SkThin is a large and complex organ that serves protective and regulatory functions and is responsible for communication between the external environment and the inner organism. To fulfill these functions, skin has evolved as an organ with a complex anatomy derived from both the ectoderm (epidermis) and mesoderm (dermis). The skin includes not only these two major compartments but also important appendages, including hair follicles, sweat and sebaceous glands, nerve endings, and blood vessels, all of which have intricate spatial arrangements that render s is an entry focused on extrusion bioprinting for skin applications. Bioprinting technologies have the ability to combine various human cell phenotypes, signaling proteins, extracellular matrix (ECM) components, and other scaffold-like biomaterials and are currently being exploited for the fabrication of human skin, broadly aiming to achieve two main goals. The first goal is to meet the urgent clinical demand for skin equivalents, which can range in complexity from advanced dressings for chronic wounds to biomimetic skin grafts to help restore the barrier function in complex ulcers, burns, or traumatic postsurgical wounds. The second important motivation for skin biofabrication of the full skin organ challengingis to create disease models for in vitro research and drug development.