Anisakidae Family: History
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Subjects: Zoology
Contributor:
Juan C. Ángeles-Hernández
,
Fabian R. Gómez-de Anda
,
Nydia E. Reyes-Rodríguez
,
Vicente Vega-Sánchez
,
Patricia B. García-Reyna
,
Rafael G. Campos-Montiel
,
Norma L. Calderón-Apodaca
,
Celene Salgado-Miranda
,
Andrea P. Zepeda-Velázquez

Nematodes of the Anisakidae family have a cosmopolitan distribution, due to their ability to infest a wide variety of aquatic hosts during the development of their larval stages, mainly marine mammals and aquatic birds, such as pelicans; being the hosts where the life cycle is completed. The participation of intermediate hosts such as cephalopods, shrimp, crustaceans and marine fish, are an important part to complete this cycle. However, its importance in human health is due to its zoonotic capacity, which causes the clinical presentation in humans, known as Anisakiasis or Anisakidosis, depending on the species of the infecting parasite.

  • anisakiasis,anisakidosis,Anisakidae,parasite, fish

1. Introduction

Transmission of diseases to humans caused mainly by the consumption of fish or fishery products is known as ichthyozoonosis [1]. These diseases are of bacterial, viral, fungal or parasitic etiology. Parasitic ichthyzoonoses are highly relevant, due to the severe clinical conditions that they can cause in humans [2].

One of the main families of parasites that have the ability to cause parasitic ichthyozoonosis is the Anisakidae family, which belongs to the phylum Nematoda and class Secernentea and the order Ascaridida, suborden Ascaridina, superfamily Ascaridoidea, family Anisakidae [3,4]. The nematodes of the Anisakidae family are distributed in a cosmopolitan way [5] and the family is made up of different genera, some of them with great zoonotic potential, such as the genus Anisakis [6,7]. For the development of the biological cycle of the parasite, the participation of marine fish is important, as they act as paratenic hosts or carriers of the L3 larval stage, where the larvae encyst or remain attached to the internal tissues [6]. The parasite has the ability to remain in the coelomic cavity or carry out larval migration to the epiaxial muscle of the infested fish; the life cycle is completed when the marine mammal and piscivorous birds consumes the paratenic host [8,9].

Acquisition of the parasite in humans occurs through the consumption of raw or semi-raw fish or marine products. Due to different existing cultural and gastronomic traditions, in the case of Mexico, the infection is acquired by the consumption of dishes such as aguachile or the popular ceviche [8], while in other countries, such as Japan, the consumption of dishes such as sushi and sashimi favor the presentation of parasitic ichthyozoonosis; in the Asian continent the average consumption of fishery products is 24 kg per year [10,11,12]. The clinical disease caused by these parasites is known as “anisakiasis”, when the infection is caused by the species A. simplex sensu stricto (s.s.), or “anisakidosis” when the infection is caused by Contracaecum spp. or Pseudoterranova spp. [13,14].

The clinical symptoms are nonspecific and may present as epigastric pain, nausea, vomiting, abdominal distention with intense pain and sometimes hypersensitivity reactions [13]. The development of molecular tests and genetic sequencing in the clinical field has allowed the correct identification of the different parasitic species related to clinical pictures, and that in turn allows understanding of the individually pathologies to which each of these genus are related [15]. On the other hand, the use of molecular tests has allowed the maintenance and/or discard of the parasitic genera that have been described morphologically, allowing clarification of which members really belong to the Anisakidae family. Based on the above, the purpose of this work was to carry out a bibliographic search of the genus and species that have been described in the Anisakidae family, identified by the use of morphological and molecular test; as well only through the use of molecular tests and the hosts that have been collected.

2. Life Cycle

Anisakarid nematodes have the ability to infest a wide variety of aquatic organisms during the development of their different stages, from egg to an adult capable of reproduction [16]. The adult stages are observed in the definitive hosts, such as marine mammals, among which are whales, belugas, dolphins, sea bears and seals [17,18,19,20,21,22,23,24,25,26]; as well as in different species of birds such as pelicans, penguins and herons [23,27,28,29,30,31,32,33,34,35,36].

To understand the life cycle of the parasite it is important to know that there are four larval stages, larvae 4 (L4) are males, and females. The females are capable of producing 1.5 million eggs. Oviposition increases in the last phase of life of the female, which is estimated to be at 30 to 60 days old [37]. The embryonated eggs are released into the intestine of the definitive hosts [38] and are eliminated through the feces to the aquatic environment, where the larval stages L1 and L2 develop [9]. It is important to mention that hatching does not occur in the digestive tract of marine mammals, due to temperature, since the action of other external requirements, such as low sea temperatures, salinity and the presence of oxygen favor the hatching of the egg [37]. In the sea, the egg with L2, will mix with plankton, krill, copepods and small crustaceans [38,39]. An important key of the Anisakidae family, to adapt and infest different hosts, radiate in the infestation of different organisms that are part of the trophic links of marine ecosystems from merozooplankton, like Nyctiphanes couchii (Euphausiacea) or Sapa fusiformis (Salpidae), just to mention a few; up to infest the top predators of importance for the life cycle [39]. The L2 uses these copepods to ingest it and release L2, L2 remains inside of these intermediate hosts until it reaches an optimal size for its molt to L3 [40], unless they are consumed by fish [41]. When marine fish consume the intermediate hosts, they act as paratenic hosts or carriers of stage L3 [9], which is trapped in the gastrointestinal tract and migrates toward the coelomic cavity; being free, it encysts in internal tissues such as liver, kidney and epiaxial muscle [42,43] or adheres to the serosa of internal tissues [6,8], causing an inflammatory response [9]. The life cycle of the parasite is completed when the fish infested with L3 is ingested by marine mammals where the larval stage L4, or the adult form, develops [9]. In birds, when they consume the infested fish, during the digestion process the L3 is released and the parasite is free to make its last molt, transforming into L4 and repeating the life cycle [40,44]. It is important to mention that L3 does not have the ability to develop to L4 in fish and humans, so parasitic reproduction in them does not take place [41] (Figure 1).

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Figure 1. General life cycle of the Anisakidae family.

3. Anisakiosis/Anisakiasis

Parasitic ichthyozoonosis caused by some genus of the Anisakidae family can be acquired by humans through the consumption of different poorly cooked, semi-raw and raw marine animals, such as fish, squid, marine mollusks and octopus, among others [13]. Likewise, the different eating habits of a particular area and/or the acquisition of these habits in new geographical areas can result from the globalization of gastronomy [10]. The existence of culinary dishes where the fish is eaten raw or semi-raw includes sushi, sashimi, tuna tartare, herring and pickled anchovies; ceviche, tiradito smoked or salted herring; gravlax or thin, thin cuts of Scandinavian salmon meat; Spanish anchovies in vinegar (pickled anchovies); raw sardines, kuai, kokoda, kelaguen, fish tripe, among others [6,7,11,133].

The consumption of fish infested with the larval stage L3 causes the disease known as “anisakidosis”, which refers to the disease produced by A. pegreffi [78], Contracaecum osculatum [43], Pseudoterranova azarazi [134,135], P. cattani [26,136], P. decipiens [43] and P. krabbei [110]. While the term “anisakiosis” refers to the pathology caused specifically by the species Anisakis simplex s.s. [7,14,15,19,20,52,89]. One of the peculiarities of A. simplex s.s. is its ability to migrate more frequently to the epiaxial muscles of the fish, due to its high adaptability and physiological tolerance, which is why it tends to be more frequent in clinical cases in humans [82]; it also increases the risk of developing “anisakiosis” [13,14]. Likewise, it has been observed that infections caused by P. decipiens tend to be less invasive compared to those caused by A. simplex s.s., as well as the absence of severe gastric signs in reported cases for P. cattani [137] and P. azarasi, which have been collected from the palatine tonsillar [134]. When humans become accidental hosts, the parasite can survive for a short period of time without the ability to develop into adulthood and reproduce [138].

The first signs of the disease may present as a sensation of having something between the teeth, respiratory symptoms and nasal congestion, “tingling throat syndrome”, epigastralgia, nausea, gastric reflux, cough, dysphagia, vomiting and in some cases hematemesis has been reported due to gastric ulceration, depending on the location of the parasite [26,122,124,137,138].

The pathogenicity of anisakiosis/anisakiasis results from two main mechanisms: (1) direct tissue damage, and (2) an allergic response. Likewise, four categories have been determined in which the zoonotic species of the Anisakidae family can cause a clinical picture: (1) gastric, which occurs more frequently [126]; (2) intestinal [122]; (3) ectopic or extra-intestinal, where larval migration to the abdominal cavity occurs [122]. Likewise, there may be extraordinary cases where the parasite can encyst in the esophagus, causing eosinophilic esophagitis [121] and palatine tonsillar infection [134]; and (4) the generation of allergies [116]. Anisakiasis can be present as an asymptomatic, acute (or subacute) symptomatic or chronic symptomatic disease [118]. Once the body comes into contact with the parasite, different degrees of inflammatory responses develop, as well as changes in the permeability of blood vessels [139,140]. The body can react by developing granulomas in the submucosa, with abundant eosinophilic infiltrate (eosinophilic granuloma) and the presence of edema at the site of injury [8,141]. The survival capacity of the larva in humans is 2 to 3 weeks after being ingested [118,123].

It has been determined that the difference between gastric and intestinal presentation lies in the time since the raw shellfish was consumed, these being 7 and 36 h, respectively [123]. Some authors consider that the manifestation of the disease can occur in a period of 7 to 12 h after consumption of the parasite [6,137]. In approximately 95% of clinical cases, the larva can penetrate the gastric mucosa [136] and be observed with relative ease anchored and manifesting epigastric pain in the host until the larva dies or is surgically removed [142]. When the presentation is intestinal, it can cause abdominal distention and intense pain in the patient, which can be present for 5 to 7 days [13]. The presence of edema and abscesses in the mucosa and submucosa have been described, with a marked eosinophilic response around the larvae in the duodenum, jejunum [139] ileum and colon [143]. The main microscopic findings at the site of the injury are characterized by the presence of moderate to severe eosinophilic infiltrate and erosion of the mucosa [144]. Encystment has also been observed in the intestinal epithelium that can trigger the presentation of cancer; however, this will depend on the mutagenicity of the cells and the tumor-promoting potential of larval antigens [145]. In a study carried out by Murata et al. [115], a case of hepatic anisakidosis caused by P. decipiens was reported, which was first diagnosed in the patient as a neoplasm; however, when analyzing the tumor, it was identified that it was an eosinophilic granuloma, in which the larva was located at the center of the lesion.

The allergic response is caused by 28 allergens, among which is found proteins with antigenic roles, excretory secretory products and enzymes, that have been identified in A. simplex s.s. and A. pegreffii [71] among which are somatic and secretory antigens released by the larva when surgically removed, expelled by the body or when it dies within the body [141]. The main allergen recognized by the human body is the serum protein Ani s 1, identified in 87% of patients who develop the clinical picture, where previously fish infested with the nematode have been consumed [146]; Ani s 7 is an excretory antigen that has not been well characterized but is detected in 100% of patients with allergy caused by the parasite, during the acute phase of infection [71,147]; and Ani s 4, which is a cysteine detected in 27–30% of patients [147]. Many of these allergens are resistant to heat and/or pepsin; however, the most recognized by patients is the protein Ani s 1, a serine protease inhibitor that is heat stable and remains present even when the fish is cooked [148]. In the case of A. pegreffii, 2 antigenic proteins have been identified, which have the role of secretion products, being A.peg-1 and A.peg-13 which are expressed by the parasite when the temperature of the environment where the parasite ranges from 20 to 37 °C, respectively; for Contracaecum rudolphii, it has an enzymatic activity, among which are the activities of hydrolases that cause damage to the epithelium of the digestive tract, which allows the parasite to migrate freely in the host [71]. The clinical manifestations of an allergy can be moderate, when the presentation can manifest as irritation, inflammation, ulceration, secondary gingivostomatitis in the areas that have been in contact with the larva [149] and urticaria, which occurs in 60–70% of cases where there is a gastric presentation [7,150]; or severe, when a type I hypersensitivity reaction occurs, which can cause the presentation of angioedema, hypotension, bronchospasms, the presentation of anaphylactic shock and even asthma or worsening of a previous asthma, rhinoconjunctivitis, bronchoconstriction and dermatitis, without an acute infectious picture being present [125,140,141,142,148,151,152]. The presentation of the allergy caused by Anisakis spp. is more prevalent than other food allergies in adult humans, which includes 10% of idiopathic anaphylactic reactions [152].

It has been suggested that, to correlate the nonspecific clinical manifestations caused by Anisakidosis/anisakiasis, it is necessary to associate the information from the medical history, where information on the consumption of foods of marine origin, raw, semi-raw, pickled or other preparation [145]. However, due to the complexity of the clinical presentation, Anisakidosis/Anisakiasis are misdiagnosed, and can be confused with other conditions, such as appendicitis, gastric ulcer, tumors, cholecystitis, peritonitis, Crohn’s colitis, diverticulitis, intestinal intussusception, abdominal obstruction, appendicitis and peptic ulcers, also food allergies, bacterial and viral gastrointestinal infections; and even other intestinal parasites [106,121,133,153]. Some of the complications that can occur along with parasitic infection include intestinal obstruction, eosinophilic enteritis, spontaneous rupture of the spleen [154], presentation of eosinophilic granuloma, marked eosinophilia and abdominal distension [155].

Gastroscopy in the first stages of the disease allows to observe the mucosa and the presence of the parasite in situ, the use of computed tomography has been very useful to observe the area with the inflammatory process, which would suggest the presence of the parasite [123]. One of the cellular manifestations that have accompanied the infestation caused by Anisakis spp is the presentation of infiltrate and degranulation of the eosinophils, in the site where the parasite is found, this in turn also generates misdiagnosis problems, etiological agents such as Baylisascaris procyonis, Gnathostoma spp., Echinocephalus spp., among others can generate a similar cellular reaction [133,145,155], when the parasite is found in the intestinal tract, surgeries are performed to collect the parasite [156].

The ability of this parasite to adapt to different hosts allows the Anisakidae family to be collected in different sea animals and should be considered as a natural event throughout the life cycle of the Anisakidae family and not as a contaminating agent on fishery products [71]. As a natural event, it is important that humans know about its existence and the different ways of preventing infestation, through food safety and sanitary measures, as well as education for people about preventing disease [1]. In addition, very important medical staff must be updated on Anisakiosis/Anisakiasis to consider it as a possible diagnosis, using specific diagnostic tests that allow the correct identification of the etiological agent and, if the medical staff does not have experience with seafood parasites, approach an expert [129,133,157].

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This entry is adapted from the peer-reviewed paper 10.3390/ani10122374

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