Nutrition, Cognition and Aging: Comparison
Please note this is a comparison between Version 2 by Conner Chen and Version 1 by Suk-yu Yau.

Consuming a balanced, nutritious diet is important for maintaining health, especially as individuals age. Several studies suggest that consuming a diet rich in antioxidants and anti-inflammatory components such as those found in fruits, nuts, vegetables, and fish may reduce age-related cognitive decline and the risk of developing various neurodegenerative diseases.

  • aging
  • cognition
  • macronutrients
  • nutrition
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References

  1. Dresler, M.; Sandberg, A.; Bublitz, C.; Ohla, K.; Trenado, C.; Mroczko-Wasowicz, A.; Kühn, S.; Repantis, D. Hacking the brain: Dimensions of cognitive enhancement. ACS Chem. Neurosci. 2019, 10, 1137–1148.
  2. Evans, J.J. Basic concepts and principles of neuropsychological assesment. In Handbook of Clinical Neuropsychology; Gurd, J., Kischka, U., Eds.; Oxford University Press: Oxford, UK, 2010; p. 894.
  3. Snow, P.J. The structural and functional organization of cognition. Front. Hum. Neurosci. 2016, 10.
  4. Preston, A.R.; Eichenbaum, H. Interplay of hippocampus and prefrontal cortex in memory. Curr. Biol. 2013, 23, R764–R773.
  5. Singer, B.H.; Gamelli, A.E.; Fuller, C.L.; Temme, S.J.; Parent, J.M.; Murphy, G.G. Compensatory network changes in the dentate gyrus restore long-term potentiation following ablation of neurogenesis in young-adult mice. Proc. Natl. Acad. Sci. USA 2011, 108, 5437–5442.
  6. Nomoto, K.; Schultz, W.; Watanabe, T.; Sakagami, M. Temporally extended dopamine responses to perceptually demanding reward-predictive stimuli. J. Neurosci. 2010, 30, 10692–10702.
  7. Fontani, G.; Corradeschi, F.; Felici, A.; Alfatti, F.; Migliorini, S.; Lodi, L. Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects. Eur. J. Clin. Investig. 2005, 35, 691–699.
  8. Han, S.; Lee, H.-S. Social capital and depression. Asia Pac. J. Public Health 2015, 27, NP2008–NP2018.
  9. Scheibel, M.E.; Lindsay, R.D.; Tomiyasu, U.; Scheibel, A.B. Progressive dendritic changes in aging human cortex. Exp. Neurol. 1975, 47, 392–403.
  10. Fjell, A.M.; Sneve, M.H.; Storsve, A.B.; Grydeland, H.; Yendiki, A.; Walhovd, K.B. Brain events underlying episodic memory changes in aging: A longitudinal investigation of structural and functional connectivity. Cereb. Cortex 2016, 26, 1272–1286.
  11. Mattson, M.P.; Arumugam, T.V. Hallmarks of brain aging: Adaptive and pathological modification by metabolic states. Cell Metab. 2018, 27, 1176–1199.
  12. Rossor, M.; Collinge, J.; Fox, N.; Mead, S.; Mummery, C.; Rohrer, J.; Schott, J.; Warren, J. Dementia and cognitive impairment. In Neurology: A Queen Square Textbook, 2nd ed.; John Wiley & Sons, Ltd.: Hoboken, NJ, USA, 2016; Volume 30, pp. 289–336.
  13. Aarsland, D.; Creese, B.; Politis, M.; Chaudhuri, K.R.; Ffytche, D.H.; Weintraub, D.; Ballard, C. Cognitive decline in parkinson disease. Nat. Rev. Neurol. 2017, 13, 217–231.
  14. World Health Organization. Essential Nutrition Actions: Mainstreaming Nutrition through the Life-Course; World Health Organization (WHO): Geneva, Switzerland, 2019.
  15. Seligman, H.K.; Lyles, C.; Marshall, M.B.; Prendergast, K.; Smith, M.C.; Headings, A.; Bradshaw, G.; Rosenmoss, S.; Waxman, E. A pilot food bank intervention featuring diabetes-appropriate food improved glycemic control among clients in three states. Health Aff. 2015, 34, 1956–1963.
  16. Trapl, E.S.; Smith, S.; Joshi, K.; Osborne, A.; Benko, M.; Matos, A.T.; Bolen, S. Dietary impact of produce prescriptions for patients with hypertension. Prev. Chronic Dis. 2018, 15, 180301.
  17. Sinnott, M.L. Structures of the open-chain forms of reducing sugar, and their carbonyl group reaction. In Carbohydrate Chemistry and Biochemistry: Structure and Mechanism; The Royal Society of Chemistry: Cambridge, UK, 2007.
  18. Sears, P.; Wong, C.H. Intervention of carbohydrate recognition by proteins and nucleic acids. Proc. Natl. Acad. Sci. USA 1996, 93, 12086–12093.
  19. Schweet, R.; Heintz, R. Protein synthesis. Annu. Rev. Biochem. 1966, 35, 723–758.
  20. Hulbert, A.J.; Turner, N.; Storlien, L.H.; Else, P.L. Dietary fats and membrane function: Implications for metabolism and disease. Biol. Rev. Camb. Philos. Soc. 2005, 80, 155–169.
  21. Casares, D.; Escribá, P.V.; Rosselló, C.A. Membrane lipid composition: Effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues. Int. J. Mol. Sci. 2019, 20, 2167.
  22. Reddy, V.S.; Palika, R.; Ismail, A.; Pullakhandam, R.; Reddy, G.B. Nutrigenomics: Opportunities & challenges for public health nutrition. Indian J. Med. Res. 2018, 148, 632.
  23. Said, H.M. Intestinal absorption of water-soluble vitamins in health and disease. Biochem. J. 2011, 437, 357–372.
  24. Johnson, E.J.; Mohn, E.S. Fat-soluble vitamins. World Rev. Nutr. Diet. 2015, 111, 38–44.
  25. Elmadfa, I.; Meyer, A.L. The role of the status of selected micronutrients in shaping the immune function. Endocr. Metab. Immune Disord. Drug Targets 2019, 19, 1100–1115.
  26. United Nations. World Population Ageing 2019: Highlights; United Nations: San Francisco, CA, USA, 2019.
  27. Patterson, C. World Alzheimer Report 2018; Alzheimer’s Disease International: London, UK, 2018; Volume 2.
  28. Prince, M.; Wimo, A.; Guerchet, M.; Ali, G.C.; Wu, Y.T.; Prina, M. World Alzheimer Report 2015; Alzheimer’s Disease International: London, UK, 2015.
  29. Dangour, A.D.; Whitehouse, P.J.; Rafferty, K.; Mitchell, S.A.; Smith, L.; Hawkesworth, S.; Vellas, B. B-vitamins and fatty acids in the prevention and treatment of alzheimer’s disease and dementia: A systematic review. J. Alzheimer’s Dis. 2010, 22, 205–224.
  30. Moreira, S.C.; Jansen, A.K.; Silva, F.M. Dietary interventions and cognition of alzheimer’s disease patients: A systematic review of randomized controlled trial. Dement. Neuropsychol. 2020, 14, 258–282.
  31. George, S.; Vlachos, N.S. Dietary interventions in mild cognitive impairment and dementia. Dialogues Clin. Neurosci. 2019, 21, 69–82.
  32. Scarmeas, N.; Anastasiou, C.A.; Yannakoulia, M. Nutrition and prevention of cognitive impairment. Lancet Neurol. 2018, 17, 1006–1015.
  33. Ngandu, T.; Lehtisalo, J.; Solomon, A.; Levälahti, E.; Ahtiluoto, S.; Antikainen, R.; Bäckman, L.; Hänninen, T.; Jula, A.; Laatikainen, T.; et al. A 2 year multidomain intervention of diet, exercise, cognitive training, and vascular risk monitoring versus control to prevent cognitive decline in at-risk elderly people (FINGER): A randomised controlled trial. Lancet 2015, 385, 2255–2263.
  34. Lehtisalo, J.; Levälahti, E.; Lindström, J.; Hänninen, T.; Paajanen, T.; Peltonen, M.; Antikainen, R.; Laatikainen, T.; Strandberg, T.; Soininen, H.; et al. Dietary changes and cognition over 2 years within a multidomain intervention trial—The finnish geriatric intervention study to prevent cognitive impairment and disability (FINGER). Alzheimer’s Dement. 2019, 15, 410–417.
  35. Samieri, C. Epidemiology and risk factors of alzheimer’s disease: A focus on diet. In Biomarkers for Preclinical Alzheimer’s Disease; Humana Press: New York, NY, USA, 2018; pp. 15–42.
  36. Morris, M.C.; Evans, D.A.; Bienias, J.L.; Tangney, C.C.; Bennett, D.A.; Wilson, R.S.; Aggarwal, N.; Schneider, J. Consumption of fish and N-3 fatty acids and risk of incident alzheimer disease. Arch. Neurol. 2003, 60, 940.
  37. Schaefer, E.J.; Bongard, V.; Beiser, A.S.; Lamon-Fava, S.; Robins, S.J.; Au, R.; Tucker, K.L.; Kyle, D.J.; Wilson, P.W.F.; Wolf, P.A. Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and alzheimer disease. Arch. Neurol. 2006, 63, 1545.
  38. Barberger-Gateau, P. Fish, meat, and risk of dementia: Cohort study. BMJ 2002, 325, 932–933.
  39. Jia, J.; Hu, J.; Huo, X.; Miao, R.; Zhang, Y.; Ma, F. Effects of vitamin D supplementation on cognitive function and blood Aβ-related biomarkers in older adults with alzheimer’s disease: A randomised, double-blind, placebo-controlled trial. J. Neurol. Neurosurg. Psychiatry 2019, 90, 1347–1352.
  40. Etgen, T.; Sander, D.; Bickel, H.; Sander, K.; Förstl, H. Vitamin D deficiency, cognitive impairment and dementia: A systematic review and meta-analysis. Dement. Geriatr. Cogn. Disord. 2012, 33, 297–305.
  41. Geriatric Assessment Center of Michigan. Functional Assessment of the Older Adult: Incremental Assessment; Michigan State University: Washington, DC, USA, 2003.
  42. Sullivan, D.H.; Patch, G.A.; Walls, R.C.; Lipschitz, D.A. Impact of nutrition status on morbidity and mortality in a select population of geriatric rehabilitation patients. Am. J. Clin. Nutr. 1990, 51, 749–758.
  43. Corrada, M.M.; Kawas, C.H.; Hallfrisch, J.; Muller, D.; Brookmeyer, R. Reduced risk of alzheimer’s disease with high folate intake: The baltimore longitudinal study of aging. Alzheimer’s Dement. 2005, 1, 11–18.
  44. Luchsinger, J.A.; Tang, M.-X.; Miller, J.; Green, R.; Mayeux, R. Relation of higher folate intake to lower risk of alzheimer disease in the elderly. Arch. Neurol. 2007, 64, 86.
  45. Bo, Y.; Zhang, X.; Wang, Y.; You, J.; Cui, H.; Zhu, Y.; Pang, W.; Liu, W.; Jiang, Y.; Lu, Q. The N-3 polyunsaturated fatty acids supplementation improved the cognitive function in the chinese elderly with mild cognitive impairment: A double-blind randomized controlled trial. Nutrients 2017, 9, 54.
  46. Zhang, Y.-P.; Miao, R.; Li, Q.; Wu, T.; Ma, F. Effects of DHA supplementation on hippocampal volume and cognitive function in older adults with mild cognitive impairment: A 12-month randomized, double-blind, placebo-controlled trial. J. Alzheimer’s Dis. 2016, 55, 497–507.
  47. Sinn, N.; Milte, C.M.; Street, S.J.; Buckley, J.D.; Coates, A.M.; Petkov, J.; Howe, P.R.C. Effects of n -3 fatty acids, EPA v . DHA, on depressive symptoms, quality of life, memory and executive function in older adults with mild cognitive impairment: A 6-month randomised controlled trial. Br. J. Nutr. 2012, 107, 1682–1693.
  48. Mayer, E.A. Gut feelings: The emerging biology of gut-brain communication. Nat. Rev. Neurosci. 2011, 12, 453–466.
  49. Allen, A.P.; Hutch, W.; Borre, Y.E.; Kennedy, P.J.; Temko, A.; Boylan, G.; Murphy, E.; Cryan, J.F.; Dinan, T.G.; Clarke, G. Bifidobacterium longum 1714 as a translational psychobiotic: Modulation of stress, electrophysiology and neurocognition in healthy volunteers. Transl. Psychiatry 2016, 6, e939.
  50. Pinto-Sanchez, M.I.; Hall, G.B.; Ghajar, K.; Nardelli, A.; Bolino, C.; Lau, J.T.; Martin, F.-P.; Cominetti, O.; Welsh, C.; Rieder, A.; et al. Probiotic bifidobacterium longum NCC3001 reduces depression scores and alters brain activity: A pilot study in patients with irritable bowel syndrome. Gastroenterology 2017, 153, 448–459.e8.
  51. Fond, G.; Loundou, A.; Hamdani, N.; Boukouaci, W.; Dargel, A.; Oliveira, J.; Roger, M.; Tamouza, R.; Leboyer, M.; Boyer, L. Anxiety and depression comorbidities in irritable bowel syndrome (IBS): A systematic review and meta-analysis. Eur. Arch. Psychiatry Clin. Neurosci. 2014, 264, 651–660.
  52. Rao, M.; Gershon, M.D. The bowel and beyond: The enteric nervous system in neurological disorders. Nat. Rev. Gastroenterol. Hepatol. 2016, 13, 517–528.
  53. Savage, D.C. Microbial ecology of the gastrointestinal tract. Annu. Rev. Microbiol. 1977, 31, 107–133.
  54. Cryan, J.F.; O’riordan, K.J.; Cowan, C.S.M.; Sandhu, K.V.; Bastiaanssen, T.F.S.; Boehme, M.; Codagnone, M.G.; Cussotto, S.; Fulling, C.; Golubeva, A.V.; et al. The microbiota-gut-brain axis. Physiol. Rev. 2019, 99, 1877–2013.
  55. Stilling, R.M.; Dinan, T.G.; Cryan, J.F. Microbial genes, brain & behaviour—Epigenetic regulation of the gut-brain axis. Genes Brain Behav. 2014, 13, 69–86.
  56. Sanada, K.; Nakajima, S.; Kurokawa, S.; Barceló-Soler, A.; Ikuse, D.; Hirata, A.; Yoshizawa, A.; Tomizawa, Y.; Salas-Valero, M.; Noda, Y.; et al. Gut microbiota and majore depressive disorder: A systematic review and meta-analysis. J. Affect. Disord. 2020, 266, 1–13.
  57. Srikantha, P.; Mohajeri, H.M. The possible role of the microbiota-gut-brain-axis in autism spectrum disorder. Int. J. Mol. Sci. 2019, 20, 2115.
  58. Foster, J.A.; McVey Neufeld, K.A. Gut-brain axis: How the microbiome influences anxiety and depression. Trends Neurosci. 2013, 36, 305–312.
  59. Westfall, S.; Lomis, N.; Kahouli, I.; Dia, S.Y.; Singh, S.P.; Prakash, S. Microbiome, probiotics and neurodegenerative diseases: Deciphering the gut brain axis. Cell. Mol. Life Sci. 2017, 74, 3769–3787.
  60. Nemani, K.; Hosseini Ghomi, R.; McCormick, B.; Fan, X. Schizophrenia and the gut-brain axis. Prog. Neuro Psychopharmacol. Biol. Psychiatry 2015, 56, 155–160.
  61. Iglesias–vázquez, L.; Riba, G.V.G.; Arija, V.; Canals, J. Composition of gut microbiota in children with autism spectrum disorder: A systematic review and meta-analysis. Nutrients 2020, 12, 792.
  62. Xu, R.; Wu, B.; Liang, J.; He, F.; Gu, W.; Li, K.; Luo, Y.; Chen, J.; Gao, Y.; Wu, Z.; et al. Altered gut microbiota and mucosal immunity in patients with schizophrenia. Brain. Behav. Immun. 2020, 85, 120–127.
  63. Zhuang, Z.Q.; Shen, L.L.; Li, W.W.; Fu, X.; Zeng, F.; Gui, L.; Lü, Y.; Cai, M.; Zhu, C.; Tan, Y.L.; et al. Gut microbiota is altered in patients with alzheimer’s disease. J. Alzheimer’s Dis. 2018, 63, 1337–1346.
  64. Petrov, V.A.; Saltykova, I.V.; Zhukova, I.A.; Alifirova, V.M.; Zhukova, N.G.; Dorofeeva, Y.B.; Tyakht, A.V.; Kovarsky, B.A.; Alekseev, D.G.; Kostryukova, E.S.; et al. Analysis of gut microbiota in patients with parkinson’s disease. Bull. Exp. Biol. Med. 2017, 162, 734–737.
  65. Wang, H.X.; Wang, Y.P. Gut microbiota-brain axis. Chin. Med. J. 2016, 129, 2373–2380.
  66. Breit, S.; Kupferberg, A.; Rogler, G.; Hasler, G. Vagus nerve as modulator of the brain-gut axis in psychiatric and inflammatory disorders. Front. Psychiatry 2018, 9, 44.
  67. Bonaz, B.; Bazin, T.; Pellissier, S. The vagus nerve at the interface of the microbiota-gut-brain axis. Front. Neurosci. 2018, 12, 49.
  68. Bravo, J.A.; Forsythe, P.; Chew, M.V.; Escaravage, E.; Savignac, H.M.; Dinan, T.G.; Bienenstock, J.; Cryan, J.F. Ingestion of lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc. Natl. Acad. Sci. USA 2011, 108, 16050–16055.
  69. Vonck, K.; Raedt, R.; Naulaerts, J.; De Vogelaere, F.; Thiery, E.; Van Roost, D.; Aldenkamp, B.; Miatton, M.; Boon, P. Vagus nerve stimulation…25 years later! What do we know about the effects on cognition? Neurosci. Biobehav. Rev. 2014, 45, 63–71.
  70. Skibicka, K.P.; Dickson, S.L. Enteroendocrine hormones—Central effects on behavior. Curr. Opin. Pharmacol. 2013, 13, 977–982.
  71. Martin, C.R.; Osadchiy, V.; Kalani, A.; Mayer, E.A. The brain-gut-microbiome axis. CMGH 2018, 6, 133–148.
  72. Morais, L.H.; Schreiber, H.L.; Mazmanian, S.K. The gut microbiota–brain axis in behaviour and brain disorders. Nat. Rev. Microbiol. 2020, 1–15.
  73. Mittal, R.; Debs, L.H.; Patel, A.P.; Nguyen, D.; Patel, K.; O’Connor, G.; Grati, M.; Mittal, J.; Yan, D.; Eshraghi, A.A.; et al. Neurotransmitters: The critical modulators regulating gut–brain axis. J. Cell. Physiol. 2017, 232, 2359–2372.
  74. Jenkins, T.A.; Nguyen, J.C.D.; Polglaze, K.E.; Bertrand, P.P. Influence of tryptophan and serotonin on mood and cognition with a possible role of the gut-brain axis. Nutrients 2016, 8, 56.
  75. Hasselmo, M.E. The role of acetylcholine in learning and memory. Curr. Opin. Neurobiol. 2006, 16, 710–715.
  76. Michels, L.; Martin, E.; Klaver, P.; Edden, R.; Zelaya, F.; Lythgoe, D.J.; Lüchinger, R.; Brandeis, D.; O’Gorman, R.L. Frontal GABA levels change during working memory. PLoS ONE 2012, 7, e31933.
  77. James, T.; Kula, B.; Choi, S.; Khan, S.S.; Bekar, L.K.; Smith, N.A. Locus coeruleus in memory formation and alzheimer’s disease. Eur. J. Neurosci. 2020, 1–12.
  78. Strandwitz, P. Neurotransmitter modulation by the gut microbiota. Brain Res. 2018, 1693, 128–133.
  79. Gao, W.; Baumgartel, K.L.; Alexander, S.A. The gut microbiome as a component of the gut–brain axis in cognitive health. Biol. Res. Nurs. 2020, 22, 485–494.
  80. Kyrou, I.; Tsigos, C. Stress hormones: Physiological stress and regulation of metabolism. Curr. Opin. Pharmacol. 2009, 9, 787–793.
  81. Lupien, S.J.; Juster, R.P.; Raymond, C.; Marin, M.F. The effects of chronic stress on the human brain: From neurotoxicity, to vulnerability, to opportunity. Front. Neuroendocrinol. 2018, 49, 91–105.
  82. Smith, S.M.; Vale, W.W. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin. Neurosci. 2006, 8, 383–395.
  83. Konturek, P.C.; Brzozowski, T.; Konturek, S.J. Stress and the gut: Pathophysiology, clinical consequences, diagnostic approach and treatment options. J. Physiol. Pharmacol. 2011, 62, 591–599.
  84. Sudo, N.; Chida, Y.; Aiba, Y.; Sonoda, J.; Oyama, N.; Yu, X.N.; Kubo, C.; Koga, Y. Postnatal microbial colonization programs the hypothalamic-pituitary-adrenal system for stress response in mice. J. Physiol. 2004, 558, 263–275.
  85. Vodička, M.; Ergang, P.; Hrnčíř, T.; Mikulecká, A.; Kvapilová, P.; Vagnerová, K.; Šestáková, B.; Fajstová, A.; Hermanová, P.; Hudcovic, T.; et al. Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress. Brain. Behav. Immun. 2018, 73, 615–624.
  86. Schwabe, L.; Joëls, M.; Roozendaal, B.; Wolf, O.T.; Oitzl, M.S. Stress effects on memory: An update and integration. Neurosci. Biobehav. Rev. 2012, 36, 1740–1749.
  87. Wingenfeld, K.; Wolf, O.T. HPA axis alterations in mental disorders: Impact on memory and its relevance for therapeutic interventions. CNS Neurosci. Ther. 2011, 17, 714–722.
  88. Yoo, B.B.; Mazmanian, S.K. The enteric network: Interactions between the immune and nervous systems of the gut. Immunity 2017, 46, 910–926.
  89. Belkaid, Y.; Hand, T.W. Role of the microbiota in immunity and inflammation. Cell 2014, 157, 121–141.
  90. Powell, N.; Walker, M.M.; Talley, N.J. The mucosal immune system: Master regulator of bidirectional gut-brain communications. Nat. Rev. Gastroenterol. Hepatol. 2017, 14, 143–159.
  91. Kaufmann, F.N.; Costa, A.P.; Ghisleni, G.; Diaz, A.P.; Rodrigues, A.L.S.; Peluffo, H.; Kaster, M.P. NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings. Brain. Behav. Immun. 2017, 64, 367–383.
  92. Becher, B.; Spath, S.; Goverman, J. Cytokine networks in neuroinflammation. Nat. Rev. Immunol. 2017, 17, 49–59.
  93. Heneka, M.T.; Carson, M.J.; El Khoury, J.; Landreth, G.E.; Brosseron, F.; Feinstein, D.L.; Jacobs, A.H.; Wyss-Coray, T.; Vitorica, J.; Ransohoff, R.M.; et al. Neuroinflammation in alzheimer’s disease. Lancet Neurol. 2015, 14, 388–405.
  94. Sternberg, E.M. Neural regulation of innate immunity: A coordinated nonspecific host response to pathogens. Nat. Rev. Immunol. 2006, 6, 318–328.
  95. Dalile, B.; Van Oudenhove, L.; Vervliet, B.; Verbeke, K. The role of short-chain fatty acids in microbiota–gut–brain communication. Nat. Rev. Gastroenterol. Hepatol. 2019, 16, 461–478.
  96. Silva, Y.P.; Bernardi, A.; Frozza, R.L. The role of short-chain fatty acids from gut microbiota in gut-brain communication. Front. Endocrinol. 2020, 11.
  97. Kowiański, P.; Lietzau, G.; Czuba, E.; Waśkow, M.; Steliga, A.; Moryś, J. BDNF: A key factor with multipotent impact on brain signaling and synaptic plasticity. Cell. Mol. Neurobiol. 2018, 38, 579–593.
  98. Cunha, C.; Brambilla, R.; Thomas, K.L. A simple role for BDNF in learning and memory? Front. Mol. Neurosci. 2010, 3, 1–14.
  99. Heijtz, R.D.; Wang, S.; Anuar, F.; Qian, Y.; Bjorkholm, B.; Samuelsson, A.; Hibberd, M.L.; Forssberg, H.; Pettersson, S. Normal gut microbiota modulates brain development and behavior. Proc. Natl. Acad. Sci. USA 2011, 108, 3047–3052.
  100. Wang, J.; Jia, Y.; Li, G.; Wang, B.; Zhou, T.; Zhu, L.; Chen, T.; Chen, Y. The dopamine receptor D3 regulates lipopolysaccharide-induced depressive-like behavior in mice. Int. J. Neuropsychopharmacol. 2018, 21, 448–460.
  101. Savignac, H.M.; Corona, G.; Mills, H.; Chen, L.; Spencer, J.P.E.; Tzortzis, G.; Burnet, P.W.J. Prebiotic feeding elevates central brain derived neurotrophic factor, N-Methyl-d-Aspartate receptor subunits and d-Serine. Neurochem. Int. 2013, 63, 756–764.
  102. Ait-Belgnaoui, A.; Colom, A.; Braniste, V.; Ramalho, L.; Marrot, A.; Cartier, C.; Houdeau, E.; Theodorou, V.; Tompkins, T. Probiotic gut effect prevents the chronic psychological stress-induced brain activity abnormality in mice. Neurogastroenterol. Motil. 2014, 26, 510–520.
  103. Sandhu, K.V.; Sherwin, E.; Schellekens, H.; Stanton, C.; Dinan, T.G.; Cryan, J.F. Feeding the microbiota-gut-brain axis: Diet, microbiome, and neuropsychiatry. Transl. Res. 2017, 179, 223–244.
  104. Agustí, A.; García-Pardo, M.P.; López-Almela, I.; Campillo, I.; Maes, M.; Romaní-Pérez, M.; Sanz, Y. Interplay between the gut-brain axis, obesity and cognitive function. Front. Neurosci. 2018, 12, 155.
  105. Rapin, J.R.; Wiernsperger, N. Possible links between intestinal permeablity and food processing: A potential therapeutic niche for glutamine. Clinics 2010, 65, 635–643.
  106. Holder, M.K.; Chassaing, B. Impact of food additives on the gut-brain axis. Physiol. Behav. 2018, 192, 173–176.
  107. Serra, D.; Almeida, L.M.; Dinis, T.C.P. Dietary polyphenols: A novel strategy to modulate microbiota-gut-brain axis. Trends Food Sci. Technol. 2018, 78, 224–233.
  108. Rowland, I.; Gibson, G.; Heinken, A.; Scott, K.; Swann, J.; Thiele, I.; Tuohy, K. Gut microbiota functions: Metabolism of nutrients and other food components. Eur. J. Nutr. 2018, 57, 1–24.
  109. Costantini, L.; Molinari, R.; Farinon, B.; Merendino, N. Impact of Omega-3 fatty acids on the gut microbiota. Int. J. Mol. Sci. 2017, 18, 2645.
  110. Pusceddu, M.M.; El Aidy, S.; Crispie, F.; O’Sullivan, O.; Cotter, P.; Stanton, C.; Kelly, P.; Cryan, J.F.; Dinan, T.G. N-3 polyunsaturated fatty acids (PUFAs) reverse the impact of early-life stress on the gut microbiota. PLoS ONE 2015, 10, e0139721.
  111. Tabatabaeizadeh, S.-A.; Tafazoli, N.; Ferns, G.; Avan, A.; Ghayour-Mobarhan, M. Vitamin D, the gut microbiome and inflammatory bowel disease. J. Res. Med. Sci. 2018, 23, 75.
  112. Yamamoto, E.A.; Jørgensen, T.N. Relationships between Vitamin D, gut microbiome, and systemic autoimmunity. Front. Immunol. 2020, 10, 3141.
  113. Ooi, J.H.; Chen, J.; Cantorna, M.T. Vitamin D regulation of immune function in the gut: Why do T cells have vitamin D receptors? Mol. Aspects Med. 2012, 33, 77–82.
  114. Iwata, M.; Hirakiyama, A.; Eshima, Y.; Kagechika, H.; Kato, C.; Song, S.-Y. Retinoic acid imprints gut-homing specificity on T cells. Immunity 2004, 21, 527–538.
  115. Biesalski, H.K.; Nohr, D. New aspects in vitamin a metabolism: The role of retinyl esters as systemic and local sources for retinol in mucous epithelia. J. Nutr. 2004, 134 (Suppl. 12), 3453S–3457S.
  116. Brown, C.C.; Noelle, R.J. Seeing through the dark: New insights into the immune regulatory functions of vitamin A. Eur. J. Immunol. 2015, 45, 1287–1295.
  117. Liu, K.Y.; Nakatsu, C.H.; Jones-Hall, Y.; Kozik, A.; Jiang, Q. Vitamin E alpha- and gamma-tocopherol mitigate colitis, protect intestinal barrier function and modulate the gut microbiota in mice. Free Radic. Biol. Med. 2021, 163, 180–189.
  118. Zackular, J.P.; Moore, J.L.; Jordan, A.T.; Juttukonda, L.J.; Noto, M.J.; Nicholson, M.R.; Crews, J.D.; Semler, M.W.; Zhang, Y.; Ware, L.B.; et al. Dietary zinc alters the microbiota and decreases resistance to clostridium difficile infection. Nat. Med. 2016, 22, 1330–1334.
  119. Vela, G.; Stark, P.; Socha, M.; Sauer, A.K.; Hagmeyer, S.; Grabrucker, A.M. Zinc in gut-brain interaction in autism and neurological disorders. Neural Plast. 2015, 2015, 1–15.
  120. Yilmaz, B.; Li, H. Gut microbiota and iron: The crucial actors in health and disease. Pharmaceuticals 2018, 11, 98.
  121. Rusu, I.G.; Suharoschi, R.; Vodnar, D.C.; Pop, C.R.; Socaci, S.A.; Vulturar, R.; Istrati, M.; Moroșan, I.; Fărcaș, A.C.; Kerezsi, A.D.; et al. Iron supplementation influence on the gut microbiota and probiotic intake effect in iron deficiency—A literature-based review. Nutrients 2020, 12, 1993.
  122. Valdes, A.M.; Glass, D.; Spector, T.D. Omics technologies and the study of human ageing. Nat. Rev. Genet. 2013, 14, 601–607.
  123. Ivanisevic, J.; Siuzdak, G. The role of metabolomics in brain metabolism research. J. Neuroimmune Pharmacol. 2015, 10, 391–395.
  124. Zierer, J.; Menni, C.; Kastenmüller, G.; Spector, T.D. Integration of ‘Omics’ data in aging research: From biomarkers to systems biology. Aging Cell 2015, 14, 933–944.
  125. Cevenini, E.; Bellavista, E.; Tieri, P.; Castellani, G.; Lescai, F.; Francesconi, M.; Mishto, M.; Santoro, A.; Valensin, S.; Salvioli, S.; et al. Systems biology and longevity: An emerging approach to identify innovative anti- aging targets and strategies. Curr. Pharm. Des. 2010, 16, 802–813.
  126. Jové, M.; Portero-Otín, M.; Naudí, A.; Ferrer, I.; Pamplona, R. Metabolomics of human brain aging and age-related neurodegenerative diseases. J. Neuropathol. Exp. Neurol. 2014, 73, 640–657.
  127. Cheng, S.; Larson, M.G.; McCabe, E.L.; Murabito, J.M.; Rhee, E.P.; Ho, J.E.; Jacques, P.F.; Ghorbani, A.; Magnusson, M.; Souza, A.L.; et al. Distinct metabolomic signatures are associated with longevity in humans. Nat. Commun. 2015, 6, 6791.
  128. Ivanisevic, J.; Stauch, K.L.; Petrascheck, M.; Benton, H.P.; Epstein, A.A.; Fang, M.; Gorantla, S.; Tran, M.; Hoang, L.; Kurczy, M.E.; et al. Metabolic drift in the aging brain. Aging 2016, 8, 1000–1020.
  129. Menni, C.; Kastenmüller, G.; Petersen, A.K.; Bell, J.T.; Psatha, M.; Tsai, P.-C.; Gieger, C.; Schulz, H.; Erte, I.; John, S.; et al. Metabolomic markers reveal novel pathways of ageing and early development in human populations. Int. J. Epidemiol. 2013, 42, 1111–1119.
  130. Vaarhorst, A.A.M.; Beekman, M.; Suchiman, E.H.D.; van Heemst, D.; Houwing-Duistermaat, J.J.; Westendorp, R.G.J.; Slagboom, P.E.; Heijmans, B.T. Lipid metabolism in long-lived families: The leiden longevity study. Age 2011, 33, 219–227.
  131. Sharma, R.; Ramanathan, A. The aging metabolome—Biomarkers to hub metabolites. Proteomics 2020, 20, 1800407.
  132. Scandalios, J.G. Oxidative stress: Molecular perception and transduction of signals. Braz. J. Med. Biol. Res. 2005, 38, 995–1014.
  133. Muralidharan, S.; Mandrekar, P. Cellular stress response and innate immune signaling: Integrating pathways in host defense and inflammation. J. Leukoc. Biol. 2013, 94, 1167–1184.
  134. Stranahan, A.M.; Mattson, M.P. Recruiting adaptive cellular stress responses for successful brain ageing. Nat. Rev. Neurosci. 2012, 13, 209–216.
  135. Hou, Y.; Ouyang, X.; Wan, R.; Cheng, H.; Mattson, M.P.; Cheng, A. Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development. Stem. Cells 2012, 30, 2535–2547.
  136. Yun, J.; Finkel, T. Mitohormesis. Cell Metab. 2014, 19, 757–766.
  137. Raefsky, S.M.; Mattson, M.P. Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance. Free Radic. Biol. Med. 2017, 102, 203–216.
  138. Mattson, M.P. Apoptosis in neurodegenerative disorders. Nat. Rev. Mol. Cell Biol. 2000, 1, 120–129.
  139. Stahon, K.E.; Bastian, C.; Griffith, S.; Kidd, G.J.; Brunet, S.; Baltan, S. Age-related changes in axonal and mitochondrial ultrastructure and function in white matter. J. Neurosci. 2016, 36, 9990–10001.
  140. Morozov, Y.M.; Datta, D.; Paspalas, C.D.; Arnsten, A.F.T. Ultrastructural evidence for impaired mitochondrial fission in the aged rhesus monkey dorsolateral prefrontal cortex. Neurobiol. Aging 2017, 51, 9–18.
  141. Kim, G.W.; Chan, P.H. Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum. Neurobiol. Dis. 2001, 8, 114–126.
  142. Santos, R.X.; Correia, S.C.; Zhu, X.; Smith, M.A.; Moreira, P.I.; Castellani, R.J.; Nunomura, A.; Perry, G. Mitochondrial DNA oxidative damage and repair in aging and alzheimer’s disease. Antioxid. Redox Signal. 2013, 18, 2444–2457.
  143. Yao, J.; Hamilton, R.T.; Cadenas, E.; Brinton, R.D. Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence. Biochim. Biophys. Acta Gen. Subj. 2010, 1800, 1121–1126.
  144. Pandya, J.D.; Grondin, R.; Yonutas, H.M.; Haghnazar, H.; Gash, D.M.; Zhang, Z.; Sullivan, P.G. Decreased mitochondrial bioenergetics and calcium buffering capacity in the basal ganglia correlates with motor deficits in anonhuman primate model of aging. Neurobiol. Aging 2015, 36, 1903–1913.
  145. Pandya, J.D.; Royland, J.E.; MacPhail, R.C.; Sullivan, P.G.; Kodavanti, P.R.S. Age- and brain region-specific differences in mitochondrial bioenergetics in brown norway rats. Neurobiol. Aging 2016, 42, 25–34.
  146. Pollard, A.K.; Craig, E.L.; Chakrabarti, L. Mitochondrial complex 1 activity measured by spectrophotometry is reduced across all brain regions in ageing and more specifically in neurodegeneration. PLoS ONE 2016, 11, e0157405.
  147. Leslie, S.W.; Chandler, L.J.; Barr, E.M.; Farrar, R.P. Reduced calcium uptake by rat brain mitochondria and synaptosomes in response to aging. Brain Res. 1985, 329, 177–183.
  148. Lin, D.T.; Wu, J.; Holstein, D.; Upadhyay, G.; Rourk, W.; Muller, E.; Lechleiter, J.D. Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes. Neurobiol. Aging 2007, 28, 99–111.
  149. Ghosh, D.; LeVault, K.R.; Barnett, A.J.; Brewer, G.J. A reversible early oxidized redox state that precedes macromolecular ROS damage in aging nontransgenic and 3xTg-AD mouse neurons. J. Neurosci. 2012, 32, 5821–5832.
  150. Halliwell, B. Role of free radicals in the neurodegenerative diseases. Drugs Aging 2001, 18, 685–716.
  151. Park, L.; Anrather, J.; Girouard, H.; Zhou, P.; Iadecola, C. Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain. J. Cereb. Blood Flow Metab. 2007, 27, 1908–1918.
  152. Mattson, M.P. Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associated vascular and neurodegenerative disorders. Exp. Gerontol. 2009, 44, 625–633.
  153. Papaioannod, N.; Tooten, P.C.J.; Van Ederen, A.M.; Jiirgen, R.E.; Rofina, J.; Tsangaris, T.; Gruys, E. Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques. J. Protein Fold. Disord. 2001, 21, 11–21.
  154. Guix, F.X.; Uribesalgo, I.; Coma, M.; Muñoz, F.J. The physiology and pathophysiology of nitric oxide in the brain. Prog. Neurobiol. 2005, 76, 126–152.
  155. Perluigi, M.; Swomley, A.M.; Butterfield, D.A. Redox proteomics and the dynamic molecular landscape of the aging brain. Ageing Res. Rev. 2014, 13, 75–89.
  156. Cooke, M.S.; Evans, M.D.; Dizdaroglu, M.; Lunec, J. Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J. 2003, 17, 1195–1214.
  157. Chow, H.M.; Herrup, K. Genomic integrity and the ageing brain. Nat. Rev. Neurosci. 2015, 16, 672–684.
  158. Yang, J.L.; Tadokoro, T.; Keijzers, G.; Mattson, M.P.; Bohr, V.A. Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving creb-mediated up-regulation of apurinic endonuclease 1. J. Biol. Chem. 2010, 285, 28191–28199.
  159. Leandro, G.S.; Sykora, P.; Bohr, V.A. The impact of base excision DNA repair in age-related neurodegenerative diseases. Mutat. Res. Mol. Mech. Mutagen. 2015, 776, 31–39.
  160. Lu, T.; Pan, Y.; Kao, S.Y.; Li, C.; Kohane, I.; Chan, J.; Yankner, B.A. Gene regulation and DNA damage in the ageing human brain. Nature 2004, 429, 883–891.
  161. Scheibye-Knudsen, M. Neurodegeneration in accelerated aging. Dan. Med. J. 2016, 63, 1–21.
  162. Thibault, O.; Hadley, R.; Landfield, P.W. Elevated Postsynaptic [CA2+]i and L-Type calcium channel activity in aged hippocampal neurons: Relationship to impaired synaptic plasticity. J. Neurosci. 2001, 21, 9744–9756.
  163. Toescu, E.C.; Verkhratsky, A.; Landfield, P.W. Ca 2+ regulation and gene expression in normal brain aging. Trends Neurosci. 2004, 27, 614–620.
  164. Gant, J.C.; Sama, M.M.; Landfield, P.W.; Thibault, O. Early and simultaneous emergence of multiple hippocampal biomarkers of aging is mediated by Ca2+-Induced Ca2+ release. J. Neurosci. 2006, 26, 3482–3490.
  165. Porte, Y.; Buhot, M.C.; Mons, N. Alteration of CREB phosphorylation and spatial memory deficits in aged 129T2/Sv Mice. Neurobiol. Aging 2008, 29, 1533–1546.
  166. Camandola, S.; Mattson, M.P. Aberrant subcellular neuronal calcium regulation in aging and alzheimer’s disease. Biochim. Biophys. Acta Mol. Cell Res. 2011, 1813, 965–973.
  167. Mattson, M.P.; Maudsley, S.; Martin, B. A Neural signaling triumvirate that influences ageing and age-related disease: Insulin/IGF-1, BDNF and serotonin. Ageing Res. Rev. 2004, 3, 445–464.
  168. Tapia-Arancibia, L.; Aliaga, E.; Silhol, M.; Arancibia, S. New insights into brain bdnf function in normal aging and alzheimer disease. Brain Res. Rev. 2008, 59, 201–220.
  169. Schliebs, R.; Arendt, T. The cholinergic system in aging and neuronal degeneration. Behav. Brain Res. 2011, 221, 555–563.
  170. Neidl, R.; Schneider, A.; Bousiges, O.; Majchrzak, M.; Barbelivien, A.; de Vasconcelos, A.P.; Dorgans, K.; Doussau, F.; Loeffler, J.P.; Cassel, J.C.; et al. Late-life environmental enrichment induces acetylation events and nuclear factor κb-dependent regulations in the hippocampus of aged rats showing improved plasticity and learning. J. Neurosci. 2016, 36, 4351–4361.
  171. Nixon, R.A. The role of autophagy in neurodegenerative disease. Nat. Med. 2013, 19, 983–997.
  172. Galluzzi, L.; Baehrecke, E.H.; Ballabio, A.; Boya, P.; Bravo-San Pedro, J.M.; Cecconi, F.; Choi, A.M.; Chu, C.T.; Codogno, P.; Colombo, M.I.; et al. Molecular definitions of autophagy and related processes. EMBO J. 2017, 36, 1811–1836.
  173. VerPlank, J.J.S.; Goldberg, A.L. Regulating protein breakdown through proteasome phosphorylation. Biochem. J. 2017, 474, 3355–3371.
  174. Keller, J.N.; Gee, J.; Ding, Q. The proteasome in brain aging. Ageing Res. Rev. 2002, 1, 279–293.
  175. Butler, D.; Bahr, B.A. Oxidative stress and lysosomes: CNS-related consequences and implications for lysosomal enhancement strategies and induction of autophagy. Antioxid. Redox Signal. 2006, 8, 185–196.
  176. Zhang, S.; Eitan, E.; Mattson, M.P. Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-Hydroxynonenal. J. Neurochem. 2017, 140, 941–954.
  177. Graham, S.H.; Liu, H. Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral ischemia. Ageing Res. Rev. 2017, 34, 30–38.
  178. Kerr, J.S.; Adriaanse, B.A.; Greig, N.H.; Mattson, M.P.; Cader, M.Z.; Bohr, V.A.; Fang, E.F. Mitophagy and alzheimer’s disease: Cellular and molecular mechanisms. Trends Neurosci. 2017, 40, 151–166.
  179. Keller, J.N.; Hanni, K.B.; Markesbery, W.R. Possible Involvement of Proteasome Inhibition in Aging: Implications for Oxidative Stress. Mech. Ageing Dev. 2000, 113, 61–70.
  180. McEwen, B.S.; Morrison, J.H. The brain on stress: Vulnerability and plasticity of the prefrontal cortex over the life course. Neuron 2013, 79, 16–29.
  181. Thambisetty, M.; Beason-Held, L.L.; An, Y.; Kraut, M.; Metter, J.; Egan, J.; Ferrucci, L.; O’Brien, R.; Resnick, S.M. Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging. Neurobiol. Aging 2013, 34, 2271–2276.
  182. Neth, B.J.; Craft, S. Insulin resistance and alzheimer’s disease: Bioenergetic linkages. Front. Aging Neurosci. 2017, 9, 1–20.
  183. Goyal, M.S.; Vlassenko, A.G.; Blazey, T.M.; Su, Y.; Couture, L.E.; Durbin, T.J.; Bateman, R.J.; Benzinger, T.L.-S.; Morris, J.C.; Raichle, M.E. Loss of brain aerobic glycolysis in normal human aging. Cell Metab. 2017, 26, 353–360.e3.
  184. Kato, T.; Inui, Y.; Nakamura, A.; Ito, K. Brain fluorodeoxyglucose (FDG) PET in dementia. Ageing Res. Rev. 2016, 30, 73–84.
  185. Mark, R.J.; Pang, Z.; Geddes, J.W.; Uchida, K.; Mattson, M.P. Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons: Involvement of membrane lipid peroxidation. J. Neurosci. 1997, 17, 1046–1054.
  186. Cunnane, S.C.; Courchesne-Loyer, A.; Vandenberghe, C.; St-Pierre, V.; Fortier, M.; Hennebelle, M.; Croteau, E.; Bocti, C.; Fulop, T.; Castellano, C.A. Can ketones help rescue brain fuel supply in later life? Implications for cognitive health during aging and the treatment of alzheimer’s disease. Front. Mol. Neurosci. 2016, 9, 1–21.
  187. Erdö, F.; Denes, L.; De Lange, E. Age-associated physiological and pathological changes at the blood-brain barrier: A review. J. Cereb. Blood Flow Metab. 2017, 37, 4–24.
  188. Oberman, L.; Pascual-Leone, A. Changes in plasticity across the lifespan: Cause of disease and target for intervention. Prog. Brain Res. 2013, 207, 91–120.
  189. Cuestas Torres, D.M.; Cardenas, F.P. Synaptic plasticity in alzheimer’s disease and healthy aging. Rev. Neurosci. 2020, 31, 245–268.
  190. Lazarov, O.; Mattson, M.P.; Peterson, D.A.; Pimplikar, S.W.; van Praag, H. When neurogenesis encounters aging and disease. Trends Neurosci. 2010, 33, 569–579.
  191. Gil-Mohapel, J.; Brocardo, P.S.; Choquette, W.; Gothard, R.; Simpson, J.M.; Christie, B.R. Hippocampal neurogenesis levels predict WATERMAZE search strategies in the aging brain. PLoS ONE 2013, 8, e75125.
  192. Stoll, E.A.; Cheung, W.; Mikheev, A.M.; Sweet, I.R.; Bielas, J.H.; Zhang, J.; Rostomily, R.C.; Horner, P.J. Aging neural progenitor cells have decreased mitochondrial content and lower oxidative metabolism. J. Biol. Chem. 2011, 286, 38592–38601.
  193. Beckervordersandforth, R.; Ebert, B.; Schäffner, I.; Moss, J.; Fiebig, C.; Shin, J.; Moore, D.L.; Ghosh, L.; Trinchero, M.F.; Stockburger, C.; et al. Role of mitochondrial metabolism in the control of early lineage progression and aging phenotypes in adult hippocampal neurogenesis. Neuron 2017, 93, 560–573.e6.
  194. Ekdahl, C.T.; Claasen, J.H.; Bonde, S.; Kokaia, Z.; Lindvall, O. Inflammation is detrimental for neurogenesis in adult brain. Proc. Natl. Acad. Sci. USA 2003, 100, 13632–13637.
  195. So, J.K.; Tae, G.S.; Hee, R.P.; Park, M.; Kim, M.S.; Hyung, S.K.; Hae, Y.C.; Mattson, M.P.; Lee, J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J. Biol. Chem. 2008, 283, 14497–14505.
  196. Regnell, C.E.; Hildrestrand, G.A.; Sejersted, Y.; Medin, T.; Moldestad, O.; Rolseth, V.; Krokeide, S.Z.; Suganthan, R.; Luna, L.; Bjørås, M.; et al. Hippocampal adult neurogenesis is maintained by Neil3-dependent repair of oxidative DNA lesions in neural progenitor cells. Cell Rep. 2012, 2, 503–510.
  197. L’Episcopo, F.; Tirolo, C.; Testa, N.; Caniglia, S.; Morale, M.C.; Impagnatiello, F.; Pluchino, S.; Marchetti, B. Aging-Induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation. J. Neurosci. 2013, 33, 1462–1485.
  198. Cribbs, D.H.; Berchtold, N.C.; Perreau, V.; Coleman, P.D.; Rogers, J.; Tenner, A.J.; Cotman, C.W. Extensive innate immune gene activation accompanies brain aging, increasing vulnerability to cognitive decline and neurodegeneration: A microarray study. J. Neuroinflamm. 2012, 9, 1–18.
  199. Norden, D.M.; Godbout, J.P. Review: Microglia of the aged brain: Primed to be activated and resistant to regulation. Neuropathol. Appl. Neurobiol. 2013, 39, 19–34.
  200. Arumugam, T.V.; Woodruff, T.M.; Lathia, J.D.; Selvaraj, P.K.; Mattson, M.P.; Taylor, S.M. Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. Neuroscience 2009, 158, 1074–1089.
  201. Stephan, A.H.; Madison, D.V.; Mateos, J.M.; Fraser, D.A.; Lovelett, E.A.; Coutellier, L.; Kim, L.; Tsai, H.H.; Huang, E.J.; Rowitch, D.H.; et al. A dramatic increase of C1q protein in the CNS during normal aging. J. Neurosci. 2013, 33, 13460–13474.
  202. Hong, S.; Beja-glasser, V.F.; Nfonoyim, B.M.; Frouin, A.; Ramakrishnan, S.; Merry, K.M.; Shi, Q.; Rosenthal, A.; Barres, A.; Lemere, C.A.; et al. ADF/Cofilin-Actin rods in neurodegenerative diseases. Curr. Alzheimer Res. 2016, 352, 712–716.
  203. McEvoy, C.T.; Leng, Y.; Peeters, G.M.; Kaup, A.R.; Allen, I.E.; Yaffe, K. Interventions involving a major dietary component improve cognitive function in cognitively healthy adults: A systematic review and meta-analysis. Nutr. Res. 2019, 66, 1–12.
  204. Petersson, S.D.; Philippou, E. Mediterranean diet, cognitive function, and dementia: A systematic review of the evidence. Adv. Nutr. 2016, 7, 889–904.
  205. Tangney, C.C.; Li, H.; Wang, Y.; Barnes, L.; Schneider, J.A.; Bennett, D.A.; Morris, M.C. Relation of DASH- and mediterranean-like dietary patterns to cognitive decline in older persons. Neurology 2014, 83, 1410–1416.
  206. Van Den Brink, A.C.; Brouwer-Brolsma, E.M.; Berendsen, A.A.M.; Van De Rest, O. The mediterranean, dietary approaches to stop hypertension (DASH), and mediterranean-DASH intervention for neurodegenerative delay (MIND) diets are associated with less cognitive decline and a lower risk of alzheimer’s disease—A review. Adv. Nutr. 2019, 10, 1040–1065.
  207. Morris, M.C.; Tangney, C.C.; Wang, Y.; Sacks, F.M.; Barnes, L.L.; Bennett, D.A.; Aggarwal, N.T. MIND diet slows cognitive decline with aging. Alzheimer’s Dement. 2015, 11, 1015–1022.
  208. Hosking, D.E.; Eramudugolla, R.; Cherbuin, N.; Anstey, K.J. MIND not mediterranean diet related to 12-year incidence of cognitive impairment in an australian longitudinal cohort study. Alzheimer’s Dement. 2019, 15, 581–589.
  209. Medawar, E.; Huhn, S.; Villringer, A.; Veronica Witte, A. The effects of plant-based diets on the body and the brain: A systematic review. Transl. Psychiatry 2019, 9, 226.
  210. Rajaram, S.; Jones, J.; Lee, G.J. Plant-based dietary patterns, plant foods, and age-related cognitive decline. Adv. Nutr. 2019, 10, 422–436.
  211. Ramey, M.M.; Shields, G.S.; Yonelinas, A.P. Markers of a plant-based diet relate to memory and executive function in older adults. Nutr. Neurosci. 2020, 1–10.
  212. McGrattan, A.M.; McGuinness, B.; McKinley, M.C.; Kee, F.; Passmore, P.; Woodside, J.V.; McEvoy, C.T. Diet and inflammation in cognitive ageing and alzheimer’s disease. Curr. Nutr. Rep. 2019, 8, 53–65.
  213. El-Swefy, S.E.; Atteia, H.H. Molecular aspects of the mediterranean diet: Adiponectin, brain amyloid precursor protein, apolipoprotein e and caspase-3 MRNA. In The Mediterranean Diet: An Evidence-Based Approach; Elsevier Inc.: Amsterdam, The Netherlands, 2015; pp. 441–448.
  214. Mcevoy, C.T.; Hoang, T.; Sidney, S.; Steffen, L.M.; Jacobs, D.R.; Shikany, J.M.; Wilkins, J.T.; Yaffe, K. Dietary patterns during adulthood and cognitive performance in midlife: The CARDIA study. Neurology 2019, 92, E1589–E1599.
  215. Chou, Y.C.; Lee, M.S.; Chiou, J.M.; Chen, T.F.; Chen, Y.C.; Chen, J.H. Association of diet quality and vegetable variety with the risk of cognitive decline in chinese older adults. Nutrients 2019, 11, 1666.
  216. Valls-Pedret, C.; Sala-Vila, A.; Serra-Mir, M.; Corella, D.; De La Torre, R.; Martínez-González, M.Á.; Martínez-Lapiscina, E.H.; Fitó, M.; Pérez-Heras, A.; Salas-Salvadó, J.; et al. Mediterranean diet and age-related cognitive decline: A randomized clinical trial. JAMA Intern. Med. 2015, 175, 1094–1103.
  217. Rita Cardoso, B.; Apolinário, D.; da Silva Bandeira, V.; Busse, A.L.; Magaldi, R.M.; Jacob-Filho, W.; Cozzolino, S.M.F. Effects of brazil nut consumption on selenium status and cognitive performance in older adults with mild cognitive impairment: A randomized controlled pilot trial. Eur. J. Nutr. 2016, 55, 107–116.
  218. O’Brien, J.; Okereke, O.; Devore, E.; Rosner, B.; Breteler, M.; Grodstein, F. Long-term intake of nuts in relation to cognitive function in older women. J. Nutr. Health Aging 2014, 18, 496–502.
  219. Arab, L.; Ang, A. A cross sectional study of the association between walnut consumption and cognitive function among adult us populations represented in NHANES. J. Nutr. Health Aging 2015, 19, 284–290.
  220. Pribis, P.; Bailey, R.N.; Russell, A.A.; Kilsby, M.A.; Hernandez, M.; Craig, W.J.; Grajales, T.; Shavlik, D.J.; Sabatè, J. Effects of walnut consumption on cognitive performance in young adults. Br. J. Nutr. 2012, 107, 1393–1401.
  221. Chauhan, A.; Chauhan, V. Beneficial effects of walnuts on cognition and brain health. Nutrients 2020, 12, 550.
  222. Angeloni, C.; Malaguti, M.; Barbalace, M.C.; Hrelia, S. Bioactivity of olive oil phenols in neuroprotection. Int. J. Mol. Sci. 2017, 18, 2230.
  223. Omar, S.H. Mediterranean and MIND diets containing olive biophenols reduces the prevalence of alzheimer’s disease. Int. J. Mol. Sci. 2019, 20, 2797.
  224. Sakurai, K.; Shen, C.; Shiraishi, I.; Inamura, N.; Hisatsune, T. Consumption of oleic acid on the preservation of cognitive functions in Japanese elderly individuals. Nutrients 2021, 13, 284.
  225. Wu, S.; Ding, Y.; Wu, F.; Li, R.; Hou, J.; Mao, P. Omega-3 fatty acids intake and risks of dementia and alzheimer’s disease: A meta-analysis. Neurosci. Biobehav. Rev. 2015, 48, 1–9.
  226. Butler, L.J.; Janulewicz, P.A.; Carwile, J.L.; White, R.F.; Winter, M.R.; Aschengrau, A. Childhood and adolescent fish consumption and adult neuropsychological performance: An analysis from the cape cod health study. Neurotoxicol. Teratol. 2017, 61, 47–57.
  227. Layé, S.; Nadjar, A.; Joffre, C.; Bazinet, R.P. Anti-inflammatory effects of Omega-3 fatty acids in the brain: Physiological mechanisms and relevance to pharmacology. Pharmacol. Rev. 2018, 70, 12–38.
  228. Wysoczański, T.; Sokoła-Wysoczańska, E.; Pękala, J.; Lochyński, S.; Czyż, K.; Bodkowski, R.; Herbinger, G.; Patkowska-Sokoła, B.; Librowski, T. Omega-3 fatty acids and their role in central nervous system—A review. Curr. Med. Chem. 2016, 23, 816–831.
  229. Pifferi, F.; Cunnane, S.C.; Guesnet, P. Evidence of the role of Omega-3 polyunsaturated fatty acids in brain glucose metabolism. Nutrients 2020, 12, 1382.
  230. Deacon, G.; Kettle, C.; Hayes, D.; Dennis, C.; Tucci, J. Omega 3 polyunsaturated fatty acids and the treatment of depression. Crit. Rev. Food Sci. Nutr. 2017, 57, 212–223.
  231. Belkouch, M.; Hachem, M.; Elgot, A.; Van, A.L.; Picq, M.; Guichardant, M.; Lagarde, M.; Bernoud-Hubac, N. The pleiotropic effects of Omega-3 docosahexaenoic acid on the hallmarks of alzheimer’s disease. J. Nutr. Biochem. 2016, 38, 1–11.
  232. Decroix, L.; De Pauw, K.; Van Cutsem, J.; Pattyn, N.; Heyman, E.; Meeusen, R. Acute Cocoa Flavanols intake improves cerebral hemodynamics while maintaining brain activity and cognitive performance in moderate hypoxia. Psychopharmacology 2018, 235, 2597–2608.
  233. Lamport, D.J.; Christodoulou, E.; Achilleos, C. Beneficial effects of dark chocolate for episodic memory in healthy young adults: A parallel-groups acute intervention with a white chocolate control. Nutrients 2020, 12, 483.
  234. Fox, M.; Meyer-Gerspach, A.C.; Wendebourg, M.J.; Gruber, M.; Heinrich, H.; Sauter, M.; Woelnerhanssen, B.; Koeberle, D.; Juengling, F. Effect of cocoa on the brain and gut in healthy subjects: A randomised controlled trial. Br. J. Nutr. 2019, 121, 654–661.
  235. Socci, V.; Tempesta, D.; Desideri, G.; De Gennaro, L.; Ferrara, M. Enhancing human cognition with cocoa flavonoids. Front. Nutr. 2017, 4, 16.
  236. Calabrò, R.S.; De Cola, M.C.; Gervasi, G.; Portaro, S.; Naro, A.; Accorinti, M.; Manuli, A.; Marra, A.; De Luca, R.; Bramanti, P. The efficacy of cocoa polyphenols in the treatment of mild cognitive impairment: A retrospective study. Medicina 2019, 55, 156.
  237. Cova, I.; Leta, V.; Mariani, C.; Pantoni, L.; Pomati, S. Exploring cocoa properties: Is theobromine a cognitive modulator? Psychopharmacology 2019, 236, 561–572.
  238. Tsang, C.; Hodgson, L.; Bussu, A.; Farhat, G.; Al-Dujaili, E. Effect of polyphenol-rich dark chocolate on salivary cortisol and mood in adults. Antioxidants 2019, 8, 149.
  239. Madhavadas, S.; Kapgal, V.K.; Kutty, B.M.; Subramanian, S. The neuroprotective effect of dark chocolate in monosodium glutamate-induced nontransgenic alzheimer disease model rats: Biochemical, behavioral, and histological studies. J. Diet. Suppl. 2016, 13, 449–460.
  240. Dong, X.; Li, S.; Sun, J.; Li, Y.; Zhang, D. Association of coffee, decaffeinated coffee and caffeine intake from coffee with cognitive performance in older adults: National health and nutrition examination survey (NHANES) 2011–2014. Nutrients 2020, 12, 840.
  241. Van Gelder, B.M.; Buijsse, B.; Tijhuis, M.; Kalmijn, S.; Giampaoli, S.; Nissinen, A.; Kromhout, D. Coffee consumption is inversely associated with cognitive decline in elderly european men: The FINE study. Eur. J. Clin. Nutr. 2007, 61, 226–232.
  242. Kim, J.W.; Byun, M.S.; Yi, D.; Lee, J.H.; Jeon, S.Y.; Jung, G.; Lee, H.N.; Sohn, B.K.; Lee, J.Y.; Kim, Y.K.; et al. Coffee intake and decreased amyloid pathology in human brain. Transl. Psychiatry 2019, 9, 270.
  243. Iriondo-Dehond, A.; Uranga, J.A.; Del Castillo, M.D.; Abalo, R. Effects of coffee and its components on the gastrointestinal tract and the brain–gut axis. Nutrients 2021, 13, 88.
  244. Prasanth, M.I.; Sivamaruthi, B.S.; Chaiyasut, C.; Tencomnao, T. A Review of the role of green tea (Camellia Sinensis) in antiphotoaging, stress resistance, neuroprotection, and autophagy. Nutrients 2019, 11, 474.
  245. Chen, S.Q.; Wang, Z.S.; Ma, Y.X.; Zhang, W.; Lu, J.L.; Liang, Y.R.; Zheng, X.Q. Neuroprotective effects and mechanisms of tea bioactive components in neurodegenerative diseases. Molecules 2018, 23, 512.
  246. Denniss, R.J.; Barker, L.A.; Day, C.J. Improvement in cognition following double-blind randomized micronutrient interventions in the general population. Front. Behav. Neurosci. 2019, 13, 115.
  247. Lopes Da Silva, S.; Vellas, B.; Elemans, S.; Luchsinger, J.; Kamphuis, P.; Yaffe, K.; Sijben, J.; Groenendijk, M.; Stijnen, T. Plasma nutrient status of patients with alzheimer’s disease: Systematic review and meta-analysis. Alzheimer’s Dement. 2014, 10, 485–502.
  248. Bourre, J.M. Effects of nutrients (in Food) on the structure and function of the nervous system: Update on dietary requirements for brain. Part 1: Micronutrients. J. Nutr. Health Aging 2006, 10, 377–385.
  249. Gibson, G.E.; Hirsch, J.A.; Fonzetti, P.; Jordan, B.D.; Cirio, R.T.; Elder, J. Vitamin B1 (Thiamine) and dementia. Ann. N. Y. Acad. Sci. 2016, 1367, 21–30.
  250. Fortune, N.C.; Harville, E.W.; Guralnik, J.M.; Gustat, J.; Chen, W.; Qi, L.; Bazzano, L.A. Dietary intake and cognitive function: Evidence from the bogalusa heart study. Am. J. Clin. Nutr. 2019, 109, 1656–1663.
  251. Smith, A.D. Hippocampus as a mediator of the role of vitamin B-12 in memory. Am. J. Clin. Nutr. 2016, 103, 959–960.
  252. Durga, J.; van Boxtel, M.P.; Schouten, E.G.; Kok, F.J.; Jolles, J.; Katan, M.B.; Verhoef, P. Effect of 3-Year folic acid supplementation on cognitive function in older adults in the FACIT Trial: A randomised, double blind, controlled trial. Lancet 2007, 369, 208–216.
  253. Balk, E.M.; Raman, G.; Tatsioni, A.; Chung, M.; Lau, J.; Rosenberg, I.H. Vitamin B6, B12, and folic acid supplementation and cognitive function: A systematic review of randomized trials. Arch. Intern. Med. 2007, 167, 21–30.
  254. Kennedy, D.O. B Vitamins and the brain: Mechanisms, dose and efficacy—A review. Nutrients 2016, 8, 68.
  255. Chen, H.; Liu, S.; Ji, L.; Wu, T.; Ji, Y.; Zhou, Y.; Zheng, M.; Zhang, M.; Xu, W.; Huang, G. Folic acid supplementation mitigates alzheimer’s disease by reducing inflammation: A randomized controlled trial. Mediat. Inflamm. 2016, 2016, 5912146.
  256. Ford, T.C.; Downey, L.A.; Simpson, T.; McPhee, G.; Oliver, C.; Stough, C. The effect of a high-dose vitamin b multivitamin supplement on the relationship between brain metabolism and blood biomarkers of oxidative stress: A randomized control trial. Nutrients 2018, 10, 1860.
  257. Zeng, J.; Chen, L.; Wang, Z.; Chen, Q.; Fan, Z.; Jiang, H.; Wu, Y.; Ren, L.; Chen, J.; Li, T.; et al. Marginal vitamin A deficiency facilitates alzheimer’s pathogenesis. Acta Neuropathol. 2017, 133, 967–982.
  258. Shahar, S.; Lee, L.K.; Rajab, N.; Lim, C.L.; Harun, N.A.; Noh, M.F.N.M.; Mian-Then, S.; Jamal, R. Association between Vitamin A, Vitamin E and apolipoprotein e status with mild cognitive impairment among elderly people in low-cost residential areas. Nutr. Neurosci. 2013, 16, 6–12.
  259. Yuan, C.; Fondell, E.; Ascherio, A.; Okereke, O.I.; Grodstein, F.; Hofman, A.; Willett, W.C. Long-term intake of dietary carotenoids is positively associated with late-life subjective cognitive function in a prospective study in US women. J. Nutr. 2020, 150, 1871–1879.
  260. Zeng, J.; Li, T.; Gong, M.; Jiang, W.; Yang, T.; Chen, J.; Liu, Y.; Chen, L. Marginal vitamin a deficiency exacerbates memory deficits following A?1-42 injection in rats. Curr. Alzheimer Res. 2017, 14, 562–570.
  261. Wołoszynowska-Fraser, M.U.; Kouchmeshky, A.; McCaffery, P. Vitamin A and retinoic acid in cognition and cognitive disease. Annu. Rev. Nutr. 2020, 40, 247–272.
  262. Soutif-Veillon, A.; Ferland, G.; Rolland, Y.; Presse, N.; Boucher, K.; Féart, C.; Annweiler, C. Increased dietary Vitamin K intake is associated with less severe subjective memory complaint among older adults. Maturitas 2016, 93, 131–136.
  263. Chouet, J.; Ferland, G.; Féart, C.; Rolland, Y.; Presse, N.; Boucher, K.; Barberger-Gateau, P.; Beauchet, O.; Annweiler, C. Dietary Vitamin K Intake is associated with cognition and behaviour among geriatric patients: The CLIP study. Nutrients 2015, 7, 6739–6750.
  264. Zhang, C.; Gu, Z.C.; Shen, L.; Pan, M.M.; Yan, Y.D.; Pu, J.; Liu, X.Y.; Lin, H.W. Non-Vitamin K antagonist oral anticoagulants and cognitive impairment in atrial fibrillation: Insights from the meta-analysis of over 90,000 patients of randomized controlled trials and real-world studies. Front. Aging Neurosci. 2018, 10, 258.
  265. Alisi, L.; Cao, R.; De Angelis, C.; Cafolla, A.; Caramia, F.; Cartocci, G.; Librando, A.; Fiorelli, M. The Relationships between vitamin K and cognition: A review of current evidence. Front. Neurol. 2019, 10, 239.
  266. Feart, C.; Helmer, C.; Merle, B.; Herrmann, F.R.; Annweiler, C.; Dartigues, J.F.; Delcourt, C.; Samieri, C. Associations of lower vitamin D concentrations with cognitive decline and long-term risk of dementia and alzheimer’s disease in older adults. Alzheimer’s Dement. 2017, 13, 1207–1216.
  267. Goodwill, A.M.; Szoeke, C. A systematic review and meta-analysis of the effect of low vitamin d on cognition. J. Am. Geriatr. Soc. 2017, 65, 2161–2168.
  268. Dursun, E.; Gezen-Ak, D. Vitamin D Basis of alzheimer’s disease: From genetics to biomarkers. Hormones 2019, 18, 7–15.
  269. Bivona, G.; Gambino, C.M.; Iacolino, G.; Ciaccio, M. Vitamin D and the nervous system. Neurol. Res. 2019, 41, 827–835.
  270. Annweiler, C. Vitamin D in dementia prevention. Ann. N. Y. Acad. Sci. 2016, 1367, 57–63.
  271. Mayne, P.E.; Burne, T.H.J. Vitamin D in synaptic plasticity, cognitive function, and neuropsychiatric illness. Trends Neurosci. 2019, 42, 293–306.
  272. Morello, M.; Landel, V.; Lacassagne, E.; Baranger, K.; Annweiler, C.; Féron, F.; Millet, P. Vitamin D improves neurogenesis and cognition in a mouse model of alzheimer’s disease. Mol. Neurobiol. 2018, 55, 6463–6479.
  273. Pearson, J.F.; Pullar, J.M.; Wilson, R.; Spittlehouse, J.K.; Vissers, M.C.M.; Skidmore, P.M.L.; Willis, J.; Cameron, V.A.; Carr, A.C. Vitamin C status correlates with markers of metabolic and cognitive health in 50-Year-Olds: Findings of the CHALICE cohort study. Nutrients 2017, 9, 831.
  274. Von Arnim, C.A.F.; Herbolsheimer, F.; Nikolaus, T.; Peter, R.; Biesalski, H.K.; Ludolph, A.C.; Riepe, M.; Nagel, G. Dietary antioxidants and dementia in a population-based case-control study among older people in south germany. J. Alzheimer’s Dis. 2012, 31, 717–724.
  275. Beydoun, M.A.; Fanelli-Kuczmarski, M.T.; Kitner-Triolo, M.H.; Beydoun, H.A.; Kaufman, J.S.; Mason, M.A.; Evans, M.K.; Zonderman, A.B. Dietary antioxidant intake and its association with cognitive function in an ethnically diverse sample of US adults. Psychosom. Med. 2015, 77, 68–82.
  276. Farina, N.; Llewellyn, D.; Isaac, M.G.E.K.N.; Tabet, N. Vitamin E for alzheimer’s dementia and mild cognitive impairment. Cochrane Database Syst. Rev. 2017, 2017, CD002854.
  277. Monacelli, F.; Acquarone, E.; Giannotti, C.; Borghi, R.; Nencioni, A. Vitamin C, aging and alzheimer’s disease. Nutrients 2017, 9, 670.
  278. Jahanshahi, M.; Nikmahzar, E.; Sayyahi, A. Vitamin E therapy prevents the accumulation of congophilic amyloid plaques and neurofibrillary tangles in the hippocampus in a rat model of alzheimer’s disease. Iran. J. Basic Med. Sci. 2020, 23, 86–92.
  279. Gugliandolo, A.; Bramanti, P.; Mazzon, E. Role of vitamin E in the treatment of alzheimer’s disease: Evidence from animal models. Int. J. Mol. Sci. 2017, 18, 2504.
  280. Reddy, V.S.; Bukke, S.; Dutt, N.; Rana, P.; Pandey, A.K. A Systematic review and meta-analysis of the circulatory, erythrocellular and CSF selenium levels in alzheimer’s disease: A metal meta-analysis (AMMA Study-I). J. Trace Elem. Med. Biol. 2017, 42, 68–75.
  281. Varikasuvu, S.R.; Prasad, V.S.; Kothapalli, J.; Manne, M. Brain selenium in alzheimer’s disease (BRAIN SEAD Study): A systematic review and meta-analysis. Biol. Trace Elem. Res. 2019, 189, 361–369.
  282. Solovyev, N.D. Importance of selenium and selenoprotein for brain function: From antioxidant protection to neuronal signalling. J. Inorg. Biochem. 2015, 153, 1–12.
  283. Martínez Leo, E.E.; Segura Campos, M.R. Effect of ultra-processed diet on gut microbiota and thus its role in neurodegenerative diseases. Nutrition 2020, 71, 110609.
  284. Fieldhouse, J.L.P.; Doorduijn, A.S.; de Leeuw, F.A.; Verhaar, B.J.H.; Koene, T.; Wesselman, L.M.P.; de van der Schueren, M.; Visser, M.; van de Rest, O.; Scheltens, P.; et al. A suboptimal diet is associated with poorer cognition: The NUDAD project. Nutrients 2020, 12, 703.
  285. Chong, C.P.; Shahar, S.; Haron, H.; Che Din, N. Habitual sugar intake and cognitive impairment among multi-ethnic malaysian older adults. Clin. Interv. Aging 2019, 14, 1331–1342.
  286. Watt, C.; Sanchez-Rangel, E.; Hwang, J.J. Glycemic variability and CNS inflammation: Reviewing the connection. Nutrients 2020, 12, 3906.
  287. Sensi, S.L.; Granzotto, A.; Siotto, M.; Squitti, R. Copper and zinc dysregulation in alzheimer’s disease. Trends Pharmacol. Sci. 2018, 39, 1049–1063.
  288. Huat, T.J.; Camats-Perna, J.; Newcombe, E.A.; Valmas, N.; Kitazawa, M.; Medeiros, R. Metal toxicity links to alzheimer’s disease and neuroinflammation. J. Mol. Biol. 2019, 431, 1843–1868.
  289. Martins, A.C.; Morcillo, P.; Ijomone, O.M.; Venkataramani, V.; Harrison, F.E.; Lee, E.; Bowman, A.B.; Aschner, M. New insights on the role of manganese in alzheimer’s disease and parkinson’s disease. Int. J. Environ. Res. Public Health 2019, 16, 3546.
  290. Pedditzi, E.; Peters, R.; Beckett, N. The risk of overweight/obesity in mid-life and late life for the development of dementia: A systematic review and meta-analysis of longitudinal studies. Age Ageing 2016, 45, 14–21.
  291. Profenno, L.A.; Porsteinsson, A.P.; Faraone, S.V. Meta-analysis of alzheimer’s disease risk with obesity, diabetes, and related disorders. Biol. Psychiatry 2010, 67, 505–512.
  292. Yang, Y.; Shields, G.S.; Guo, C.; Liu, Y. Executive function performance in obesity and overweight individuals: A meta-analysis and review. Neurosci. Biobehav. Rev. 2018, 84, 225–244.
  293. Longo, V.D.; Panda, S. Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan. Cell Metab. 2016, 23, 1048–1059.
  294. Manoogian, E.N.C.; Panda, S. Circadian rhythms, time-restricted feeding, and healthy aging. Ageing Res. Rev. 2017, 39, 59–67.
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