1. Introduction

A revised classification containing 13 subtypes was published by the International EDS Consortium, with a number of clinical conditions to guide and improve the diagnosis of each subtype^[1] [2]. In the European Union, a disease is considered ‘rare’ if it affects fewer than one in two thousand people^[2] [3]. In the case of EDS, the prevalence varies, depending on the type: between 1:30,000 (classical type) and < 1:1,000,000 (arthrochalasia type), whereas for the rarest form (the periodontitis type), the prevalence is unknown^[3] [1].

EDS’ oral conditions have been described as periodontitis^[1][4][5] [2,4,5], temporomandibular dysfunctions^[1][6] [2,6], bleeding tendencies^[7][8] [7,8], enamel hypoplasia^[1][9] [2,9], shape abnormalities of the teeth and changes in the number of teeth^[1][8] [2,8], a high palate^[1][10] [2,10], dysgnathia, and malocclusion^[1][11] [2,11], as well as decreased effects of local anesthesia^[12][13] [12,13].

2. Latest Research, Data, Model, Management, Applications or Influences or …

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