Vitamin D Deficiency and T2DM: Comparison
Please note this is a comparison between Version 2 by Conner Chen and Version 1 by Agnieszka Sliwinska.

It seems that vitamin D deficiency may be one of the crucial factors responsible for increased cancer risk among T2DM patients. Vitamin D via alleviation of insulin resistance, hyperglycemia, oxidative stress and inflammation reduces diabetes driven cancer risk factors. Moreover, vitamin D strengthens the DNA repair process, and regulates apoptosis and autophagy of cancer cells as well as signaling pathways involved in tumorigenesis i.e., tumor growth factor β (TGFβ), insulin-like growth factor (IGF) and Wnt-β-Cathenin. It should also be underlined that many types of cancer cells present alterations in vitamin D metabolism and action as a result of Vitamin D Receptor (VDR) and CYP27B1 expression dysregulation.

  • vitamin D deficiency
  • type 2 diabetes (T2DM)
  • cancer
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