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Phthalates (PAEs) are a group of synthetic esters of phthalic acid compounds mostly used as plasticizers in plastic materials but are widely applied in most industries and products. As plasticizers in plastic materials, they are not chemically bound to the polymeric matrix and easily leach out. Logically, PAEs should be prevalent in the environment, but their prevalence, transport, fate, and effects have been largely unknown until recently. This has been attributed, inter alia, to a lack of standardized analytical procedures for identifying them in complex matrices.
The selection of an extraction method not only depends on the sample type and its physiochemical characteristics but can also be determined by the priorities and concerns of the analysis. Table 1 summarizes the advantages and disadvantages of the above-discussed methods from the perspective of PAE extraction.
Method | Advantages | Disadvantages |
---|---|---|
SPE | Simplicity, accuracy, high throughput and high recovery, low solvent consumption, ease of automation | Inability to extract from large sample volumes, susceptibility to sorbent vulnerability, high probability of column blockage [30] |
SPME | Simplicity, rapidity, minimal solvent usage, ease of automation | The short lifespan of the fiber, high cost, potential for cross-contamination [31] |
SBSE | High sample capacity, high recovery and sensitivity, and low detection limits eliminate the need for a cleanup step in liquid samples. | Limited repeatability [32] |
LLE | Simplicity, convenience, popularity | Time consuming, labor intensive, requires large sample volumes, involves toxic organic solvents, and is inapplicable for trace analytes [33] |
LPME | Low cost, limited organic solvent consumption, simplicity and possibility of full automation, low chance of cross-contamination | Time consuming, limited sample volume [34] |
SLE | Limited organic solvent consumption, higher selectivity compared to LLE extraction | Potential of cross-contamination, low stability of the extractant [35] |
MMLLE | Capability to operate online with GC and HPLC | Limited selection of organic solvents suitable for all PAEs [16] |
SDME | Limited organic solvent consumption, fast merging sample preparation, preconcentration, and introduction step minimized the risk of cross-contamination. | Requires multiple solvents [20] |
HF-LPME | Capability for full automation, minimization of cross-contamination | There is a high risk of contamination during the fiber placement process [36] |
DLLME | Simplicity, high efficiency, rapidity, low sample volume requirement, cost-effectiveness, high enrichment factor | Use of toxic organic solvents, difficulty of automation, high-cost preparation process, low stability of the extractant drop [37] |
CPE | Environmentally friendly | Incompatibility with GC [38] |
ASE | Compatibility with different matrices, fast and low-solvent consumption | Utilizes harsh physical conditions and has a high risk of detection errors [24][39] |
CFM | Rapid and online extraction | Limited reproducibility [40] |