COVID 19 –A COMPRENSIVE MATHEMATICAL APPROACH

COVID 19 –A COMPRENSIVE MATHEMATICAL APPROACH: Comparison

Please note this is a comparison between Version 5 by JAYDIP DATTA and Version 9 by JAYDIP DATTA.

In this approach we will summarise the the last three publications highlighting the key mathematical approach like Exponential F ( x ) to further exponential –Gaussian F ( x ) and finally the Linear Combination of Atomic Orbital ( LCAO ) ie a hybridised SPp orbital overlapping to Remdesivir ( Drug ) –Covid19 approach.

.Sigmoid Statistics or Logistics regression is a method to applied to Infection fatality rate ( IFR ) the most important epidemological parameters is also under consideration .

Covid19
Sp Hybridisation
LCAO
Pharmacokinetics
Exponential Function
Gaussiun
Remdesivir
IFR
Logistic regression
Remdesivir

Approach -1 : In the first one we have analysed the microbial Ist - Order growth kinetics where Exponential phase is most important. This sharp exponential phase is the main cause of virulent spreading of viral infection .

Approach -2 : In the 2nd one we have reviewed the entire growth kinetics pattern to a more appropriate manner similar to Exponential – Gaussian F ( x ) relationship which points out the more prominent part of the short stationary phase or infinitesimally small linear relationship followed by sudden down to declining or recovery phase with a negative slope of linearity .It is also termed as Pseudo-Gaussian contour curve.

Approach – 3 : In the 3rd one we will correlate the LCAO approach to Pharmacokinetic Phenomenon. The Remdesivir is approved as the most effective drug ( WHO ) – This drug Binds with Covid19 antigen SARS –COV -2 as compared to Sp Hybridised Drug – Antigen Linear overlap stabilising the complex.

.Aproach 4.The IFR is a special case of CFR where number of deaths to be considered as total number of deaths due to symptomatic as well as asymptomatic infection within the same population per unit time .The model equation can be correlated as X ( Age) = Sigmoid f [ Y ( IFR ) ] . A sharp rise of S is observed we.f 46 yrs and the IFR is more probable w.e.f. 70 yrs for symptomatic and asymptomatic pateints .

REFERENCE :

1. MICROBIAL GROWTH KINETICS : A MATHEMATICAL REVIEW ( SPECIAL ADDENDUM - COVID19 ), JAYDIP DATTA , May ,11, 2020 .

2. Covid19 – A Mathematical modelling of a PSEUDO-GAUSSIUN Contour , JAYDIP DATTA , May ,18 ,2020 .

3. COVID19 Vs Hybridisation : An Approach to Chemical Bonding, JAYDIP DATTA ,June , 22 ,2020 .

4. Justification of Lopinavir - Ritonavir & Finally Remdesivir ( higher generation of acyclovir analog ) used in Covid19 treatment ? (Researgate.net) asked by JAYDIP DATTA on May ,13,2020 .

5. What are the BASIC mathematical methods specially used in COMPUTATIONALCHEMISTRY covering Covid19 ? ( Researchgate.net ) asked by JAYDIP DATTA ,( Revised query on June , 10 , 2020 ) .

6.INFECTION FATALITY RATE OF COVID19 – A LOGISTIC MODEL, osf.io , JAYDIP DATTA .

N.B : Publised as Preprints on 26.06.2020 in osf.io - https://osf.io/vgf3m/

7. Mallapaty Smriti - https://www.nature.com/articles/d41586-020-02483-2 .