Labrie et al. (2002) | Patients with localized PC treated with either total prostatectomy, radiation therapy, watchful waiting, hormone therapy, or other treatment |
844 |
Patients who received ADT alone already had an increased risk of PCSM at 5 years (HR 3.5, 95% CI 1.4–8.7) |
[ |
prospective study83] |
Patients with newly diagnosed locally advanced or localized PC who have undergone CAB |
57 |
In patients with stage T2–T3 cancer who continued CAB for more than 6.5 years and discontinued treatment there were only two cases of PSA elevation. Long-term continuous CAB was suggested to be a possibility for long-term control or cure of localized PC |
[ | 88 | ] |
Lee et al. (2018) |
retrospective study |
Patients diagnosed with localized PC who underwent ADT or treatment-free follow-up |
340 |
In clinically unfavorable localized intermediate- and high-risk PC, initiation of ADT within 12 months of diagnosis was not associated with improved 5-year all-cause mortality or PCSM compared with patients who received no conservative treatment |
[84] |
Akaza et al. (2006) |
prospective cohort study |
Patients with newly diagnosed locally advanced or localized PC who have undergone ADT |
151 |
In men with localized or locally advanced PC, primary ADT inhibited PC progression and resulted in a life expectancy similar to that of the normal population |
[89] |
Lu-Yao et al. (2008) |
retrospective cohort study |
Patients diagnosed with localized PC who underwent ADT or treatment-free follow-up |
19,271 |
ADT is not associated with improved survival among the majority of elderly men with localized prostate cancer when compared with conservative management |
[85] |
Kawakami et al. (2006) |
retrospective cohort study |
Newly diagnosed localized PC patients with or without ADT |
7044 |
The use of ADT therapy appeared to control disease in the majority of patients who received it, at least for an intermediate period |
[90] |
Potosky et al. (2014) |
retrospective cohort study |
Newly diagnosed patients with localized PC |
15,170 |
ADT was associated with neither a risk of all-cause mortality (HR 1.04, 95% CI 0.97–1.11) nor PCSM (HR 1.03, 95% CI 0.89–1.19). |
[86] |
Akaza et al. (2010) |
retrospective cohort study |
Patients with newly diagnosed locally advanced or localized PC who have undergone ADT |
15,461 |
ADT resulted in a long-term survival rate comparable to the general population |
[91] |
Lu-Yao et al. (2014) |
retrospective cohort study |
Patients aged 66 years or older with localized PC who did not receive curative treatment |
66,717 |
ADT is not associated with improved long-term overall or disease-specific survival for men with localized PC. |
[87] |
Matsumoto et al. (2014) |
Sammon et al. (2015) |
retrospective cohort study |
Newly diagnosed patients with locally advanced or localized PC |
46,376 |
There was an increased risk of all-cause mortality in the ADT group compared to the observation group (HR 1.37, 95% CI 1.20–1.56) |
[82] |