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Compartment syndrome occurs when increased pressure inside a closed anatomical space compromises tissue perfusion. The sudden increase in pressure inside these spaces requires rapid decompression by means of surgical intervention. In the case of abdominal compartment syndrome (ACS), surgical decompression consists of a laparostomy.
- abdominal compartment syndrome
- intra-abdominal pressure
- decompression laparotomy
- acute pancreatitis
- abdominal aortic aneurysm
- severe burn
1. Introduction
Compartment syndrome occurs when increased pressure inside a closed anatomical space compromises tissue perfusion [1]. In the human body there are multiple inextensible anatomical compartments in which the increase in pressure causes changes in homeostasis by directly or indirectly decreasing the vascular supply to the tissues [1]. Examples of anatomical spaces are the cranial box, the orbit, the thoracic cavity, the pericardium, the abdominal cavity, and the musculoskeletal compartments of the upper and lower limbs. The sudden increase in pressure inside these spaces requires rapid decompression by means of surgical intervention.
Compartment syndrome was first described in the lower limbs in 1811 by German surgeon Richard von Volkman in Centralblatt für Chirurgie [2]. The characteristics of abdominal compartment syndrome (ACS) were first described in 1984 by I. Kron, P.K. Harman and S.P. Nolan [3]. However, the terminology of “abdominal compartment syndrome” was introduced only five years later, by Fietsam et al. [4]. Throughout this time span of about two centuries, numerous studies have been conducted on methods of measuring pressure in the abdomen, its influence on respiratory [5] and cardiovascular [6] systems, and the effects of closing the abdomen in tension [7][8][7,8]. In 2006, following the International Conference of Experts on Intra-Abdominal Hypertension and Abdominal Compartment Syndrome [9], the definitions of the concepts of intra-abdominal hypertension (IAH) and ACS were established, and one year later a series of recommendations were formulated regarding the management of these entities. These guidelines were last updated in 2013 [10] and at present ACS is defined as a sustained intra-abdominal pressure (IAP) >20 mmHg (with or without an abdominal perfusion pressure (APP) <60 mmHg) that is associated with new organ failure.
In the case of abdominal compartment syndrome, surgical decompression consists
of a laparostomy that can be performed using several techniques, most often by median
laparotomy extended from the pubis to the xiphoidal process [11][12][11,12]. Another method of
laparotomy consists of an extended transverse incision in the flanks placed a few centimeters below the costal margin. The third option of surgical decompression involves making
3 transverse incisions 2–3 cm long located on the midline through which the white line will
be sectioned vertically leaving the peritoneum intact [13]. Regarding decompression laparotomy (DL), the indications from World Society of Abdominal Compartment Syndrome
(WSACS) are limited. To summarize, decompression laparotomy is recommended in cases
of overt ACS in critically ill adults with ACS. In the diagnosis of IAH/ACS, establishing
the indication of DL and the appropriate time for performing it is an important step. Early
surgery can have an overall unfavorable impact due to surgical stress, while delaying
this procedure can produce irreversible complications with fatal potential. The criteria for
defining IAH/ACS are relatively clear and intensively studied, while for establishing the
surgical indication as part of diagnostic management there are no standardized protocols
or algorithms.
of a laparostomy that can be performed using several techniques, most often by median
laparotomy extended from the pubis to the xiphoidal process [11][12][11,12]. Another method of
laparotomy consists of an extended transverse incision in the flanks placed a few centimeters below the costal margin. The third option of surgical decompression involves making
3 transverse incisions 2–3 cm long located on the midline through which the white line will
be sectioned vertically leaving the peritoneum intact [13]. Regarding decompression laparotomy (DL), the indications from World Society of Abdominal Compartment Syndrome
(WSACS) are limited. To summarize, decompression laparotomy is recommended in cases
of overt ACS in critically ill adults with ACS. In the diagnosis of IAH/ACS, establishing
the indication of DL and the appropriate time for performing it is an important step. Early
surgery can have an overall unfavorable impact due to surgical stress, while delaying
this procedure can produce irreversible complications with fatal potential. The criteria for
defining IAH/ACS are relatively clear and intensively studied, while for establishing the
surgical indication as part of diagnostic management there are no standardized protocols
or algorithms.
There is still a debate around the clinical characteristics which prompt for surgical
intervention in ACS. WSACS guidelines include a recommendation for attempting to
lower the IAP by means less invasive than a laparotomy, such as percutaneous catheter
drainage. A study comparing percutaneous catheter decompression with open abdominal
decompression on 62 patients divided equally according to the two types of treatment
showed that failure to drain at least 1000 mL of fluid and decrease the patient’s IAP
by at least 9 mm Hg within the first 4 h following PCD should prompt early surgical
decompression to improve the patient’s survival chances from IAH/ACS. Selected patients
developed ACS in the context of general, vascular, or oncological surgery (36%), trauma
(23%), sepsis or multiple organ failure (12%) and burns (29%) [14].
ACS was classified by the WSACS based on the underlying mechanism into primary
ACS or ACS secondary to a pre-existing condition [10][15][10,15]. Primary ACS is a complication
of injuries located in the abdomino-pelvic region, whereas secondary ACS occurs in the
context of conditions that affect other regions of the body. In general, in patients with abdominal trauma, ACS is the consequence of clinical situations which can sometimes coexist,
such as massive volume resuscitation with consecutive visceral edema, the presence of
retroperitoneal hematoma, hemostatic packing performed during damage control laparotomy (DCL), post-injury bowel paresis, and associated third degree burn of the abdominal
wall [16][17][18][16–18]. In patients with abdominal trauma, the indication for laparotomy is given
primarily by life-threatening visceral injuries regardless of intra-abdominal pressure.
Also, in order to combat the lethal triad represented by acidosis (pH ≤ 7.2, lactate
levels ≥ 5 mmol/L, base deficit (BD) ≥ −6), hypothermia (≤34 ◦C) and coagulopathy
(blood loss ≥ 4 L during the operation, and/or transfusion requirement ≥ 10 U of packed
red blood cells, INR/PT > 1.5 times normal) surgeons introduced into practice the concept of
DCL [19]. DCL practice involves three stages, starting with laparotomy to control bleeding
and sources of intra-abdominal contamination completed by methods of temporary closure
of the abdomen, continuing with a period of resuscitation and rebalancing of the patient
in the intensive care unit and ending with surgery and permanent parietoraphy [11][20][11,20].
Thus, the second stage of DCL, namely the open abdomen period, represents a strategy to
prevent ACS in trauma patients, but does not represent the topic of the current research.
We Twill further discuss the indications for DL in two examples of primary ACS (acute
pancreatitis and ruptured abdominal aortic aneurysm) and in one example of secondary
ACS (extensive burn lesions) will be further discussed.
intervention in ACS. WSACS guidelines include a recommendation for attempting to
lower the IAP by means less invasive than a laparotomy, such as percutaneous catheter
drainage. A study comparing percutaneous catheter decompression with open abdominal
decompression on 62 patients divided equally according to the two types of treatment
showed that failure to drain at least 1000 mL of fluid and decrease the patient’s IAP
by at least 9 mm Hg within the first 4 h following PCD should prompt early surgical
decompression to improve the patient’s survival chances from IAH/ACS. Selected patients
developed ACS in the context of general, vascular, or oncological surgery (36%), trauma
(23%), sepsis or multiple organ failure (12%) and burns (29%) [14].
ACS was classified by the WSACS based on the underlying mechanism into primary
ACS or ACS secondary to a pre-existing condition [10][15][10,15]. Primary ACS is a complication
of injuries located in the abdomino-pelvic region, whereas secondary ACS occurs in the
context of conditions that affect other regions of the body. In general, in patients with abdominal trauma, ACS is the consequence of clinical situations which can sometimes coexist,
such as massive volume resuscitation with consecutive visceral edema, the presence of
retroperitoneal hematoma, hemostatic packing performed during damage control laparotomy (DCL), post-injury bowel paresis, and associated third degree burn of the abdominal
wall [16][17][18][16–18]. In patients with abdominal trauma, the indication for laparotomy is given
primarily by life-threatening visceral injuries regardless of intra-abdominal pressure.
Also, in order to combat the lethal triad represented by acidosis (pH ≤ 7.2, lactate
levels ≥ 5 mmol/L, base deficit (BD) ≥ −6), hypothermia (≤34 ◦C) and coagulopathy
(blood loss ≥ 4 L during the operation, and/or transfusion requirement ≥ 10 U of packed
red blood cells, INR/PT > 1.5 times normal) surgeons introduced into practice the concept of
DCL [19]. DCL practice involves three stages, starting with laparotomy to control bleeding
and sources of intra-abdominal contamination completed by methods of temporary closure
of the abdomen, continuing with a period of resuscitation and rebalancing of the patient
in the intensive care unit and ending with surgery and permanent parietoraphy [11][20][11,20].
Thus, the second stage of DCL, namely the open abdomen period, represents a strategy to
prevent ACS in trauma patients, but does not represent the topic of the current research.
We Twill further discuss the indications for DL in two examples of primary ACS (acute
pancreatitis and ruptured abdominal aortic aneurysm) and in one example of secondary
ACS (extensive burn lesions) will be further discussed.
2. Decompression Laparotomy in ACS from Acute Pancreatitis
ACS is one of the complications of severe acute pancreatitis, with an incidence of 4–27% [11][12][13][21,22,23]. However, the timing, indications and threshold value for surgical decompression are controversial and current evidence is unclear in terms of which approach should be selected in any particular setting (Table 1).
Table 1. Abdominal compartment syndrome in the context of acute pancreatitis in different studies. ACS—abdominal compartment syndrome; DL—decompression laparotomy; IAP—intra-abdominal pressure; IAP1—intra-abdominal pressure before decompression; IAP2—intra-abdominal pressure after decompression; Δ IAP—decrease in IAP after decompression; nr—not reported; SLAF—subcutaneous linea alba fasciotomy.
In a retrospective study which included 12 patients with AAA for whom EVAR was performed, Ko et al. [22][33] identified three patients who developed ACS in the first 48 h after the procedure. The diagnosis of ACS and the indication for DL were not established on the basis of PIA measurements, but on clinical-paraclinical arguments, such as decrease in blood pressure, decrease in hemoglobin value and organ dysfunction. Moreover, the authors report a high level of suspicion for ongoing bleeding, which dictated the decision for immediate laparotomy. Both of the patients who underwent DL at an early stage of ACS survived. The only mortality case was represented by the patient with ACS who refused surgical intervention.
In an attempt to identify a marker to diagnose the onset of ACS early, Horer et al. [31][42] proposed to calculate the lactate/pyruvate ratio and the value of glycerol in the peritoneal fluid obtained from the peritoneal microdialysis technique. In his study, Horer compared a group of patients who underwent DL with a group of non-decompressed patients in terms of lactate/pyruvate levels and glycerol levels after REVAR. In the group of decompressed patients, one patient had IAH grade I, one had IAH grade II, 3 had IAH grade III and one had IAH grade IV. In this study, the authors demonstrate the existence of metabolic changes in the peritoneal fluid that precedes the installation of ACS and that could be used as an indication for performing DL. In contrast to the early DL practiced in the study of Horer et al., Djavani Gidlund et al. [32][43] suggests that after AAA repair, IAP should be monitored every 4 h and medical treatment should be initiated immediately if the IAP exceeds 12 mmHg.
4. Decompression Laparotomy in ACS from Extensive Burn Lesion
Among the complications that develop in patients with burns >15% total body surface area (TBSA), ACS occurs with a prevalence of 4.1–16.6%, and is most often associated with burns on >70% TBSA [36][47]. There are no clinical trials to indicate the optimal treatment for patients with ACS secondary to severe burns, and studies to date include a small number of patients [37][38][39][40][41][42][43][48,49,50,51,52,53,54] (Table 3). The groups of patients who underwent DL usually include both pediatric and adult patients, most with burns >50% TBSA and a mean IAP pre-decompression >40, in whom conservative treatment instituted for at least 24 h failed (Table 3). The post-laparotomy survival of decompression reported by the studies identified so far varies between 0% and 66% [37][38][39][40][41][42][43][48,49,50,51,52,53,54].
Table 3. Abdominal compartment syndrome in the context of burns. ACS—abdominal compartment syndrome; IAP1—intra-abdominal pressure before decompression laparotomy; IAP2—intra-abdominal pressure after decompression; nr—not reported; SLAF—subcutaneous linea alba fasciotomy; TBSA—total body surface area, DL—decompression laparotomy.
| Study Type | Total No. | Pediactric | Adults | %TBSA Burned | IAP | 1 | IAP | 2 | Conservative Treatment Attempted |
DL Timing | Mortality |
|---|
| nr |
| Hobson, 2002 [37] | Hobson, 2002 [48] |
retrospective | 8 | Midline Laparotomy | ||||||||||||||||||
| 4 | 4 | 71% | 40 ± 10 | 26 ± 5 | yes | >24 h | 62% | Leppäniemi, 2011 [15] | Leppäniemi, 2011 [25] | Retrospective | 10 | 10 | 10 | |||||||||
| Latenser, | 31 (23–45) | 20 (10–33) | 10 | 2002 | nr | Subcutaneous linea alba fasciotomy | ||||||||||||||||
| [38] | Latenser, 2002 [49] |
retrospective | 4 | 0 | 4 | >80% | 34 ± 6 | 30 * | yes | >24 h | 100% | Mentula, 2010 [16] | Mentula, 2010 [26] | Miranda, 2018 [ | Retrospective | 24] | Miranda,26 | 26 |
26 | 2018 [35] | retrospective | 25 |
| Hershberger, 2007 [39] | Hershberger, 2007 [50] |
retrospective | 3 | 3 | 25 | 7 | 1831.5 (27–35) |
immediatelynr | 16 (9–21) after midline laparotomy | >5 days (9 cases) from pancreatitis onset—no survivors 1–4 days (17 cases) from pancreatitis onset—14 survivors |
67%midline laparotomy—18 patients, transverse bilateral subcostal laparotomy—1 patient SLAF—7 patients, 2 of whom underwent completion midline laparotomy on postoperative day 1 | |||||||||||
| 64.6 ± 3.9% | 57 ± 4.2 | nr | yes | 13.3 ± 1.3 h | 88% | Bezmarevic, 2012 [17] | Bezmarevic, 2012 [27] | Adkar, 2017 [25] | Adkar,Prospective | 51 |
6 | 2017 [36]5 | retrospective | 1241 | ||||||||
| Oda, 2007 [44] | Oda, 2007 [55] | 21.2 | (20–23) | nr | nr | 1–4 days | Midline Laparotomy | |||||||||||||||
| retrospective | Chen, 2008 [13] | Chen, 2008 [23] |
Retrospective | 74 | 20 | 5 | 36.69 ± 5.33 | 18.31 ± 3.25 | 18 | 28.38 ± 2.29 h | Midline Laparotomy | |||||||||||
| Davis, 2013 [18] | Davis, 2013 [28] |
Retrospective | 45 | 16 | 16 | 29.5 | nr | nr | 3.1 h | Midline Laparotomy | ||||||||||||
| Peng T, 2016 [19] | Peng T, 2016 [29] |
Retrospective, comparative | 61 | 61 | 61 | nr | nr | 15 | 63 h (range, 2–101 h)—from pancreatitis onset | Midline Laparotomy |
A meta-analysis [20][30] that includes seven studies performed between 2003 and 2012 on 103 patients with acute pancreatitis complicated by ACS reports surgical decompression in 76 cases (73%) either as first intervention or after percutaneous catheter drainage of intra-abdominal fluid. Of the 11 patients who initially underwent PCD, 8 patients subsequently required DL. Surgical decompression consisted in most cases of a median laparotomy (n = 66), but subcutaneous white line fasciotomy (n = 17), or full thickness transverse bilateral subcostal laparotomy (n = 1) were also performed. A decrease in IAP was reported in 60 cases, from a median initial IAP value of 33 mmHg to 18 mmHg.
Based on a retrospective study, Chen et al. [13][23] consider that decompression by invasive methods in acute pancreatitis should be considered starting from IAP values of 20–25 mmHg, without waiting to reach values of 30–40 mmHg. A delay in establishing invasive decompression procedures from the moment of ACS installation could potentially lead to bacterial invasion of the pancreas through the intact intestine, due to splanchnic ischemia-reperfusion syndrome. This argument is supported by significantly higher rates of pancreatic infection, septic shock, multiple organ dysfunction syndrome and mortality in the group of patients with acute pancreatitis who developed ACS, compared to the group of patients who did not develop this complication. In this study, invasive decompression was established at the mean IAP value of 36.69 ± 5.33 mmHg and at an average interval of 28.38 ± 2.29 h from the occurrence of ACS. The authors also recommend rebalancing hypovolemia, acidosis, and coagulation disorders before any invasive decompression intervention.
3. Decompression Laparotomy in ACS after Ruptured Abdominal Aortic Aneurysms (AAA) Repair
There are 2 techniques for repairing a ruptured abdominal aortic aneurysm (AAA): the open technique and the endovascular technique. Both of them are associated with the risk of postoperative ACS, either due to the high amount of fluids administered in open repair or to the retroperitoneal hematoma from the endovascular repair. The incidence of ACS after endovascular aneurysm repair for ruptured abdominal aortic aneurysms varies significantly in the literature of the last 20 years. On average, the incidence is about 9%, ranging between 0% and 40% [21][32] (Table 2).
Table 2. Abdominal compartment syndrome in the context of ruptured aortic aneurysm. AAA—aortic abdominal aneurysm; ACS—abdominal compartment syndrome; DL—decompression laparotomy; nr—not reported; REVAR—endovascular aneurysm repair.
| Study Design | Patients with Ruptured AAA ( | n | ) | Patients with ACS ( | n | ) | DL ( | n | ) | Laparotomy Timing | Mortality of Patients with ACS |
|---|
| Ko, 2019 [22] | Ko, 2019 [33] |
retrospective | 12 | 3 | 2 | first 48 h after the procedure | 33% | |||||||
| Ersryd, 2019 [23] | Ersryd, 2019 [34] |
prospective | 8765 | 120 | 117 | <24 h after AAA repair in 56 (48.7%) | ||||||||
| 91 | ||||||||||||||
| 91 | 14 | nr | nr | during REVAR | 60% | |||||||||
| 78.5 ± 10.6% | 47 ± 11 | 20 ± 10 | yes | nr | nr | Papazoglou, 2017 [26] | Papazoglou, 2017 [37] |
retrospective | 2 | |||||
| Markell, 2009 [40] | Markell, 2009 [51] |
retrospective | 3 | 1 | 32 | nr | nrimmediately | 66% | ||||||
| nr | nr | nr | nr | nr | 84% | Oyague, 2015 [27] | Oyague, 2015 [38] |
retrospective | 25 | 6 | nr | |||
| Ramirez, | nr | 2018 [41] | Ramirez, 2018 [52] | 100% | ||||||||||
| retrospective | 41 | 31 | 15 | 62% (children) | 58% (adults) |
28 (children) 43 (adults) |
nr | nr | 1 h | 44% | Rubenstein, 2015 [28] | Rubenstein, 2015 [39] |
retrospective | 73 |
| Boehm, 2019 [42] | Boehm, | 21 | 2019 [53] | retrospective | 38 | nrnr | nr | 62% | ||||||
| nr | 50% | nr | nr | nr | >24 h | 84% | Fossaceca, 2014 [29] | Fossaceca, 2014 [40] |
||||||
| Wise, 2016 [43] | Wise,retrospective | 44 |
5 | 2016 [5 | 54nr | ] | retrospective | 3 | nr | nr0% | ||||
| 39.6 ± 26.4% | nr | nr | yes | >24 h | 66% | Mehta, 2013 [30] | Mehta, 2013 [41] |
retrospective | 136 | 17 | nr | nr | 59% | |
| Horer, 2013 [31] | Horer, 2013 [42] |
prospective | 15 | 6 | 6 | 12 h (5–33 h) | 16% | |||||||
| Djavani Gidlund, 2011 [32] | Djavani Gidlund, 2011 [43] |
prospective | 29 | 3 | 2 | >12 h | 33% | |||||||
| Hsiao, 2011 [33] | Hsiao, 2011 [44] |
retrospective | 6 | 1 | 1 | 4 days after AAA | 0% | |||||||
| Saqib, 2012 [34] | Saqib, 2012 [45] |
prospective | 148 | 15 | 15 | nr | nr | |||||||
| Noorani, 2012 [35] | Noorani, 2012 [46] |
prospective | 102 | 1 | 1 | nr | nr |
* reported in only 1 patient.
Only when the patient’s clinical condition does not improve after all these steps is it recommended to perform DL. In this study, the mean age of the patients was 28 ± 3.8 years (seven patients were under 18 years of age), the mean intra-abdominal pressure before decompression was 57 ± 4.2, the mean time from burning to the time of DL was 13.3 ± 1.3 h, and mortality was 88% (22 of 25 patients).
On the other hand, Oda claims from a study conducted in 2007 on 38 patients that DL has an unfavorable impact on the evolution of burned patients, aggravating multiple organ failure and acute long-term injury [44][55]. Some authors consider that DL should even be avoided in certain categories of patients, such as those over 80 years of age who have a higher mortality rate than young people [45][57].
