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platelet derived growth factor receptor alpha

genes
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Entry Collection: MedlinePlus
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Update Time: 25 Dec 2020

1.  Introduction

The PDGFRA gene provides instructions for making a protein called platelet-derived growth factor receptor alpha (PDGFRA), which is part of a family of proteins called receptor tyrosine kinases (RTKs). Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. The PDGFRA protein is found in the cell membrane of certain cell types where a specific protein, called platelet-derived growth factor, attaches (binds) to it. This binding turns on (activates) the PDGFRA protein, which then activates other proteins inside the cell by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions (a process called phosphorylation). This process leads to the activation of a series of proteins in multiple signaling pathways.

The signaling pathways stimulated by the PDGFRA protein control many important cellular processes such as cell growth and division (proliferation) and cell survival. PDGFRA protein signaling is important for the development of many types of cells throughout the body.

2. Health Conditions Related to Genetic Changes

2.1. PDGFRA-associated chronic eosinophilic leukemia

Genetic abnormalities that involve the PDGFRA gene cause a type of blood cell cancer called PDGFRA-associated chronic eosinophilic leukemia. This condition is characterized by an increased number of eosinophils, a type of white blood cell involved in allergic reactions. These genetic abnormalities are somatic mutations, which are mutations acquired during a person's lifetime that are present only in certain cells. The most common of these genetic abnormalities is a deletion of genetic material from chromosome 4 that brings together parts of two genes, FIP1L1 and PDGFRA, creating the FIP1L1-PDGFRA fusion gene. Occasionally, genes other than FIP1L1 are fused with the PDGFRA gene. Mutations that change single DNA building blocks in the PDGFRA gene (point mutations) can also cause this condition, although these mutations are seen very rarely.

The protein produced from the FIP1L1-PDGFRA fusion gene (as well as other PDGFRA fusion genes) has the function of the PDGFRA protein. However, unlike the normal PDGFRA protein, the fusion protein does not require binding of the platelet-derived growth factor protein to be activated. Similarly, point mutations in the PDGFRA gene can result in a PDGFRA protein that is activated without ligand binding. As a result, the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells. When the FIP1L1-PDGFRA fusion gene mutation or point mutations in the PDGFRA gene occur in early blood cells, the growth of eosinophils (and occasionally other blood cells) is poorly controlled, leading to PDGFRA-associated chronic eosinophilic leukemia. It is unclear why eosinophils are preferentially affected by this genetic change.

2.2. Gastrointestinal stromal tumor

Mutations in the PDGFRA gene are associated with gastrointestinal stromal tumors (GISTs). GISTs are a type of tumor that occurs in the gastrointestinal tract, most commonly in the stomach or small intestine. The majority of GISTs associated with a mutation in the PDGFRA gene occur in the stomach. In most cases, the genetic changes are acquired during a person's lifetime and are called somatic mutations. Somatic mutations, which lead to sporadic GISTs, are present only in the tumor cells and are not inherited. Less commonly, PDGFRA gene mutations that increase the risk of developing GISTs are inherited from a parent, which can lead to familial GISTs.

PDGFRA gene mutations associated with GISTs create a protein that no longer requires binding of the platelet-derived growth factor protein to be activated. As a result, the PDGFRA protein and the signaling pathways are constitutively activated, which increases cell proliferation and survival, leading to tumor formation.

2.3. Other disorders

PDGFRA gene mutations that lead to a constitutively active PDGFRA protein are also associated with inflammatory fibroid polyps, which are small, noncancerous (benign) tumors that form in the gastrointestinal tract. These tumors are made up of fibrous tissue and usually contain cells known to cause inflammation (inflammatory cells). As in GISTs, the constitutively active PDGFRA protein leads to the overgrowth of cells and formation of tumors.

3. Other Names for This Gene

  • CD140 antigen-like family member A
  • CD140A
  • CD140a antigen
  • GAS9
  • PDGFR-alpha
  • PDGFR2
  • PGFRA_HUMAN
  • platelet-derived growth factor receptor 2
  • platelet-derived growth factor receptor alpha
  • platelet-derived growth factor receptor, alpha polypeptide

References

  1. Bain BJ. Relationship between idiopathic hypereosinophilic syndrome,eosinophilic leukemia, and systemic mastocytosis. Am J Hematol. 2004Sep;77(1):82-5. Review.
  2. Buitenhuis M, Verhagen LP, Cools J, Coffer PJ. Molecular mechanisms underlyingFIP1L1-PDGFRA-mediated myeloproliferation. Cancer Res. 2007 Apr 15;67(8):3759-66.
  3. Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, ClarkJ, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL,Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, KantarjianH, Marynen P, Coutre SE, Stone R, Gilliland DG. A tyrosine kinase created byfusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib inidiopathic hypereosinophilic syndrome. N Engl J Med. 2003 Mar 27;348(13):1201-14.
  4. Elling C, Erben P, Walz C, Frickenhaus M, Schemionek M, Stehling M, Serve H,Cross NC, Hochhaus A, Hofmann WK, Berdel WE, Müller-Tidow C, Reiter A,Koschmieder S. Novel imatinib-sensitive PDGFRA-activating point mutations inhypereosinophilic syndrome induce growth factor independence and leukemia-likedisease. Blood. 2011 Mar 10;117(10):2935-43. doi: 10.1182/blood-2010-05-286757.
  5. Fukushima K, Matsumura I, Ezoe S, Tokunaga M, Yasumi M, Satoh Y, Shibayama H, Tanaka H, Iwama A, Kanakura Y. FIP1L1-PDGFRalpha imposes eosinophil lineagecommitment on hematopoietic stem/progenitor cells. J Biol Chem. 2009 Mar20;284(12):7719-32. doi: 10.1074/jbc.M807489200.
  6. Heinrich MC, Corless CL, Duensing A, McGreevey L, Chen CJ, Joseph N, Singer S,Griffith DJ, Haley A, Town A, Demetri GD, Fletcher CD, Fletcher JA. PDGFRAactivating mutations in gastrointestinal stromal tumors. Science. 2003 Jan31;299(5607):708-10.
  7. Hirota S, Ohashi A, Nishida T, Isozaki K, Kinoshita K, Shinomura Y, KitamuraY. Gain-of-function mutations of platelet-derived growth factor receptor alphagene in gastrointestinal stromal tumors. Gastroenterology. 2003 Sep;125(3):660-7.
  8. Lasota J, Wang ZF, Sobin LH, Miettinen M. Gain-of-function PDGFRA mutations,earlier reported in gastrointestinal stromal tumors, are common in smallintestinal inflammatory fibroid polyps. A study of 60 cases. Mod Pathol. 2009Aug;22(8):1049-56. doi: 10.1038/modpathol.2009.62.
  9. Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007 Sep 11;2:37. Review.
  10. Schildhaus HU, Cavlar T, Binot E, Büttner R, Wardelmann E, Merkelbach-Bruse S.Inflammatory fibroid polyps harbour mutations in the platelet-derived growthfactor receptor alpha (PDGFRA) gene. J Pathol. 2008 Oct;216(2):176-82. doi:10.1002/path.2393.
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View Times: 79
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Time: 25 Dec 2020
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    Guo, L.Y. PDGFRA Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/5735 (accessed on 03 October 2022).
    Guo LY. PDGFRA Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/5735. Accessed October 03, 2022.
    Guo, Lily Yueming. "PDGFRA Gene," Encyclopedia, https://encyclopedia.pub/entry/5735 (accessed October 03, 2022).
    Guo, L.Y. (2020, December 25). PDGFRA Gene. In Encyclopedia. https://encyclopedia.pub/entry/5735
    Guo, Lily Yueming. ''PDGFRA Gene.'' Encyclopedia. Web. 25 December, 2020.
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