Remote management of DFD: History
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Subjects: Others

This entry describes developments in remote management to prevent diabetes-related foot disease.

  • diabetes, foot disease, remote management

Diabetes-related foot disease (DFD), which includes foot ulcers, infection and gangrene, is a leading cause of the global disability burden. About half of people who develop DFD experience a recurrence within one year. Long-term medical management to reduce the risk of recurrence is therefore important to reduce the global DFD burden. This review describes research assessing the value of sensors, wearables and telehealth in preventing DFD. Sensors and wearables have been developed to monitor foot temperature, plantar pressures, glucose, blood pressure and lipids. The monitoring of these risk factors along with telehealth consultations has promise as a method for remotely managing people who are at risk of DFD. This approach can potentially avoid or reduce the need for face-to-face consultations. Home foot temperature monitoring, continuous glucose monitoring and telehealth consultations are the approaches for which the most highly developed and user-friendly technology has been developed. A number of clinical studies in people at risk of DFD have demonstrated benefits when using one of these remote monitoring methods. Further development and evidence are needed for some of the other approaches, such as home plantar pressure and footwear adherence monitoring. As yet, no composite remote management program incorporating remote monitoring and the management of all the key risk factors for DFD has been developed and implemented. Further research assessing the feasibility and value of combining these remote monitoring approaches as a holistic way of preventing DFD is needed.

1. Introduction

Diabetes-related foot disease (DFD), including foot ulcers, infection and gangrene, is one of the 10 leading causes of the global disability burden [1][2][3]. About 40% of people who develop DFD experience a recurrence within one year, and thus DFD represents a chronic disease; the focus of research into this should be on avoiding remission and preventing major consequences, such as amputation and death [4]. Key risk factors for DFD recurrence and complications in people at risk of DFD include high plantar pressures, abnormal gait, hyperglycaemia, hypertension and
dyslipidemia [5][6][7]. Randomised controlled trials and meta-analyses show that foot disease is preventable by the control of these key reversible risk factors using interventions such as appropriate foot care, footwear and medical management [5][6][7][8]. A range of sensors and wearables have been developed or are currently under development for the remote monitoring of these key risk factors and this combined with telehealth management offers a way to remotely care for people at risk of DFD, as shown in Table 1. The implementation of these approaches could also minimize the risk to patients and staff of exposure to the current global SARS-CoV-2 pandemic [2][3].

This review summarizes the potential application of remote monitoring systems using sensors and wearables to prevent DFD in the at-risk population, as shown in Figure 1 and Table 1. The challenges of implementing remote DFD prevention and how sensors and wearables could be applied to better prevent DFD are discussed below.

Table 1. Examples of sensors and wearables with potential value for preventing DFD.

Risk factor

Current Management Approach

Sensors or Wearable Devices


Potential Value of Sensor/Wearable

Potential Impact on Prevention

Pre-ulcerative lesions

Visits to podiatrist

Home foot temperature monitor and mobile phone applications


Offloading of “hot spots” following confirmed persistent temperature differences

Reduced progression of at-risk sites prone to develop foot ulcers

Elevated plantar pressures

Offloading footwear

Plantar pressure monitor


Warning systems to stimulate offloading and better design and modification of footwear

Improved offloading with reduced ulcer development

Elevated plantar pressures

Patient education

Footwear adherence monitor


Behaviour change support counselling informed by objective data

Improved offloading adherence


Capillary glucose monitoring

Continuous glucose monitor


Intensive glycaemic control

Better informed management of hyper and hypoglycaemia and reduced progression of macro and microvascular disease


Outpatient blood pressure measurement

Cuff-less blood pressure monitor



Better implementation of anti-hypertensive medications and more frequent monitoring 

Better informed management of blood pressure and reduced progression of macro and microvascular disease and mortality

Abnormal gait

Not routinely managed

Gait and activity monitor



Gait retraining and encouraging remote physical activity

Reduce gait abnormalities potentially reducing plantar pressures and ulcer incidence

Peripheral artery disease

Vascular laboratory assessment using ultrasound or Doppler

Foot blood supply sensor



Earlier identification of complications and prompt medical management

Reduced progression of macro and microvascular disease

Legend: The table outlines the risk factors for the development of diabetes-related foot disease and how sensors and wearables could be used to remotely monitor these factors. References are provided for the relevant research articles assessing the impact or implementation of such technologies for further reading.

Figure 1. Key aspects of existing standard care compared with a future remote prevention program for diabetes-related foot disease.

2. Remotely Monitoring Medical Management

The optimal control of glucose, blood pressure and lipids is frequently not well implemented among people that develop DFD [16]. People with DFD have an increased risk of all-cause mortality (relative risk (RR) 1.89, 95% confidence intervals (CI) 1.60, 2.23) and fatal myocardial infarction
(RR 2.22, 95% CI 1.09, 4.53) compared to people with diabetes without DFD [17]. In people with a history of diabetes-related foot ulcers, the risk of cardiovascular mortality is about 50% over 10 years and the annual mortality rate is estimated to be about 6% [18]. This emphasizes the importance of optimizing medical management in this population.

Glycaemic control is important for preventing both macro and microvascular complications, and a meta-analysis of past randomised trials suggests that intensive glycaemic control prevents amputations [19]. In clinical practice, diabetes management is usually informed by self-monitoring of blood glucose [20]. Wearable or implantable sensors are now available for the continuous monitoring of glucose [20]; these use enzymatic technology to monitor interstitial fluid rather than blood glucose[21]. These sensors can measure glucose up to every 5 min non-invasively for a period of about one week, after which most devices need to be replaced . Such sensors have been incorporated into closed loop systems which provide automated insulin delivery to people with type 1 diabetes with improvements in glycaemic control [22]. Recent meta-analyses of randomised trials comparing self-monitoring and the continuous automated monitoring of glucose in people with type 2 diabetes suggest that continuous monitoring facilitates better glycaemic control [23][24][25]. The use of such devices is now recommended by the North American guidelines for some patients, such as those with poor glycaemic control (HbA1c ≥ 9%) [26]. A recent trial showed that flash glucose monitoring (measuring interstitial fluid glucose) can be implemented in the primary care environment, although it may not be superior to traditional methods as measured by HbA1c at 12 months [12]. The application of continuous glucose monitoring for people with diabetes who are at a high risk of complications such as DFD may have substantial benefits, but access to this technology is currently limited to selected patients due to the current high expense of such monitoring systems.

High blood pressure is another important risk factor for complications in people with DFD.
Anti-hypertensive medications, such as angiotensin-converting enzyme inhibitors and angiotensin receptor blockers, have been shown to reduce the incidence of cardiovascular events in people at risk of DFD, such as those with PAD [27]. Control of blood pressure is, however, frequently suboptimal in people at risk of DFD [28]. In a recent study of 2773 people with PAD, about 40% had a systolic blood pressure above the target level of 140 mmHg [28]. Currently, blood pressure is monitored through the assessment of pulsation linked with an inflatable cuff placed around the upper arm. Novel cuff-less wearable devices have now been developed for the estimation of blood pressure and may provide a more practical way of repeatedly monitoring blood pressure and facilitating better management [29]. These devices use varying methods, such as pulse transit time, laser Doppler flowmetry and artery vibration, to calculate blood pressure. Some of these devices are available commercially, such as from TMART Technologies Limited, China and Somnomedics, Germany, and some—but not all—have been shown to accurately measure blood pressure in small numbers of people with comparable results to classical cuff-dependent machines and also intra-arterial assessments [30][31][32]. The accuracy and value of these devices in improving the medical management of people at risk of DFD need further evaluation.

People at risk of DFD also require lipid control. The intensive lowering of low-density lipoprotein has proven efficacy in reducing major adverse cardiovascular and limb events in people at risk of DFD, such as those with PAD and diabetes [32]. Low-density lipoprotein sensors have also been built, although further development and testing is needed before they will be ready for widespread use [33].

Medication non-adherence is often defined as taking less than 80% of the prescribed
treatment [34]. Due to a variety of factors including cost and regimen complexity, adherence to diabetes treatment is often poor and is reported to vary from 23% to 77% across differing
populations [35][36]. In order to achieve optimal control of risk factors, it is important that patients adhere to prescribed medications. Sensors have now been developed that are capable of monitoring medication ingestion; for example, Proteus Discover provides data on medication taking and physical activity to both patients and practitioners[37]. It consists of an ingestible sensor, a wearable sensor patch, a patient mobile app and a provider Web portal. After being swallowed, the ingestible sensor is activated and sends a signal with a specific code that is detected by the patch. When the ingestible sensor pill is taken with medication, it can measure medication ingestion adherence. The patch also can measure activity, heart rate and step count. Data from the patch are transmitted to a mobile device to be viewed by the patient and then to the Cloud and onto a Web portal for a practitioner to view. The mobile device app prompts the patient to take their medication doses as scheduled. A previous study suggested that Proteus Discover can improve control of blood pressure, low-density lipoprotein and HbA1c [37]. Such sensors could have a role in people at risk of DFD, but this needs further testing and consultation with patients and other key stakeholders. There is a lack of
head-to-head clinical trials comparing the various types of sensors or monitors available for remote medical management described above; more importantly, the control arms in clinical trials of remote monitoring systems have varied substantially. Therefore, there is an ongoing need to assess the suitability of these sensors for optimizing medical management in people at risk of DFD.

3. Telehealth

For people with DFD, treatment and education typically occur in an outpatient clinic weekly or bi-weekly. Although remote monitoring methods for people with DFD using smartphone applications have been developed, these are still in their infancy and have not been widely tested or implemented [38][39][40]. Despite their potential application in remote DFD monitoring, the diagnostic accuracy of mobile phone images is reported to be poor and therefore should not be used as a
stand-alone diagnostic instrument for DFD [41]. This is a rapidly evolving area; therefore, novel mobile phone applications and remote monitoring methods may improve over time.

Telehealth is an established means of performing medical consultations [42]. The benefit of using telehealth for managing foot ulcers has been demonstrated in several meta-analyses and systematic reviews [43][44][45]. Most of the evidence comes from two clinical trials [46][47]: the first trial evaluated the effectiveness of a telehealth intervention made up of 2:1 online:standard outpatient consultations compared to a usual care intervention consisting of three standard outpatient clinic visits on ulcer healing in 374 people [46]. The authors reported no significant difference in ulcer healing or amputation between the two methods but did show an increased risk of mortality in the remote monitoring group (HR = 8.68, 95% CI: 6.9–10.88). This was a surprising finding that was not explained by any of the studied covariates [46].

A more recent cluster randomised controlled non-inferiority trial of 182 adults evaluated telehealth [94]. Weekly telemedicine consultations via an interactive Web-based ulcer record and a mobile phone for communication with the healthcare specialist in addition to outpatient clinic visits every 6 weeks was compared to visiting the outpatient clinic every second week [47]. The trial showed no difference in time to ulcer healing and a superiority in prevention against amputation (mean difference: 8.3%, 95% CI: 16.3%, −0.5%) in the intervention group [94]. An important factor to note in these trials was that the intervention arms all included some face-to-face consultations with a health care professional. Based on anecdotal evidence, at present, there appears to be a range of different approaches to telemedicine that are used globally, ranging from mobile phone-based consultations, hospital-based remote management consultations and the phone-based review of patients. However, how such approaches should be designed in line with face-to face care has not been well defined in the literature.

There has been limited study of the value of telehealth consultations in preventing rather than treating DFD. The COVID-19 pandemic has provided a stimulus for studies testing the use of remote monitoring technologies and telehealth consultations in preventing DFD (see Table 2).

Table 2. Currently available and required evidence for the remote assessment and prevention of diabetes-related foot disease.

Remote Monitoring

Available Evidence

Current Limitations of Available Evidence 

Relevant Studies

Home foot temperature monitor

A number of small RCTs show a decreased incidence of foot ulcers in people performing home-based temperature monitoring

Lack of a widely tested and user-friendly way of identifying “hot spots”

Generalizability from prior smaller studies in select populations


Plantar pressure monitor

Possible to monitor plantar pressure remotely and use patient alarms to warn patients of impending sites of tissue breakdown as reported in one small RCT

Unclear if technology can be further developed to be more user-friendly and whether the findings are applicable and would be effective on a widespread basis


Footwear adherence monitor

Technology has been developed to accurately measure footwear adherence

Need for widespread testing of value of using devices

Patients’ views on use of adherence monitoring is still unclear


Continuous glucose monitor

Highly developed area of monitoring and tested in multiple RCTs with proven benefit in improving glycaemic control (HbA1c)

Whether this remote monitoring improves outcomes in people at risk of developing DFD remains unclear


Cuff-less blood pressure monitor

Technology developed to assess this reported to be accurate in a small number of studies

Currently unclear whether these devices can be used on a widespread scale


Foot blood supply and sensation assessment

Technology still in the early developmental stages for monitoring


The benefit of these devices in improving clinical outcomes need to be further evaluated in RCTs


Legend: PAD= peripheral artery disease, RCT= randomised controlled trial, HbA1c= glycated haemoglobin A1c, DFD = diabetes-related foot disease

This entry is adapted from the peer-reviewed paper 10.3390/s20164527


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