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Zhou, V. CHRNB2 Gene. Encyclopedia. Available online: (accessed on 23 June 2024).
Zhou V. CHRNB2 Gene. Encyclopedia. Available at: Accessed June 23, 2024.
Zhou, Vicky. "CHRNB2 Gene" Encyclopedia, (accessed June 23, 2024).
Zhou, V. (2020, December 24). CHRNB2 Gene. In Encyclopedia.
Zhou, Vicky. "CHRNB2 Gene." Encyclopedia. Web. 24 December, 2020.

cholinergic receptor nicotinic beta 2 subunit


1. Normal Function

The CHRNB2 gene provides instructions for making one part (subunit) of a larger protein called a neuronal nicotinic acetylcholine receptor (nAChR). Each nAChR protein is made up of a combination of five subunits, usually two alpha (α) and three beta (β) subunits. Many different combinations are possible, and the characteristics of each nAChR protein depend on which subunits it contains. In the brain, nAChR proteins most commonly consist of two α4 subunits and three β2 subunits. The CHRNB2 gene is responsible for producing the β2 subunit.

In the brain, nAChR proteins are widely distributed and play an important role in chemical signaling between nerve cells (neurons). The nAChR proteins act as channels, allowing charged atoms (ions) including calcium, sodium, and potassium to cross the cell membrane. These channels open when attached to a brain chemical (neurotransmitter) called acetylcholine. The channels also open in response to nicotine, the addictive substance in tobacco.

Communication between neurons depends on neurotransmitters, which are released from one neuron and taken up by neighboring neurons. The release and uptake of these chemicals are tightly regulated to ensure that signals are passed efficiently and accurately between neurons. Researchers believe that nAChR channels play an important role in controlling the normal release and uptake of neurotransmitters.

A wide range of brain functions depend on nAChR channels, including sleep and arousal, fatigue, anxiety, attention, pain perception, and memory. The channels are also active before birth, which suggests that they are involved in early brain development. At least one drug that targets nAChR channels in the brain has been developed to help people quit smoking; other medications targeting these channels are under study for the treatment of schizophrenia, Alzheimer disease, and pain.

2. Health Conditions Related to Genetic Changes

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

At least three mutations in the CHRNB2 gene have been identified in people with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE). Each of these mutations changes a single protein building block (amino acid) in the β2 subunit of nAChR channels.

CHRNB2 mutations make nAChR channels more sensitive to the neurotransmitter acetylcholine, allowing the channels to open more easily than usual. The resulting increase in ion flow across the cell membrane alters the release of neurotransmitters, which changes signaling between neurons. Researchers believe that the overexcitement of certain neurons in the brain triggers the abnormal brain activity associated with seizures. It is unclear why the seizures seen in ADNFLE start in the frontal lobes of the brain and occur most often during sleep.

3. Other Names for This Gene

  • Acetylcholine receptor, neuronal nicotinic, beta-2 subunit
  • cholinergic receptor, nicotinic beta 2
  • cholinergic receptor, nicotinic, beta 2 (neuronal)
  • cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal)
  • EFNL3
  • nAChRB2
  • neuronal nicotinic acetylcholine receptor beta 2


  1. Arneric SP, Holladay M, Williams M. Neuronal nicotinic receptors: aperspective on two decades of drug discovery research. Biochem Pharmacol. 2007Oct 15;74(8):1092-101.
  2. Bertrand D, Elmslie F, Hughes E, Trounce J, Sander T, Bertrand S, SteinleinOK. The CHRNB2 mutation I312M is associated with epilepsy and distinct memorydeficits. Neurobiol Dis. 2005 Dec;20(3):799-804.
  3. Bertrand D, Picard F, Le Hellard S, Weiland S, Favre I, Phillips H, BertrandS, Berkovic SF, Malafosse A, Mulley J. How mutations in the nAChRs can causeADNFLE epilepsy. Epilepsia. 2002;43 Suppl 5:112-22.
  4. Bertrand S, Weiland S, Berkovic SF, Steinlein OK, Bertrand D. Properties ofneuronal nicotinic acetylcholine receptor mutants from humans suffering fromautosomal dominant nocturnal frontal lobe epilepsy. Br J Pharmacol. 1998Oct;125(4):751-60.
  5. De Fusco M, Becchetti A, Patrignani A, Annesi G, Gambardella A, Quattrone A,Ballabio A, Wanke E, Casari G. The nicotinic receptor beta 2 subunit is mutant innocturnal frontal lobe epilepsy. Nat Genet. 2000 Nov;26(3):275-6.
  6. di Corcia G, Blasetti A, De Simone M, Verrotti A, Chiarelli F. Recent advanceson autosomal dominant nocturnal frontal lobe epilepsy: "understanding thenicotinic acetylcholine receptor (nAChR)". Eur J Paediatr Neurol.2005;9(2):59-66. Review.
  7. Hoda JC, Gu W, Friedli M, Phillips HA, Bertrand S, Antonarakis SE, Goudie D,Roberts R, Scheffer IE, Marini C, Patel J, Berkovic SF, Mulley JC, Steinlein OK, Bertrand D. Human nocturnal frontal lobe epilepsy: pharmocogenomic profiles ofpathogenic nicotinic acetylcholine receptor beta-subunit mutations outside theion channel pore. Mol Pharmacol. 2008 Aug;74(2):379-91. doi:10.1124/mol.107.044545.
  8. Marini C, Guerrini R. The role of the nicotinic acetylcholine receptors insleep-related epilepsy. Biochem Pharmacol. 2007 Oct 15;74(8):1308-14.
  9. Phillips HA, Favre I, Kirkpatrick M, Zuberi SM, Goudie D, Heron SE, SchefferIE, Sutherland GR, Berkovic SF, Bertrand D, Mulley JC. CHRNB2 is the secondacetylcholine receptor subunit associated with autosomal dominant nocturnalfrontal lobe epilepsy. Am J Hum Genet. 2001 Jan;68(1):225-31.
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Update Date: 24 Dec 2020
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