Aminopeptidases in Cardiovascular and Renal: Comparison
Please note this is a comparison between Version 2 by Conner Chen and Version 1 by Joaquin Garcia-Estañ.

The article tries to summarize our current understanding of the role of aminopeptidases in the control of blood pressure, through their effects on kidney function. Their possible role as biomarkers on acute or chronic kidney injury is also analyzed.

  • renin angiotensin system
  • Blood pressure
  • renal biomarkers
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References

  1. Johnston, C.I. Biochemistry and pharmacology of the renin-angiotensin system. Drugs 1990, 39, 21–31, doi:10.2165/00003495-199000391-00005.
  2. Reudelhuber, T.L. The renin-angiotensin system: Peptides and enzymes beyond angiotensin II. Curr. Opin. Nephrol. Hypertens. 2005, 14, 155–159, doi:10.1097/00041552-200503000-00011.
  3. Ferrario, C.M.; Chappell, M.C. Novel Angiotensin peptides. Cell. Mol. Life. Sci. 2004, 61, 2720–2727.
  4. Vauquelin, G.; Michotte Smolders, Y.I.; Sarre, S.; Ebinger, G.; Dupont, A.; Vanderheyden, P. Cellular targets for angiotensin II fragments: Pharmacological and molecular evidence. J. Renin Angiotensin Aldosterone Syst. 2002, 3, 195–204.
  5. Enzyme Nomenclature. Recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology on the Nomenclature and Classification of Enzymes by the Reactions they Catalyse. Available online: https://www.qmul.ac.uk/sbcs/iubmb/enzyme/ (accessed on 18 June 2020).
  6. De Gasparo, M.; Catt, K.J.; Inagami, T.; Wright, J.W.; Unger, T. International union of pharmacology. XXIII. The angiotensin II receptors. Pharmacol. Rev. 2000, 52, 415–472.
  7. Dinh, D.T.; Frauman, A.G.; Johnston, C.I.; Fabiani, M.E. Angiotensin receptors: Distribution, signalling and function. Clin. Sci. 2001, 100, 481–492.
  8. Chappell, M.C. Nonclassical renin-angiotensin system and renal function. Compr. Physiol. 2012, 2, 2733–2735.
  9. Prieto, I.; Villarejo, A.B.; Segarra, A.B.; Banegas, I.; Wangensteen, R.; Martinez-Cañamero, M.; de Gasparo, M.; Vives, F.; Ramírez-Sánchez, M. Brain, heart and kidney correlate for the control of blood pressure and water balance: Role of angiotensinases. Neuroendocrinology 2014, 100, 198–208.
  10. Ramírez, M.; Prieto, I.; Alba, F.; Vives, F.; Banegas, I.; de Gasparo, M. Role of central and peripheral aminopeptidase activities in the control of blood pressure: A working hypothesis. Heart Fail. Rev. 2008, 13, 339–353.
  11. Ramírez, M.; Prieto, I.; Martinez, J.M.; Vargas, F.; Alba, F. Renal aminopeptidase activities in animal models of hypertension. Regul. Pept. 1997, 72, 155–159.
  12. Prieto, I.; Martinez, A.; Martinez, J.M.; Ramírez, M.J.; Vargas, F.; Alba, F.; Ramírez, M. Activities of aminopeptidases in a rat saline model of volume hypertension. Horm. Metab. Res. 1998, 30, 246–248.
  13. Tsujimoto, M.; Goto, Y.; Maruyama,M.; Hattori, A. Biochemical and enzymatic properties of the m1 family of aminopeptidases involved in the regulation of blood pressure. Heart Fail. Rev. 2008, 13, 285–291.
  14. Hattori, A.; Kitatani, K.; Matsumoto, H.; Miyazawa, S.; Rogi, T.; Tsuruoka, N.; Mizutani, S.; Natori, Y.; Tsujimoto, M. Characterization of recombinant human adipocyte-derived leucine aminopeptidase expressed in Chinese hamster ovary cells. J. Biochem. 2000, 128, 755–762.
  15. Tanioka, T.; Hattori, A.; Masuda, S.; Nomura, Y.; Nakayama, H.; Mizutani, S.; Tsujimoto, M. Human leukocytederived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. J. Biol. Chem. 2003, 278, 32275–32283.
  16. Hisatsune, C.; Ebisui, E.; Usui, M.; Ogawa, N.; Suzuki , A.; Mataga , N.; Hiromi Takahashi-Iwanaga , H.; Katsuhiko Mikoshiba, K. ERp44 exerts redox dependent control of blood pressure at the ER. Mol. Cell 2015, 58, 1015–1027.
  17. Yamamoto, N.; Nakayama, J.; Yamakawa-Kobayashi, K.; Hamaguchi, H.; Miyazaki, R.; Arinami, T. Identification of 33 polymorphisms in the adipocyte-derived leucine aminopeptidase (ALAP) gene and possible association with hypertension. Hum. Mutat. 2002, 19, 251–257.
  18. Robert, Y.; Zee, L.; Rivera, A.; Inostroza, Y.;Ridker, P.M.; Daniel, I.; Chasman, D.I.; Romero, J.R. Gene variation of endoplasmic reticulum aminopeptidases 1 and 2, and risk of blood pressure progression and incident hypertension among 17,255 initially healthy women. Intern. J. Genom. 2018, 2018, 2308585.
  19. Hallberg, P.; Lind, L.; Michaelsson, K.; Kurland, L.; Kahan, T.; Malmqvist, K.; Ohman, K.P.; Nystrom, F.; Liljedahl, U.; Syvanen, A.C.; et al. Adipocyte-derived leucine aminopeptidase genotype and response to antihypertensive therapy. BMC Cardiovasc. Disord. 2003, 3, 11.
  20. Johnson, M.P.; Roten, L.T.; Dyer, T.D.; East, C.E.; Forsmo, S.; Blangero, J.; Brennecke, S.P.; Austgulen, R.; Moses, E.K. The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations. Hum. Genet. 2009, 126, 655–666.
  21. Taranta, A.; Gianviti, A.; Palma, A.; De Luca, V.; Mannucci, L.; Procaccino, M.A.; Ghiggeri, G.M.; Caridi, G.; Fruci, D.; Ferracuti, S.; et al.Genetic risk factors in typical haemolytic uraemic syndrome. Nephrol. Dial. Transplant. 2009, 24, 1851–1857.
  22. Banegas, I.; Ramírez, M.; Vives, F.; Alba, F.; Segarra, A.B.; Duran, R.; De Gasparo, M.; Prieto, I. Aminopeptidase activity in the nigrostriatal system and prefrontal cortex of rats with experimental hemiparkinsonism. Horm. Metab. Res. 2005, 37, 53–55.
  23. Prieto, I.; Segarra, A.B.; de Gasparo, M.; Martínez-Cañamero, M.; Ramírez-Sánchez, M. Divergent profile between hypothalamic and plasmatic aminopeptidase activities in WKY and SHR. Influence of beta-adrenergic blockade. Life Sci. 2018, 192, 9–17.
  24. Prieto, I.; Segarra, A.B.; Villarejo, A.B.; de Gasparo, M.; Martínez-Cañamero, M.M.; Ramírez-Sánchez, M. Neuropeptidase activity in the frontal cortex of Wistar-Kyoto and spontaneously hypertensive rats treated with vasoactive drugs: A bilateral study. J. Hypertens. 2019, 37, 612–628.
  25. Villarejo, A.B.; Ramírez-Sánchez, M.; Segarra, A.B.; Martínez-Cañamero, M.; Prieto, I. Influence of extra virgin olive oil on blood pressure and kidney angiotensinase activities in spontaneously hypertensive rats. Planta Med. 2015, 81, 664–669.
  26. Marc, Y.; Llorens-Cortes, C. The role of the brain renin-angiotensin system in hypertension: Implications for new treatment. Prog. Neurobiol. 2011, 95, 89–103.
  27. Morton, J.J.; Casals-Stenzel, J.; Lever, A.F. Inhibitors of the renin-angiotensin system in experimental hypertension, with a note on the measurement of angiotensin I, II and III during infusion of converting-enzyme inhibitor. Br. J. Clin. Pharmacol. 1979, 2, 233S–241S.
  28. Fournie-Zaluski, M.C.; Fassot, C.; Valentin, B.; Djordjijevic, D.; Reaux-Le Goazigo, A.; Corvol, P.; Roques, B.P.; Llorens-Cortes, C. Brain renin-angiotensin system blockade by systemically active aminopeptidase A inhibitors: A potential treatment of salt-dependent hypertension. Proc. Natl. Acad. Sci. USA 2004, 101, 7775–7780.
  29. Song, L.; Wilk, S.; Healy, D.P. Aminopeptidase A antiserum inhibits intracerebroventricular angiotensin IIinduced dipsogenic and pressor responses. Brain Res. 1997, 744, 1–6.
  30. Bodineau, L.; Frugière, A.; Marc, Y.; eInguimbert, N.; Fassot, C.; Balavoine, F.; Roques, B.; Llorens-Cortes, C. Orally active aminopeptidase A inhibitors reduce blood pressure: A new strategy for treating hypertension. Hypertension 2008, 51, 1318–1325.
  31. Wright, J.W.; Harding, J.W. Brain renin-angiotensin-A new look at an old system. Prog. Neurobiol. 2011, 95, 49–67.
  32. Goto, Y.; Hattori, A.; Ishii, Y.; Tsujimoto, M. Reduced activity of the hypertension-associated Lys528Arg mutant of human adipocyte-derived leucine aminopeptidase (ALAP)/ ER-aminopeptidase-1. FEBS Lett. 2006, 580, 1833–1838.
  33. Ishii, M.; Hattori, A.; Numaguchi, Y.; Tsujimoto, M.; Ishiura, S.; Kobayashi, H.; Murohara, T.; Wrght, J.W.; Mizutani, S. The effect of recombinant aminopeptidase A on hypertension in spontaneously hypertensive rats: Its effect in comparison with candesartan. Horm. Metab. Res. 2008, 40, 887–891.
  34. Mizutani, S.; Okano, K.; Hasegawa, E. Human placental leucine aminopeptidase (P-LAP) as a hypotensive agent. Experientia 1982, 38, 821–822.
  35. Nakashima, Y.; Ohno, Y.; Itakura, A.; Takeuchi, M.; Murata, Y.; Kuno, N.; Mizutani, S. Possible involvement of aminopeptidase A in hypertension in spontaneously hypertensive rats (SHRs) and change of refractoriness in response to angiotensin II in pregnant SHRs. J. Hypertens. 2002, 20, 2233–2238.
  36. Mizutani, S.; Wright, J.; Kobayashi, H. A new approach regarding the treatment of preeclampsia and preterm labor. Life Sci. 2011, 88, 17–23.
  37. Kobayashi, H.; Mizutani, S.; Wright, J.W. Placental leucine aminopeptidase- and aminopeptidase A-deficient mice offer insight concerning the mechanisms underlying preterm labor and preeclampsia. J. Biomed. Biotechnol. 2011, 2011, 286947.
  38. Carey, R.M.; Padia, S.H. Role of angiotensin at2 receptors in natriuresis: Intrarenal mechanisms and therapeutic potential. Clin. Exp. Pharmacol. Physiol. 2013, 40, 527–534, doi:10.1111/1440-1681.12059.
  39. Padia, S.H.; Howell, N.L.; Kemp, B.A.; Fournie-Zaluski, M.C.; Roques, B.P.; Carey, R.M. Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats. Hypertension 2010, 55, 474–480.
  40. Padia, S.H.; Kemp, B.A.; Howell, N.L.; Gildea, J.J.; Keller, S.R.; Carey, R.M. Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats. Hypertension 2009, 53, 338–343.
  41. Vaidya, V.S.; Ferguson, M.A.; Bonventre, J.V. Biomarkers of acute kidney injury. Annu. Rev. Pharmacol. Toxicol. 2008, 48, 463–493.
  42. Bonventre, J.V.; Vaidya, V.S.; Schmouder, R.; Feig, P.; Dieterle, F. Nextgeneration biomarkers for detecting kidney toxicity. Nat. Biotechnol. 2010, 28, 436–440.
  43. Devarajan, P. Emerging biomarkers of acute kidney injury. Contrib. Nephrol. 2007, 156, 203–212.
  44. Lisowska-Myjak, B. Serum and urinary biomarker of acute kidney injury. Blood. Purif. 2010, 29, 357–365.
  45. Holdt, B.; Peters, E.; Nagel, H.R.; Steiner, M. An automated assay of urinary alanine aminopeptidase activity. Clin. Chem. Lab. Med. 2008, 46, 537–540.
  46. Song, L.; Ye, M.; Troyanovskaya, M.; Wilk, E.; Wilk, S.; Healy, D.P. Rat kidney glutamyl aminopeptidase (aminopeptidase A): Molecular identity and cellular localization. Am. J. Physiol. 1994, 267, F546–F557.
  47. Segarra, A.B., Ramírez, M.; Banegas, I.; Hermoso, F.; Vargas, F.; Vives, F.; Alba, F.; de Gasparo, M.; Prieto, I. Influence of thyroid disorders on kidney angiotensinase activity. Horm. Metab. Res. 2006, 38, 48–52.
  48. Peters, J.E.; Mampel, E.; Schneider, I.; Burchardt, U.; Fukala, E.; Ahrens, I.; Haschen, R.J. Alanine aminopeptidase in urine in renal diseases. Clin. Chim. Acta 1972, 37, 213–224.
  49. Marchewka, Z.; Długosz, A.; Kúzniar, J. Diagnostic application of AAP isoenzyme separation. Int. Urol. Nephrol. 1999, 31, 409–416.
  50. Marchewka, Z.; Kúzniar, J., Długosz, A. Enzymuria and β2-Mikroglobulinuria in the assessment of the influence of proteinuria on the progression of glomerulopathies. Int. Urol. Nephrol. 2001, 33, 673–676.
  51. Idasiak-Piechocka, I.; Krzymánski, M. The role of tubulointerstitial changes in progression of chronic glomerulonephritis (GN). Przegl. Lek. 1996, 53, 443–453.
  52. Naghibi, B.; Ghafghazi, T.; Hajhashemi, V.; Talebi, A. Vancomycin-induced nephrotoxicity in rats: Is enzyme elevation a consistent finding in tubular injury? J. Nephrol. 2007, 20, 482–488.
  53. Jung, K.; Hempel, A.; Grutzmann, K.D.; Hempel, R.D.; Schreiber, G. Age-dependent excretion of alanine aminopeptydase, alkaline phosphatase, γ -glutamyltransferase and N-acetyl-β-D-glucosaaminidase in human urine. Enzyme 1990, 43, 10–16.
  54. Inselmann, G.; Balaschke, M.; Heidemann, H.T. Enzymuria following amphotericin B application in the rat. Mycoses 2003, 46, 169–173.
  55. Mitic, B.; Lazarevic, G.; Vlahovic, P.; Rajic, M.; Stefanovic, V. Diagnostic value of the aminopeptidase N, N-acetyl-beta-D-glucosaminidase and dipeptidylpeptidase IV in evaluating tubular dysfunction in patients with glomerulopathies. Ren. Fail. 2008, 30, 896–903.
  56. Moon, P.G.; Lee, J.E.; You, S.; Kim, T.K.; Cho, J.H.; Kim, I.S.; Kwon, T.H.; Kim, C.D.; Park, S.H.; Hwang, D.; et al. Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy. Proteomics 2011, 11, 2459–2475.
  57. Lazarevic, G.; Antic, S.; Vlahovic, P.; Djordjevic, V.; Zvezdanovic, L.; Stefanovic, V.Effects of aerobic exercise on microalbuminuria and enzymuria in type 2 diabetic patients. Ren. Fail. 2007, 29, 199–205.
  58. Kuzniar, J.; Marchewka, Z.; Krasnowski, R.; Boratynska, M.; Długosz, A.; Klinger, M. Enzymuria and low molecular weight protein excretion as the differentiating marker of complications in the early post kidney transplantation period. Int. Urol. Nephrol. 2006, 38, 753–758.
  59. Marchewka, Z.; Kuzniar, J.; Zynek-Litwin, M.; Falkiewicz, K.; Szymanska, B.; Roszkowska, A.; Klinger, M. Kidney graft function in long-term cyclosporine and tacrolimus treatment: Comparative study with nephrotoxicity markers. Transplant. Proc. 2009, 41, 1660–1665.
  60. Molitoris, B.A.; Levin, A.; Warnock, D.G.; Joannidis, M.; Mehta, R. L.; eKellum, J.A.; Ronco, C.; Shah, S. Improving outcomes from acute kidney injury. J. Am. Soc. Nephrol. 2007, 18, 1992–1994.
  61. Safirstein, R.; Winston, J.; Moel, D.; Dikman, S.; Guttenplan, J. Cisplatin nephrotoxicity-insights into mechanism. Int. J. Androl. 1987, 10, 325–346.
  62. Winston, J.A.; Safirstein, R. Reduced renal blood-flow in early cisplatin induced acute renal failure in the rat. Am. J. Physiol. 1985, 249, F490–F496.
  63. Yao, X.; Panichpisal, K.; Kurtzman, N.; Nugent, K. Cisplatin nephrotoxicity: A review. Am. J. Med. Sci. 2007, 334, 115–124.
  64. Quesada, A.; Vargas, F.; Montoro-Molina, S.; O’Valle, F.; Rodríguez-Martínez, M.D.; Osuna, A.; Prieto, I.; Ramírez, M.; Wangensteen, F. Urinary Aminopeptidase Activities as Early and Predictive Biomarkers of Renal Dysfunction in Cisplatin-Treated Rats. PLoS ONE 2012, 7, e40402.
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