Piezo1, a non-selective cation channel directly activated by mechanical forces, is widely expressed in the digestive system and participates in biological functions physiologically and pathologically.
Piezo1 | Study | Piezo2 | Study | |
---|---|---|---|---|
Gene region | 16q24.3 | [12] | 18p11.22-p11.21 | [17] |
Amino acid residues | 2520 | [12] | 2752 | [17] |
Distribution | almost all cell types | - | mainly nerve cells and some specific cell types | [18] |
Detection threshold (fJ) * | 213.7 ± 16.6 | [19] | 86.8 ± 7.1 | [19] |
Work resolution (fJ) * | 1.2 ± 0.4 | [19] | 1.0 ± 0.2 | [19] |
Transduction Speed (ms) * | 8.2 ± 2.2 | [19] | 1.5 ± 0.5 | [19] |
Inactivation kinetics (ms) * | 16.5 ± 1.4 | [11] | 7.3 ± 0.7 | [11] |
Activator | Yoda1, Jedi1/2 | [20][21] | - | - |
Inhibitor | Dooku1, GsMTx4, ruthenium red (RR), gadolinium (Gd3+) | [11][22] | GsMTx4, ruthenium red, gadolinium | [23] |
Hereditary human disorders | dehydrated hereditary stomatocytosis, congenital lymphatic dysplasia with non-immune fetal hydrops | [24][25][26] | recessive distal arthrogryposis syndrome, dominant distal arthrogryposis syndrome (type III and V), Marden-Walker Syndrome | [27][28] |
Region | Distribution | Cellular Effect | Species | Intervention * | Study |
---|---|---|---|---|---|
Oral cavity | odontoblast cell | generate dentinal sensitivity, suppress dentinogenesis, conduct sensory | human | probe, micropipettes, fluid shear stress, shRNA | [40][41] |
trigeminal ganglion neuron | transduct acute pain perception | human, rat | n.a. | [42] | |
dental pulp stem cell | stimulate stem cell proliferation and migration | human, rat | LIPUS, siRNA | [43][44] | |
squamous carcinoma cell | promote cell growth and proliferation | human | siRNA, shRNA | [45] | |
acinar cell and duct-forming regions | modulate early differentiation | mouse | siRNA | [46] | |
Pharyngeal | stratified squamous epithelial cell | n.a. | human | n.a. | [47] |
pharyngeal muscle, pharyngeal gland, sensory neuron | regulate pharyngeal pumping and defecation | nematode Caenorhabditis elegans | RNAi | [48] | |
Esophagus | squamous carcinoma cell | regulate cell apoptosis, migration, and invasion | human | shRNA | [49] |
Stomach | G cell | stimulate gastrin secretion | mouse | n.a. | [50] |
submucosal and myenteric plexus cell | n.a. | human, guinea pig, mouse | intraganglionic injections | [51] | |
gastric cancer cell | promote cell proliferation, migration, invasion; suppress cell apoptosis; maintain cellular morphology | human, mouse | siRNA, in vivo xenograft | [52][53] | |
Small intestine | enterochromaffin cell | mediate 5-HT synthesis | mouse, rat | cyclic stretching, siRNA, sgRNA | [54] |
epithelial cell | activate NLRP3 inflammasome and initiate immune gene expression | human | beads, siRNA, gRNA | [55][56] | |
intestinal stem cell | trigger stem-cell proliferation and differentiation | Drosophila | microfluidic chip, gRNA | [57] | |
fibroblast reticular cell | promote lymphocyte recruitment, initiate mucosal antibody responses | mice | n.a. | [58] | |
submucosal plexus and myenteric plexus | n.a. | human, mouse, guinea pig | intraganglionic injection | [51] | |
Large intestine | goblet cell | promote mucin2 expression and mucus secretion | human, mouse | hydrostatic pressure, mechanical traction, shear force, siRNA | [59][60] |
epithelial cell | activate cell autophagy, regulate expression of tight junction protein, promote Hg2+ transport | human | fluid shear stress, cyclic strain, shRNA, sgRNA | [61][62][63] | |
adenocarcinoma cell | promote cell migration and metastasis, mediate apoptosis | human | siRNA | [64] | |
macrophage | promote aerobic glycolysis and secretion of IL-6, TNF-α, IL-1β | mouse | static pressure, cyclic hydrostatic pressure, lps | [65] | |
microvascular endothelial cell | promote cell migration, organization and alignment | human, mouse | shear stress | [66] | |
Liver | hepatocyte | reduce mitochondrial ROS, mediate cell apoptosis/necrosis, regulate expression of hepcidin | human, mouse | siRNA, pLVX-EF1α-IRES-ZsGreen1-PIEZO1 mutant constructs | [67][68] |
hepatocellular carcinoma | promote cell proliferation, migration, invasion, EMT and angiogenesis | human, mouse, rat | matrix stiffness, shRNA, in vivo xenograft | [69][70] | |
hepatoblastoma | promote cell proliferation and migration | human | siRNA | [71] | |
macrophage | enhance phagocytosis, regulate expression of hepcidin | mouse | membrane stretch | [72] | |
hepatic sinus endothelial cell | promote CXCL1 generation and secretion | mouse | cyclic stretch | [73] | |
Biliary tract | bile canaliculi | promote the contraction of peritubular actin cortex | rat | n.a. | [74] |
cholangiocyte | trigger ATP secretion | mouse | osmotic pressure, siRNA | [75] | |
Pancreas | pancreatic acinar cell | trigger intracellular trypsin activation and cell necrosis | mouse | pancreatic duct injection | [76] |
islet β cell | induce insulin secretion | mouse, rat | circular shear stress, hypotonicity, siRNA | [77] | |
pancreatic stellate cell | promote cell migration, mediate fibrogenic responses and loss of perinuclear fat droplets | human, mouse | glass pipette, fluid shear stress, spheroid traction, acidification | [78][79] |
This entry is adapted from the peer-reviewed paper 10.3390/ijms241612953