Magnetic nanoparticles: coating and applications: Comparison
Please note this is a comparison between Version 2 by Alexey Chubarov and Version 1 by Alexey Chubarov.

Magnetic nanoparticles (MNPs) have great potential in material science, drug delivery, magnetic resonance imaging, and therapeutic applications. Indeed, a number of iron oxide nanoparticles have been withdrawn due to their poor clinical performance and/or toxicity issues. MNPs have successfully been converted into water-soluble, stable, bio-accessible systems using the proprietary various coating strategy. Herein, we summarize the data of applications and coating strategies of MNPs.

  • iron oxide nanoparticles
  • functionalization
  • coating
  • nanomedicine
  • applications

1. Introduction

Magnetic nanoparticles (MNPs) represent a significant doorway for various biomedical applications.[1][2][3][4][5][6][7] MNPs have become vital for drug delivery,[1][2] magnetic resonance imaging (MRI), [8][9][10][11] hyperthermia therapy,[4][12] biosensing,[13] and biocatalysis.[1][2][3][8][9][10][11][12][13]  MNPs are particularly promising tags due to their high physical and chemical stability, cost-effectivity, and optimal surface-to-volume ratio.[14] Iron oxide NPs are promising nanomaterials among magnetic materials due to their excellent biocompatibility, easy synthesis, and price. MNPs can be easily manipulated using an external magnetic field which provides magnetic field nanoparticles quickly separation and drugs release ator tumor targets tissueing. The most promising Fe3O4 magnetite MNPs are due to their supferior rrimagnetic propertiesm characteristics. Numerous works about the synthesis, functionalization, and applications of Fe3O4 MNPs have been reported.[15][16][17] The synthesis method plays a key role in determining the morphology, particles sizes, and shape. However, MNPs may not be stable upon oxidation and possess high surface energy, leading to aggregation.[18] Therefore, it is essential to consider the coating of such MNPs. The wrong coating leads to instability in wan aterqueous solution and biological liquids, toxicity, and high reactive oxygen species formation.[18][19][20]

2. MNPs Coating

MNPs have become materials with great potential. However, stability coating procedures are required for better water or biological systems. Due to the high surface energy MNPs have some limitations in use because of the ability to form aggregates spontaneously. Therefore, some coating procedures are required for better stability in an aqueous solution. MNPs with a hydrophobic surface isare easily absorbed in the protein surface and have low circulation time. Moreover, non-functionalized iron nanoparticles can form reactive oxygen species, which are highly toxic for organisms. Covering tThe magnetite core with a coating may be can be coated with organic or inorganic compounds, surfactants (oleic acid, lauric acid, etc.), and artificial or natural polymers that lead to stabilization (Figure 1).[20][21] Biocompatible organic polymers such as polyethylene glycol (PEG), chitosan, dextran are among them. Other pcossibilitieating options are liposomes coating or , silica, silica oxide, and ceramics surface. One advantage of coatings is surface protein absorbance, which can increase circulation time, protect from blood components, and «decrease the toxicity to zero.»[22][23][24] Protein immobilization may facilitate targeted delivery or the formation of a protein-ligand complex. The ligands, for example, can be drug systems for cancer treatment. One protein that can be used for such a procedure is human serum albumin (HSA).[2225][2326][2427] HSA is the most abundant protein in plasma. It is a monomeric multidomain biomolecule, representing the main determinant of plasma oncotic pressure, and displays an extraordinary ligand binding capacity. HSA is a wide platform for drug discovery, suitable transport for therapy, and diagnostics. According to its properties, HSA can lead the transport to cancer tissue due to passive transport (Enhanced permeability and retention effect, EPR-effect) or cancer cells receptors binding (gp60, FcRn, SPARC, etc.).[28]

Figure 1. Schematic representation of possible surface coating of MNPs.

3. Applications

Various applications of MNPs can be attributed to the difference in the behavior of particles in nanoscale compared to their bulk counterparts. High magnetic properties can be used for manipulation by an external magnetic field which leads to possible targeted delivery, magnetic separation, MRI, and hyperthermia effect (Table 1).[1][2][3][4][5][6][7][2529][2630][2731][2832] The high surface capacity of MNPs makes it possible to form MNPs-drug or gene complexes that can solve cancer immune resistance and hereditary diseases. Furthermore, drug targeting is promising for avoiding the side effects of conventional chemotherapy by reducing the distribution of drugs, increasing tissue selectivity, and lowering the doses of cytotoxic compounds. Possible surface functionalization can be a primary factor in producing various smart systems for therapy and diagnostics. Furthermore, incorporating a drug or gene can be achieved by the previous coating with agents that provide coupling points for conjugation, complexation, or encapsulation. The use of MNPs in the drug delivery area is a specific, sensitive, and cost-effective strategy with excellent efficiency potential.

Table 1. Various applications of MNPs.

1 contrast agents for MRI [8][9][10][11][30]
2 carriers for target-specific drug delivery [1][2][33]
3 carriers for gene therapy[1][2][29][33]
4 hyperthermia based cancer treatments[4][12]
5 carriers for vaccine and antibody production
6 nanoplatforms for therapy (the nucleus of smart nanoconstructions)[6]
7 magnetic separation with further preparation of pure compound or detection of compounds, metabolites, etc.
8 magnetic sensing probes for in vitro or in vivo diagnostics[13][33]

AnoFurther possible area is aapplications include an enhanced separation and detection of low concentration targets. These MMPs can also help isolate nucleic acids, proteins, hormones, pathogens, and small molecules in a complex biological matrix. Some Certain molecules presented in low amounts of molecules ccan predict the diseases, and their detection is appropriate for lifesaving the lives of patients. For example, nucleic acid diagnostics plays a vital role in many fields, such as biology and medicine. MPPs method toThe use of MNPs to discriminate wild-type and mutant type DNA detection and single nucleotide polymorphism (SNP) is t DNA is vital for cancer diagnostics. Short RNA detection is helpful for the detection ofhelps to identify the deregulation of various biological pathways, such as cell proliferation, differentiation, and apoptosis. Like nucleic acids, proteins are key biological molecules in organisms. Numerous examples of proteins are dispersed through an organism, including hormones, antibodies, enzymes, etc. As abnormal protein quantities or the appearance of antibodies can lead to disease or be a predictor of disease. Therefore, sensitive and specific diagnosis techniques are necessary.

MRI is a great non-invasive diagnostic tool in various research fields and medical diagnostics. Usually, MNPs generate local magnetic fields that interfere with the transverse relaxation time (T2) of protons, resulting in a darker signal in tissue. Furthermore, producing MNPs with targeting moieties leads to the possible detection of targeted molecules or diseases on the organism level. The possibility of producing imaging probes and the e use of MNPs for hyperthermia therapy possesses nanotheranostics structures imaging and constructions production.hyperthermia therapy opens the area of theranostics production.

4. Conclusion

MNPs demonstrate high potential for various areas that combine the synergistic effects of magnetic and multifunctional nanomaterial parts. An exciting possibility of imaging and hyperthermia techniques can solve the problem of cancer treatment. MNPs can be efficiently used in various systems to detect molecules or targets or to be a biocompatible nucleus for smart construction. The next-generation MNPs may solve many problems in different areas of research and medicine.An ideal nanoparticle for biological application should have the following features: easy administration, excellent in vivo stability and biocompatibility, and selectivity. The ability to observe the accumulation of the MNPs in real-time, disease progression, and simultaneous hyperthermia and chemotherapeutic therapy can solve the problem of drug-resistance cancer. However, multifunctional smart MNPs exhibiting all these features are extremely rare. The next-generation MNPs may solve many problems in different areas of research and medicine.

This research was supported by Russian Science Foundation (grant no. 21-74-00120)  

References

  1. Simon Anderson; Vanessa V. Gwenin; Christopher D. Gwenin; Magnetic Functionalized Nanoparticles for Biomedical, Drug Delivery and Imaging Applications. Nanoscale Research Letters 2019, 14, 1-16, 10.1186/s11671-019-3019-6.
  2. Nisha Lamichhane; Shalini Sharma; Parul; Anita Verma; Indrajit Roy; Tapas Sen; Iron Oxide-Based Magneto-Optical Nanocomposites for In Vivo Biomedical Applications. Biomedicines 2021, 9, 288, 10.3390/biomedicines9030288.
  3. Raghuraj Chouhan; Milena Horvat; Jahangeer Ahmed; Norah Alhokbany; Saad Alshehri; Sonu Gandhi; Magnetic Nanoparticles—A Multifunctional Potential Agent for Diagnosis and Therapy. Cancers 2021, 13, 2213, 10.3390/cancers13092213.
  4. Tatyana I. Shabatina; Olga I. Vernaya; Vladimir P. Shabatin; Mikhail Ya. Melnikov; Magnetic Nanoparticles for Biomedical Purposes: Modern Trends and Prospects. Magnetochemistry 2020, 6, 30, 10.3390/magnetochemistry6030030.
  5. Lokesh Srinath Ganapathe; Mohd Ambri Mohamed; Rozan Mohamad Yunus; Dilla Duryha Berhanuddin; Magnetite (Fe3O4) Nanoparticles in Biomedical Application: From Synthesis to Surface Functionalisation. Magnetochemistry 2020, 6, 68, 10.3390/magnetochemistry6040068.
  6. Maria Hepel; Magnetic Nanoparticles for Nanomedicine. Magnetochemistry 2020, 6, 3, 10.3390/magnetochemistry6010003.
  7. Joanna Dulińska-Litewka; Agnieszka Łazarczyk; Przemysław Hałubiec; Oskar Szafrański; Karolina Karnas; Anna Karewicz; Superparamagnetic Iron Oxide Nanoparticles—Current and Prospective Medical Applications. Materials 2019, 12, 617, 10.3390/ma12040617.
  8. Sofia Caspani; Ricardo Magalhães; João Pedro Araújo; Célia Tavares Sousa; Magnetic Nanomaterials as Contrast Agents for MRI. Nina Kostevšek; A Review on the Optimal Design of Magnetic Nanoparticle-Based T2 MRI Contrast Agents. Magneterialochemis try 2020, 13, 2586, 10.3390/ma13112586., 6, 11, 10.3390/magnetochemistry6010011.
  9. Nina Kostevšek; A Review on the Optimal Design of Magnetic Nanoparticle-Based T2 MRI Contrast Agents. Bianca Crețu; Gianina Dodi; Amin Shavandi; Ioannis Gardikiotis; Ionela Șerban; Vera Balan; Imaging Constructs: The Rise of Iron Oxide Nanoparticles. Magnoletochemiculestry 2020, 1, 26, 11, 10.3390/magnetochemistry6010011., 3437, 10.3390/molecules26113437.
  10. Irene Fernández-Barahona; María Muñoz-Hernando; Jesus Ruiz-Cabello; Fernando Herranz; Juan Pellico; Iron Oxide Nanoparticles: An Alternative for Positive Contrast in Magnetic Resonance Imaging. InoSofia Caspani; Ricardo Magalhães; João Pedro Araújo; Célia Tavares Sousa; Magnetic Nanomaterials as Contrast Agents for MRI. Matergianicls 2020, 8, 28, 10.3390/inorganics8040028., 13, 2586, 10.3390/ma13112586.
  11. Connor M. Ellis; Juan Pellico; Jason J. Davis; Magnetic Nanoparticles Supporting Bio-responsive T1/T2 Magnetic Resonance Imaging. MJustine Wallyn; Nicolas Anton; Thierry F. Vandamme; Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications—A Review. Pharmaceuterialics 2019, , 112, 4096, 10.3390/ma12244096., 601, 10.3390/pharmaceutics11110601.
  12. Justine Wallyn; Nicolas Anton; Thierry F. Vandamme; Synthesis, Principles, and Properties of Magnetite Nanoparticles for In Vivo Imaging Applications—A Review. PhIhab M. Obaidat; Venkatesha Narayanaswamy; Sulaiman Alaabed; Sangaraju Sambasivam; Chandu V. V. Muralee Gopi; Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles. Marmagnetoceutichemis try 2019, 11, 601, 10.3390/pharmaceutics11110601., 5, 67, 10.3390/magnetochemistry5040067.
  13. Ihab M. Obaidat; Venkatesha Narayanaswamy; Sulaiman Alaabed; Sangaraju Sambasivam; Chandu V. V. Muralee Gopi; Principles of Magnetic Hyperthermia: A Focus on Using Multifunctional Hybrid Magnetic Nanoparticles. Sadagopan Krishnan; K. Yugender Goud; Goud; Magnetic Particle Bioconjugates: A Versatile Sensor Approach. Magnetochemistry 2019, 5, 67, 10.3390/magnetochemistry5040067., 64, 10.3390/magnetochemistry5040064.
  14. Lazhen Shen; Bei Li; Yongsheng Qiao; Fe3O4 Nanoparticles in Targeted Drug/Gene Delivery Systems. Materials 2018, 11, 324, 10.3390/ma11020324.
  15. Minh Dang Nguyen; Hung-Vu Tran; Shoujun Xu; T. Randall Lee; Fe3O4 Nanoparticles: Structures, Synthesis, Magnetic Properties, Surface Functionalization, and Emerging Applications. Applied Sciences 2021, 11, 11301, 10.3390/app112311301.
  16. Mark Geppert; Martin Himly; Iron Oxide Nanoparticles in Bioimaging – An Immune Perspective. Frontiers in Immunology 2021, 12, 688927, 10.3389/fimmu.2021.688927.
  17. J. Hai; H. Piraux; E. Mazarío; J. Volatron; N. T. Ha-Duong; P. Decorse; J. S. Lomas; P. Verbeke; S. Ammar; C. Wilhelm; et al.J.-M. El Hage ChahineM. Hémadi Maghemite nanoparticles coated with human serum albumin: combining targeting by the iron-acquisition pathway and potential in photothermal therapies. Journal of Materials Chemistry B 2017, 5, 3154-3162, 10.1039/c7tb00503b.
  18. Maxim A. Abakumov; Alevtina S. Semkina; Alexander S. Skorikov; Daniil A. Vishnevskiy; Anna V. Ivanova; Elena Mironova; Galina A. Davydova; Alexander G. Majouga; Vladimir P. Chekhonin; Toxicity of iron oxide nanoparticles: Size and coating effects. Journal of Biochemical and Molecular Toxicology 2018, 32, e22225, 10.1002/jbt.22225.
  19. Roberto Canaparo; Federica Foglietta; Tania Limongi; Loredana Serpe; Biomedical Applications of Reactive Oxygen Species Generation by Metal Nanoparticles. Materials 2020, 14, 53, 10.3390/ma14010053.
  20. Nemi Malhotra; Jiann-Shing Lee; Rhenz Alfred D. Liman; Johnsy Margotte S. Ruallo; Oliver B. Villaflores; Tzong-Rong Ger; Chung-Der Hsiao; Potential Toxicity of Iron Oxide Magnetic Nanoparticles: A Review. Molecules 2020, 25, 3159, 10.3390/molecules25143159.
  21. Nicholas R. Nelson; John D. Port; Mukesh K. Pandey; Use of Superparamagnetic Iron Oxide Nanoparticles (SPIONs) via Multiple Imaging Modalities and Modifications to Reduce Cytotoxicity: An Educational Review. Journal of Nanotheranostics 2020, 1, 105-135, 10.3390/jnt1010008.
  22. Adi Tzameret; Hadas Ketter-Katz; Victoria Edelshtain; Ifat Sher; Enav Corem-Salkmon; Itay Levy; David Last; David Guez; Yael Mardor; Shlomo Margel; et al.Ygal Rotenstrich In vivo MRI assessment of bioactive magnetic iron oxide/human serum albumin nanoparticle delivery into the posterior segment of the eye in a rat model of retinal degeneration. Bappaditya Samanta; Haoheng Yan; Nicholas Fischer; Jing Shi; D. Joseph Jerry; Vincent M. Rotello; Protein-passivated Fe3O4 nanoparticles: low toxicity and rapid heating for thermal therapy. Journal of NManobiotechnologterials Chemistry 2019, 08, 17, 3, 10.1186/s12951-018-0438-y.8, 1204-1208, 10.1039/b718745a.
  23. Pavel Khramtsov; Irina Barkina; Maria Kropaneva; Maria Bochkova; Valeria Timganova; Anton Nechaev; Il’Ya Byzov; Svetlana Zamorina; Anatoly Yermakov; Mikhail Rayev; et al. Magnetic Nanoclusters Coated with Albumin, Casein, and Gelatin: Size Tuning, Relaxivity, Stability, Protein Corona, and Application in Nuclear Magnetic Resonance Immunoassay. Muzahidul I. Anik; M. Khalid Hossain; Imran Hossain; A. M. U. B. Mahfuz; M. Tayebur Rahman; Isteaque Ahmed; Recent progress of magnetic nanoparticles in biomedical applications: A review. Nanomat Serials lect 20219, 9, 1345, 10.3390/nano9091345., 2, 1146-1186, 10.1002/nano.202000162.
  24. Mariane Gonçalves Santos; Diailison Teixeira de Carvalho; Lucas Belga Caminitti; Bruna Bueno Alves de Lima; Marcello Henrique Da Silva Cavalcanti; Daniel Felipe Rocha dos Santos; Luciano Sindra Virtuoso; Daniela Battaglia Hirata; Eduardo Costa Figueiredo; Use of magnetic Fe3O4 nanoparticles coated with bovine serum albumin for the separation of lysozyme from chicken egg white. FAbdulkader Baki; Amani Remmo; Norbert Löwa; Frank Wiekhorst; Regina Bleul; Albumin-Coated Single-Core Iron Oxide Nanoparticles for Enhanced Molecular Magnetic Imaging (MRI/MPI). International Journal od Chemif Molecular Sciencestry 2021, 353, 129442, 10.1016/j.foodchem.2021.129442., 22, 6235, 10.3390/ijms22126235.
  25. Ekaterina Bobrikova; Alexey Chubarov; Elena Dmitrienko; The Effect of pH and Buffer on Oligonucleotide Affinity for Iron Oxide Nanoparticles. MAdi Tzameret; Hadas Ketter-Katz; Victoria Edelshtain; Ifat Sher; Enav Corem-Salkmon; Itay Levy; David Last; David Guez; Yael Mardor; Shlomo Margel; et al.Ygal Rotenstrich In vivo MRI assessment of bioactive magnetic iron oxide/human serum albumin nanoparticle delivery into the posterior segment of the eye in a rat model of retinal degeneration. Journal of Nagnetochemistrobiotechnology 2021, 9, 17, 128, 10.3390/magnetochemistry7090128., 3, 10.1186/s12951-018-0438-y.
  26. Natalia E. Gervits; Andrey A. Gippius; Alexey V. Tkachev; Evgeniy I. Demikhov; Sergey Starchikov; Igor S. Lyubutin; Alexander L. Vasiliev; Vladimir P. Chekhonin; Maxim Abakumov; Alevtina S. Semkina; et al.Alexander G. Mazhuga Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents. Beilstein Journal of Pavel Khramtsov; Irina Barkina; Maria Kropaneva; Maria Bochkova; Valeria Timganova; Anton Nechaev; Il’Ya Byzov; Svetlana Zamorina; Anatoly Yermakov; Mikhail Rayev; et al. Magnetic Nanoclusters Coated with Albumin, Casein, and Gelatin: Size Tuning, Relaxivity, Stability, Protein Corona, and Application in Nuclear Magnetic Resonance Immunoassay. Nanomatechnology rials 2019, 10, 1964-1972, 10.3762/bjnano.10.193., 9, 1345, 10.3390/nano9091345.
  27. Evgeny Katz; Synthesis, Properties and Applications of Magnetic Nanoparticles and Nanowires—A Brief Introduction. MagnetMariane Gonçalves Santos; Diailison Teixeira de Carvalho; Lucas Belga Caminitti; Bruna Bueno Alves de Lima; Marcello Henrique Da Silva Cavalcanti; Daniel Felipe Rocha dos Santos; Luciano Sindra Virtuoso; Daniela Battaglia Hirata; Eduardo Costa Figueiredo; Use of magnetic Fe3O4 nanoparticles coated with bovine serum albumin for the separation of lysozyme from chicken egg white. Foocd Chemistry 20219, , 35, 61, 10.3390/magnetochemistry5040061.3, 129442, 10.1016/j.foodchem.2021.129442.
  28. Ivan V. Zelepukin; Alexey V. Yaremenko; Ilya N. Ivanov; Mikhail V. Yuryev; Vladimir R. Cherkasov; Sergey M. Deyev; Petr I. Nikitin; Maxim P. Nikitin; Long-Term Fate of Magnetic Particles in Mice: A Comprehensive Study. AIslam Hassanin; Ahmed Elzoghby; Albumin-based nanoparticles: a promising strategy to overcome cancer drug resistance. CSancer Drug Nano Resistance 2021, 15, 11341–11357, 10.1021/acsnano.1c00687.0, 3, 930-946, 10.20517/cdr.2020.68.
  29. Ekaterina Bobrikova; Alexey Chubarov; Elena Dmitrienko; The Effect of pH and Buffer on Oligonucleotide Affinity for Iron Oxide Nanoparticles. Magnetochemistry 2021, 7, 128, 10.3390/magnetochemistry7090128.
  30. Natalia E. Gervits; Andrey A. Gippius; Alexey V. Tkachev; Evgeniy I. Demikhov; Sergey Starchikov; Igor S. Lyubutin; Alexander L. Vasiliev; Vladimir P. Chekhonin; Maxim Abakumov; Alevtina S. Semkina; et al.Alexander G. Mazhuga Magnetic properties of biofunctionalized iron oxide nanoparticles as magnetic resonance imaging contrast agents. Beilstein Journal of Nanotechnology 2019, 10, 1964-1972, 10.3762/bjnano.10.193.
  31. Evgeny Katz; Synthesis, Properties and Applications of Magnetic Nanoparticles and Nanowires—A Brief Introduction. Magnetochemistry 2019, 5, 61, 10.3390/magnetochemistry5040061.
  32. Ivan V. Zelepukin; Alexey V. Yaremenko; Ilya N. Ivanov; Mikhail V. Yuryev; Vladimir R. Cherkasov; Sergey M. Deyev; Petr I. Nikitin; Maxim P. Nikitin; Long-Term Fate of Magnetic Particles in Mice: A Comprehensive Study. ACS Nano 2021, 15, 11341–11357, 10.1021/acsnano.1c00687.
  33. Deanna Stueber; Jake Villanova; Itzel Aponte; Zhen Xiao; Vicki Colvin; Magnetic Nanoparticles in Biology and Medicine: Past, Present, and Future Trends. Pharmaceutics 2021, 13, 943, 10.3390/pharmaceutics13070943.
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