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Homogeneous Catalysis: History
Please note this is an old version of this entry, which may differ significantly from the current revision.
Subjects: Chemistry, Organic
Contributor: Helena Kang

Homogeneous catalysis occurs when the catalyst and reactants are present in the same macroscopic phase, most commonly as molecularly dispersed species in a liquid solution. The catalyst may be a neutral molecule, coordination complex, ion, or ion pair, but it undergoes a sequence of elementary steps that regenerates the catalytically active species. For metal complexes, these steps can include ligand association or dissociation, oxidative addition, migratory insertion, and reductive elimination; homogeneous organocatalysis instead proceeds through covalent or noncovalent activation by an organic catalyst. The defining criterion is phase and molecular dispersion, not catalyst composition: both metal and metal-free catalysts can be homogeneous. Molecular catalysts that transform carboxylic acids illustrate the breadth of substrates addressed by homogeneous cycles [1]. The concept is distinguished from heterogeneous catalysis, where the catalyst forms a separate phase and reaction occurs at an interface, although immobilized or biphasic systems can combine features of both classes [2].

  • homogeneous catalysis
  • molecular catalysts
  • solution-phase catalysis
  • catalyst recovery

Synthesis and Catalytic Reactions • Organic Chemistry • Chemistry • Physical Sciences

References

  1. Lukas J. Gooßen; Nuria Rodríguez; Käthe Gooßen; Carboxylic Acids as Substrates in Homogeneous Catalysis. Angew. Chem. Int. Ed. 2008, 47, 3100-3120, 10.1002/anie.200704782.
  2. David J. Cole-Hamilton; Homogeneous Catalysis--New Approaches to Catalyst Separation, Recovery, and Recycling. Science 2003, 299, 1702-1706, 10.1126/science.1081881.
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