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TNF receptor superfamily member 13B: The TNFRSF13B gene provides instructions for making a protein called TACI.

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Entry Collection: MedlinePlus
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Update Time: 25 Dec 2020

1. Normal Function

The TNFRSF13B gene provides instructions for making a protein called TACI. The TACI protein is found on the surface of immune system cells called B cells. These specialized white blood cells help protect the body against infection from foreign invaders such as bacteria and viruses. When B cells mature, they produce special proteins called antibodies (also known as immunoglobulins). Antibodies attach to specific foreign invaders, marking them for destruction. Through interactions with other proteins, TACI promotes cell signaling, plays a role in B cell survival and maturation, and is involved in the production of antibodies.

2. Health Conditions Related to Genetic Changes

2.1. Common variable immune deficiency

More than 25 mutations in the TNFRSF13B gene have been associated with common variable immune deficiency (CVID). This condition impairs the immune system, resulting in increased risk for recurrent infections; autoimmune disorders, which occur when the immune system malfunctions and attacks the body's tissues and organs; and certain cancers.

Most of the TNFRSF13B gene mutations associated with CVID change single protein building blocks (amino acids) in the TACI protein. The most common mutation seen in people with CVID replaces the amino acid cysteine with the amino acid arginine at position 104 in the TACI protein (written as Cys104Arg or C104R). This mutation impairs the ability of TACI to interact with other proteins, disrupting cell signaling and preventing normal B cell maturation and antibody production. A shortage (deficiency) of certain antibodies makes it difficult for people to fight off infections. Abnormal and deficient immune responses over time likely contribute to the increased cancer risk in people with CVID.

Some people with TNFRSF13B gene mutations do not develop the signs and symptoms of CVID. In these individuals, additional genetic or environmental factors are probably needed for the condition to occur.

3. Other Names for This Gene

  • CD267
  • IGAD2
  • TACI
  • TR13B_HUMAN
  • transmembrane activator and CAML interactor
  • tumor necrosis factor receptor 13B
  • tumor necrosis factor receptor superfamily member 13B
  • tumor necrosis factor receptor superfamily, member 13B

References

  1. Martinez-Gallo M, Radigan L, Almejún MB, Martínez-Pomar N, Matamoros N,Cunningham-Rundles C. TACI mutations and impaired B-cell function in subjectswith CVID and healthy heterozygotes. J Allergy Clin Immunol. 2013Feb;131(2):468-76. doi: 10.1016/j.jaci.2012.10.029.
  2. Pan-Hammarström Q, Salzer U, Du L, Björkander J, Cunningham-Rundles C, Nelson DL, Bacchelli C, Gaspar HB, Offer S, Behrens TW, Grimbacher B, Hammarström L.Reexamining the role of TACI coding variants in common variable immunodeficiency and selective IgA deficiency. Nat Genet. 2007 Apr;39(4):429-30.
  3. Poodt AE, Driessen GJ, de Klein A, van Dongen JJ, van der Burg M, de Vries E. TACI mutations and disease susceptibility in patients with common variableimmunodeficiency. Clin Exp Immunol. 2009 Apr;156(1):35-9. doi:10.1111/j.1365-2249.2008.03863.x.
  4. Salzer U, Bacchelli C, Buckridge S, Pan-Hammarström Q, Jennings S, Lougaris V,Bergbreiter A, Hagena T, Birmelin J, Plebani A, Webster AD, Peter HH, Suez D,Chapel H, McLean-Tooke A, Spickett GP, Anover-Sombke S, Ochs HD, Urschel S,Belohradsky BH, Ugrinovic S, Kumararatne DS, Lawrence TC, Holm AM, Franco JL,Schulze I, Schneider P, Gertz EM, Schäffer AA, Hammarström L, Thrasher AJ, GasparHB, Grimbacher B. Relevance of biallelic versus monoallelic TNFRSF13B mutationsin distinguishing disease-causing from risk-increasing TNFRSF13B variants inantibody deficiency syndromes. Blood. 2009 Feb 26;113(9):1967-76. doi:10.1182/blood-2008-02-141937.
  5. Sathkumara HD, De Silva NR, Handunnetti S, De Silva AD. Genetics of commonvariable immunodeficiency: role of transmembrane activator and calcium modulator and cyclophilin ligand interactor. Int J Immunogenet. 2015 Aug;42(4):239-53. doi:10.1111/iji.12217.
  6. Zhang L, Radigan L, Salzer U, Behrens TW, Grimbacher B, Diaz G, Bussel J,Cunningham-Rundles C. Transmembrane activator and calcium-modulating cyclophilin ligand interactor mutations in common variable immunodeficiency: clinical andimmunologic outcomes in heterozygotes. J Allergy Clin Immunol. 2007Nov;120(5):1178-85.
  7. Zhang Y, Li J, Zhang YM, Zhang XM, Tao J. Effect of TACI signaling on humoral immunity and autoimmune diseases. J Immunol Res. 2015;2015:247426. doi:10.1155/2015/247426.
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View Times: 65
Entry Collection: MedlinePlus
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Update Time: 25 Dec 2020
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    Liu, R. TNFRSF13B Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5804 (accessed on 04 October 2022).
    Liu R. TNFRSF13B Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5804. Accessed October 04, 2022.
    Liu, Rui. "TNFRSF13B Gene," Encyclopedia, https://encyclopedia.pub/entry/5804 (accessed October 04, 2022).
    Liu, R. (2020, December 25). TNFRSF13B Gene. In Encyclopedia. https://encyclopedia.pub/entry/5804
    Liu, Rui. ''TNFRSF13B Gene.'' Encyclopedia. Web. 25 December, 2020.
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