Thioxanthenes: History
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Subjects: Biochemistry & Molecular Biology
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Stephen Fey

Thioxanthenes are one of the three major groups of antipsychotics (the others being phenothiazines and butyrophenones). 

Thioxanthene is a chemical compound having a central triple ring structure closely related to one of the other group of antipsychotics (phenothiazines, which also has the triple ring). The major structural difference between the two classes is that the carbon in position 10 in thioxanthenes is replaced by a nitrogen atom in phenothiazines. In thioxanthenes, this C10  shares a double bond with the side chain.

Thioxanthenes are represented in two geometric stereoisomers: Z- and E-compounds.

  • thioxanthenes
  • antipsychotic drugs
  • non-antibiotics

1. Thioxanthene Definition

1.1. Characteristic Structure

Thioxanthenes are one of the three major groups of antipsychotics (the others being phenothiazines and butyrophenones)[1].

Thioxanthene is a chemical compound having a central triple ring structure closely related to one of the other group of antipsychotics (phenothiazines, which also has the triple ring). The major structural difference between the two classes is that the carbon in position 10 in thioxanthenes is replaced by a nitrogen atom in phenothiazines. In thioxanthenes, this C10  shares a double bond with the side chain[2].

Thioxanthenes are represented in two geometric stereoisomers: Z- and E-compounds [3][4].

Basic ring structure:

1.2. Therapeutic Use

Thioxanthenes are prescribed for patients suffering from schizophrenia and other psychoses. They were synthesized and developed with the hope of eliminating the toxic effects of chlorpromazine, the first antipsychotic drug that was primarily used as an anesthetic agent in surgery [2].

Thioxanthenes block the action of D2 neuroreceptors in the dopamine pathway in the brain, resulting in a reduction in the release of dopamine and a large number of other hypothalamic and hypophyseal hormones [3].

1.3. Major Derivatives of Thioxanthenes

Several derivatives of thioxanthenes are used as typical antipsychotics in the treatment of schizophrenia and other psychoses. The first thioxanthene, chlorprothixene, was found to have an excellent effect in schizophrenic patients [5]. Some of the major used derivatives and their use are listed below.

Chlorprothixene: Treatment of neuroses with anxiety, tension, insomnia, psychosomatic disorders and depression due to sedative and calming effect [5][6].

Clopenthixol: Treatment of delusion, aggressiveness, destructiveness, impulsiveness, hallucination and paranoid schizophrenia [7][8].

Flupenthixol: Effective against hallucinations and delusions [2][9][10][11][12].

Thiothixene: Used for treatment of psychoses like schizophrenia and bipolar mania.

Zuclopenthixol: Used for schizophrenia, bipolar disorders, aggression and other psychotic disorders.

1.4. Other Potential Uses

Numerous in vitro and in vivo studies have shown the varying effects of widely used psychotropics on microorganisms [13][14]. Beside the therapeutic use of thioxanthenes as antipsychotics, they have also been shown to possess not only antibacterial effects but also to possess anti-mycobacterial, antiviral (anti-HIV and anti-SARS-CoV-2) as well as anti-parasitic properties [15][16][17][18]. The antimicrobial effect has been reported to not only be exerted by the drug itself but also in a symbiotic combination with antibiotics resulting in even stronger effects using lower doses of the drugs. In this context, the compounds are collectively known as ´non-antibiotics´ [14].

2. Introduction

The first goal of antipsychotic medication is to minimize or eliminate the symptoms within a short period of time. Originally, antipsychotic drugs were designed and tested empirically on psychiatric patients to determine their effectiveness. The first antipsychotic drug that was primarily used as an anesthetic agent in surgery was chlorpromazine [19]. In the beginning, chlorpromazine was administered to psychiatric patients to determine its calming effects. However, it was soon realized that the drug also reduced psychosis. Antipsychotic drugs have been classified as either low or high potency based on their ability to bind to dopamine receptors and not on their effectiveness on patients. Antipsychotic drugs tend to block the action of D2 neuroreceptors in the dopamine pathway in the brain, resulting in reduction of the release of dopamine in the relevant synapses [20]. Thus, an antipsychotic drug should be able to also block the D2 receptors in the mesolimbic pathway of the brain [21][22].
Currently there are two main types of antipsychotics in use, typical and atypical. The main difference between typical and atypical antipsychotic drugs is the ability of the latter to address the negative symptoms of schizophrenia. These atypical neuroleptics, known as newer drugs, date back to the introduction of clozaril [23]. These atypical drugs usually do not cause unpleasant side effects. Atypical drugs may improve cognitive symptoms and can be effective in patients resistant to typical antipsychotic drugs. Such drugs can be active on other receptors, in addition to the dopamine receptor, and many have no extra-pyramidal side effects. Atypical antipsychotics possess an almost identical effect on D2 receptors but are usually more selective, targeting the intended pathway to a larger degree than other drugs.
Typical antipsychotics are sometimes referred to as major tranquilizers, since many of them, in large doses, can sedate and tranquilize [24].
Typical antipsychotics can be classified into three major groups (phenothiazines, butyrophenones and thioxanthenes). Of these, phenothiazines are the most widely used. Table 1 lists the chemical classification of the neuroleptics, illustrated by a selection of the most commonly prescribed drugs from each class along with their structures.
Table 1. Chemical classification of antipsychotic drugs.
Class of Antipsychotics Drugs and Their Chemical Structures
1. Phenothiazines
Molecules 27 00196 i001
Phenothiazine basic ring structure		  
a. Amino alkyl compounds:
(Low/medium potency agents that can antagonize
α1-adenoreceptors, histamine H1 receptors and
muscarinic cholinergic receptors)		 Chlorpromazine:
Molecules 27 00196 i002
b. Piperidine compounds:
(Low/medium potency agents and also
muscarinic antagonist)		 Thioridazine:
Molecules 27 00196 i003
c. Piperazine compounds:
(Medium/high potency agents)		 Trifluoperazine:
Molecules 27 00196 i004
2. Butyrophenones
Molecules 27 00196 i005
Butyrophenone basic ring structure (High potency agents)		 Haloperidol:
Molecules 27 00196 i006
Droperidol:
Molecules 27 00196 i007
3. Thioxanthenes
Molecules 27 00196 i008
Thioxanthene basic ring structure (Medium potency agents)		 Chlorprothixene:
Molecules 27 00196 i009
Flupenthixol:
Molecules 27 00196 i010

Clopenthixol:

Molecules 27 00196 i011
(Note: The terms “low/medium/high potency” indicates their potency in binding to the dopamine D2 receptor).
Thioxanthenes, the third group of antipsychotics, are represented in two geometric stereoisomers: Z- and E-compounds, of which the former have been shown to be more neuroleptically active [25][26]. Due to structural similarity, the antipsychotic activities of flupenthixol and clopenthixol are quite similar to the ‘piperazine group’, one of three groups in the phenothiazine class. These compounds are able to benefit psychotic patients by blocking postsynaptic dopamine receptors in the brain. Thioxanthenes also produce an alpha-adrenergic blocking effect and depress the release of a large number of hypothalamic and hypophyseal hormones [26].
Thioxanthenes were synthesized and developed with the hope of eliminating the toxic effects of chlorpromazine. The first thioxanthene that came to the market in Scandinavia in 1959 was chlorprothixene. A more potent compound, clopenthixol, was introduced in Denmark and other European countries in 1961, followed by introduction of thiothixene and flupenthixol [27].

3. Therapeutic Usage of Thioxanthenes

Much like the other neuroleptics, thioxanthenes are prescribed for patients suffering from schizophrenia. In addition to this, some of the drugs in this group possess specific characteristics that justify their application in clinical medicine.
Table 2 includes a comparative summary of these three classes of neuroleptics, listing some of the common risks of antipsychotic medications [28][29][30][31][32][33][34][35][36][37].
Table 2. Comparative summary of antipsychotic side effects.
Adverse
Effects		 Drugs
(1) Phenothiazines (2) Butyro-
Phenones		 (3) Thioxanthenes
Chlorpromazine Thioridazine Trifluoperazine Haloperidol Chlorprothixene Flupenthixol Clopenthixol
Extra Pyramidal Side Effects:
The muscle related side effects observed with antipsychotic medications are termed as ‘Extra -Pyramidal Side
Effects’ or EPS [28]		 Low Low High Very high In a comparative study it was
observed that
Parkinsonian symptoms were more often found with
chlorpromazine than
chlorprothixene [29]		 Develops in high dosages, can be controlled by
anti-parkinsonian drugs [30][31]		 High
Anti-cholinergic
Effects:
This includes
symptoms like
urinary difficulties, constipation, dry mouth, blurred
visions and may lead to cognitive
impairments.		 High High Low Very low Moderate Low Both clopenthixol and flupenthixol were found to have lower effect in comparison to chlorprothixene [32]
Sedation:
This is common with antipsychotic medications and is dose dependent.		 High High Low Produces much lesser sleepiness and calming effect than
chlorpromazine [33]		 High Low Low
Hypotension:
Antipsychotics
commonly cause
orthostatic
hypotension,
depending on the degree of
α1 adrenoreceptor antagonism.		 High High Low Very low High Moderate Treatment with clopenthixol is
often associated with orthostatic hypotension [37]
Other Effects: Photosensitivity:
Chlorpromazine is known to induce
photosensitivity and skin pigmentation [34].
An intensive study with phenothiazines and
thioxanthenes on schizophrenic patients [35]
reported that patients receiving chlorpromazine showed statistically significant changes in the lens and cornea while patients treated with
thioxanthenes did not.		   Hyperprolactinemia:
Thioxanthenes cause high prolactin levels due to the blockade of prolactin inhibitory factors (PIF), that
inhibits release of prolactin from the pituitary gland [36].
The first thioxanthene, chlorprothixene, was found to have an excellent effect in schizophrenic patients [38]. Chlorprothixene had been used in the treatment of neuroses, not only due to its sedative and calming effects but also due to its low level of toxicity and side effects. Treatment with rather low doses results in favorable results in neuroses with anxiety, tension, insomnia, psychosomatic disorders, and depression. Chlorprothixene had also been found useful for treating alcoholics and alcohol psychoses [39].
Flupenthixol is the highly potent thioxanthene analogue of the phenothiazine fluphenazine [40]. Flupenthixol possesses a distinct anxiolytic property. At low and, sometimes, rather higher doses, this drug is effective against hallucinations and delusions. Flupenthixol manifests stimulating or activating properties in low doses; sometimes even apathetic patients show greater alertness. Schizophrenic patients treated with chlorpromazine, levomepromazine, or other thioxanthenes are sometimes given flupenthixol in low doses as aftercare. It can control psychotic symptoms without affecting the alertness or working ability of the patients [27][41]. The action of flupenthixol is much similar to that of trifluoperazine, but the former induces much less extra-pyramidal effects [42]. Flupenthixol is often prescribed for mood stabilization when psychiatric patients suffer from depressive neurosis. During the early 1970′s, intensive clinical studies repeatedly proved the excellent efficacy of flupenthixol over other neuroleptics in depressive patients [43][44]. Administration of this drug in low dosages does not usually produce side effects, however, sleep disturbances may occur in some patients who are treated after 5 pm [27].
Clopenthixol has a narrower field of application compared to chlorprothixene, although often it produces quick action on patients suffering from delusions, aggressiveness, destructiveness, impulsiveness, and even hallucination, and has also been proven to be definitely better than chlorpromazine for treating paranoid schizophrenics [45]. It produces highly satisfactory results in paranoids and catatonics [46]. Treatment with clopenthixol may start with a low dose followed by a gradual increase. However, therapy has to be continued on a regular basis with one tablet in the evening.

3. Pharmacological Properties of Thioxanthenes

Much like the phenothiazines, thioxanthenes exhibit varied pharmacological actions, peripheral as well as central. However, therapeutic uses of these compounds depend on their psychopharmacological activity. The neuroleptic potency of a synthesized thioxanthene depends on the structure of the side chain in position 9. The compounds with β-hydroxyethylpiperazinopropyl or β-hydroxyethylpiperidinopropyl side chains are more potent neuroleptically than those with a dimethylaminopropyl side chain [47]. The antagonistic effect against methylphenidate-induced stereotypes in mice was employed to determine the exact duration of neuroleptic action of a compound. It was found that the peak effect was between 2 and 6 h, and by 24 h, effects of all the compounds were gone [27][48].
Neuroleptics are known to block the dopamine-induced formation of cyclic adenosine monophosphate (cAMP). In an elaborate study, Iversen et al. (1974) [49] observed that Z-flupenthixol was the most potent neuroleptic among all the test phenothiazines, thioxanthenes, and tyrophenones. Interestingly, they noted that E-flupenthixol was completely inactive.
It is known that neuroleptics have to be administered to psychiatric patients on a long term basis. In 1974, Moller et al. [50] observed that the antagonistic effect of neuroleptics undergoes tolerance development in animal models after prolonged therapy. They reported that when rats were pre-treated with flupenthixol for 12 days, followed by 3 days withdrawal, the antagonistic potency against apomorphine stereotypes was decreased. This reduction in potency subsequently gradually disappeared.
Neuroleptics are known for their α-adrenolytic function. Between phenothiazines and thioxanthenes, the adrenolytic activity was found to be more prominent in the Z-isomers of chlorprothixene, flupenthixol, and clopenthixol, while chlorpromazine and fluphenazine (which has no E/Z center) revealed much less activity [51].
Nasrallah & Tandon (2013) [27] observed that there was a moderate reduction in adrenaline pressor response after administration of either chlorprothixene or flupenthixol to anaesthetized cats. Furthermore, in vagotomized cats, the carotid occlusion reflex was reduced. After administration of chlorprothixene in these animals, respiration remained unaffected, although initially there was a transient rise in respiratory minute volume, due to increased tidal volume. Intravenous infusion of chlorprothixene or flupenthixol in conscious dogs resulted in the fall of blood pressure, without any change in pulse pressure. Treatment of dogs exhibiting tachycardia with flupenthixol resulted in a normalization of heart rate for 15 min [27][32].

This entry is adapted from the peer-reviewed paper 10.3390/molecules27010196

References

  1. Meltzer, H. Y. Update on Typical and Atypical Antipsychotic Drugs. Annu. Rev. Med. 2013, 64, 393–406. https://doi.org/10.1146/annurev-med-050911-161504.
  2. Nasrallah, H.; Tandon, R. Classic Antipsychotic Medications. In Essentials of Clinical Psychopharmacology; Schatzberg, A. F., Nemeroff, C. B., Eds.; American Psychiatric Publishing Inc.: Arlington, 2013; pp 219–236.
  3. Behere, P. B.; Das, A.; Behere, A. P. Antipsychotics. In Clinical Psychopharmacology; Springer Singapore: Singapore, 2019; pp 39–87. https://doi.org/10.1007/978-981-13-2092-7_2.
  4. Baumann, P.; Kirchherr, H.; Berney, P.; Hiemke, C. Flupentixol: Relevance of Stereoselective Therapeutic Drug Monitoring. Psychopharmacology (Berl). 2012, 221 (4), 719–720. https://doi.org/10.1007/s00213-012-2699-8.
  5. Li, P.; L. Snyder, G.; E. Vanover, K. Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future. Curr. Top. Med. Chem. 2016, 16 (29), 3385–3403. https://doi.org/10.2174/1568026616666160608084834.
  6. Novir, S. B. A Theoretical Study of the Structural and Electronic Properties of Trans and Cis Structures of Chlorprothixene as a Nano-Drug. Curr. Appl. Phys. 2017, 17 (12), 1754–1764. https://doi.org/10.1016/j.cap.2017.08.020.
  7. Leucht, S.; Cipriani, A.; Spineli, L.; Mavridis, D.; Örey, D.; Richter, F.; Samara, M.; Barbui, C.; Engel, R. R.; Geddes, J. R.; Kissling, W.; Stapf, M. P.; Lässig, B.; Salanti, G.; Davis, J. M. Comparative Efficacy and Tolerability of 15 Antipsychotic Drugs in Schizophrenia: A Multiple-Treatments Meta-Analysis. Lancet 2013, 382 (9896), 951–962. https://doi.org/10.1016/S0140-6736(13)60733-3.
  8. Ravn, J.; Rud, C.; Wendelboe, J. 252 Mit Dem Neuen Psykofarmakon Clopenthixol (Sordinol, Ciatyl) Behandelte Psychiatrische Patienten. In Neuro-psychopharmacology; Bradley, P. B., Flugel, F., Hoch, P. ., Eds.; Elsevier Publishing Co., 1964; pp 285–289.
  9. Bostwick, J. R.; Guthrie, S. K.; Ellingrod, V. L. Antipsychotic-Induced Hyperprolactinemia. Pharmacotherapy 2009, 29 (1), 64–73. https://doi.org/10.1592/phco.29.1.64.
  10. Tardy, M.; Dold, M.; Engel, R. R.; Leucht, S. Flupenthixol versus Low-Potency First-Generation Antipsychotic Drugs for Schizophrenia. Cochrane Database Syst. Rev. 2014, 2014 (9), 1–26. https://doi.org/10.1002/14651858.CD009227.pub2.
  11. Van Coller, P. E. Flupenthixol (Fluanxol) in the Treatment of Psychosomatic Disorders in Medicine. Psychosomatics 1971, 12 (4), 256–259. https://doi.org/10.1016/S0033-3182(71)71516-3.
  12. Trueman, H. R.; Valentine, M. G. Flupenthixol Decanoate in Schizophrenia. Br. J. Psychiatry 1974, 124 (578), 58–59.
  13. Geiger, H.; Finkeistein, B. A. [Largactil in the Treatment of Tuberculosis]. Schweiz. Med. Wochenschr. 1954, 84 (37), 1063–1064.
  14. Kristiansen, J. E. The Antimicrobial Activity of Non-Antibiotics. Report from a Congress on the Antimicrobial Effect of Drugs Other than Antibiotics on Bacteria, Viruses, Protozoa, and Other Organisms. Acta Pathol. Microbiol. Immunol. Scand. Suppl. 1992, 100 (30), 7–14.
  15. Mortensen, I.; Kristiansen, J. E.; Christensen, A. V; Hvidberg, E. F. The Antibacterial Effect of Some Neuroleptics on Strains Isolated from Patients with Meningitis. Pharmacol. Toxicol. 1992, 71 (6), 449–451.
  16. Jeyaseeli, L.; Gupta, A. Das; Asok Kumar, K.; Mazumdar, K.; Dutta, N. K.; Dastidar, S. G. Antimicrobial Potentiality of the Thioxanthene Flupenthixol through Extensive in Vitro and in Vivo Experiments. Int. J. Antimicrob. Agents 2006, 27 (1), 58–62. https://doi.org/10.1016/j.ijantimicag.2005.08.014.
  17. Kristiansen, J. E.; Andersen, L. P.; Vestergaard, B. F.; Hvidberg, E. F. Effect of Selected Neuroleptic Agents and Stereo‐Isomeric Analogues on Virus and Eukaryotic Cells. Pharmacol. Toxicol. 1991, 69 (5), 399–403. https://doi.org/10.1111/j.1600-0773.1991.tb01260.x.
  18. Kristiansen, J. E.; Jepsen, S. The Susceptibility of Plasmodium Falciparum in Vitro to Chlorpromazine and the Stereo-Isomeric Compounds Cis(Z)- and Trans(E)-Clopenthixol. Acta Pathol. Microbiol. Immunol. Scand. B. 1985, 93 (3), 249–251.
  19. Ahmed, U.; Jones, H.; Adams, C.E. Chlorpromazine for psychosis induced aggression or agitation. Cochrane Database Syst. Rev. 2010, 4.
  20. Baumeister, A.A. The Chlorpromazine Enigma. J. Hist. Neurosci. 2013, 22, 14–29.
  21. Tomida, K.; Takahashi, N.; Saito, S.; Maeno, N.; Iwamoto, K.; Yoshida, K.; Kimura, H.; Iidaka, T.; Ozaki, N. Relationship of psychopathological symptoms and cognitive function to subjective quality of life in patients with chronic schizophrenia. Psychiatry Clin. Neurosci. 2010, 64, 62–69.
  22. Renard, J.; Norris, C.; Rushlow, W.; Laviolette, S.R. Neuronal and molecular effects of cannabidiol on the mesolimbic dopamine system: Implications for novel schizophrenia treatments. Neurosci. Biobehav. Rev. 2017, 75, 157–165.
  23. Newman, W.J.; Newman, B.M. Rediscovering clozapine: After a turbulent history, current guidance on initiating and monitoring. Curr. Psychiatr. 2016, 15, 42–49.
  24. Meltzer, H.Y. Update on typical and atypical antipsychotic drugs. Annu. Rev. Med. 2013, 64, 393–406.
  25. Baumann, P.; Kirchherr, H.; Berney, P.; Hiemke, C. Flupentixol: Relevance of stereoselective therapeutic drug monitoring. Psychopharmacology 2012, 221, 719–720.
  26. Behere, P.B.; Das, A.; Behere, A.P. Antipsychotics. In Clinical Psychopharmacology; Springer: Singapore, 2019; pp. 39–87.
  27. Nasrallah, H.; Tandon, R. Classic Antipsychotic Medications. In Essentials of Clinical Psychopharmacology; Schatzberg, A.F., Nemeroff, C.B., Eds.; American Psychiatric Publishing Inc.: Arlington, TX, USA, 2013; pp. 219–236.
  28. Kendall, T. The rise and fall of the atypical antipsychotics. Br. J. Psychiatry 2011, 199, 266–268.
  29. Remvig, J.; Sonne, L.M. Chlorprothixene (“Truxal”) compared to chlorpromazine. Psychopharmacologia 1961, 2, 203–208.
  30. Madhusoodanan, S.; Alexeenko, L.; Sanders, R.; Brenner, R. Extrapyramidal symptoms associated with antidepressants—A review of the literature and an analysis of spontaneous reports. Ann. Clin. Psychiatry 2010, 22, 148–156.
  31. Correll, C.U. Mechanism of Action of Antipsychotic Medications. J. Clin. Psychiatry 2014, 75, e23.
  32. Taylor, D. Psychopharmacology and adverse effects of antipsychotic long-acting injections: A review. Br. J. Psychiatry 2009, 195, s13–s19.
  33. Suzuki, H.; Gen, K.; Inoue, Y. Comparison of the anti-dopamine D2 and anti-serotonin 5-HT 2A activities of chlorpromazine, bromperidol, haloperidol and second-generation antipsychotics parent compounds and metabolites thereof. J. Psychopharmacol. 2013, 27, 396–400.
  34. Dhanasekaran, S.; Kar, S.; Yadav, S. Chlorpromazine-induced severe exfoliative photoallergic reaction. Int. J. Nutr. Pharm. Neurol. Dis. 2015, 5, 34–36.
  35. Edler, K.; Gottfries, C.G.; Haslund, J.; Ravn, J. Eye changes in connection with neuroleptic treatment especially concerning phenothiazines and thioxanthenes. Acta Psychiatr. Scand. 1971, 47, 377–384.
  36. Ayano, G. First Generation Antipsychotics: Pharmacokinetics, Pharmacodynamics, Therapeutic Effects and Side effects: A review. RRJChem 2016, 4, 90–94.
  37. Lambert, T.; Taylor, D. Pharmacology of antipsychotic long-acting injections. In Antipsychotic Long-Acting Injections; Haddad, P., Lambert, T., Lauriello, J., Eds.; Oxford University Press Inc.: New York, NY, USA, 2011; pp. 23–47. ISBN 978-0-19-958604-2.
  38. Li, P.L.; Snyder, G.E.; Vanover, K. Dopamine Targeting Drugs for the Treatment of Schizophrenia: Past, Present and Future. Curr. Top. Med. Chem. 2016, 16, 3385–3403.
  39. Novir, S.B. A theoretical study of the structural and electronic properties of trans and cis structures of chlorprothixene as a nano-drug. Curr. Appl. Phys. 2017, 17, 1754–1764.
  40. de Wit, H. Flupenthixol. In Encyclopedia of Psychopharmacology; Stolerman, I.P., Ed.; Springer: Berlin/Heidelberg, Germany, 2010; pp. 538–539.
  41. Bostwick, J.R.; Guthrie, S.K.; Ellingrod, V.L. Antipsychotic-induced hyperprolactinemia. Pharmacotherapy 2009, 29, 64–73.
  42. Tardy, M.; Dold, M.; Engel, R.R.; Leucht, S. Flupenthixol versus low-potency first-generation antipsychotic drugs for schizophrenia. Cochrane Database Syst. Rev. 2014, 2014, 1–26.
  43. Van Coller, P.E. Flupenthixol (fluanxol) in the treatment of psychosomatic disorders in medicine. Psychosomatics 1971, 12, 256–259.
  44. Trueman, H.R.; Valentine, M.G. Flupenthixol decanoate in schizophrenia. Br. J. Psychiatry 1974, 124, 58–59.
  45. Leucht, S.; Cipriani, A.; Spineli, L.; Mavridis, D.; Örey, D.; Richter, F.; Samara, M.; Barbui, C.; Engel, R.R.; Geddes, J.R.; et al. Comparative efficacy and tolerability of 15 antipsychotic drugs in schizophrenia: A multiple-treatments meta-analysis. Lancet 2013, 382, 951–962.
  46. Ravn, J.; Rud, C.; Wendelboe, J. 252 mit dem neuen Psykofarmakon Clopenthixol (Sordinol, Ciatyl) behandelte psychiatrische Patienten. In Neuro-Psychopharmacology; Bradley, P.B., Flugel, F., Hoch, P., Eds.; Elsevier Publishing Co.: Amsterdam, The Netherlands, 1964; pp. 285–289.
  47. Gordon, M. (Ed.) Psychopharmacological Agents; Elsevier: Amsterdam, The Netherlands, 2017; ISBN 1483274462/9781483274461.
  48. Schatzberg, A.F.; DeBattista, C. Manual of Clinical Psychopharmacology; American Psychiatric Publishing: Washington, DC, USA, 2015; ISBN 1-58562-481-0.
  49. Iversen, L.L.; Miller, R.J.; Horn, A.S. Effects of dopaminergic agonist and antagonist drugs on cyclic 3′,5′ –adenosine Monophosphate (cyclic AMP) production in rat brain homogenates. J. Pharmacol. 1974, 5, 117–118.
  50. Moller Nielsen, I.; Fjalland, B.; Pedersen, V.; Nymark, M. Pharmacology of neuroleptics upon repeated administration. Psychopharmacologia 1974, 34, 95–104.
  51. Casey, D.; Christensen, A. (Eds.) Psychopharmacology: Current Trends: Current Trends; Springer Science & Business Media: Berlin/Heidelberg, Germany, 2012; ISBN 3642732801/9783642732805.
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