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Vitamin A in Retinal Diseases: Comparison
Please note this is a comparison between Version 2 by Beatrix Zheng and Version 5 by Beatrix Zheng.

Vitamin A is an essential fat-soluble vitamin that occurs in various chemical forms. It is essential for several physiological processes. Either hyper- or hypovitaminosis can be harmful. One of the most important vitamin A functions is its involvement in visual phototransduction, where it serves as the crucial part of photopigment, the first molecule in the process of transforming photons of light into electrical signals. In this process, large quantities of vitamin A in the form of 11-cis-retinal are being isomerized to all-trans-retinal and then quickly recycled back to 11-cis-retinal. Complex machinery of transporters and enzymes is involved in this process (i.e., the visual cycle). Any fault in the machinery may not only reduce the efficiency of visual detection but also cause the accumulation of toxic chemicals in the retina. 

  • vitamin A
  • visual cycle
  • retinal diseases
  • ABCA4
  • RHO
  • RDH5
  • RDH12
  • treatment
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