Encyclopedia
Bergenia(s) are evergreen, perennial, drought-resistant, herbaceous plants that bear pink flowers produced in a cyme. Due to the leaf shape and leathery texture, Bergenia(s) have earned some interesting nicknames such as “pigsqueak”, “elephant-ear”, “heartleaf”, “leather cabbage”, or “picnic plates”. The plants should be planted about two feet apart as they spread horizontally up to 45–60 cm. Bergenia species possess several other biological activities like diuretic, antidiabetic, antitussive, insecticidal, anti-inflammatory, antipyretic, anti-bradykinin, antiviral, antibacterial, antimalarial, hepatoprotective, antiulcer, anticancer, antioxidant, antiobesity, and adaptogenic.
- Bergenia species,botanical description,traditional uses,phytochemistry
1. Introduction
The use of herbs for healing diseases and disorders can be dated back to at least 1500 BC [1]. The traditional system of medicine (TCM) is a source of >60% of the commercialized drugs and is still used by the population in lower-income countries for the cure of chronic diseases [2]. As far as primary healthcare is concerned, approximately 75% of Indians rely on Ayurvedic formulations [3,4]. Many medicinal plants containing various phytochemicals have been successfully used to cure diabetes, cancers, gastrointestinal disorders, cardiovascular, and urological disorders [1].
Among the urological disorders, “urolithiasis” is the third most common disorder with a high relapse rate [5,6,7,8]. The invasive treatments of urolithiasis are costly and precarious, so the search for natural anti-urolithiatic drugs is of immense importance [9,10].
The Ayurvedic preparations have used Bergenia species down the centuries to dissolve bladder and kidney stones and to treat piles, abnormal leucorrhea, and pulmonary infections [11,12,13]. These pharmacological properties can be attributed to wide-range polyphenols, flavonoids, and quinones present in Bergenia species. The polyphenols constitute a major share of the active ingredients, and the elite among them are ”arbutin” and “bergenin” [14,15,16,17,18,19]. Bergenin alone possesses burn-wound healing, antiulcer, anti-arrhythmic, antihepatotoxic, neuroprotective, antifungal, antidiabetic, antilithiatic, anti-inflammatory, anti-nociceptive, anti-HIV, and immunomodulatory properties [20,21,22]. Bergenia ligulata Wall. Engl. [synonym of B. pacumbis] is an essential ingredient of an Ayurvedic formulation, “Pashanbheda” (Paashan = rockstone, bheda = piercing), which is used as a kidney stone dissolver in the indigenous system of medicine [23,24]. This drug has been listed in ancient Indian chronicles of medicine including “Charak Samhita”, “Sushruta Samhita” and “Ashtang-Hridaya”. B. ligulata is reputedly known by other names such as “Pashana”, “Ashmabhid”, “Ashmabhed”, “Asmaribheda”, “Nagabhid”, “Parwatbhed”, “Upalbhedak”, and “Shilabhed” [25].
2. Distribution
The plant family Saxifragaceae encompasses 48 genera and 775 species,which are mostly distributed
in South East Asia. The name “Bergenia” was coined by Conrad Moench in 1794, in the memory
of Karl August von Bergen (German botanist and physician). Genus Bergenia harbors 32 species of
flowering plants, including highly valued ornamental, rhizomatous, and temperate medicinal herbs [16].
Central Asia is the native place for genus Bergenia [26,27]. Among the seven species, four (B. yunnanensis,
B. scopulosa, B. emeiensis, and B. tianquanensis) are endemic to China [28–30]. The botanical description of Bergenia species [31–34] is described in Supplementary Table S1.
3. Traditional Medicinal Uses
Bergenia species have been used in traditional medicines for a long time. In Unani and
Ayurvedic systems of medicine, Bergenia spp. rhizomes and roots have been used for curing kidney
and, bladder diseases, dysuria, heart diseases, lung and liver diseases, spleen enlargement, tumors,
ulcers, piles, dysentery, menorrhagia, hydrophobia, biliousness, eyesores, cough, and fever [35–37].
The burns or wounds may be treated with rhizome paste for three to four days [38–40]. The paste
can be applied on dislocated bones after setting, or consumed to treat diarrhea or along with honey
in fevers [41,42].
The leaf extract of B. ciliata possesses antimalarial property [43]. Its leaves are revered to as
“Pashanabheda”, which designates the litholytic property [44]. In Nepal, 1:1 mixture (one teaspoon) of
the dried B. ciliata rhizome-juice and honey is administered to post-partum women 2–3 times a day
as a tonic and remedy for digestive disorders (carminative) [38]. The rhizome-decoction may also be
consumed orally as antipyretic and antihelmintic [45].
Since ancient times, consumption of water-extract of B. ligulata has cured urogenital and
kidney-stone complaints [23,35,46,47]. In Nepal, the rhizome paste of B. ligulata is consumed for
treating many diseases including diarrhea, ulcer, dysuria, spleen enlargement, pulmonary infusion,
cold, cough, and fever [45]. The intestinal worms can also be removed by consuming rhizomes along
with molasses (two times/day, 3–4 days) [38]. The Indians use the dried roots of B. ligulata for treating
burns, boils, wounds, and ophthalmia [46,48]. The dried leaf powder of B. pacumbis may be inhaled to
bring relief from heavy sneezing [49]. In Lahul (Punjab), the locals use B. stratecheyi plants to prepare a
poultice, which is applied to heal the joint-stiffness [50]. Bergenia species are also used for the treatment
of boils and even blisters [19].
In Russian tradition, B. crassifolia leaves are commonly used to prepare a health drink. Buryats
and Mongols used B. crassifolia-young leaves of to prepare tea. Interestingly, in Altai, tea is prepared
from old blackened leaves (chagirsky tea having lesser amounts of tannins) [51]. The rhizome infusions
can treat fevers, cold, headache, gastritis, dysentery, and enterocolitis [52]. They are also used to treat
oral diseases (bleeding gums, periodontitis, gingivitis, and stomatitis) and also possess adaptogenic
properties [51,53–55]. Mongols used the extracts for treating typhoid, gastro-intestinal ailments,
diarrhoea, and lung inflammation. The rhizome extract is also used to strengthen capillary walls
to stop bleeding after abortions, alleviate excessive menstruation, and cervical erosion. Therefore,
the roots and rhizomes of B. crassifolia are claimed as antimicrobial, anti-inflammatory, haemostatic,
and as astringent in the officinal medicine of Mongolia [54].
Tibetans apply fresh leaf-paste on their skin to protect them from harmful ultraviolet radiations [56].
The chewing of leaf helps in relieving constipation and the leaf-juice can treat earaches [11,38,42].
The bullocks and cows are fed on a mixture of Bergenia inflorescence and barley-flour to treat
hematuria [38]. Bergenia roots are also effective in preventing venereal diseases [57]. Thick leaves
of Bergenias are used in Chinese Medicine to stop bleeding, treat cough, dizziness, hemoptysis,
and asthma, and to strengthen immunity [27,58].
4. Phytochemistry
Nowadays, HPLC and HPTLC have become routine analytical techniques due to their reliability in
quantitation of analytes at the micro or even nanogram levels plus the cost effectiveness. Phytochemical
investigation of nine Bergenia species (B. ciliata, B. crassifolia, B. emeiensis, B. ligulata, B. scopulosa,
B. stracheyi, B. hissarica, B. purpurascens, and B. tianquanesis) led to the characterization of several
chemical constituents [16,59–63]. The constituents have been categorized into polyphenols, flavonoids, quinones, sterols,
terpenes, tannins, lactones, and others [16,26,64–67]. The major bioactive compounds are bergenin (1),
(+)-catechin (2), gallic acid (3), -sitosterol (4), catechin-7-O- -d-glucoside (5), (+)-afzelechin (6), arbutin
(10),4-O-galloylbergenin (12), 11-O-galloylbergenin (13), caffeoylquinic acid (21), pashaanolactone (26),
3,11-di-O-galloylbergenin (64), bergapten (66), kaempferol-3-O-rutinoside (70), quercetin-3-O-rutinoside
(79), (+)-catechin-3-O-gallate (83), 2-O-caffeoylarbutin (86), leucocyanidin (124), methyl gallate (gallicin)
(125), sitoinoside I (126), -sitosterol-d-glucoside (127), avicularin (128), reynoutrin (129), procyanidin
B1 (135), afzelin (140), and aloe-emodin (146).
Arbutin (10) inhibits tyrosinase, prevents the formation of melanin and thus prevents skin
darkening [68]. Bergenin (1) is a pharmaceutically important molecule that has hepatoprotective
and immunomodulatory potential [69]. It is used clinically for eliminating phlegm, relieving cough,
inflammation, etc. [20,70,71]. (+)-catechin (2) possesses antioxidant, glucosidase, renoprotective,
matrix-metalloproteinase inhibitory, and cancer preventive activity. Gallicin (125) exhibits antioxidant,
anti-tumor, antimicrobial, anti-inflammatory, and cyclooxygenase-2/5-lipoxygenase inhibitory activity [72].
Gallic acid (3) possesses anti-inflammatory, antioxidant, cytotoxic, bactericidal, gastroprotective,
and antiangiogenic activity. -sitosterol (4) is well-known for its antioxidant, anti-inflammatory, analgesic,
and anti-helminthic effects. It is also efficient in the curing prostate enlargement [73].
References
1. Koul, B. Herbs for Cancer Treatment, 1st ed.; Springer: New York, NY, USA, 2020.
2. Cragg, G.M.; Newman, D.J. Natural products: A continuing source of novel drug leads. Biochim. Biophys.
Acta Gen. Subj. 2013, 1830, 3670–3695. [CrossRef]
3. Pandey, M.; Rastogi, S.; Rawat, A. Indian traditional ayurvedic system of medicine and nutritional
supplementation. Evid. Based Complement. Alternat. Med. 2013, 2013, 1–12. [CrossRef]
4. Sen, S.; Chakraborty, R. Toward the integration and advancement of herbal medicine: A focus on traditional
Indian medicine. Bot. Target Ther. 2015, 5, 33–44. [CrossRef]
5. Kasote, D.M.; Jagtap, S.D.; Thapa, D.; Khyade, M.S.; Russell,W.R. Herbal remedies for urinary stones used in
India and China: A review. J. Ethnopharmacol. 2017, 203, 55–68. [CrossRef]
6. Liu, Y.; Chen, Y.; Liao, B.; Luo, D.;Wang, K.; Li, H.; Zeng, G. Epidemiology of urolithiasis in Asia. Asian J. Urol.
2018, 5, 205–214. [CrossRef]
7. Vitale, C.; Croppi, E.; Marangella, M. Biochemical evaluation in renal stone disease. Clin. Cases Miner.
Bone Metab. 2008, 5, 127.
8. Ramello, A.; Vitale, C.;Marangella,M. Epidemiology of nephrolithiasis. J. Nephrol. 2000, 13 (Suppl. S3), S45–S50.
9. Sharma, I.; Khan, W.; Parveen, R.; Alam, M.; Ahmad, I.; Ansari, M.H.R.; Ahmad, S. Antiurolithiasis
activity of bioactivity guided fraction of Bergenia ligulata against ethylene glycol induced renal calculi in rat.
Biomed. Res. Int. 2017, 2017, 1–11.
10. Wadkar, K.A.; Kondawar,M.S.; Lokapure, S.G. Standardization ofmarketed cystone tablet: Aherbal formulation.
J. Pharmacogn. Phytochem. 2017, 6, 10–16.
11. Ahmad, M.; Butt, M.A.; Zhang, G.; Sultana, S.; Tariq, A.; Zafar, M. Bergenia ciliata: A comprehensive review
of its traditional uses, phytochemistry, pharmacology and safety. Biomed. Pharmacother. 2018, 97, 708–721.
[CrossRef]
12. Ruby, K.; Chauhan, R.; Dwivedi, J. Himalayan bergenia a comprehensive review. Int. J. Pharm. Sci. 2012,
14, 139–141.
13. Srivastava, S.; Rawat, A.K.S. Botanical and phytochemical comparison of three bergenia species. J. Sci. Ind. Res.
2008, 67, 65–72.
14. Árok, R.; Végh, K.; Alberti, Á.; Kéry, Á. Phytochemical comparison and analysis of Bergenia crassifolia
l.(fritsch.) and Bergenia cordifolia sternb. Eur. Chem. Bull. 2012, 1, 31–34.
15. de Oliveira, C.M.; Nonato, F.R.; de Lima, F.O.; Couto, R.D.; David, J.P.; David, J.M.; Soares, M.B.P.;
Villarreal, C.F. Antinociceptive properties of bergenin. J. Nat. Prod. 2011, 74, 2062–2068. [CrossRef]
16. Dhalwal, K.; Shinde, V.; Biradar, Y.; Mahadik, K. Simultaneous quantification of bergenin, catechin, and gallic
acid from Bergenia ciliata and Bergenia ligulata by using thin-layer chromatography. J. Food Compos. Anal.
2008, 21, 496–500. [CrossRef]
17. Li, F.; Zhou, D.; Qin, X.; Zhang, Z.-R.; Huang, Y. Studies on the physicochemical properties of bergenin.
Chin. Pharm. J. 2009, 44, 92–95.
18. Rastogi, S.; Rawat, A. A comprehensive review on bergenin, a potential hepatoprotective and antioxidative
phytoconstituent. Herba Polonica 2008, 54, 66–79.
19. Singh, D.P.; Srivastava, S.K.; Govindarajan, R.; Rawat, A.K.S. High-performance liquid chromatographic
determination of bergenin in di erent bergenia species. Acta Chromatogr. 2007, 19, 246–252.
20. Nazir, N.; Koul, S.; Qurishi, M.A.; Najar, M.H.; Zargar, M.I. Evaluation of antioxidant and antimicrobial
activities of bergenin and its derivatives obtained by chemoenzymatic synthesis. Eur. J. Med. Chem. 2011,
46, 2415–2420. [CrossRef]
21. Rousseau, C.; Martin, O.R. Synthesis of bergenin-related natural products by way of an intramolecular
c-glycosylation reaction. Tetrahedron: Asymmetry 2000, 11, 409–412. [CrossRef]
22. Suh, K.S.; Chon, S.; Jung,W.W.; Choi, E.M. E ect of bergenin on rankl-induced osteoclast di erentiation in
the presence of methylglyoxal. Toxicol. In Vitro 2019, 61, 104613. [CrossRef]
23. Gurav, S.; Gurav, N. A comprehensive review: Bergenia ligulata wall-a controversial clinical candidate. Int. J.
Pharm. Sci. Rev. Res. 2014, 5, 1630–1642.
24. Singh, N.; Gupta, A.; Juyal, V. A review on Bergenia ligulata wall. IJCAS 2010, 1, 71–73.
25. Chitme, H.R.; Alok, S.; Jain, S.; Sabharwal, M. Herbal treatment for urinary stones. Int. J. Pharm. Sci. Res.
2010, 1, 24–31.
26. Chandrareddy, U.D.; Chawla, A.S.; Mundkinajeddu, D.; Maurya, R.; Handa, S.S. Paashaanolactone from
Bergenia ligulata. Phytochemistry 1998, 47, 907–909. [CrossRef]
27. Khan, M.Y.; Vimal, K.V. Phytopharmacological and chemical profile of Bergenia ciliate. Int. J. Phytopharm.
2016, 6, 90–98.
28. Hendrychová, H.; T°umová, L. Bergenia genus-content matters and biological activity. Ceska a Slovenska
farmacie Casopis Ceske farmaceuticke spolecnosti a Slovenske farmaceuticke spolecnosti 2012, 61, 203–209.
29. Liu, S.J.; Yu, B.; Hu, C.H. In The variation of pod activities in Bergenla tianquanensis in tissue culture progress.
In Advanced Materials Research; Trans Tech Publications Ltd.: Stafa-Zurich, Switzerland, 2011; pp. 196–200.
30. Wu, Z.-Y.; Raven, P.H. Flora of China; Science Press (Beijing) & Missouri Botanical Garden Press: St. Louis,
MO, USA, 2001; Volume 8.
31. Zhang, Y.; Liao, C.; Liu, X.; Li, J.; Fang, S.; Li, Y.; He, D. Biological advances in bergenia genus plant.
Afr. J. Biotechnol. 2011, 10, 8166–8169.
32. Jin-tang, P. New taxa of the genus bergenia from Hengduan mountains. Acta Phytotax. Sin. 1994, 32, 571–573.
33. Jin-tang, P.; Soltis, D.E. Flora China. Bergenia 2001, 8, 278–280.
34. Zhou, G.Y.; Li, W.C.; Guo, F.G. Resource investigation and observation of biological characteristics of
Bergenia purpurascens (Hook. f. et. Thoms.). Engl. Chin. Agric. Sci. Bull. 2007, 23, 390–392.
35. Alok, S.; Jain, S.K.; Verma, A.; Kumar, M.; Sabharwal, M. Pathophysiology of kidney, gallbladder and urinary
stones treatment with herbal and allopathic medicine: A review. Asian Pac. J. Trop. Dis. 2013, 3, 496–504.
[CrossRef]
36. Chowdhary, S.; Verma, D.; Kumar, H. Biodiversity and traditional knowledge of Bergenia spp. In kumaun
himalaya. Sci. J. 2009, 2, 105–108.
37. Rajbhandari, M.; Mentel, R.; Jha, P.; Chaudhary, R.; Bhattarai, S.; Gewali, M.; Karmacharya, N.; Hipper, M.;
Lindequist, U. Antiviral activity of some plants used in nepalese traditional medicine. Evid. Based Complement.
Alternat. Med. 2009, 6, 517–522. [CrossRef]
38. Kumar, V.; Tyagi, D. Review on phytochemical, ethnomedical and biological studies of medically useful
genus bergenia. Int. J. Curr. Microbiol. App. Sci 2013, 2, 328–334.
39. Patel, A.M.; Kurbetti, S.; Savadi, R.; Thorat, V.; Takale, V.; Horkeri, S. Preparation and evaluation of wound
healing activity of new polyherbal formulations in rats. Am. J. Phytomed. Clin. Ther. 2013, 1, 498–506.
40. Raina, R.; Prawez, S.; Verma, P.; Pankaj, N. Medicinal plants and their role in wound healing. Vet. Scan. 2008,
3, 1–7.
41. Shakya, A.K. Medicinal plants: Future source of new drugs. Int. J. Herb. Med. 2016, 4, 59–64.
42. Singh, K.J.; Thakur, A.K. Medicinal plants of the shimla hills, himachal pradesh: A survey. Int. J. Herbal Med.
2014, 2, 118–127.
43. Walter, N.S.; Bagai, U.; Kalia, S. Antimalarial activity of Bergenia ciliata (haw.) sternb. against Plasmodium
berghei. Parasitol. Res. 2013, 112, 3123–3128. [CrossRef]
44. Bahu, C.P.; Seshadri, R.T. Advances in Research in “Indian Medicine; “Pashanbedi” Drugs for Urinary Calculus;
Udupa, K.N., Ed.; Banaras Hindu University: Varanasi, India, 1970; pp. 77–98.
45. Manandhar, N.P. A survey of medicinal plants of jajarkot district, Nepal. J. Ethnopharmacol. 1995, 48, 1–6.
[CrossRef]
46. Kapur, S. Ethno-medico plants of kangra valley (Himachal Pradesh). J. Econ. Taxon. Bot. 1993, 17, 395–408.
47. Mukerjee, T.; Bhalla, N.; Singh, A.; Jain, H. Herbal drugs for urinary stones. Indian Drugs 1984, 21, 224–228.
48. Shah, N.; Jain, S. Ethnomedico-botany of the kumaon himalaya, india. Soc. Pharmacol. 1988, 2, 359–380.
49. Rani, S.; Rana, J.C. Ethnobotanical uses of some plants of bhattiyat block in district chamba, Himachal
Pradesh (Western Himalaya). Ethnobot. Res. Appl. 2014, 12, 407–414. [CrossRef]
50. Koelz,W.N. Notes on the ethnobotany of lahul, a province of the Punjab. Q. J. Crude Drug Res. 1979, 17, 1–56.
[CrossRef]
51. Vereschagin, V.; Sobolevskaya, K.; Yakubova, A. Useful Plants of West Siberia; Publishing of Academy of
Science of USSR: Moscow-Leningrad, Russia, 1959.
52. Gammerman, A.; Kadaev, G.; Yacenko-Khmelevsky, A. Medicinal Plants (Herbs-Healers); High School: Moscow,
Russia, 1984.
53. Panossian, A.G. Adaptogens: Tonic herbs for fatigue and stress. Altern. Complement. Ther. 2003, 9, 327–331.
54. Sokolov, S.Y. Phytotherapy and Phytopharmacology: The Manual for Doctors; Medical News Agency: Moscow,
Russia, 2000; pp. 197–199.
55. Suslov, N.; Churin, A.; Skurikhin, E.; Provalova, N.; Stal’bovski˘ı, A.; Litvinenko, V.; Dyga˘ı, A. E ect of natural
nootropic and adaptogen preparations on the cortex bioelectrical activity in rats. Eksp. Klin. Farmakol. 2002,
65, 7–10.
56. Li,W.-C.; Gou, F.-G.; Zhang, L.-M.; Yu, H.-M.; Li, X.; Lin, C. The situation and prospect of research on Bergenia
purpurascens. J. -Yunnan Agric. Univ. 2006, 21, 845.
57. Pokhrel, P.; Parajuli, R.R.; Tiwari, A.K.; Banerjee, J. A short glimpse on promising pharmacological e ects of
Begenia ciliata. J. Appl. Pharm. Res. 2014, 2, 1–6.
58. Xie, G.; Zhou, J.; Yan, X. Encyclopedia of Traditional Chinese Medicines: Molecular Structures, Pharmacological
Activities, Natural Sources and Applications; Springer: Berlin/Heidelberg, Germany, 2011; Volume 2.
59. Chen, Y.; Jia, X.; Zhang, Y. Studies on chemical compositions of Bergenia scopulosa T. P. Wang. J. Chin.
Med. Mater. 2008, 31, 1006–1007.
60. Hasan, A.; Husain, A.; Khan, M.A. Flavonol glycosides from leaves of Bergenia himalaica. Asian J. Chem. 2005,
17, 822.
61. Saijyo, J.; Suzuki, Y.; Okuno, Y.; Yamaki, H.; Suzuki, T.; Miyazawa, M. A-glucosidase inhibitor from Bergenia
ligulata. J. Oleo Sci. 2008, 57, 431–435. [CrossRef] [PubMed]
62. Xin-Min, C.; Yoshida, T.; Hatano, T.; Fukushima, M.; Okuda, T. Galloylarbutin and other polyphenols from
Bergenia purpurascens. Phytochemistry 1987, 26, 515–517. [CrossRef]
63. Yang, X.; Wang, Z.; Wang, Z.; Li, R. Analysis of nutritive components and mineral element of Bergenae
pacumbis intibet. J. Chang. Veg. 2009, 22, 57–58.
64. Carmen, P.; Vlase, L.; Tamas, M. Natural resources containing arbutin. Determination of arbutin in the
leaves of Bergenia crassifolia (L.) fritsch. Acclimated in romania. Not. Bot. Horti Agrobot. Cluj-Napoca 2009,
37, 129–132.
65. Chen, J.; Li, Y.; Cai, L. Determination of total flavonoids in Bergenia emeiensis leaf and rhizome by
spectrophotometry. J. China West Norm. Univ. (Nat. Sci.) 2008, 29, 141–143.
66. Lu, X. Studies on chemical compositions of Bergenia scopulosa TP Wang. Zhong Yao Cai 2003, 26, 791–792.
67. Wang, J.; Lu, X. Studies on chemical compositions of Bergenia scopulosa T. P. Wang. J. Chin. Med. Mater. 2005,
28, 23–24. [CrossRef]
68. Lim, Y.-J.; Lee, E.H.; Kang, T.H.;Ha, S.K.;Oh,M.S.; Kim, S.M.; Yoon, T.-J.; Kang,C.; Park, J.-H.; Kim, S.Y. Inhibitory
effects of arbutin on melanin biosynthesis of -melanocyte stimulating hormone-induced hyperpigmentation in
cultured brownish guinea pig skin tissues. Arch. Pharm. Res 2009, 32, 367–373. [CrossRef]
69. Samant, S.; Pant, S. Diversity, distribution pattern and conservation status of the plants used in liver
diseases/ailments in Indian himalayan region. J. Mt. Sci. 2006, 3, 28–47. [CrossRef]
70. Jiang, H.; Guo, F.; Zhang, L.; Chen, Y.; Yang, S. Comparison of bergenin contents of Bergenia purpurascens
among di erent regions in yunnan province. J. Yunnan Agric. Univ. 2010, 25, 895–898.
71. Siddiqui, B.S.; Hasan, M.; Mairaj, F.; Mehmood, I.; Hafizur, R.M.; Hameed, A.; Shinwari, Z.K. Two new
compounds from the aerial parts of Bergenia himalaica boriss and their anti-hyperglycemic effect in
streptozotocin-nicotinamide induced diabetic rats. J. Ethnopharmacol. 2014, 152, 561–567. [CrossRef] [PubMed]
72. Ivanov, S.A.; Nomura, K.; Malfanov, I.L.; Sklyar, I.V.; Ptitsyn, L.R. Isolation of a novel catechin from bergenia
rhizomes that has pronounced lipase-inhibiting and antioxidative properties. Fitoterapia 2011, 82, 212–218.
[CrossRef] [PubMed]
73. Dharmender, R.; Madhavi, T.; Reena, A.; Sheetal, A. Simultaneous quantification of bergenin,(+)-catechin,
gallicin and gallic acid; and quantification of -sitosterol using hptlc from Bergenia ciliata (haw.) sternb.
Forma ligulata yeo (pasanbheda). Pharm. Anal. Acta 2010, 1, 104. [CrossRef]
This entry is adapted from the peer-reviewed paper 10.3390/molecules25235555
