Acetylcholinesterase Inhibitors in Alzheimer’s Disease: Comparison
Please note this is a comparison between Version 2 by Rita Xu and Version 1 by Don Moss.

Acetylcholinesterase (AChE) inhibitors are the only drugs that have demonstrated success in slowing shrinkage (atrophy) of the cortex, hippocampus, and basal forebrain, major areas of Alzheimer's disease (AD)-associated brain damage and dementia. The main barrier to taking advantage of this new success in treating, or even preventing, AD is that the old available AChE inhibitors are weak 

reversible

inhibitors that cause intolerable nausea, vomiting, and diarrhea if given in the higher doses needed. A promising new strategy for producing high-level AChE inhibition in the brain as needed for effective treatment of AD is the use of AChE inhibitors that are of a different type, the 

irreversible

inhibitors. 

  • Acetylcholinesterase inhibitor
  • Alzheimer's
  • irreversible inhibitor
  • prophylaxis
Please wait, diff process is still running!

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  97. Haruo Kobayashi; Takuma Nakano; E.Moss Donald; Tadahiko Suzuki; Effects of a Central Anticholinesterase, Methanesulfonyl Fluoride on The Cerebral Cholinergic System and Behavior in Mice : Comparison with an Organophosphate DDVP. JOURNAL OF HEALTH SCIENCE 1999, 45, 191-202, 10.1248/jhs.45.191.
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  106. Kai-Xin Dou; Meng-Shan Tan; Chen-Chen Tan; Xi-Peng Cao; Xiao-He Hou; Qi-Hao Guo; Lan Tan; Vincent Chung-Tong Mok; Jin-Tai Yu; Comparative safety and effectiveness of cholinesterase inhibitors and memantine for Alzheimer’s disease: a network meta-analysis of 41 randomized controlled trials. Alzheimer's Research & Therapy 2018, 10, 126, 10.1186/s13195-018-0457-9.
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  112. David H. Malin; Robert E. Plotner; Sarah J. Radulescu; Robert N. Ferebee; J.Ronald Lake; Pilar G. Negrete; Peggy J. Schaefer; Marie K. Crothers; Donald E. Moss; Chronic methanesulfonyl fluoride enhances one-trial per day reward learning in aged rats. Neurobiology of Aging 1993, 14, 393-395, 10.1016/0197-4580(93)90127-w.
  113. Myers, D.; Kemp, A; Inhibition of esterases by the fluorides of organic acids. Nature 1954, 173, 33–34.
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  117. Sulfonyl Fluorides and the Promotion of Diisopropyl Fluorophosphate Neuropathy. Toxicological Sciences 1996, 33, 294-297, 10.1093/toxsci/33.2.294.
  118. Moss, D.; Keathley, S. Pilot Study to Test Sulfnates’ Ability to Provide Prophylaxis Against Nerve Agents; Technical Report; (Contract No. DAMD 17-87-C-7064); The U.S. Army Medical Research and Development Command: Frederick, MD, USA, 1 July 1988.
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  121. Cesar V. Borlongan; Isabel C. Sumaya; Donald E. Moss; Methanesulfonyl fluoride, an acetylcholinesterase inhibitor, attenuates simple learning and memory deficits in ischemic rats. Brain Research 2005, 1038, 50-58, 10.1016/j.brainres.2005.01.028.
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