Candidiasis (either mucocutaneous or systemic) is an opportunistic infection caused mainly by Candida albicans, a yeast and natural commensal of the human digestive tract and vagina. Unlike true pathogens, the presence of yeasts alone does not indicate their pathogenic character, which depends essentially on the susceptibility of the host and the expression of pathogenicity factors by some yeast strains. It is therefore essential to have markers associated with pathogenicity to understand the mechanisms of infection and to diagnose these infections as accurately as possible. The development of hybridoma technology/advent of monoclonal antibodies (mAbs) led to considerable progress in answering some of these questions. Among the monoclonal antibodies (mAbs) developed, mAb 5B2 allowed us to make considerable progress in understanding the mechanisms of pathogenesis and also contributed to the diagnosis of candidiasis and the tracing of more pathogenic strains.
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