Twin-Screw Granulation: Comparison
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Please note this is a comparison between Version 2 by Karina Chen and Version 1 by Dennis Douroumis.

Twin-screw granulation (TSG) is a pharmaceutical process that has gained increased interest from the pharmaceutical industry for its potential for the development of oral dosage forms. The technology has evolved rapidly due to the flexibility of the equipment design, the selection of the process variables and the wide range of processed materials. Most importantly, TSG offers the benefits of both batch and continuous manufacturing for pharmaceutical products, accompanied by excellent process control, high product quality which can be achieved through the implementation of Quality by Design (QbD) approaches and the integration of Process Analytical Tools (PAT). 

  • twin-screw granulation
  • granulation mechanisms
  • PAT tools
  • QbD
  • continuous processing
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References

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