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Ion Trap Spectrometry: History
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Contributor: Helena Kang

Radiofrequency electric fields that confine ions in a three-dimensional or linear quadrupole trap, with subsequent mass-selective ejection or isolation, define ion-trap spectrometry. Ions of a chosen mass-to-charge window are stored, optionally fragmented by resonant excitation or ion–molecule reactions, and then scanned out to a detector, so that the trap is both an ion store and a mass analyzer [1]. Quadrupole ion traps coupled to gas or liquid chromatography therefore provide tandem mass spectra from a single analyzer rather than from a beam-type collision cell [2]. Conceptual boundaries exclude magnetic-sector, time-of-flight, and Fourier-transform ICR analyzers, and they exclude ion-mobility spectrometry that separates ions by collision cross section in a drift gas without RF trapping as the mass-analysis principle. Essential features are an RF trapping potential, a means of mass-selective instability or resonance ejection, and, for tandem work, a controlled activation step inside the trap [3]. The recorded observable remains the mass-to-charge ratio of precursor and product ions.

  • ion trap
  • quadrupole ion trap
  • tandem mass spectrometry
  • mass-selective ejection

Mass Spectrometry Techniques and Applications • Spectroscopy • Chemistry • Physical Sciences

References

  1. Zhi-Rong Tan; Dong-Sheng Ouyang; Gan Zhou; Lian-Sheng Wang; Zhi Li; Dan Wang; Hong-Hao Zhou; Sensitive bioassay for the simultaneous determination of pseudoephedrine and cetirizine in human plasma by liquid-chromatography–ion trap spectrometry. J. Pharm. Biomed. Anal. 2006, 42, 207-212, 10.1016/j.jpba.2006.02.057.
  2. S Blair; M Song; B Hall; J Brodbelt; Determination of Gamma-hydroxybutyrate in Water and Human Urine by Solid Phase Microextraction-Gas Chromatography/Quadrupole Ion Trap Spectrometry. J. Forensic Sci. 2001, 46, 688-693, 10.1520/jfs15023j.
  3. Pei-Xi Zhu; Dan-Hua Wang; Cui-Rong Sun; Zhi-Quan Shen; Characterization of impurities in the bulk drug lisinopril by liquid chromatography/ion trap spectrometry. J. Zhejiang Univ. B 2008, 9, 385-390, 10.1631/jzus.B0820031.
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