Your browser does not fully support modern features. Please upgrade for a smoother experience.
Submitted Successfully!
Thank you for your contribution! You can also upload a video entry or images related to this topic. For video creation, please contact our Academic Video Service.
Version Summary Created by Modification Content Size Created at Operation
1 Rita Xu + 473 word(s) 473 2020-12-15 07:34:39

Video Upload Options

We provide professional Academic Video Service to translate complex research into visually appealing presentations. Would you like to try it?
No, upload directly Yes
Cite
If you have any further questions, please contact Encyclopedia Editorial Office.
Xu, R. Paroxysmal Extreme Pain Disorder. Encyclopedia. Available online: https://encyclopedia.pub/entry/5060 (accessed on 22 September 2026).
Xu R. Paroxysmal Extreme Pain Disorder. Encyclopedia. Available at: https://encyclopedia.pub/entry/5060. Accessed September 22, 2026.
Xu, Rita. "Paroxysmal Extreme Pain Disorder" Encyclopedia, https://encyclopedia.pub/entry/5060 (accessed September 22, 2026).
Xu, R. (2020, December 24). Paroxysmal Extreme Pain Disorder. In Encyclopedia. https://encyclopedia.pub/entry/5060
Xu, Rita. "Paroxysmal Extreme Pain Disorder." Encyclopedia. Web. 24 December, 2020.
Paroxysmal Extreme Pain Disorder
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/paroxysmal-extreme-pain-disorder

Paroxysmal extreme pain disorder is a condition characterized by skin redness and warmth (flushing) and attacks of severe pain in various parts of the body.

genetic conditions

References

  1. Dabby R. Pain disorders and erythromelalgia caused by voltage-gated sodiumchannel mutations. Curr Neurol Neurosci Rep. 2012 Feb;12(1):76-83. doi:10.1007/s11910-011-0233-8. Review.
  2. Estacion M, Han C, Choi JS, Hoeijmakers JG, Lauria G, Drenth JP, Gerrits MM,Dib-Hajj SD, Faber CG, Merkies IS, Waxman SG. Intra- and interfamily phenotypicdiversity in pain syndromes associated with a gain-of-function variant of NaV1.7.Mol Pain. 2011 Dec 2;7:92. doi: 10.1186/1744-8069-7-92.
  3. Fertleman CR, Baker MD, Parker KA, Moffatt S, Elmslie FV, Abrahamsen B, OstmanJ, Klugbauer N, Wood JN, Gardiner RM, Rees M. SCN9A mutations in paroxysmalextreme pain disorder: allelic variants underlie distinct channel defects andphenotypes. Neuron. 2006 Dec 7;52(5):767-74.
  4. Fertleman CR, Ferrie CD, Aicardi J, Bednarek NA, Eeg-Olofsson O, Elmslie FV,Griesemer DA, Goutières F, Kirkpatrick M, Malmros IN, Pollitzer M, Rossiter M,Roulet-Perez E, Schubert R, Smith VV, Testard H, Wong V, Stephenson JB.Paroxysmal extreme pain disorder (previously familial rectal pain syndrome).Neurology. 2007 Aug 7;69(6):586-95.
  5. Fischer TZ, Waxman SG. Familial pain syndromes from mutations of the NaV1.7sodium channel. Ann N Y Acad Sci. 2010 Jan;1184:196-207. doi:10.1111/j.1749-6632.2009.05110.x. Review.
  6. Lampert A, O'Reilly AO, Reeh P, Leffler A. Sodium channelopathies and pain.Pflugers Arch. 2010 Jul;460(2):249-63. doi: 10.1007/s00424-009-0779-3.
More
©Text is available under the terms and conditions of the Creative Commons-Attribution ShareAlike (CC BY-SA) license; additional terms may apply. By using this site, you agree to the Terms and Conditions and Privacy Policy.
Upload a video for this entry
Information
Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Rita Xu
View Times: 829
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
Table of Contents
    Notice
    You are not a member of the advisory board for this topic. If you want to update advisory board member profile, please contact office@encyclopedia.pub.
    OK
    Confirm
    Only members of the Encyclopedia advisory board for this topic are allowed to note entries. Would you like to become an advisory board member of the Encyclopedia?
    Yes
    No
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    There is no comment~
    ${ textCharacter }/${ maxCharacter }
    Submit
    Cancel
    ${ selectedItem.replyTextCharacter }/${ selectedItem.replyMaxCharacter }
    Submit
    Cancel
    Confirm
    Are you sure to Delete?
    Yes No
    Academic Video Service
    Feedback