COVID 19 –A COMPRENSIVE MATHEMATICAL APPROACH: History
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Subjects: Biophysics | Others
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In this approach we will summarise the the last three publications highlighting the key mathematical approach like Exponential F ( x ) to further exponential –Gaussian F ( x ) and finally the Linear Combination of Atomic Orbital ( LCAO ) ie a hybridised Sp orbital overlapping to Remdesivir ( Drug ) –Covid19 approach.

  • Covid19
  • Sp Hybridisation
  • LCAO
  • Pharmacokinetics
  • Exponential Function
  • Gaussiun
  • Remdesivir

Approach -1 : In the first one we have analysed the microbial Ist - Order growth kinetics where
Exponential phase is most important. This sharp exponential phase is the main cause of
virulent spreading of viral infection .
Approach -2 : In the 2nd one we have reviewed the entire growth kinetics pattern to a more appropriate manner similar to Exponential – Gaussian F ( x ) relationship which points out the more prominent part of the short stationary phase or infinitesimally small linear relationship followed by sudden down to declining or recovery phase with a negative slope of linearity .It is also termed as Pseudo-Gaussian contour curve.
Approach – 3 : In the 3rd one we will correlate the LCAO approach to Pharmacokinetic Phenomenon. The Remdesivir is approved as the most effective drug ( WHO ) – This drug Binds with Covid19 antigen SARS –COV -2 as compared to Sp Hybridised Drug – Antigen Linear overlap stabilising the complex.

REFERENCE :

1. MICROBIAL GROWTH KINETICS : A MATHEMATICAL REVIEW ( SPECIAL ADDENDUM - COVID19 ), JAYDIP DATTA , May ,11, 2020 .

2. Covid19 – A Mathematical modelling of a PSEUDO-GAUSSIUN Contour , JAYDIP DATTA , May ,18 ,2020 .

3. COVID19 Vs Hybridisation : An Approach to Chemical Bonding, JAYDIP DATTA ,June , 22 ,2020 .

4. Justification of Lopinavir - Ritonavir & Finally Remdesivir ( higher generation of
acyclovir analog ) used in Covid19 treatment ? (Researgate.net) asked by JAYDIP
DATTA on May ,13,2020 .

5. What are the BASIC mathematical methods specially used in COMPUTATIONAL
CHEMISTRY covering Covid19 ? ( Researchgate.net ) asked by JAYDIP DATTA ,
( Revised query on June , 10 , 2020 ) .

N.B : Publised as Preprints on 26.06.2020 in osf.io - https://osf.io/vgf3m/  

 

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