Xanthophylls from the Sea: Comparison
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Please note this is a comparison between Version 2 by Camila Xu and Version 1 by Miguel Prieto Lage.

Xanthophylls (fucoxanthin, astaxanthin, lutein, zeaxanthin, and β-cryptoxanthin) are a type of carotenoids with anti-tumor and anti-inflammatory activities, due to their chemical structure rich in double bonds that provides them with antioxidant properties.

  • carotenoids
  • xanthophylls
  • natural compounds
  • algae
  • bioactive
  • health
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References

  1. Plaza, M.; Santoyo, S.; Jaime, L.; García-Blairsy Reina, G.; Herrero, M.; Señoráns, F.J.; Ibáñez, E. Screening for Bioactive Compounds from Algae. J. Pharm. Biomed. Anal. 2010, 51, 450–455.
  2. Yamamoto, K.; Ishikawa, C.; Katano, H.; Yasumoto, T.; Mori, N. Fucoxanthin and Its Deacetylated Product, Fucoxanthinol, Induce Apoptosis of Primary Effusion Lymphomas. Cancer Lett. 2011.
  3. Kanda, H.; Kamo, Y.; Machmudah, S.; Wahyudiono; Goto, M. Extraction of Fucoxanthin from Raw Macroalgae Excluding Drying and Cell Wall Disruption by Liquefied Dimethyl Ether. Mar. Drugs 2014, 12, 2383–2396.
  4. Alves, C.; Pinteus, S.; Simões, T.; Horta, A.; Silva, J.; Tecelão, C.; Pedrosa, R. Bifurcaria Bifurcata: A Key Macro-Alga as a Source of Bioactive Compounds and Functional Ingredients. Int. J. Food Sci. Technol. 2016, 51, 1638–1646.
  5. AGRIOS, G.N. Plant diseases caused by parasitic higher plants, invasive climbing plants, and parasitic green algae. In Plant Pathology; Springer: San Diego, CA, USA, 2005; pp. 705–722.
  6. Ibañez, E.; Cifuentes, A. Benefits of Using Algae as Natural Sources of Functional Ingredients. J. Sci. Food Agric. 2013, 93, 703–709.
  7. Barkia, I.; Saari, N.; Manning, S.R. Microalgae for High-Value Products towards Human Health and Nutrition. Mar. Drugs 2019, 17, 304.
  8. Kosanić, M.; Ranković, B.; Stanojković, T. Biological Activities of Two Macroalgae from Adriatic Coast of Montenegro. Saudi J. Biol. Sci. 2015, 22, 390–397.
  9. Poojary, M.M.; Barba, F.J.; Aliakbarian, B.; Donsì, F.; Pataro, G.; Dias, D.A.; Juliano, P. Innovative Alternative Technologies to Extract Carotenoids from Microalgae and Seaweeds. Mar. Drugs 2016, 14, 1–34.
  10. El Gamal, A.A. Biological Importance of Marine Algae. Saudi Pharm. J. 2010, 18, 1–25.
  11. García, J.L.; de Vicente, M.; Galán, B. Microalgae, Old Sustainable Food and Fashion Nutraceuticals. Microb. Biotechnol. 2017, 10, 1017–1024.
  12. Andersen, R.A. Diversity of Eukaryotic Algae. Biodivers. Conserv. 1992, 1, 267–292.
  13. Gong, M.; Bassi, A. Carotenoids from Microalgae: A Review of Recent Developments. Biotechnol. Adv. 2016, 34, 1396–1412.
  14. Vílchez, C.; Forján, E.; Cuaresma, M.; Bédmar, F.; Garbayo, I.; Vega, J.M. Marine Carotenoids: Biological Functions and Commercial Applications. Mar. Drugs 2011, 9, 319–333.
  15. Beutner, S.; Bloedorn, B.; Frixel, S.; Blanco, I.H.; Hoffmann, T.; Martin, H.D.; Mayer, B.; Noack, P.; Ruck, C.; Schmidt, M.; et al. Quantitative Assessment of Antioxidant Properties of Natural Colorants and Phytochemicals: Carotenoids, Flavonoids, Phenols and Indigoids. The Role of β-Carotene in Antioxidant Functions. J. Sci. Food Agric. 2001, 81, 559–568.
  16. Saadaoui, I.; Rasheed, R.; Abdulrahman, N.; Bounnit, T.; Cherif, M.; Al Jabri, H.; Mraiche, F. Algae-Derived Bioactive Compounds with Anti-Lung Cancer Potential. Mar. Drugs 2020, 18, 197.
  17. Bolhassani, A. Cancer Chemoprevention by Natural Carotenoids as an Efficient Strategy. Anticancer. Agents Med. Chem. 2015, 15, 1026–1031.
  18. Garewal, H. Antioxidants in Oral Cancer Prevention. Am. J. Clin. Nutr. 1995, 62, 1410S–1416S.
  19. Kim, J.; Leite, J.; DeOgburn, R.; Smyth, J.; Clark, R.; Fernandez, M. A Lutein-Enriched Diet Prevents Cholesterol Accumulation and Decreases Oxidized LDL and Inflammatory Cytokines in the Aorta of Guinea Pigs. J. Nutr. 2011, 141, 1458–1463.
  20. Kim, K.N.; Heo, S.J.; Yoon, W.J.; Kang, S.M.; Ahn, G.; Yi, T.H.; Jeon, Y.J. Fucoxanthin Inhibits the Inflammatory Response by Suppressing the Activation of NF-ΚB and MAPKs in Lipopolysaccharide-Induced RAW 264.7 Macrophages. Eur. J. Pharmacol. 2010, 649, 369–375.
  21. Bhatt, T.; Patel, K. Carotenoids: Potent to Prevent Diseases Review. Nat. Products Bioprospect. 2020, 10, 109–117.
  22. Jain, A.; Sirisha, V.L. Algal Carotenoids: Understanding Their Structure, Distribution and Potential Applications in Human Health. Encycl. Mar. Biotechnol. 2020, 33–64.
  23. Pangestuti, R.; Kim, S.K. Biological Activities and Health Benefit Effects of Natural Pigments Derived from Marine Algae. J. Funct. Foods 2011, 3, 255–266.
  24. Wang, W.J.; Wang, G.C.; Zhang, M.; Tseng, C.K. Isolation of Fucoxanthin from the Rhizoid of Laminaria Japonica Aresch. J. Integr. Plant Biol. 2005, 47, 1009–1015.
  25. Peng, J.; Yuan, J.P.; Wu, C.F.; Wang, J.H. Fucoxanthin, a Marine Carotenoid Present in Brown Seaweeds and Diatoms: Metabolism and Bioactivities Relevant to Human Health. Mar. Drugs 2011, 9, 1806–1828.
  26. Ojulari, O.V.; Gi Lee, S.; Nam, J.O. Therapeutic Effect of Seaweed Derived Xanthophyl Carotenoid on Obesity Management; Overview of the Last Decade. Int. J. Mol. Sci. 2020, 21, 2502.
  27. Guerin, M.; Huntley, M.E.; Olaizola, M. Haematococcus Astaxanthin: Applications for Human Health and Nutrition. Trends Biotechnol. 2003, 21, 210–216.
  28. Camacho, F.; Macedo, A.; Malcata, F. Potential Industrial Applications and Commercialization of Microalgae in the Functional Food and Feed Industries: A Short Review. Mar. Drugs 2019, 17, 312.
  29. Lorenz, R.; Cysewski, G. Commercial Potential for Haematococcus Microalgae as a Natural Source of Astaxanthin. Trends Biotechnol. 2000, 18, 160–167.
  30. Murthy, K.N.C.; Vanitha, A.; Rajesha, J.; Swamy, M.M.; Sowmya, P.R.; Ravishankar, G.A. In Vivo Antioxidant Activity of Carotenoids from Dunaliella Salina - A Green Microalga. Life Sci. 2005, 76, 1381–1390.
  31. Silva, S.C.; Ferreira, I.C.F.R.; Dias, M.M.; Barreiro, M.F. Microalgae-Derived Pigments: A 10-Year Bibliometric Review and Industry and Market Trend Analysis. Molecules 2020, 25, 3406.
  32. Christaki, E.; Bonos, E.; Giannenasa, I.; Florou-Paneria, P. Functional Properties of Carotenoids Originating from Algae. J. Sci. Food Agric. 2013, 93, 5–11.
  33. Esteban, R.; Martínez, B.; Fernández-Marín, B.; Becerril, J.M.; García-Plazaola, J.I. Carotenoid Composition in Rhodophyta: Insights into Xanthophyll Regulation in Corallina Elongata. Eur. J. Phycol. 2009, 44, 221–230.
  34. Careri, M.; Furlattini, L.; Mangia, A.; Musci, M.; Anklam, E.; Theobald, A.; Von Holst, C. Supercritical Fluid Extraction for Liquid Chromatographic Determination of Carotenoids in Spirulina Pacifica Algae: A Chemometric Approach. J. Chromatogr. A 2001, 912, 61–71.
  35. Sugawara, T.; Ganesan, P.; Li, Z.; Manabe, Y.; Hirata, T. Siphonaxanthin, a Green Algal Carotenoid, as a Novel Functional Compound. Mar. Drugs 2014, 12, 3660–3668.
  36. Graham, J.E.; Bryant, D.A. The Biosynthetic Pathway for Myxol-2′ Fucoside (Myxoxanthophyll) in the Cyanobacterium Synechococcus Sp. Strain PCC 7002. J. Bacteriol. 2009, 191, 3292–3300.
  37. Michalak, I.; Chojnacka, K. Algae as Production Systems of Bioactive Compounds. Eng. Life Sci. 2015, 15, 160–176.
  38. Joel, J. Carotenoids Market by Type (Astaxanthin, Beta-Carotene, Lutein, Lycopene, Canthaxanthin, Zeaxanthin, and Others) for Feed, Food, Supplements, Cosmetics, and Pharmaceuticals-Global Industry Perspective, Comprehensive Analysis, Size, Share, Growth, Segmen. Available online: (accessed on 12 February 2021).
  39. da Silva Vaz, B.; Moreira, J.B.; de Morais, M.G.; Costa, J.A.V. Microalgae as a New Source of Bioactive Compounds in Food Supplements. Curr. Opin. Food Sci. 2016, 7, 73–77.
  40. Mulders, K.J.M.; Lamers, P.P.; Martens, D.E.; Wijffels, R.H. Phototrophic Pigment Production with Microalgae: Biological Constraints and Opportunities. J. Phycol. 2014, 50, 229–242.
  41. Ma, R.; Wang, B.; Chua, E.T.; Zhao, X.; Lu, K.; Ho, S.H.; Shi, X.; Liu, L.; Xie, Y.; Lu, Y.; et al. Comprehensive Utilization of Marine Microalgae for Enhanced Co-Production of Multiple Compounds. Mar. Drugs 2020, 18, 467.
  42. Rao, A.V.; Rao, L.G. Carotenoids and Human Health. Pharmacol. Res. 2007, 55, 207–216.
  43. Kotake-Nara, E.; Nagao, A. Absorption and Metabolism of Xanthophylls. Mar. Drugs 2011, 9, 1024–1037.
  44. Sugawara, T.; Baskaran, V.; Tsuzuki, W.; Nagao, A. Brown Algae Fucoxanthin Is Hydrolyzed to Fucoxanthinol during Absorption by Caco-2 Human Intestinal Cells and Mice. J. Nutr. 2002.
  45. Asai, A.; Sugawara, T.; Ono, H.; Nagao, A. Biotransformation of Fucoxanthinol into Amarouciaxanthin a in Mice and HepG2 Cells: Formation and Cytotoxicity of Fucoxanthin Metabolites. Drug Metab. Dispos. 2004.
  46. Yim, M.J.; Hosokawa, M.; Mizushina, Y.; Yoshida, H.; Saito, Y.; Miyashita, K. Suppressive Effects of Amarouciaxanthin A on 3T3-L1 Adipocyte Differentiation through down-Regulation of PPARγ and C/EBPα MRNA Expression. J. Agric. Food Chem. 2011, 59, 1646–1652.
  47. Hashimoto, T.; Ozaki, Y.; Taminato, M.; Das, S.K.; Mizuno, M.; Yoshimura, K.; Maoka, T.; Kanazawa, K. The Distribution and Accumulation of Fucoxanthin and Its Metabolites after Oral Administration in Mice. Br. J. Nutr. 2009, 102, 242–248.
  48. Wang, X.; Li, H.; Wang, F.; Xia, G.; Liu, H.; Cheng, X.; Kong, M.; Liu, Y.; Feng, C.; Chen, X.; et al. Isolation of Fucoxanthin from Sargassum Thunbergii and Preparation of Microcapsules Based on Palm Stearin Solid Lipid Core. Front. Mater. Sci. 2017, 11, 66–74.
  49. Li, H.; Xu, Y.; Sun, X.; Wang, S.; Wang, J.; Zhu, J.; Wang, D.; Zhao, L. Stability, Bioactivity, and Bioaccessibility of Fucoxanthin in Zein-Caseinate Composite Nanoparticles Fabricated at Neutral PH by Antisolvent Precipitation. Food Hydrocoll. 2018, 84, 379–388.
  50. Dai, J.; Kim, S.M.; Shin, I.S.; Kim, J.D.; Lee, H.Y.; Shin, W.C.; Kim, J.C. Preparation and Stability of Fucoxanthin-Loaded Microemulsions. J. Ind. Eng. Chem. 2014, 20, 2103–2110.
  51. Salvia-Trujillo, L.; Sun, Q.; Um, B.H.; Park, Y.; McClements, D.J. In Vitro and in Vivo Study of Fucoxanthin Bioavailability from Nanoemulsion-Based Delivery Systems: Impact of Lipid Carrier Type. J. Funct. Foods 2015.
  52. Ravi, H.; Baskaran, V. Chitosan-Glycolipid Nanocarriers Improve the Bioavailability of Fucoxanthin via up-Regulation of PPARγ and SRB1 and Antioxidant Activity in Rat Model. J. Funct. Foods 2017, 28, 215–226.
  53. Barros, M.P.; Marin, D.P.; Bolin, A.P.; De Cássia Santos Macedo, R.; Campoio, T.R.; Fineto, C.; Guerra, B.A.; Polotow, T.G.; Vardaris, C.; Mattei, R.; et al. Combined Astaxanthin and Fish Oil Supplementation Improves Glutathione-Based Redox Balance in Rat Plasma and Neutrophils. Chem. Biol. Interact. 2012, 197, 58–67.
  54. Burgos-Díaz, C.; Opazo-Navarrete, M.; Soto-Añual, M.; Leal-Calderón, F.; Bustamante, M. Food-Grade Pickering Emulsion as a Novel Astaxanthin Encapsulation System for Making Powder-Based Products: Evaluation of Astaxanthin Stability during Processing, Storage, and Its Bioaccessibility. Food Res. Int. 2020, 134, 109244.
  55. Liu, C.; Tan, Y.; Xu, Y.; McCleiments, D.J.; Wang, D. Formation, Characterization, and Application of Chitosan/Pectin-Stabilized Multilayer Emulsions as Astaxanthin Delivery Systems. Int. J. Biol. Macromol. 2019, 140, 985–997.
  56. Liu, G.; Hu, M.; Zhao, Z.; Lin, Q.; Wei, D.; Jiang, Y. Enhancing the Stability of Astaxanthin by Encapsulation in Poly (l-Lactic Acid) Microspheres Using a Supercritical Anti-Solvent Process. Particuology 2019, 44, 54–62.
  57. Fratter, A.; Biagi, D.; Cicero, A.F.G. Sublingual Delivery of Astaxanthin through a Novel Ascorbyl Palmitate-Based Nanoemulsion: Preliminary Data. Mar. Drugs 2019, 17, 508.
  58. Ligia Focsan, A.; Polyakov, N.E.; Kispert, L.D. Supramolecular Carotenoid Complexes of Enhanced Solubility and Stability — The Way of Bioavailability Improvement. Molecules 2019, 24, 3947.
  59. Tudor, C.; Bohn, T.; Iddir, M.; Dulf, F.V.; Focşan, M.; Rugină, D.O.; Pintea, A. Sea Buckthorn Oil as a Valuable Source of Bioaccessible Xanthophylls. Nutrients 2020, 12, 76.
  60. Bernaerts, T.M.M.; Verstreken, H.; Dejonghe, C.; Gheysen, L.; Foubert, I.; Grauwet, T.; Van Loey, A.M. Cell Disruption of Nannochloropsis Sp. Improves in Vitro Bioaccessibility of Carotenoids and Ω3-LC-PUFA. J. Funct. Foods 2020, 65, 103770.
  61. Khachik, F.; Steck, A.; Pfander, H. Bioavailability, Metabolism, and Possible Mechanism of Chemoprevention by Lutein and Lycopene in Humans. Food Factors Cancer Prev. 1997, 542–547.
  62. Arathi, B.P.; Sowmya, P.R.-R.; Vijay, K.; Baskaran, V.; Lakshminarayana, R. Biofunctionality of Carotenoid Metabolites: An Insight into Qualitative and Quantitative Analysis. In Metabolomics - Fundamentals and Applications; IntechOpen: London, UK, 2016; p. 19.
  63. Khachik, F.; Englert, G.; Beecher, G.R.; Cecil Smith, J. Isolation, Structural Elucidation, and Partial Synthesis of Lutein Dehydration Products in Extracts from Human Plasma. J. Chromatogr. B Biomed. Sci. Appl. 1995, 670, 219–233.
  64. Giordano, E.; Quadro, L. Lutein, Zeaxanthin and Mammalian Development: Metabolism, Functions and Implications for Health. Arch. Biochem. Biophys. 2018, 647, 33–40.
  65. Berg, J.; Lin, D. Lutein and Zeaxanthin: An Overview of Metabolism and Eye Health. J. Hum. Nutr. Food Sci. 2014, 2, 1039.
  66. Eggersdorfer, M.; Wyss, A. Carotenoids in Human Nutrition and Health. Arch. Biochem. Biophys. 2018, 652, 18–26.
  67. Maiani, G.; Castón, M.J.P.; Catasta, G.; Toti, E.; Cambrodón, I.G.; Bysted, A.; Granado-Lorencio, F.; Olmedilla-Alonso, B.; Knuthsen, P.; Valoti, M.; et al. Carotenoids: Actual Knowledge on Food Sources, Intakes, Stability and Bioavailability and Their Protective Role in Humans. Mol. Nutr. Food Res. 2009, 53, 194–218.
  68. Genç, Y.; Bardakci, H.; Yücel, Ç.; Karatoprak, G.Ş.; Akkol, E.K.; Barak, T.H.; Sobarzo-Sánchez, E. Oxidative Stress and Marine Carotenoids: Application by Using Nanoformulations. Mar. Drugs 2020, 18, 423.
  69. Fernández-García, E.; Carvajal-Lérida, I.; Pérez-Gálvez, A. In Vitro Bioaccessibility Assessment as a Prediction Tool of Nutritional Efficiency. Nutr. Res. 2009, 29, 751–760.
  70. Helena de Abreu-Martins, H.; Artiga-Artigas, M.; Hilsdorf Piccoli, R.; Martín-Belloso, O.; Salvia-Trujillo, L. The Lipid Type Affects the in Vitro Digestibility and β-Carotene Bioaccessibility of Liquid or Solid Lipid Nanoparticles. Food Chem. 2020, 311, 126024.
  71. Iddir, M.; Dingeo, G.; Porras Yaruro, J.F.; Hammaz, F.; Borel, P.; Schleeh, T.; Desmarchelier, C.; Larondelle, Y.; Bohn, T. Influence of Soy and Whey Protein, Gelatin and Sodium Caseinate on Carotenoid Bioaccessibility. Food Funct. 2020, 11, 5446–5459.
  72. Huo, T.; Ferruzzi, M.G.; Schwartz, S.J.; Failla, M.L. Impact of Fatty Acyl Composition and Quantity of Triglycerides on Bioaccessibility of Dietary Carotenoids. J. Agric. Food Chem. 2007, 55, 8950–8957.
  73. Bohn, T.; Mcdougall, G.J.; Alegría, A.; Alminger, M.; Arrigoni, E.; Aura, A.M.; Brito, C.; Cilla, A.; El, S.N.; Karakaya, S.; et al. Mind the Gap-Deficits in Our Knowledge of Aspects Impacting the Bioavailability of Phytochemicals and Their Metabolites-a Position Paper Focusing on Carotenoids and Polyphenols. Mol. Nutr. Food Res. 2015, 59, 1307–1323.
  74. Chitchumroonchokchai, C.; Failla, M.L. Bioaccessibility and Intestinal Cell Uptake of Astaxanthin from Salmon and Commercial Supplements. Food Res. Int. 2017, 99, 936–943.
  75. Tyssandier, V.; Lyan, B.; Borel, P. Main Factors Governing the Transfer of Carotenoids from Emulsion Lipid Droplets to Micelles. Biochim. Biophys. Acta - Mol. Cell Biol. Lipids 2001, 1533, 285–292.
  76. Borel, P.; Lietz, G.; Goncalves, A.; Szabo de Edelenyi, F.; Lecompte, S.; Curtis, P.; Goumidi, L.; Caslake, M.J.; Miles, E.A.; Packard, C.; et al. CD36 and Sr-Bi Are Involved in Cellular Uptake of Provitamin a Carotenoids by Caco-2 and Hek Cells, and Some of Their Genetic Variants Are Associated with Plasma Concentrations of These Micronutrients in Humans. J. Nutr. 2013, 143, 448–456.
  77. O’Connell, O.F.; Ryan, L.; O’Brien, N.M. Xanthophyll Carotenoids Are More Bioaccessible from Fruits than Dark Green Vegetables. Nutr. Res. 2007, 27, 258–264.
  78. Borel, P.; Grolier, P.; Armand, M.; Partier, A.; Lafont, H.; Lairon, D.; Azais-Braesco, V. Carotenoids in Biological Emulsions: Solubility, Surface-to-Core Distribution, and Release from Lipid Droplets. J. Lipid Res. 1996, 37, 250–261.
  79. Bohn, T.; Desmarchelier, C.; Dragsted, L.O.; Nielsen, C.S.; Stahl, W.; Rühl, R.; Keijer, J.; Borel, P. Host-Related Factors Explaining Interindividual Variability of Carotenoid Bioavailability and Tissue Concentrations in Humans. Mol. Nutr. Food Res. 2017, 61, 1–37.
  80. Sy, C.; Gleize, B.; Dangles, O.; Landrier, J.F.; Veyrat, C.C.; Borel, P. Effects of Physicochemical Properties of Carotenoids on Their Bioaccessibility, Intestinal Cell Uptake, and Blood and Tissue Concentrations. Mol. Nutr. Food Res. 2012, 56, 1385–1397.
  81. Reboul, E. Mechanisms of Carotenoid Intestinal Absorption: Where Do We Stand? Nutrients 2019, 11, 838.
  82. Guo, B.; Oliviero, T.; Fogliano, V.; Ma, Y.; Chen, F.; Capuano, E. Gastrointestinal Bioaccessibility and Colonic Fermentation of Fucoxanthin from the Extract of the Microalga Nitzschia Laevis. J. Agric. Food Chem. 2020, 68, 1844–1850.
  83. Sugawara, T.; Kushiro, M.; Zhang, H.; Nara, E.; Ono, H.; Nagao, A. Lysophosphatidylcholine Enhances Carotenoid Uptake from Mixed Micelles by Caco-2 Human Intestinal Cells. J. Nutr. 2001, 131, 2921–2927.
  84. Mikami, N.; Hosokawa, M.; Miyashita, K.; Sohma, H.; Ito, Y.M.; Kokai, Y. Reduction of HbA1c Levels by Fucoxanthin-Enriched Akamoku Oil Possibly Involves the Thrifty Allele of Uncoupling Protein 1 (UCP1): A Randomised Controlled Trial in Normal-Weight and Obese Japanese Adults. Sapporo Med. J. 2017, 86, 108–109.
  85. Asai, A.; Yonekura, L.; Nagao, A. Low Bioavailability of Dietary Epoxyxanthophylls in Humans. Br. J. Nutr. 2008, 100, 273–277.
  86. Mimoun-Benarroch, M.; Hogot, C.; Rhazi, L.; Niamba, C.N.; Depeint, F. The Bioavailability of Astaxanthin Is Dependent on Both the Source and the Isomeric Variants of the Molecule. Bull. Univ. Agric. Sci. Vet. Med. Cluj-Napoca. Food Sci. Technol. 2016, 73, 61.
  87. Yang, C.; Zhang, H.; Liu, R.; Zhu, H.; Zhang, L.; Tsao, R. Bioaccessibility, Cellular Uptake, and Transport of Astaxanthin Isomers and Their Antioxidative Effects in Human Intestinal Epithelial Caco-2 Cells. J. Agric. Food Chem. 2017, 65, 10223–10232.
  88. Park, J.S.; Chyun, J.H.; Kim, Y.K.; Line, L.L.; Chew, B.P. Astaxanthin Decreased Oxidative Stress and Inflammation and Enhanced Immune Response in Humans. Nutr. Metab. 2010, 7, 1–10.
  89. Vollmer, D.L.; West, V.A.; Lephart, E.D. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int. J. Mol. Sci. 2018, 19, 3059.
  90. Odeberg, J.M.; Lignell, Å.; Pettersson, A.; Höglund, P. Oral Bioavailability of the Antioxidant Astaxanthin in Humans Is Enhanced by Incorporation of Lipid Based Formulations. Eur. J. Pharm. Sci. 2003, 19, 299–304.
  91. Liu, Y.; Huang, L.; Li, D.; Wang, Y.; Chen, Z.; Zou, C.; Liu, W.; Ma, Y.; Cao, M.J.; Liu, G.M. Re-Assembled Oleic Acid-Protein Complexes as Nano-Vehicles for Astaxanthin: Multispectral Analysis and Molecular Docking. Food Hydrocoll. 2020, 103, 105689.
  92. Olson, J.A. Absorption, Transport, and Metabolism of Carotenoids in Humans. Pure Appl. Chem. 1994, 66, 1011–1016.
  93. do Nascimento, T.C.; Pinheiro, P.N.; Fernandes, A.S.; Murador, D.C.; Neves, B.V.; de Menezes, C.R.; de Rosso, V.V.; Jacob-Lopes, E.; Zepka, L.Q. Bioaccessibility and Intestinal Uptake of Carotenoids from Microalgae Scenedesmus Obliquus. LWT 2021, 140, 110780.
  94. Dhuique-Mayer, C.; Borel, P.; Reboul, E.; Caporiccio, B.; Besancon, P.; Amiot, M.J. β-Cryptoxanthin from Citrus Juices: Assessment of Bioaccessibility Using an in Vitro Digestion/Caco-2 Cell Culture Model. Br. J. Nutr. 2007, 97, 883–890.
  95. Burri, B.J.; Chang, J.S.T.; Neidlinger, T.R. Βcryptoxanthin- and α-Carotene-Rich Foods Have Greater Apparent Bioavailability than Βcarotene-Rich Foods in Western Diets. Br. J. Nutr. 2011, 105, 212–219.
  96. Johnson, E.J. Role of Lutein and Zeaxanthin in Visual and Cognitive Function throughout the Lifespan. Nutr. Rev. 2014, 72, 605–612.
  97. Bernstein, P.S.; Li, B.; Vachali, P.P.; Gorusupudi, A.; Shyam, R.; Henriksen, B.S.; Nolan, J.M. Lutein, Zeaxanthin, and Meso-Zeaxanthin: The Basic and Clinical Science Underlying Carotenoid-Based Nutritional Interventions against Ocular Disease. Prog. Retin. Eye Res. 2016, 50, 34–66.
  98. Torregrosa-Crespo, J.; Montero, Z.; Fuentes, J.L.; García-Galbis, M.R.; Garbayo, I.; Vílchez, C.; Martínez-Espinosa, R.M. Exploring the Valuable Carotenoids for the Large-Scale Production by Marine Microorganisms. Mar. Drugs 2018, 16, 203.
  99. Fernández-García, E.; Carvajal-Lérida, I.; Jarén-Galán, M.; Garrido-Fernández, J.; Pérez-Gálvez, A.; Hornero-Méndez, D. Carotenoids Bioavailability from Foods: From Plant Pigments to Efficient Biological Activities. Food Res. Int. 2012, 46, 438–450.
  100. Hempel, J.; Schädle, C.N.; Sprenger, J.; Heller, A.; Carle, R.; Schweiggert, R.M. Ultrastructural Deposition Forms and Bioaccessibility of Carotenoids and Carotenoid Esters from Goji Berries (Lycium Barbarum L.). Food Chem. 2017, 218, 525–533.
  101. Gille, A.; Neumann, U.; Louis, S.; Bischoff, S.C.; Briviba, K. Microalgae as a Potential Source of Carotenoids: Comparative Results of an in Vitro Digestion Method and a Feeding Experiment with C57BL/6J Mice. J. Funct. Foods 2018, 49, 285–294.
  102. Rodrigues, D.B.; Chitchumroonchokchai, C.; Mariutti, L.R.B.; Mercadante, A.Z.; Failla, M.L. Comparison of Two Static in Vitro Digestion Methods for Screening the Bioaccessibility of Carotenoids in Fruits, Vegetables, and Animal Products. J. Agric. Food Chem. 2017, 65, 11220–11228.
  103. Niranjana, R.; Gayathri, R.; Nimish Mol, S.; Sugawara, T.; Hirata, T.; Miyashita, K.; Ganesan, P. Carotenoids Modulate the Hallmarks of Cancer Cells. J. Funct. Foods 2015, 18, 968–985.
  104. Marco, G.J. A Rapid Method for Evaluation of Antioxidants. J. Am. Oil Chem. Soc. 1968, 45, 594–598.
  105. Kaulmann, A.; Bohn, T. Carotenoids, Inflammation, and Oxidative Stress-Implications of Cellular Signaling Pathways and Relation to Chronic Disease Prevention. Nutr. Res. 2014, 34, 907–929.
  106. Moloney, J.N.; Cotter, T.G. ROS Signalling in the Biology of Cancer. Semin. Cell Dev. Biol. 2018, 80, 50–64.
  107. Crusz, S.M.; Balkwill, F.R. Inflammation and Cancer: Advances and New Agents. Nat. Rev. Clin. Oncol. 2015, 12, 584–596.
  108. Heo, S.J.; Yoon, W.J.; Kim, K.N.; Oh, C.; Choi, Y.U.; Yoon, K.T.; Kang, D.H.; Qian, Z.J.; Choi, I.W.; Jung, W.K. Anti-Inflammatory Effect of Fucoxanthin Derivatives Isolated from Sargassum Siliquastrum in Lipopolysaccharide-Stimulated RAW 264.7 Macrophage. Food Chem. Toxicol. 2012, 50, 3336–3342.
  109. Kim, E.A.; Kim, S.Y.; Ye, B.R.; Kim, J.; Ko, S.C.; Lee, W.W.; Kim, K.N.; Choi, I.W.; Jung, W.K.; Heo, S.J. Anti-Inflammatory Effect of Apo-9′-Fucoxanthinone via Inhibition of MAPKs and NF-KB Signaling Pathway in LPS-Stimulated RAW 264.7 Macrophages and Zebrafish Model. Int. Immunopharmacol. 2018, 59, 339–346.
  110. Shiratori, K.; Ohgami, K.; Ilieva, I.; Jin, X.H.; Koyama, Y.; Miyashita, K.; Yoshida, K.; Kase, S.; Ohno, S. Effects of Fucoxanthin on Lipopolysaccharide-Induced Inflammation in Vitro and in Vivo. Exp. Eye Res. 2005, 81, 422–428.
  111. Kim, K.; Ahn, G.; Heo, S.; Kang, S.; Kang, M.; Yang, H.; Kim, D.; Woon, S.; Kim, S.; Jeon, B.; et al. Inhibition of Tumor Growth in Vitro and in Vivo by Fucoxanthin against Melanoma B16F10 Cells. Environ. Toxicol. Pharmacol. 2012, 35, 39–46.
  112. Hosokawa, M.; Wanezaki, S.; Miyauchi, K.; Kurihara, H.; Kohno, H.; Kawabata, J.; Odashima, S.; Takahashi, K. Apoptosis-Inducing Effect of Fucoxanthin on Human Leukemia Cell Line HL-60. Food Sci. Technol. Res. 1999, 5, 243–246.
  113. Farruggia, C.; Kim, M.B.; Bae, M.; Lee, Y.; Pham, T.X.; Yang, Y.; Han, M.J.; Park, Y.K.; Lee, J.Y. Astaxanthin Exerts Anti-Inflammatory and Antioxidant Effects in Macrophages in NRF2-Dependent and Independent Manners. J. Nutr. Biochem. 2018, 62, 202–209.
  114. Bi, J.; Cui, R.; Li, Z.; Liu, C.; Zhang, J. Astaxanthin Alleviated Acute Lung Injury by Inhibiting Oxidative/Nitrative Stress and the Inflammatory Response in Mice. Biomed. Pharmacother. 2017, 95, 974–982.
  115. Palozza, P.; Torelli, C.; Boninsegna, A.; Simone, R.; Catalano, A.; Mele, M.C.; Picci, N. Growth-Inhibitory Effects of the Astaxanthin-Rich Alga Haematococcus Pluvialis in Human Colon Cancer Cells. Cancer Lett. 2009, 283, 108–117.
  116. Yasui, Y.; Hosokawa, M.; Mikami, N.; Miyashita, K.; Tanaka, T. Dietary Astaxanthin Inhibits Colitis and Colitis-Associated Colon Carcinogenesis in Mice via Modulation of the Inflammatory Cytokines. Chem. Biol. Interact. 2011, 193, 79–87.
  117. Xu, X.R.; Zou, Z.Y.; Xiao, X.; Huang, Y.M.; Wang, X.; Lin, X.M. Effects of Lutein Supplement on Serum Inflammatory Cytokines, ApoE and Lipid Profiles in Early Atherosclerosis Population. J. Atheroscler. Thromb. 2013, 20, 170–177.
  118. Rubin, L.P.; Chan, G.M.; Barrett-Reis, B.M.; Fulton, A.B.; Hansen, R.M.; Ashmeade, T.L.; Oliver, J.S.; MacKey, A.D.; Dimmit, R.A.; Hartmann, E.E.; et al. Effect of Carotenoid Supplementation on Plasma Carotenoids, Inflammation and Visual Development in Preterm Infants. J. Perinatol. 2012, 32, 418–424.
  119. Narisawa, T.; Fukaura, Y.; Hasebe, M.; Ito, M.; Aizawa, R.; Murakoshi, M.; Uemura, S.; Khachik, F.; Nishino, H. Inhibitory Effects of Natural Carotenoids, α-Carotene, β-Carotene, Lycopene and Lutein, on Colonic Aberrant Crypt Foci Formation in Rats. Cancer Lett. 1996, 107, 137–142.
  120. Altieri, M.; Nicholls, C.; Molina, M.G.D.; Ugas, R.; Midas, P.; Méndez, V.E. Plan and Operation of the Third National Health and Nutrition Examination Survey, 1988-94. Series 1: Programs and Collection Procedures. Vital Health Stat. 1. 1994, 7, 1–407.
  121. Min, K.B.; Min, J.Y. Serum Carotenoid Levels and Risk of Lung Cancer Death in US Adults. Cancer Sci. 2014, 105, 736–743.
  122. Gao, M.; Dang, F.; Deng, C. β-Cryptoxanthin Induced Anti-Proliferation and Apoptosis by G0/G1 Arrest and AMPK Signal Inactivation in Gastric Cancer. Eur. J. Pharmacol. 2019, 859, 172528.
  123. Iskandar, A.R.; Liu, C.; Smith, D.E.; Hu, K.Q.; Choi, S.W.; Ausman, L.M.; Wang, X.D. β-Cryptoxanthin Restores Nicotine-Reduced Lung SIRT1 to Normal Levels and Inhibits Nicotine-Promoted Lung Tumorigenesis and Emphysema in A/J Mice. Cancer Prev. Res. 2013, 6, 309–320.
  124. Liu, C.; Bronson, R.T.; Russell, R.M.; Wang, X.-D. β-Cryptoxanthin Supplementation Prevents Cigarette Smoke-Induced Lung Inflammation, Oxidative Damage, and Squamous Metaplasia in Ferrets. Cancer Prev. Res. 2011, 4, 1255–1266.
  125. Ganesan, P.; Noda, K.; Manabe, Y.; Ohkubo, T.; Tanaka, Y.; Maoka, T.; Sugawara, T.; Hirata, T. Siphonaxanthin, a Marine Carotenoid from Green Algae, Effectively Induces Apoptosis in Human Leukemia (HL-60) Cells. Biochim. Biophys. Acta - Gen. Subj. 2011, 1810, 497–503.
  126. Palozza, P.; Sestito, R.; Picci, N.; Lanza, P.; Monego, G.; Ranelletti, F.O. The Sensitivity to β-Carotene Growth-Inhibitory and Proapoptotic Effects Is Regulated by Caveolin-1 Expression in Human Colon and Prostate Cancer Cells. Carcinogenesis 2008, 29, 2153–2161.
  127. Rubin, L.P.; Ross, A.C.; Stephensen, C.B.; Bohn, T.; Tanumihardjo, S.A. Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models. Adv. Nutr. An Int. Rev. J. 2017, 8, 197–212.
  128. Gallicchio, L.; Boyd, K.; Matanoski, G.; Tao, X.; Chen, L.; Lam, T.K.; Shiels, M.; Hammond, E.; Robinson, K.A.; Caulfield, L.E.; et al. Carotenoids and the Risk of Developing Lung Cancer: A Systematic Review. Am. J. Clin. Nutr. 2008, 88, 372–383.
  129. The ATBC Cancer Prevention Study Group. The Alpha-Tocopherol, Beta-Carotene Lung Cancer Prevention Study: Design, Methods, Participant Characteristics, and Compliance. Ann. Epidemiol. 1994, 4, 1–10.
  130. Lai, G.Y.; Weinstein, S.J.; Taylor, P.R.; McGlynn, K.A.; Virtamo, J.; Gail, M.H.; Albanes, D.; Freedman, N.D. Effects of α-Tocopherol and β-Carotene Supplementation on Liver Cancer Incidence and Chronic Liver Disease Mortality in the ATBC Study. Br. J. Cancer 2014, 111, 2220–2223.
  131. Huang, J.; Weinstein, S.J.; Yu, K.; Männistö, S.; Albanes, D. Serum Beta Carotene and Overall and Cause-Specific Mortality: A Prospective Cohort Study. Circ. Res. 2018, 123, 1339–1349.
  132. Erhardt, J.G.; Meisner, C.; Bode, J.C.; Bode, C. Lycopene, β-Carotene, and Colorectal Adenomas. Am. J. Clin. Nutr. 2003, 78, 1219–1224.
  133. Zhao, L.G.; Zhang, Q.L.; Zheng, J.L.; Li, H.L.; Zhang, W.; Tang, W.G.; Xiang, Y.B. Dietary, Circulating Beta-Carotene and Risk of All-Cause Mortality: A Meta-Analysis from Prospective Studies. Sci. Rep. 2016, 6, 1–10.
  134. Wang, Y.; Cui, R.; Xiao, Y.; Fang, J.; Xu, Q. Effect of Carotene and Lycopene on the Risk of Prostate Cancer: A Systematic Review and Dose-Response Meta-Analysis of Observational Studies. PLoS One 2015, 10, 1–20.
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