References

1. Balch, C.M.; Gershenwald, J.E.; Soong, S.J.; Thompson, J.F.; Atkins, M.B.; Byrd, D.R.; Buzaid, A.C.; Cochran, A.J.; Coit, D.G.; Ding, S.; et al. Final version of 2009 AJCC melanoma staging and classification. J. Clin. Oncol. 2009, 27, 6199. [Google Scholar] [CrossRef] [PubMed]
2. Obenauf, A.C.; Massague, J. Surviving at a distance: Organ-specific metastasis. Trends Cancer 2015, 1, 76–91. [Google Scholar] [CrossRef] [PubMed]
3. Shibue, T.; Weinberg, R.A. Metastatic colonization: Settlement, adaptation and propagation of tumor cells in a foreign tissue environment. Semin. Cancer Biol. 2011, 21, 99–106. [Google Scholar] [CrossRef] [PubMed]
4. Obenauf, A.C.; Zou, Y.; Ji, A.L.; Vanharanta, S.; Shu, W.; Shi, H.; Kong, X.; Bosenberg, M.C.; Wiesner, T.; Rosen, N.; et al. Therapy-induced tumour secretomes promote resistance and tumour progression. Nature 2015, 520, 368–372. [Google Scholar] [CrossRef] [PubMed]
5. Plaks, V.; Kong, N.; Werb, Z. The cancer stem cell niche: How essential is the niche in regulating stemness of tumor cells? Cell Stem Cell 2015, 16, 225–238. [Google Scholar] [CrossRef] [PubMed]
6. Herrmann, J.L.; Menter, D.G.; Hamada, J.; Marchetti, D.; Nakajima, M.; Nicolson, G.L. Mediation of ngf-stimulated extracellular matrix invasion by the human melanoma low-affinity p75 neurotrophin receptor: Melanoma p75 functions independently of trka. Mol. Biol. Cell 1993, 4, 1205–1216. [Google Scholar] [CrossRef]
7. Marchetti, D.; Menter, D.; Jin, L.; Nakajima, M.; Nicolson, G.L. Nerve growth factor effects on human and mouse melanoma cell invasion and heparanase production. Int. J. Cancer 1993, 55, 692–699. [Google Scholar] [CrossRef]
8. Boiko, A.D.; Razorenova, O.V.; van de Rijn, M.; Swetter, S.M.; Johnson, D.L.; Ly, D.P.; Butler, P.D.; Yang, G.P.; Joshua, B.; Kaplan, M.J.; et al. Human melanoma-initiating cells express neural crest nerve growth factor receptor cd271. Nature 2010, 466, 133–137. [Google Scholar] [CrossRef]
9. Quintana, E.; Shackleton, M.; Foster, H.R.; Fullen, D.R.; Sabel, M.S.; Johnson, T.M.; Morrison, S.J. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010, 18, 510–523. [Google Scholar] [CrossRef]
10. Vandamme, N.; Berx, G. From neural crest cells to melanocytes: Cellular plasticity during development and beyond. Cell Mol. Life Sci. 2019, 76, 1919–1934. [Google Scholar] [CrossRef]
11. Moscatelli, I.; Pierantozzi, E.; Camaioni, A.; Siracusa, G.; Campagnolo, L. P75 neurotrophin receptor is involved in proliferation of undifferentiated mouse embryonic stem cells. Exp. Cell Res. 2009, 315, 3220–3232. [Google Scholar] [CrossRef] [PubMed]
12. Morrison, S.J.; White, P.M.; Zock, C.; Anderson, D.J. Prospective identification, isolation by flow cytometry, and in vivo self-renewal of multipotent mammalian neural crest stem cells. Cell 1999, 96, 737–749. [Google Scholar] [CrossRef]
13. Betters, E.; Liu, Y.; Kjaeldgaard, A.; Sundstrom, E.; Garcia-Castro, M.I. Analysis of early human neural crest development. Dev. Biol. 2010, 344, 578–592. [Google Scholar] [CrossRef] [PubMed]
14. Wislet, S.; Vandervelden, G.; Rogister, B. From neural crest development to cancer and vice versa: How p75(ntr) and (pro)neurotrophins could act on cell migration and invasion? Front. Mol. Neurosci. 2018, 11, 244. [Google Scholar] [CrossRef]
15. Lee, G.; Kim, H.; Elkabetz, Y.; al Shamy, G.; Panagiotakos, G.; Barberi, T.; Tabar, V.; Studer, L. Isolation and directed differentiation of neural crest stem cells derived from human embryonic stem cells. Nat. Biotechnol. 2007, 25, 1468–1475. [Google Scholar] [CrossRef]
16. Tomellini, E.; Lagadec, C.; Polakowska, R.; le Bourhis, X. Role of p75 neurotrophin receptor in stem cell biology: More than just a marker. Cell Mol. Life Sci. 2014, 71, 2467–2481. [Google Scholar] [CrossRef]
17. Mundell, A.N.; Labosky, P.A. Neural crest stem cell multipotency requires foxd3 to maintain neural potential and repress mesenchymal fates. Development 2011, 138, 641–652. [Google Scholar] [CrossRef]
18. Teng, L.; Mundell, N.A.; Frist, A.Y.; Wang, Q.; Labosky, P.A. Requirement for foxd3 in the maintenance of neural crest progenitors. Development 2008, 135, 1615–1624. [Google Scholar] [CrossRef]
19. Douarin, L.M.N.; Dupin, E. Multipotentiality of the neural crest. Curr. Opin. Genet. Dev. 2003, 13, 529–536. [Google Scholar] [CrossRef]
20. Mort, R.L.; Jackson, I.J.; Patton, E.E. The melanocyte lineage in development and disease. Development 2015, 142, 620–632. [Google Scholar] [CrossRef]
21. Britsch, S.; Goerich, D.E.; Riethmacher, D.; Peirano, R.I.; Rossner, M.; Nave, K.A.; Birchmeier, C.; Wegner, M. The transcription factor sox10 is a key regulator of peripheral glial development. Genes Dev. 2001, 15, 66–78. [Google Scholar] [CrossRef] [PubMed]
22. Shakhova, O.; Zingg, D.; Schaefer, S.M.; Hari, L.; Civenni, G.; Blunschi, J.; Claudinot, S.; Okoniewski, M.; Beermann, F.; Mihic-Probst, D.; et al. Sox10 promotes the formation and maintenance of giant congenital naevi and melanoma. Nat. Cell Biol. 2012, 14, 882–890. [Google Scholar] [CrossRef] [PubMed]
23. Barrallo-Gimeno, A.; Nieto, M.A. The snail genes as inducers of cell movement and survival: Implications in development and cancer. Development 2005, 132, 3151–3161. [Google Scholar] [CrossRef] [PubMed]
24. White, M.R.; Zon, L.I. Melanocytes in development, regeneration, and cancer. Cell Stem Cell 2008, 3, 242–252. [Google Scholar] [CrossRef]
25. Blake, J.A.; Ziman, M.R. Pax genes: Regulators of lineage specification and progenitor cell maintenance. Development 2014, 141, 737–751. [Google Scholar] [CrossRef] [PubMed]
26. Pincelli, C. P75 neurotrophin receptor in the skin: Beyond its neurotrophic function. Front. Med. (Lausanne) 2017, 4, 22. [Google Scholar] [CrossRef]
27. Truzzi, F.; Saltari, A.; Palazzo, E.; Lotti, R.; Petrachi, T.; Dallaglio, K.; Gemelli, C.; Grisendi, G.; Dominici, M.; Pincelli, C.; et al. Cd271 mediates stem cells to early progeny transition in human epidermis. J. Investig. Dermatol. 2015, 135, 786–795. [Google Scholar] [CrossRef]
28. Peacocke, M.; Yaar, M.; Mansur, C.P.; Chao, M.V.; Gilchrest, B.A. Induction of nerve growth factor receptors on cultured human melanocytes. Proc. Natl. Acad. Sci. USA 1988, 85, 5282–5286. [Google Scholar] [CrossRef]
29. Yaar, M.; Grossman, K.; Eller, M.; Gilchrest, B.A. Evidence for nerve growth factor-mediated paracrine effects in human epidermis. J. Cell Biol. 1991, 115, 821–828. [Google Scholar] [CrossRef]
30. Tron, V.A.; Coughlin, M.D.; Jang, D.E.; Stanisz, J.; Sauder, D.N. Expression and modulation of nerve growth factor in murine keratinocytes (pam 212). J. Clin. Investig. 1990, 85, 1085–1089. [Google Scholar] [CrossRef]
31. Menzies, A.M.; Haydu, L.E.; Visintin, L.; Carlino, M.S.; Howle, J.R.; Thompson, J.F.; Kefford, R.F.; Scolyer, R.A.; Long, G.V. Distinguishing clinicopathologic features of patients with v600e and v600k braf-mutant metastatic melanoma. Clin. Cancer Res. 2012, 18, 3242–3249. [Google Scholar] [CrossRef] [PubMed]
32. Pollock, P.M.; Harper, U.L.; Hansen, K.S.; Yudt, L.M.; Stark, M.; Robbins, C.M.; Moses, T.Y.; Hostetter, G.; Wagner, U.; Kakareka, J.; et al. High frequency of braf mutations in nevi. Nat. Genet. 2003, 33, 19–20. [Google Scholar] [CrossRef] [PubMed]
33. Cheung, M.; Sharma, A.; Madhunapantula, S.V.; Robertson, G.P. Akt3 and mutant v600e b-raf cooperate to promote early melanoma development. Cancer Res. 2008, 68, 3429–3439. [Google Scholar] [CrossRef] [PubMed]
34. Davies, H.; Bignell, G.R.; Cox, C.; Stephens, P.; Edkins, S.; Clegg, S.; Teague, J.; Woffendin, H.; Garnett, M.J.; Bottomley, W.; et al. Mutations of the braf gene in human cancer. Nature 2002, 417, 949–954. [Google Scholar] [CrossRef] [PubMed]
35. Shain, A.H.; Bastian, B.C. From melanocytes to melanomas. Nat. Rev. Cancer 2016, 16, 345–358. [Google Scholar] [CrossRef]
36. Shain, A.H.; Bastian, B.C. Author correction: From melanocytes to melanomas. Nat. Rev. Cancer 2020, 20, 355. [Google Scholar] [CrossRef]
37. Dankort, D.; Curley, D.P.; Nelson, A.N.; Karnezis, W.E.; Damsky, J.; You, R.A.D.; Bosenberg, M. Braf(v600e) cooperates with pten loss to induce metastatic melanoma. Nat. Genet. 2009, 41, 544–552. [Google Scholar] [CrossRef]
38. Perez-Guijarro, E.; Day, C.P.; Merlino, G.; Zaidi, M.R. Genetically engineered mouse models of melanoma. Cancer 2017, 123, 2089–2103. [Google Scholar] [CrossRef]
39. Stahl, J.M.; Sharma, A.; Cheung, M.; Zimmerman, M.; Cheng, J.Q.; Bosenberg, M.W.; Kester, M.; Sandirasegarane, L.; Robertson, G.P. Deregulated akt3 activity promotes development of malignant melanoma. Cancer Res. 2004, 64, 7002–7010. [Google Scholar] [CrossRef]
40. Redmer, T.; Welte, Y.; Behrens, D.; Fichtner, I.; Przybilla, D.; Wruck, W.; Yaspo, M.L.; Lehrach, H.; Schafer, R.; Regenbrecht, C.R. The nerve growth factor receptor cd271 is crucial to maintain tumorigenicity and stem-like properties of melanoma cells. PLoS ONE 2014, 9, e92596. [Google Scholar] [CrossRef]
41. Adameyko, I.; Lallemend, F.; Furlan, A.; Zinin, N.; Aranda, S.; Kitambi, S.S.; Blanchart, A.; Favaro, R.; Nicolis, S.; Lubke, M.; et al. Sox2 and mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest. Development 2012, 139, 397–410. [Google Scholar] [CrossRef] [PubMed]
42. Hartman, M.L.; Czyz, M. Mitf in melanoma: Mechanisms behind its expression and activity. Cell Mol. Life Sci. 2015, 72, 1249–1260. [Google Scholar] [CrossRef] [PubMed]
43. Redmer, T.; Walz, I.; Klinger, B.; Khouja, S.; Welte, Y.; Schafer, R.; Regenbrecht, C. The role of the cancer stem cell marker cd271 in DNA damage response and drug resistance of melanoma cells. Oncogenesis 2017, 6, e291. [Google Scholar] [CrossRef] [PubMed]
44. Lehraiki, A.; Cerezo, M.; Rouaud, F.; Abbe, P.; Allegra, M.; Kluza, J.; Marchetti, P.; Imbert, V.; Cheli, Y.; Bertolotto, C.; et al. Increased cd271 expression by the nf-kb pathway promotes melanoma cell survival and drives acquired resistance to braf inhibitor vemurafenib. Cell Discov. 2015, 1, 15030. [Google Scholar] [CrossRef] [PubMed]
45. Zubrilov, I.; Sagi-Assif, O.; Izraely, S.; Meshel, T.; Ben-Menahem, S.; Ginat, R.; Pasmanik-Chor, M.; Nahmias, C.; Couraud, P.O.; Hoon, D.S.; et al. Vemurafenib resistance selects for highly malignant brain and lung-metastasizing melanoma cells. Cancer Lett. 2015, 361, 86–96. [Google Scholar] [CrossRef]
46. Baeza-Raja, B.; Eckel-Mahan, K.; Zhang, L.; Vagena, E.; Tsigelny, I.F.; Sassone-Corsi, P.; Ptacek, L.J.; Akassoglou, K. P75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J. Neurosci. 2013, 33, 10221–10234. [Google Scholar] [CrossRef]
47. Boyle, S.E.; Fedele, C.G.; Corbin, V.; Wybacz, E.; Szeto, P.; Lewin, J.; Young, R.J.; Wong, A.; Fuller, R.; Spillane, J.; et al. Cd271 expression on patient melanoma cells is unstable and unlinked to tumorigenicity. Cancer Res. 2016, 76, 3965–3977. [Google Scholar] [CrossRef]
48. Cheli, Y.; Bonnazi, V.F.; Jacquel, A.; Allegra, M.; de Donatis, G.M.; Bahadoran, P.; Bertolotto, C.; Ballotti, R. Cd271 is an imperfect marker for melanoma initiating cells. Oncotarget 2014, 5, 5272–5283. [Google Scholar] [CrossRef]
49. Filipp, F.V.; Li, C.; Boiko, A.D. Cd271 is a molecular switch with divergent roles in melanoma and melanocyte development. Sci. Rep. 2019, 9, 7696. [Google Scholar] [CrossRef]
50. Radke, J.; Rossner, F.; Redmer, T. Cd271 determines migratory properties of melanoma cells. Sci. Rep. 2017, 7, 9834. [Google Scholar] [CrossRef]
51. Civenni, G.; Walter, A.; Kobert, N.; Mihic-Probst, D.; Zipser, M.; Belloni, B.; Seifert, B.; Moch, H.; Dummer, R.; van den Broek, M.; et al. Human cd271-positive melanoma stem cells associated with metastasis establish tumor heterogeneity and long-term growth. Cancer Res. 2011, 71, 3098–3109. [Google Scholar] [CrossRef] [PubMed]
52. Mandalos, N.; Rhinn, M.; Granchi, Z.; Karampelas, I.; Mitsiadis, T.; Economides, A.N.; Dolle, P.; Remboutsika, E. Sox2 acts as a rheostat of epithelial to mesenchymal transition during neural crest development. Front. Physiol. 2014, 5, 345. [Google Scholar] [CrossRef] [PubMed]
53. Restivo, G.; Diener, J.; Cheng, P.F.; Kiowski, G.; Bonalli, M.; Biedermann, T.; Reichmann, E.; Levesque, M.P.; Dummer, R.; Sommer, L. Publisher correction: The low affinity neurotrophin receptor cd271 regulates phenotype switching in melanoma. Nat. Commun. 2018, 9, 314. [Google Scholar] [CrossRef] [PubMed]
54. Ackermann, J.; Frutschi, M.; Kaloulis, K.; McKee, T.; Trumpp, A.; Beermann, F. Metastasizing melanoma formation caused by expression of activated n-rasq61k on an ink4a-deficient background. Cancer Res. 2005, 65, 4005–4011. [Google Scholar] [CrossRef] [PubMed]
55. Sandru, A.; Voinea, S.; Panaitescu, E.; Blidaru, A. Survival rates of patients with metastatic malignant melanoma. J. Med. Life 2014, 7, 572–576. [Google Scholar]
56. Redmer, T. Deciphering mechanisms of brain metastasis in melanoma-the gist of the matter. Mol. Cancer 2018, 17, 106. [Google Scholar] [CrossRef]
57. Bailey, C.M.; Morrison, J.A.; Kulesa, P.M. Melanoma revives an embryonic migration program to promote plasticity and invasion. Pigment Cell Melanoma Res. 2012, 25, 573–583. [Google Scholar] [CrossRef]
58. Larribere, L.; Utikal, J. Stem cell-derived models of neural crest are essential to understand melanoma progression and therapy resistance. Front. Mol. Neurosci. 2019, 12, 111. [Google Scholar] [CrossRef]
59. Marchetti, D.; McCutcheon, I.; Ross, M.; Nicolson, G. Inverse expression of neurotrophins and neurotrophin receptors at the invasion front of human-melanoma brain metastases. Int J. Oncol. 1995, 7, 87–94. [Google Scholar] [CrossRef]
60. Truzzi, F.; Marconi, A.; Lotti, R.; Dallaglio, K.; French, L.E.; Hempstead, B.L.; Pincelli, C. Neurotrophins and their receptors stimulate melanoma cell proliferation and migration. J. Investig. Dermatol. 2008, 128, 2031–2040. [Google Scholar] [CrossRef]
61. Liu, X.; Gao, Y.; Lu, Y.; Zhang, J.; Li, L.; Yin, F. Upregulation of nek2 is associated with drug resistance in ovarian cancer. Oncol Rep. 2014, 31, 745–754. [Google Scholar] [CrossRef] [PubMed]
62. Xu, H.; Zeng, L.; Guan, Y.; Feng, X.; Zhu, Y.; Lu, Y.; Shi, C.; Chen, S.; Xia, J.; Guo, J.; et al. High nek2 confers to poor prognosis and contributes to cisplatin-based chemotherapy resistance in nasopharyngeal carcinoma. J. Cell Biochem. 2019, 120, 3547–3558. [Google Scholar] [CrossRef] [PubMed]
63. Chang, Y.Y.; Yen, C.J.; Chan, S.H.; Chou, Y.W.; Lee, Y.P.; Bao, C.Y.; Huang, C.J.; Huang, W. Nek2 promotes hepatoma metastasis and serves as biomarker for high recurrence risk after hepatic resection. Ann. Hepatol. 2018, 17, 843–856. [Google Scholar] [CrossRef]
64. Huang, J.; Sun, S.G.; Hou, S. Aberrant NEK2 expression might be an independent predictor for poor recurrence-free survival and overall survival of skin cutaneous melanoma. Eur. Rev. Med. Pharmacol. Sci. 2018, 22, 3694–3702. [Google Scholar] [CrossRef]
65. Wen, S.; Liu, Y.; Yang, M.; Yang, K.; Huang, J.; Feng, D. Increased nek2 in hepatocellular carcinoma promotes cancer progression and drug resistance by promoting pp1/akt and wnt activation. Oncol. Rep. 2016, 36, 2193–2199. [Google Scholar] [CrossRef]
66. Zhang, Y.; Wang, W.; Wang, Y.; Huang, X.; Zhang, Z.; Chen, B.; Xie, W.; Li, S.; Shen, S.; Peng, B. Nek2 promotes hepatocellular carcinoma migration and invasion through modulation of the epithelial-mesenchymal transition. Oncol. Rep. 2018, 39, 1023–1033. [Google Scholar] [CrossRef]
67. Sankaran, D.; Pakala, S.B.; Nair, V.S.; Sirigiri, D.N.; Cyanam, D.; Ha, N.H.; Li, D.Q.; Santhoshkumar, T.R.; Pillai, M.R.; Kumar, R. Mechanism of mta1 protein overexpression-linked invasion: Mta1 regulation of hyaluronan-mediated motility receptor (hmmr) expression and function. J. Biol. Chem. 2012, 287, 5483–5491. [Google Scholar] [CrossRef] [PubMed]
68. Tilghman, J.; Wu, H.; Sang, Y.; Shi, X.; Guerrero-Cazares, H.; Quinones-Hinojosa, A.; Eberhart, C.G.; Laterra, J.; Ying, M. Hmmr maintains the stemness and tumorigenicity of glioblastoma stem-like cells. Cancer Res. 2014, 74, 3168–3179. [Google Scholar] [CrossRef]
69. Kauffmann, A.; Rosselli, F.; Lazar, V.; Winnepenninckx, V.; Mansuet-Lupo, A.; Dessen, P.; van den Oord, J.J.; Spatz, A.; Sarasin, A. High expression of DNA repair pathways is associated with metastasis in melanoma patients. Oncogene 2008, 27, 565–573. [Google Scholar] [CrossRef]
70. Lu, H.; Liu, S.; Zhang, G.; Kwong, L.N.; Zhu, Y.; Miller, J.P.; Hu, Y.; Zhong, W.; Zeng, J.; Wu, L.; et al. Oncogenic braf-mediated melanoma cell invasion. Cell Rep. 2016, 15, 2012–2024. [Google Scholar] [CrossRef]
71. Ravindran Menon, D.; Das, S.; Krepler, C.; Vultur, A.; Rinner, B.; Schauer, S.; Kashofer, K.; Wagner, K.; Zhang, G.; Rad, E.B.; et al. A stress-induced early innate response causes multidrug tolerance in melanoma. Oncogene 2015, 34, 4448–4459. [Google Scholar] [CrossRef] [PubMed]
72. Tong, B.; Pantazopoulou, V.; Johansson, E.; Pietras, A. The p75 neurotrophin receptor enhances hif-dependent signaling in glioma. Exp. Cell Res. 2018, 371, 122–129. [Google Scholar] [CrossRef] [PubMed]
73. Calvo-Anguiano, G.; Lugo-Trampe, J.J.; Camacho, A.; Said-Fernandez, S.; Mercado-Hernandez, R.; Zomosa-Signoret, V.; Rojas-Martinez, A.; Ortiz-Lopez, R. Comparison of specific expression profile in two in vitro hypoxia models. Exp. Ther. Med. 2018, 15, 4777–4784. [Google Scholar] [CrossRef] [PubMed]
74. Dusedau, H.P.; Kleveman, J.; Figueiredo, C.A.; Biswas, A.; Steffen, J.; Kliche, S.; Haak, S.; Zagrebelsky, M.; Korte, M.; Dunay, I.R. P75(ntr) regulates brain mononuclear cell function and neuronal structure in toxoplasma infection-induced neuroinflammation. Glia 2019, 67, 193–211. [Google Scholar] [CrossRef]
75. Cragnolini, A.B.; Huang, Y.; Gokina, P.; Friedman, W.J. Nerve growth factor attenuates proliferation of astrocytes via the p75 neurotrophin receptor. Glia 2009, 57, 1386–1392. [Google Scholar] [CrossRef]
76. Schachtrup, C.; Ryu, J.K.; Mammadzada, K.; Khan, A.S.; Carlton, P.M.; Perez, A.; Christian, F.; le Moan, N.; Vagena, E.; Baeza-Raja, B.; et al. Nuclear pore complex remodeling by p75(ntr) cleavage controls tgf-beta signaling and astrocyte functions. Nat. Neurosci. 2015, 18, 1077–1080. [Google Scholar] [CrossRef]
77. Landsberg, J.; Kohlmeyer, J.; Renn, M.; Bald, T.; Rogava, M.; Cron, M.; Fatho, M.; Lennerz, V.; Wolfel, T.; Holzel, M.; et al. Melanomas resist t-cell therapy through inflammation-induced reversible dedifferentiation. Nature 2012, 490, 412–416. [Google Scholar] [CrossRef]
78. Guida, M.; Tommasi, S.; Strippoli, S.; Natalicchio, M.I.; de Summa, S.; Pinto, R.; Cramarossa, A.; Albano, A.; Pisconti, S.; Aieta, M.; et al. The search for a melanoma-tailored chemotherapy in the new era of personalized therapy: A phase ii study of chemo-modulating temozolomide followed by fotemustine and a cooperative study of goim (gruppo oncologico italia meridionale). BMC Cancer 2018, 18, 552. [Google Scholar] [CrossRef]
79. Ngo, M.; Han, A.; Lakatos, A.; Sahoo, D.; Hachey, S.J.; Weiskopf, K.; Beck, A.H.; Weissman, I.L.; Boiko, A.D. Antibody therapy targeting cd47 and cd271 effectively suppresses melanoma metastasis in patient-derived xenografts. Cell Rep. 2016, 16, 1701–1716. [Google Scholar] [CrossRef]
80. Tirosh, I.; Izar, B.; Prakadan, S.M.; Wadsworth, M.H.; Treacy, D.; Trombetta, J.J.; Rotem, A.; Rodman, C.; Lian, C.; Murphy, G.; et al. Dissecting the multicellular ecosystem of metastatic melanoma by single-cell rna-seq. Science 2016, 352, 189–196. [Google Scholar] [CrossRef]
81. Hoek, K.S.; Eichhoff, O.M.; Schlegel, N.C.; Dobbeling, U.; Kobert, N.; Schaerer, L.; Hemmi, S.; Dummer, R. In vivo switching of human melanoma cells between proliferative and invasive states. Cancer Res. 2008, 68, 650–656. [Google Scholar] [CrossRef] [PubMed]
82. Muller, J.; Krijgsman, O.; Tsoi, J.; Robert, L.; Hugo, W.; Song, C.; Kong, X.; Possik, P.A.; Cornelissen-Steijger, P.D.; Foppen , M.H.; et al. Low mitf/axl ratio predicts early resistance to multiple targeted drugs in melanoma. Nat. Commun. 2014, 5, 5712. [Google Scholar] [CrossRef] [PubMed]
83. Chen, G.; Chakravarti, N.; Aardalen, K.; Lazar, A.J.; Tetzlaff, M.T.; Wubbenhorst, B.; Kim, S.B.; Kopetz, S.; Ledoux, A.A.; Gopal, Y.N.; et al. Molecular profiling of patient-matched brain and extracranial melanoma metastases implicates the pi3k pathway as a therapeutic target. Clin. Cancer Res. 2014, 20, 5537–5546. [Google Scholar] [CrossRef]
84. Rankin, E.B.; Giaccia, A.J. Hypoxic control of metastasis. Science 2016, 352, 175–180. [Google Scholar] [CrossRef] [PubMed]
85. Widmer, D.S.; Hoek, K.S.; Cheng, P.F.; Eichhoff, O.M.; Biedermann, T.; Raaijmakers, M.I.G.; Hemmi, S.; Dummer, R.; Levesque, M.P. Hypoxia contributes to melanoma heterogeneity by triggering hif1alpha-dependent phenotype switching. J. Investig. Dermatol. 2013, 133, 2436–2443. [Google Scholar] [CrossRef] [PubMed]
86. Rappa, G.; Fodstad, O.; Lorico, A. The stem cell-associated antigen cd133 (prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells 2008, 26, 3008–3017. [Google Scholar] [CrossRef]
87. Guo, R.; Fierro-Fine, A.; Goddard, L.; Russell, M.; Chen, J.; Liu, C.Z.; Fung, K.M.; Hassell, L.A. Increased expression of melanoma stem cell marker cd271 in metastatic melanoma to the brain. Int. J. Clin. Exp. Pathol. 2014, 7, 8947–8951. [Google Scholar]
88. Podlesniy, P.; Kichev, A.; Pedraza, C.; Saurat, J.; Encinas, M.; Perez, B.; Ferrer, I.; Espinet, C. Pro-ngf from alzheimer’s disease and normal human brain displays distinctive abilities to induce processing and nuclear translocation of intracellular domain of p75ntr and apoptosis. Am. J. Pathol. 2006, 169, 119–131. [Google Scholar] [CrossRef]
89. Bilderback, T.R.; Grigsby, R.J.; Dobrowsky, R.T. Association of p75(ntr) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae. J. Biol. Chem. 1997, 272, 10922–10927. [Google Scholar] [CrossRef]
90. Ceni, C.; Kommaddi, R.P.; Thomas, R.; Vereker, E.; Liu, X.; McPherson, P.S.; Ritter, B.; Barker, P.A. The p75ntr intracellular domain generated by neurotrophin-induced receptor cleavage potentiates trk signaling. J. Cell Sci. 2010, 123, 2299–2307. [Google Scholar] [CrossRef]
91. van Strien, M.E.; Sluijs, J.A.; Reynolds, B.A.; Steindler, D.A.; Aronica, E.; Hol, E.M. Isolation of neural progenitor cells from the human adult subventricular zone based on expression of the cell surface marker cd271. Stem Cells Transl. Med. 2014, 3, 470–480. [Google Scholar] [CrossRef] [PubMed]
92. Young, K.M.; Merson, T.D.; Sotthibundhu, A.; Coulson, E.J.; Bartlett, P.F. P75 neurotrophin receptor expression defines a population of bdnf-responsive neurogenic precursor cells. J. Neurosci. 2007, 27, 5146–5155. [Google Scholar] [CrossRef] [PubMed]
93. Meeker, R.B.; Williams, K.S. The p75 neurotrophin receptor: At the crossroad of neural repair and death. Neural. Regen. Res. 2015, 10, 721–725. [Google Scholar] [CrossRef] [PubMed]
94. Sofroniew, M.V. Astrogliosis. Cold Spring Harb. Perspect. Biol. 2014, 7, a020420. [Google Scholar] [CrossRef]
95. Kisiswa, L.; Fernandez-Suarez, D.; Sergaki, M.C.; Ibanez, C.F. Rip2 gates traf6 interaction with death receptor p75(ntr) to regulate cerebellar granule neuron survival. Cell Rep. 2018, 24, 1013–1024. [Google Scholar] [CrossRef]
96. Meeker, R.; Williams, K. Dynamic nature of the p75 neurotrophin receptor in response to injury and disease. J. Neuroimmune Pharmacol. 2014, 9, 615–628. [Google Scholar] [CrossRef]
97. Lee, R.; Kermani, P.; Teng, K.K.; Hempstead, B.L. Regulation of cell survival by secreted proneurotrophins. Science 2001, 294, 1945–1948. [Google Scholar] [CrossRef]
98. Nykjaer, A.; Willnow, T.E. Sortilin: A receptor to regulate neuronal viability and function. Trends Neurosci. 2012, 35, 261–270. [Google Scholar] [CrossRef]
99. Fujita, Y.; Yamashita, T. Axon growth inhibition by rhoa/rock in the central nervous system. Front. Neurosci. 2014, 8, 338. [Google Scholar] [CrossRef]
100. Clucas, J.; Valderrama, F. Erm proteins in cancer progression. J. Cell Sci. 2014, 127, 267–275. [Google Scholar] [CrossRef] [PubMed]
101. Roux, P.P.; Barker, P.A. Neurotrophin signaling through the p75 neurotrophin receptor. Prog. Neurobiol. 2002, 67, 203–233. [Google Scholar] [CrossRef]
102. Maguire, L.H.; Thomas, A.R.; Goldstein, A.M. Tumors of the neural crest: Common themes in development and cancer. Dev. Dyn. 2015, 244, 311–322. [Google Scholar] [CrossRef] [PubMed]
103. Shonukan, O.; Bagayogo, I.; McCrea, P.; Chao, M.; Hempstead, B. Neurotrophin-induced melanoma cell migration is mediated through the actin-bundling protein fascin. Oncogene 2003, 22, 3616–3623. [Google Scholar] [CrossRef]
104. Marchetti, D.; McQuillan, D.J.; Spohn, W.C.; Carson, D.D.; Nicolson, G.L. Neurotrophin stimulation of human melanoma cell invasion: Selected enhancement of heparanase activity and heparanase degradation of specific heparan sulfate subpopulations. Cancer Res. 1996, 56, 2856–2863. [Google Scholar] [CrossRef]
105. Walch, T.E.; Albino, A.P.; Marchetti, D. Correlation of overexpression of the low-affinity p75 neurotrophin receptor with augmented invasion and heparanase production in human malignant melanoma cells. Int J. Cancer 1999, 82, 112–120. [Google Scholar] [CrossRef]
106. Yamada, K.; Nomura, N.; Yamano, A.; Yamada, Y.; Wakamatsu, N. Identification and characterization of splicing variants of plekha5 (plekha5) during brain development. Gene 2012, 492, 270–275. [Google Scholar] [CrossRef]
107. Bao, X.; Shi, J.; Xie, F.; Liu, Z.; Yu, J.; Chen, W.; Zhang, Z.; Xu, Q. Proteolytic release of the p75(ntr) intracellular domain by adam10 promotes metastasis and resistance to anoikis. Cancer Res. 2018, 78, 2262–2276. [Google Scholar] [CrossRef]
108. Verbeke, S.; Tomellini, E.; Dhamani, F.; Meignan, S.; Adriaenssens, E.; Xuefen le, B. Extracellular cleavage of the p75 neurotrophin receptor is implicated in its pro-survival effect in breast cancer cells. FEBS Lett. 2013, 587, 2591–2596. [Google Scholar] [CrossRef]
109. Becker, K.; Cana, A.; Baumgartner, W.; Spitzbarth, I. P75 neurotrophin receptor: A double-edged sword in pathology and regeneration of the central nervous system. Vet. Pathol. 2018, 55, 786–801. [Google Scholar] [CrossRef]
110. Johnston, A.L.; Lun, X.; Rahn, J.J.; Liacini, A.; Wang, L.; Hamilton, M.G.; Parney, I.F.; Hempstead, B.L.; Robbins, S.M.; Forsyth, P.A.; et al. The p75 neurotrophin receptor is a central regulator of glioma invasion. PLoS Biol. 2007, 5, e212. [Google Scholar] [CrossRef] [PubMed]
111. Wrensch, M.; Minn, Y.; Chew, T.; Bondy, M.; Berger, M.S. Epidemiology of primary brain tumors: Current concepts and review of the literature. Neuro. Oncol. 2002, 4, 278–299. [Google Scholar] [CrossRef] [PubMed]
112. Ahn, B.Y.; Saldanha-Gama, R.F.; Rahn, J.J.; Hao, X.; Zhang, J.; Dang, N.H.; Alshehri, M.; Robbins, S.M.; Senger, D.L. Glioma invasion mediated by the p75 neurotrophin receptor (p75(ntr)/cd271) requires regulated interaction with pdlim1. Oncogene 2016, 35, 1411–1422. [Google Scholar] [CrossRef] [PubMed]
113. Higuchi, H.; Yamashita, T.; Yoshikawa, H.; Tohyama, M. Pka phosphorylates the p75 receptor and regulates its localization to lipid rafts. EMBO J. 2003, 22, 1790–1800. [Google Scholar] [CrossRef]
114. Chen, C.; Shin, J.H.; Eggold, J.T.; Chung, M.K.; Zhang, L.H.; Lee, J.; Sunwoo, J.B. Esm1 mediates ngfr-induced invasion and metastasis in murine oral squamous cell carcinoma. Oncotarget 2016, 7, 70738–70749. [Google Scholar] [CrossRef]
115. Chung, M.K.; Jung, Y.H.; Lee, J.K.; Cho, S.Y.; Murillo-Sauca, O.; Uppaluri, R.; Shin, J.H.; Sunwoo, J.B. Cd271 confers an invasive and metastatic phenotype of head and neck squamous cell carcinoma through the upregulation of slug. Clin. Cancer Res. 2018, 24, 674–683. [Google Scholar] [CrossRef]
116. Mochizuki, M.; Tamai, K.; Imai, T.; Sugawara, S.; Ogama, N.; Nakamura, M.; Matsuura, K.; Yamaguchi, K.; Satoh, K.; Sato, I.; et al. Cd271 regulates the proliferation and motility of hypopharyngeal cancer cells. Sci. Rep. 2016, 6, 30707. [Google Scholar] [CrossRef]
117. Mochizuki, M.; Nakamura, M.; Sibuya, R.; Okazaki, T.; Abe, J.; Nakagawa, T.; Takahashi, S.; Yamazaki, T.; Imai, T.; Takano, A.; et al. Cd271 is a negative prognostic factor and essential for cell proliferation in lung squamous cell carcinoma. Lab. Investig. 2019, 99, 1349–1362. [Google Scholar] [CrossRef]
118. Morita, S.; Mochizuki, M.; Wada, K.; Shibuya, R.; Nakamura, M.; Yamaguchi, K.; Yamazaki, T.; Imai, T.; Asada, Y.; Matsuura, K.; et al. Humanized anti-cd271 monoclonal antibody exerts an anti-tumor effect by depleting cancer stem cells. Cancer Lett. 2019, 461, 144–152. [Google Scholar] [CrossRef]
119. Krygier, S.; Djakiew, D. Neurotrophin receptor p75(ntr) suppresses growth and nerve growth factor-mediated metastasis of human prostate cancer cells. Int. J. Cancer 2002, 98, 1–7. [Google Scholar] [CrossRef]
120. Rosenberg, S.A.; Yang, J.C.; Sherry, R.M.; Kammula, U.S.; Hughes, M.S.; Phan, G.Q.; Citrin, D.E.; Restifo, N.P.; Robbins, P.F.; Wunderlich, J.R.; et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using t-cell transfer immunotherapy. Clin. Cancer Res. 2011, 17, 4550–4557. [Google Scholar] [CrossRef] [PubMed]
121. Rosenberg, S.A.; Yang, J.C.; Sherry, R.M.; Kammula, U.S.; Hughes, M.S.; Phan, G.Q.; Citrin, D.E.; Restifo, N.P.; Robbins, P.F.; Wunderlich, J.R.; et al. Durable complete responses in heavily pretreated patients with metastatic melanoma using t-cell transfer immunotherapy. Clin. Cancer Res. 2011, 17, 4550–4557. [Google Scholar] [CrossRef] [PubMed]