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Suárez, C.E.; Aktaş, M. Bovine Babesiosis. Encyclopedia. Available online: (accessed on 14 June 2024).
Suárez CE, Aktaş M. Bovine Babesiosis. Encyclopedia. Available at: Accessed June 14, 2024.
Suárez, Carlos E., Münir Aktaş. "Bovine Babesiosis" Encyclopedia, (accessed June 14, 2024).
Suárez, C.E., & Aktaş, M. (2020, December 29). Bovine Babesiosis. In Encyclopedia.
Suárez, Carlos E. and Münir Aktaş. "Bovine Babesiosis." Encyclopedia. Web. 29 December, 2020.
Bovine Babesiosis

Bovine babesiosis is a global tick-borne disease that causes important cattle losses and has potential zoonotic implications. The impact of bovine babesiosis in Turkey remains poorly characterized, but several Babesia spp., including B. bovis, B. bigemina, and B. divergens, among others and competent tick vectors, except Rhipicephalus microplus, have been recently identified in the country.

bovine babesiosis Babesia bovine

1. Introduction

An important chapter on animal infectious diseases began in 1888 with the sudden deaths of thousands of cows in Romania [1]. At the time, Victor Babes associated the animal deaths with an intraerythrocytic organism, which he named as “haematococcus.” These organisms were later identified as protozoan parasites, and renamed Babesia to honor its discoverer [2]. A few years later, two researchers in the US, Smith and Kilbourne, found out that Babesia parasites were transmitted by Ixodid ticks, demonstrating for the first time transmission of a parasite by an arthropod vector [3]. Follow up studies have characterized several species of Babesia as tick-transmitted apicomplexan protozoan hemoparasites with veterinary and human importance, and great economic impact worldwide [4]. Babesiosis is a disease that affects many vertebrate hosts, from humans to bats, as well as farm animals, such as cattle, horses, and small ruminants, and companion animals [5]. There are more than 100 Babesia species reported so far, with different host specificities [6]. Here, we focus on bovine babesiosis, a disease with a particular large impact on cattle worldwide. In addition to major economic losses derived from death of animals and decreased production of meat and dairy products, there are other important costs associated with tick control, diagnosis, and treatments required to prevent the disease. Despite the importance, there is no reliable specific quantification of the impact of bovine babesiosis at the global scale, but only independent regional assessments performed in individual countries, such as Brazil, Argentina, Australia, among others, and the estimated losses are in the order of hundreds of millions of US dollars per year.

Babesia parasites have a complex life cycle that includes the development of asexual stages in mammalian hosts and sexual stages inside their definitive tick vectors. Two characteristics that define sensu stricto Babesia parasites are their ability to be transmitted transovarially by tick vectors and exclusively infect red blood cells (RBC) in their vertebrate host. These aspects are particularly important for B. bovis, B. bigemina, and B. divergens, the major causative agents of bovine babesiosis [6][7].

Growth of asexual stages of Babesia parasites inside the vertebrate host RBC causes severe intravascular hemolytic anemia, which is a pathognomonic sign of the acute disease and highly debilitating for the host. Additionally, fever, prostration, abortion, and temporary infertility are also common clinical findings during acute infection. Hemoglobinuria is also usually present at the peak of the hemolytic crisis in B. bigemina or B. divergens infection and in late stages of the disease caused by B. bovis. In addition, residues and toxic metabolites released as a result of the infection and RBC destruction can negatively affect host organ systems [6][7][8]. Moreover, B. bovis has the unique ability to evade the cattle immune system by expressing proteins that facilitate cytoadhesion of infected RBC to capillaries, such as in the brain, causing neurological symptoms and generalized organ failure, a feature that results in increased virulence. Altogether, these pathological mechanisms frequently lead to rapid death of cattle during the acute stage of the disease, especially when affecting adult naïve animals.

Upon infection, the immune system of the host responds differentially, depending on the age of the animals. While young animals, less than seven months old, are frequently able to control severe acute babesiosis and can survive re-exposures to the parasites, older than one-year-old animals often succumb rapidly to infection. Features associated with resistance in young animals include early and strong activation of the innate and adaptive immune effectors. Briefly, the parasite expresses molecules able to bind pathogen associated molecular patterns (PAMPs) receptors expressed on the surface of dendritic cells (DC), macrophages, neutrophils, and monocytes, especially TLR9 [9][10], and an immune response is initiated. Cytokines, such as IL-1β, TNF-α, and IL-12, and nitric oxide (NO) are released from monocytes and neutrophils, and chemokines attract immature DC to the site of infection, especially at the spleen. These stimulate natural killer cells (NKs) that release early IFNγ. The mature DC migrating to the spleen presents Babesia antigens to naive T cells. Spleen macrophages are activated by IFNγ, phagocytize infected RBC, and kill the parasites by releasing reactive nitrogen and oxygen intermediates. In turn, cytokines, such as 1L-1β, IL-12, and TNF-α, released from activated macrophages may inhibit the growth of B. bovis. Activated CD4+ T cells and specific B-cell producing antibodies are also important in maintaining immunity and overcoming the infection [11][12][13][14]. Despite mounting protective adaptive immune responses, animals that survive acute babesiosis develop persistent infection, which allows transmission and perpetuation of Babesia parasites in endemic areas. These areas usually have elevated prevalence of bovine babesiosis but low numbers of clinical cases due to the establishment of endemic stability, a condition of herd immunity that develops when more than 75% of the animals have acquired protective immunity by exposure to the parasite before one year of age, when animals are less susceptible to the parasites. A highly unstable state may occur, in contrast, when less than 30% of the herd is naïve for the disease [15][16][17].

B. bovis and B. bigemina, which are transmitted by Rhipicephalus ticks, are the most important causative agents of bovine babesiosis in tropical and subtropical regions worldwide. In addition, B. divergens is another important Babesia species that is transmitted by Ixodes ticks and affects cattle in Europe and North Africa. Apart from its impact on bovines, B. divergens is especially important as a zoonotic pathogen implicated in human babesiosis in Europe [6][7][8]. Acute bovine babesiosis caused by B. bovis is often severe due to cytoadhesion of infected RBC in the lung, kidney, and brain capillaries, which leads to hypotension, respiratory stress syndrome, neurological symptoms, and death [8][18]. In contrast, B. bigemina induces massive hemolytic anemia without causing the symptoms associated with cytoadhesion [4][6][19]. Also of importance as causative agents of bovine babesiosis are B. ovata, B. major, B. occultans, and additional unclassified Babesia that are characterized by their low pathogenicity in cattle compared to B. bovis, B. bigemina, and B. divergens [8][20][21][22][23][24].

2. An Overview of the Cattle Industry in Turkey

Turkey is a transcontinental country located in the Northern hemisphere with a territory spanning the Anatolian peninsula in Western Asia and a small portion on the Balkan Peninsula in Southeastern Europe. Geographic coordinates of the country lie at latitude 39 and longitude 35. It is a peninsula with a strategic position as a land connection between Europe and Asia. Considering its location, the country has been also regarded as a natural bridge for transcontinental transmission of tick species and tick-borne diseases (TBD) [25]. Turkey covers an area of 783,582 km2 with a population of 82 million people. The country’s economy is based on modern industry, tourism, and trade, and is also heavily supported by the agricultural sector. Therefore, the presence of emerging tick populations and TBD can pose a serious risk to the cattle industry that may impact the overall economy of Turkey and neighboring countries [25][26].

Although the importance of cattle has been different in every society throughout the history of humanity, these animals have always had significant importance in several cultures and religions, and still remain an important economic asset in Turkey and worldwide. There are approximately 66 million farm animals in Turkey, and 27% of which (18 million) are cattle. In Turkey, milk production consisted of 90.5% cattle, 6.6% sheep, and 2.5% goat. As for meat production, 89.5% of the total meat produced in Turkey comes from cattle. According to a report from 2018, approximately 1.5 million live animals are imported to Turkey [27]. Some of these animals come from countries that are endemic for cattle ticks, bovine babesiosis, and other cattle TBD, such as Brazil, from where Turkey obtains 42% of its total imported animals [27][28]. Considering that cattle are a very important source of protein, especially meat and milk production, the cattle industry is a significant sector to secure food supply and sustain the economy in Turkey [27]. Assuring constant supply of cattle milk and meat requires keeping high animal sanitary standards and rational strategies for industry development. In addition, particular attention should be placed in controlling diseases that limit cattle production and may compromise public health. This should be extended to the potential introduction of additional animal health risk factors, such as foreign pathogenic organisms. Taking into consideration the social and economic importance of cattle in Turkey, we argue that the development of a national intensive research program on TBD, specifically in bovine babesiosis, and the implementation of informed animal health policies of disease control based on the state-of-the-art knowledge should be considered issues of crucial importance for the country.

3. Economic Impact of Bovine Babesiosis on the Cattle Industry in Turkey

It is estimated that more than 500 million cattle are at risk of babesiosis worldwide; therefore, this disease poses a major threat to animal health and human livelihood in areas where Babesia parasites and competent tick vectors are present [4]. As an attempt to contain such threat, a radical tick control campaign was launched in the US at the beginning of the 20th century, lasting 40 years and demanding the use of millions of taxpayer’s dollars. With this effective, but costly campaign, bovine babesiosis was eradicated in the US, and consequently approximately $3 billion US dollars annually were saved for the livestock industry [6][29][30]. Unfortunately, the success of this approach was not reproduced in other countries that also attempted similar tick eradication schemes [31], and given a current scenario of increased acaricide resistance in ticks and climate change, among other factors, it is unlikely that this achievement can be duplicated elsewhere [30][31][32].

Annual economic losses due to bovine babesiosis and anaplasmosis in the world range from $16.9 million US dollars in Australia, $21.6 million US dollars in South Africa, and $57.2 million US dollars in China [8]. These losses are not only due to animal mortality, but also abortion, decrease in meat and milk production, and disease control costs (e.g., spraying, vaccination, disease treatments, professional veterinary support, and others). In addition, disease-related deaths are frequently observed in naïve cattle imported to regions with enzootic stability for bovine babesiosis [6][8][33], a factor that causes additional economic losses and complicates the attempts to carry out genetic improvement of herds. In this way, preventing clinical cases of bovine babesiosis by strategies based on maintaining enzootic stability may also interfere with the efforts to improve productivity, such as increased weight and milk production, heavily affecting the meat and dairy industries, respectively, which increases production costs [6][8][17].

Turkey’s geographic location and climatic conditions, in addition to the country’s animal management systems, encourage the occurrence of ticks and TBD [25][26]. The emergence of tick populations and TBD have increased around the globe in the recent years, including in Turkey [25]. Estimation of the amount of TBD drugs sale per year during the disease seasons indirectly shows the importance of these diseases on animal health and in the economy of Turkey [26]. The economic impact of topical theileriosis caused by Theileria annulata, a tick-borne apicomplexa parasite related to Babesia sp., was estimated at a total annual loss of approximately 600,000 US dollars in Turkey [34]. However, despite being considered as a costly burden, the actual economic impact of bovine babesiosis on the cattle industry in Turkey remains largely unknown. Therefore, a well-designed national surveillance study to evaluate the real impact of the disease on the cattle industry in the country is urgently needed.

4. Competent Tick Vectors for Babesia Parasites Identified in Turkey

Tick vectors are essential components for the completion of the life cycle of Babesia parasites. Thus, competent ticks must provide the environment required for sexual reproduction, which occurs in their midgut, and for invasion of tick eggs by the kinete stage of parasites that circulates in the tick hemolymph, an event that ultimately guarantees transovarial transmission of Babesia. A large number of Ixodid tick species are listed as competent Babesia vectors in the literature [5]. Of these, 22 were confirmed vectors for 18 different Babesia species that infect livestock, companion animals, and humans [5]. Identification of pathogen DNA in adult ticks cannot be accepted alone as evidence of vector competence, and more detailed studies on tick-Babesia interactions are needed to establish the tick competence. Additionally, the presence of Babesia DNA in the salivary glands, eggs, and unfed larvae, though more convincing, also requires confirmation as a measure of tick competence [5]. B. bovis and B. bigemina are transmitted by R. annulatus, R. microplus, and R. geigyi ticks found in tropical and temperate regions of the world. B. bigemina can also be transmitted by R. decoloratus and R. evertsi, making it the most common Babesia species infecting cattle in Africa [8][35]. B. divergens are transmitted mainly by I. ricinus, which develops only in moisture-saturated microhabitats [19]. B. occultans, B. major, B. orientalis, and B. ovata are transmitted by Hyalomma rufipes, Haemaphysalis punctata, R. haemaphysaloides, and Hae. longicornis, respectively [5]. A summary of known competent tick vectors implicated in bovine babesiosis is shown in Table 1, where we highlight the species present in Turkey.

Table 1. Babesia spp. currently identified in cattle with proven vectors and geographical distribution.


To date, R. annulatus, R. bursa, R. turanicus, R. sanguineus, Hy. anatolicum, Hy. dromedari, Hy. detritum, Hy. excavatum, Hy. marginatum, Hy. rufipes, Hy. aegyptium, Dermacentor marginatus, D. niveus, I. ricinus, and Hae. parva ticks have been reported infesting cattle in Turkey [25][46], and some of them were associated with transmission of cattle Babesia parasites (Table 1). In a study using ticks collected from cattle in the Black Sea region, Babesia parasites were reported in Hy. marginatum, Hy. Excavatum, and R. turanicus at the rates of 3.5%, 2.3%, and 6.6%, respectively [47]. Babesia sp. Kayseri 1, a novel parasite isolate, was identified in Hy. marginatum feeding on cattle in the Kayseri province located in Central Anatolia [48]. B. bigemina was also reported in unfed larvae from R. annulatus in this same province [48]. In another study in the same region, B. bigemina was found in tick populations of R. annulatus, R. turanicus, Hy. marginatum, and Hy. Anatolicum, whereas B. bovis positive samples were detected in Hy. marginatum ticks [49]. B. occultans was reported in Hy. marginatum and R. turanicus, as well as in their eggs, and thus, these findings suggest that this later tick can also be a competent vector for B. occultans [50]. In another study, B. occultans was identified in questing Hy. marginatum [51]; however, despite the findings, effective transmission of Babesia by these ticks remains to be demonstrated in Turkey.

Collectively, currently available data indicate the presence and expansion of tick populations in Turkey. In addition, most of these tick species have been shown to be competent in transmitting Babesia parasites implicated in bovine babesiosis. Considering the current environmental changes and the importance of the cattle industry in Turkey, epidemiological and entomological studies focused on ticks associated with Babesia transmission are urgently needed in the country. Given the absolute dependence of ticks for parasite survival, identifying all competent vectors for Babesia species circulating in the country and a more complete understanding of the dynamics of the Babesia-tick interactions will be essential to achieve improved control of bovine babesiosis in Turkey.


  1. Babes, V. Sur l’hémoglobinurie bactérienne du boeuf. CR Acad. Sci. Paris 1888, 107, 692–694. [Google Scholar]
  2. Mihalca, A.D.C.; Suteu, E.V.; Marinculic, A.; Boireanu, P. The quest for piroplasms: From babes to smith to molecules. Sci. Parasitol. 2010, 11, 14–19. [Google Scholar]
  3. Smith, T.; Kilbourne, F.L. Investigations into the Nature, Causation, and Prevention of Texas or Southern Cattle Fever, 8th and 9th Reports; U.S. Department of Agriculture, Bureau of Animal Industry: Washington, DC, USA, 1893. [Google Scholar]
  4. Suarez, C.E.; Noh, S. Emerging perspectives in the research of bovine babesiosis and anaplasmosis. Vet. Parasitol. 2011, 180, 109–125. [Google Scholar] [CrossRef] [PubMed]
  5. Gray, J.S.; Estrada-Peña, A.; Zintl, A. Vectors of Babesiosis. Annu. Rev. Èntomol. 2019, 64, 149–165. [Google Scholar] [CrossRef] [PubMed]
  6. Schnittger, L.; Rodriguez, A.E.; Florin-Christensen, M.; Morrison, D.A. Babesia: A world emerging. Infect. Genet. Evol. 2012, 12, 1788–1809. [Google Scholar] [CrossRef] [PubMed]
  7. Uilenberg, G. Babesia—A historical overview. Vet. Parasitol. 2006, 138, 3–10. [Google Scholar] [CrossRef]
  8. Bock, R.; Jackson, L.; De Vos, A.; Jorgensen, W. Babesiosis of cattle. Parasitology 2004, 129, S247–S269. [Google Scholar] [CrossRef] [PubMed]
  9. Brown, W.C.; Estes, D.M.; Chantler, S.E.; Kegerreis, K.A.; Suarez, C.E. DNA and a CpG Oligonucleotide Derived from Babesia bovis Are Mitogenic for Bovine B Cells. Infect. Immun. 1998, 66, 5423–5432. [Google Scholar] [CrossRef] [PubMed]
  10. Brown, W.C.; Norimine, J.; Goff, W.L.; Suarez, C.E.; McElwain, T.F. Prospects for recombinant vaccines against Babesia bovis and related parasites. Parasite Immunol. 2006, 28, 315–327. [Google Scholar] [CrossRef]
  11. Gallego-Lopez, G.M.; Cooke, B.M.; Suarez, C.E. Interplay between Attenuation- and Virulence-Factors of Babesia bovis and Their Contribution to the Establishment of Persistent Infections in Cattle. Pathogens 2019, 8, 97. [Google Scholar] [CrossRef]
  12. Shoda, L.K.M.; Palmer, G.H.; Florin-Christensen, J.; Florin-Christensen, M.; Godson, D.L.; Brown, W.C. Babesia bovis-Stimulated Macrophages Express Interleukin-1β, Interleukin-12, Tumor Necrosis Factor Alpha, and Nitric Oxide and Inhibit Parasite Replication In Vitro. Infect. Immun. 2000, 68, 5139–5145. [Google Scholar] [CrossRef] [PubMed]
  13. Goff, W.; Storset, A.K.; Johnson, W.C.; Brown, W.C. Bovine splenic NK cells synthesize IFN-gamma in response to IL-12-containing supernatants from Babesia bovis-exposed monocyte cultures. Parasite Immunol. 2006, 28, 221–228. [Google Scholar] [CrossRef] [PubMed]
  14. Brown, W.C.; Logan, K.S. Babesia bovis: Bovine helper T cell lines reactive with soluble and membrane antigens of merozoites. Exp. Parasitol. 1992, 74, 188–199. [Google Scholar] [CrossRef]
  15. Wright, I.G.; Goodger, B.V.; Leatch, G.; Aylward, J.H.; Rode-Bramanis, K.; Waltisbuhl, D.J. Protection of Babesia bigemina-immune animals against subsequent challenge with virulent Babesia bovis. Infect. Immun. 1987, 55, 364–368. [Google Scholar] [CrossRef] [PubMed]
  16. Homer, M.J.; Aguilar-Delfin, I.; Telford, S.R.; Krause, P.J.; Persing, D.H. Babesiosis. Clin. Microbiol. Rev. 2000, 13, 451–469. [Google Scholar] [CrossRef] [PubMed]
  17. Florin-Christensen, M.; Suarez, C.E.; Rodriguez, A.E.; Flores, D.A.; Schnittger, L. Vaccines against bovine babesiosis: Where we are now and possible roads ahead. Parasitology 2014, 141, 1563–1592. [Google Scholar] [CrossRef]
  18. Zintl, A.; Mulcahy, G.; Skerrett, H.E.; Taylor, S.M.; Gray, J.S. Babesia divergens, a Bovine Blood Parasite of Veterinary and Zoonotic Importance. Clin. Microbiol. Rev. 2003, 16, 622–636. [Google Scholar] [CrossRef]
  19. Ganzinelli, S.R.; Schnittger, L.A.E.; Florin-Christensen, M. Babesia of Domestic Ruminants. In Parasitic Protozoa of Farm Animals and Pets; Florin-Christensen, M., Ed.; Springer Nature: Berlin, Germany, 2018; pp. 215–239. [Google Scholar]
  20. Thomas, S.E.; Mason, T.E. Isolation and transmission of an unidentified Babesia sp. infective for cattle. Onderstepoort J. Vet. Res. 1981, 48, 155–158. [Google Scholar]
  21. De Waal, D.T.; Potgieter, F.T.; Combrink, M.P.; Mason, T.E. The isolation and transmission of an unidentified Babesia sp. to cattle by Hyalomma truncatum Koch 1844. Onderstepoort J. Vet. Res. 1990, 57, 229–232. [Google Scholar]
  22. Ohta, M.; Tsuji, M.; Tsuji, N.; Fujisaki, K. Morphological, Serological and Antigenic Characteristics, and Protein Profile of Newly Isolated Japanese Bovine Babesia Parasite with Particular Reference to Those of B. ovata. J. Vet. Med. Sci. 1995, 57, 671–675. [Google Scholar] [CrossRef]
  23. Luo, J.; Yin, H.; Liu, Z.; Yang, D.; Guan, G.; Liu, A.; Ma, M.; Dang, S.; Lu, B.; Sun, C.; et al. Molecular phylogenetic studies on an unnamed bovine Babesia sp. based on small subunit ribosomal RNA gene sequences. Vet. Parasitol. 2005, 133, 1–6. [Google Scholar] [CrossRef] [PubMed]
  24. Aktas, M. A survey of ixodid tick species and molecular identification of tick-borne pathogens. Vet. Parasitol. 2014, 200, 276–283. [Google Scholar] [CrossRef] [PubMed]
  25. Inci, A.; Yildirim, A.; Düzlü, O.; Doganay, M.; Aksoy, S. Tick-Borne Diseases in Turkey: A Review Based on One Health Perspective. PLoS Neglected Trop. Dis. 2016, 10, e0005021. [Google Scholar] [CrossRef] [PubMed]
  26. Sevinc, F.; Xuan, X. Major tick-borne parasitic diseases of animals: A frame of references in Turkey. Eurasian J. Vet. Sci. 2015, 31, 132. [Google Scholar] [CrossRef]
  27. Turkstat. Turkısh Statistical Institute, I.A. Available online: (accessed on 5 May 2020).
  28. Pupin, R.C.; Guizelini, C.D.C.; De Lemos, R.A.A.; Martins, T.B.; Borges, F.D.A.; Borges, D.G.L.; Gomes, D.C. Retrospective study of epidemiological, clinical and pathological findings of bovine babesiosis in Mato Grosso do Sul, Brazil (1995–2017). Ticks Tick-Borne Dis. 2019, 10, 36–42. [Google Scholar] [CrossRef]
  29. Graham, O.H.; Hourrigan, J.L. Review Article1: Eradication Programs for the Arthropod Parasites of Livestock2. J. Med. Èntomol. 1977, 13, 629–658. [Google Scholar] [CrossRef]
  30. Esteve-Gasent, M.D.; Rodríguez-Vivas, R.I.; Medina, R.F.; Ellis, D.; Schwartz, A.; Garcia, B.C.; Hunt, C.; Tietjen, M.; Bonilla, D.; Thomas, D.; et al. Research on Integrated Management for Cattle Fever Ticks and Bovine Babesiosis in the United States and Mexico: Current Status and Opportunities for Binational Coordination. Pathogens 2020, 9, 871. [Google Scholar] [CrossRef]
  31. De León, A.A.P.; Teel, P.D.; Auclair, A.N.; Messenger, M.T.; Guerrero, F.D.; Schuster, G.; Miller, R.J. Integrated Strategy for Sustainable Cattle Fever Tick Eradication in USA Is Required to Mitigate the Impact of Global Change. Front. Physiol. 2012, 3. [Google Scholar] [CrossRef]
  32. León, A.A.P.D.; Strickman, D.; Knowles, D.P.; Fish, D.; Thacker, E.L.; De La Fuente, J.; Krause, P.J.; Wikel, S.K.; Miller, R.S.; Wagner, G.G.; et al. One Health approach to identify research needs in bovine and human babesioses: Workshop report. Parasites Vectors 2010, 3. [Google Scholar] [CrossRef]
  33. Ekici, O.D.; Sevinc, F. Seroepidemiology of Babesia bigemina in Cattle in the Konya Province, Turkey: Endemic Status. B. Vet. I. Pulawy. 2009, 53, 645–649. [Google Scholar]
  34. Inci, A.; Ica, A.; Yildirim, A.; Vatansever, Z.; Cakmak, A.; Albasan, H.; Cam, Y.; Atasever, A.; Sariozkan, S.; Duzlu, O. Economical impact of tropical theileriosis in the Cappadocia region of Turkey. Parasitol. Res. 2007, 101, 171–174. [Google Scholar] [CrossRef] [PubMed]
  35. Rodriguez, A.E.S.; Tomazic, M.L.L.; Florin-Christensen, M. Current and Prospective Tools for the Control of Cattle-Infecting Babesia Parasites. In Protozoa: Biology, Classification and Role in Disease; Castillo, V., Harris, R., Eds.; Nova Publishers: Hauppauge, NY, USA, 2013; pp. 1–44. [Google Scholar]
  36. Hadani, A.P.E.; Tsafrir, N.; Rauchbach, K.; Mayer, E. The transmission of Babesia bigemina and Babesiella berbera and Anaplasma centrale by Boophilus annulatus (Say). Refuah Vet. 1974, 31, 149–154. [Google Scholar]
  37. Mahoney, D.; Mirre, G. A note on the transmission of Babesia bovis (syn B. argentina) by the one-host tick, Boophilus microplus. Res. Vet. Sci. 1979, 26, 253–254. [Google Scholar] [CrossRef]
  38. Smith, R.; Osorno, B.; Brener, J.; De La Rosa, R.; Ristic, M. Bovine babesiosis: Severity and reproducibility of Babesia bovis infections induced by Boophilus microplus under laboratory conditions. Res. Vet. Sci. 1978, 24, 287–292. [Google Scholar] [CrossRef]
  39. Callow, L.L. The infection of Boophilus microplus with Babesia bigemina. Parasitology 1968, 58, 663–670. [Google Scholar] [CrossRef] [PubMed]
  40. Morzaria, S.P.; Young, A.S.; Hudson, E.B. Babesia bigemina in Kenya: Experimental transmission by Boophilus decoloratus and the production of tick-dervied stabilates. Parasitology 1977, 74, 291–298. [Google Scholar] [CrossRef]
  41. Büscher, G. The infection of various tick species with Babesia bigemina, its transmission and identification. Parasitol. Res. 1988, 74, 324–330. [Google Scholar] [CrossRef]
  42. Donnelly, J.; Peirce, M. Experiments on the transmission of Babesia divergens to cattle by the tick Ixodes ricinus. Int. J. Parasitol. 1975, 5, 363–367. [Google Scholar] [CrossRef]
  43. Gray, J.S.; De Vos, A.J. Studies on a bovine Babesia transmitted by Hyalomma marginatum rufipes Koch, 1844. Onderstepoort J. Vet. Res. 1981, 48, 215–223. [Google Scholar]
  44. Ma, L.H.L.; Zhao, J.L. An investigation of water buffalo babesiosis in Hubei province V. adult Rhipicephalus haemaphysaloides transmits the parasites transovarially. Chin. J. Anim. Vet. Sci. 1989, 1, 67–70. [Google Scholar]
  45. Takahashi, K.W.; Kawai, S.A.; Yokota, H.; Kurosawa, T.; Sonoda, M. Investigation of isolation, transmission and virulence of bovine Babesia sp. in Hokkaido. J. Coll. Dairying 1983, 10, 171–181. [Google Scholar]
  46. Aydin, L.; Bakirci, S. Geographical distribution of ticks in Turkey. Parasitol. Res. 2007, 101, 163–166. [Google Scholar] [CrossRef] [PubMed]
  47. Aktas, M.; Altay, K.; Ozubek, S.; Dumanlı, N. A survey of ixodid ticks feeding on cattle and prevalence of tick-borne pathogens in the Black Sea region of Turkey. Vet. Parasitol. 2012, 187, 567–571. [Google Scholar] [CrossRef] [PubMed]
  48. Ica, A.; Vatansever, Z.; Yildirim, A.; Duzlu, O.; Inci, A. Detection of Theileria and Babesia species in ticks collected from cattle. Vet. Parasitol. 2007, 148, 156–160. [Google Scholar] [CrossRef] [PubMed]
  49. Meyilli, T.D.; Yildirim, A.O.; Onder, Z.; Ciloglu, A.; Inci, A. Investigation of Babesia bovis and Babesia bigemina by real time pcr in tick species collected from cattle in Kayseri province. Erciyes Üniv. Vet. Fak Derg 2016, 13, 201–208. [Google Scholar]
  50. Aktas, M.; Vatansever, Z.; Ozubek, S. Molecular evidence for trans-stadial and transovarial transmission of Babesia occultans in Hyalomma marginatum and Rhipicephalus turanicus in Turkey. Vet. Parasitol. 2014, 204, 369–371. [Google Scholar] [CrossRef] [PubMed]
  51. Orkun, Ö.; Çakmak, A.; Nalbantoğlu, S.; Karaer, Z. Turkey tick news: A molecular investigation into the presence of tick-borne pathogens in host-seeking ticks in Anatolia; Initial evidence of putative vectors and pathogens, and footsteps of a secretly rising vector tick, Haemaphysalis parva. Ticks Tick-Borne Dis. 2020, 11. [Google Scholar] [CrossRef]
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