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Xu, R. Primary Localized Cutaneous Amyloidosis. Encyclopedia. Available online: https://encyclopedia.pub/entry/5452 (accessed on 21 September 2026).
Xu R. Primary Localized Cutaneous Amyloidosis. Encyclopedia. Available at: https://encyclopedia.pub/entry/5452. Accessed September 21, 2026.
Xu, Rita. "Primary Localized Cutaneous Amyloidosis" Encyclopedia, https://encyclopedia.pub/entry/5452 (accessed September 21, 2026).
Xu, R. (2020, December 24). Primary Localized Cutaneous Amyloidosis. In Encyclopedia. https://encyclopedia.pub/entry/5452
Xu, Rita. "Primary Localized Cutaneous Amyloidosis." Encyclopedia. Web. 24 December, 2020.
Primary Localized Cutaneous Amyloidosis
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/primary-localized-cutaneous-amyloidosis

Primary localized cutaneous amyloidosis (PLCA) is a condition in which clumps of abnormal proteins called amyloids build up in the skin, specifically in the wave-like projections (dermal papillae) between the top two layers of skin (the dermis and the epidermis). The primary feature of PLCA is patches of skin with abnormal texture or color. The appearance of these patches defines three forms of the condition: lichen amyloidosis, macular amyloidosis, and nodular amyloidosis.

genetic conditions

References

  1. Arita K, South AP, Hans-Filho G, Sakuma TH, Lai-Cheong J, Clements S, OdashiroM, Odashiro DN, Hans-Neto G, Hans NR, Holder MV, Bhogal BS, Hartshorne ST,Akiyama M, Shimizu H, McGrath JA. Oncostatin M receptor-beta mutations underliefamilial primary localized cutaneous amyloidosis. Am J Hum Genet. 2008Jan;82(1):73-80. doi: 10.1016/j.ajhg.2007.09.002.
  2. Chang YT, Lin CH, Lee CT, Lin MW, Liu LY, Chen CC, Lee DD, Liu HN, Tsai SF,Matsuura I. Detection of common mutations in sporadic primary localized cutaneousamyloidosis by DNA mass spectrometry. Br J Dermatol. 2014 Apr;170(4):974-6. doi: 10.1111/bjd.12733.
  3. Chang YT, Wong CK, Chow KC, Tsai CH. Apoptosis in primary cutaneousamyloidosis. Br J Dermatol. 1999 Feb;140(2):210-5.
  4. Hermanns HM. Oncostatin M and interleukin-31: Cytokines, receptors, signaltransduction and physiology. Cytokine Growth Factor Rev. 2015 Oct;26(5):545-58.doi: 10.1016/j.cytogfr.2015.07.006.
  5. Kaltoft B, Schmidt G, Lauritzen AF, Gimsing P. Primary localised cutaneousamyloidosis--a systematic review. Dan Med J. 2013 Nov;60(11):A4727. Review.
  6. Lin MW, Lee DD, Liu TT, Lin YF, Chen SY, Huang CC, Weng HY, Liu YF, Tanaka A, Arita K, Lai-Cheong J, Palisson F, Chang YT, Wong CK, Matsuura I, McGrath JA,Tsai SF. Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis. Eur J Hum Genet. 2010 Jan;18(1):26-32. doi:10.1038/ejhg.2009.135.
  7. Tanaka A, Arita K, Lai-Cheong JE, Palisson F, Hide M, McGrath JA. New insight into mechanisms of pruritus from molecular studies on familial primary localized cutaneous amyloidosis. Br J Dermatol. 2009 Dec;161(6):1217-24. doi:10.1111/j.1365-2133.2009.09311.x.
  8. Vijaya B, Dalal BS; Sunila, Manjunath GV. Primary cutaneous amyloidosis: aclinico-pathological study with emphasis on polarized microscopy. Indian J PatholMicrobiol. 2012 Apr-Jun;55(2):170-4. doi: 10.4103/0377-4929.97853.
  9. Wali A, Liu L, Takeichi T, Jelani M, Rahman OU, Heng YK, Thng S, Lee J,Akiyama M, McGrath JA, Betz RC. Familial primary localized cutaneous amyloidosis results from either dominant or recessive mutations in OSMR. Acta Derm Venereol. 2015 Nov;95(8):1005-7. doi: 10.2340/00015555-2104.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Rita Xu
View Times: 815
Entry Collection: MedlinePlus
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Update Date: 24 Dec 2020
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