and proposing an international cooperation system. Nine Amazon countries are represented: Bolivia, Brazil , Colombia, Ecuador, Guyana, French Guiana, Peru, Surinam and Venezuela.[5] Brazil (Manaus)
2006 Eradication Control over the transmission of Chagas disease infection by vector triatoma infestans is certified in Brazil by the Pan American Health Organization.[5] Brazil
2008 Eradication Guatemala becomes the first country in Central America to be formally certified as free of Chagas disease transmission due to rhodnius prolixus.[1][12] Guatemala
2011 Eradication All the previously endemic countries of Central America, in addition to Mexico, are formally certified as free of Chagas disease transmission due to their main domestic vector, rhodnius prolixus.[1] Mexico, Belize, El Salvador, Guatemala, Honduras, Nicaragua, Costa Rica

The content is sourced from: https://handwiki.org/wiki/Medicine:Timeline_of_Chagas_disease

References

  1. Hashimoto, Ken; Schofield, Christopher J (2012). "Elimination of Rhodnius prolixus in Central America". Parasites & Vectors 5: 45. doi:10.1186/1756-3305-5-45. PMID 22357219.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3310830
  2. Steverding, Dietmar (2014). "The history of Chagas disease". Parasites & Vectors 7: 317. doi:10.1186/1756-3305-7-317. PMID 25011546.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4105117
  3. Steverding, Dietmar (2014). "The history of Chagas disease". Parasites & Vectors 7: 317. doi:10.1186/1756-3305-7-317. PMID 25011546.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4105117
  4. Marcondes de Rezende, Joffre (2009-01-01). À sombra do Plátano: crônicas de história da medicina. ISBN 9788561673635. https://books.google.com/?id=hJwnBgAAQBAJ&pg=PA308&lpg=PA308&dq=%22mal+de+engasgo%22+%22langaard%22#v=onepage&q=%22mal%20de%20engasgo%22%20%22langaard%22&f=false. Retrieved 8 February 2017. 
  5. Rodrigues Coura, José; Albajar Viñas, Pedro; Junqueira, Angela (2014). "Ecoepidemiology, short history and control of Chagas disease in the endemic countries and the new challenge for non-endemic countries". Memórias do Instituto Oswaldo Cruz 109 (7): 856–862. doi:10.1590/0074-0276140236. PMID 25410988.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4296489
  6. Kropf, SP; Sá, MR (2009). "The discovery of Trypanosoma cruzi and Chagas disease (1908-1909): tropical medicine in Brazil.". Historia, Ciencias, Saude--Manguinhos 16 Suppl 1: 13–34. doi:10.1590/S0104-59702009000500002. PMID 20027916.  https://dx.doi.org/10.1590%2FS0104-59702009000500002
  7. Norman, Francesca F.; López-Vélez, Rogelio (2013). "Chagas Disease and Breast-feeding". Emerging Infectious Diseases 19 (10): 1561–1566. doi:10.3201/eid1910.130203. PMID 24050257.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3810739
  8. "The Nobel Prize in Physiology or Medicine 1948". Nobelprize. https://www.nobelprize.org/nobel_prizes/medicine/laureates/1948/. Retrieved 16 December 2016. 
  9. Gürtler, Ricardo E; Diotaiuti, Liléia; Kitron, Uriel. Commentary: Chagas disease: 100 years since discovery and lessons for the future. https://academic.oup.com/ije/article/37/4/698/740634/Commentary-Chagas-disease-100-years-since. Retrieved 28 February 2017. 
  10. Rodrigues Coura, José (2013). "Chagas disease: control, elimination and eradication. Is it possible?". Memórias do Instituto Oswaldo Cruz 108 (8): 962–967. doi:10.1590/0074-0276130565. PMID 24402148.  http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4005548
  11. Guhl, F (2007). "Chagas disease in Andean countries.". Memórias do Instituto Oswaldo Cruz 102 Suppl 1: 29–38. doi:10.1590/S0074-02762007005000099. PMID 17891273.  https://dx.doi.org/10.1590%2FS0074-02762007005000099
  12. Trypanosomiasis—Advances in Research and Treatment: 2012 Edition. Scholarly Editions. 2012-12-26. ISBN 9781481608909. https://books.google.com/?id=e_LY1heZbkgC&pg=PT14&lpg=PT14&dq=%222008%22+%22guatemala%22+%22prolixus%22#v=onepage&q=%222008%22%20%22guatemala%22%20%22prolixus%22&f=false. Retrieved 2 March 2017. 
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