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Ortiz-Ramírez, J.A.; Cuéllar-Cruz, M.; Villagómez-Castro, J.C.; López-Romero, E. Sporothrix and Sporotrichosis. Encyclopedia. Available online: https://encyclopedia.pub/entry/49748 (accessed on 01 July 2024).
Ortiz-Ramírez JA, Cuéllar-Cruz M, Villagómez-Castro JC, López-Romero E. Sporothrix and Sporotrichosis. Encyclopedia. Available at: https://encyclopedia.pub/entry/49748. Accessed July 01, 2024.
Ortiz-Ramírez, Jorge A., Mayra Cuéllar-Cruz, Julio C. Villagómez-Castro, Everardo López-Romero. "Sporothrix and Sporotrichosis" Encyclopedia, https://encyclopedia.pub/entry/49748 (accessed July 01, 2024).
Ortiz-Ramírez, J.A., Cuéllar-Cruz, M., Villagómez-Castro, J.C., & López-Romero, E. (2023, September 28). Sporothrix and Sporotrichosis. In Encyclopedia. https://encyclopedia.pub/entry/49748
Ortiz-Ramírez, Jorge A., et al. "Sporothrix and Sporotrichosis." Encyclopedia. Web. 28 September, 2023.
Sporothrix and Sporotrichosis
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This entry is adapted from the peer-reviewed paper 10.3390/jof9090919

Sporothrix belongs to the fungal class Ascomycota and the order Ophiostomatales. It is a genus formed by filamentous fungi found in soil, plants, and decaying organic matter and includes pathogenic species for both humans and animals as well as environmental members. 

fungal glycosidases Sporothrix substrates glycoproteins

1. General Aspects

In general, members of the environmental clade do not infect mammals, except for some members of the S. pallida and S. stenoceras complexes [1][2][3]. Species of the pathogenic clinical clade of the genus include S. schenckii sensu stricto, S. brasiliensis, S. globosa, and S. luriei, which are responsible for the mycosis known as sporotrichosis of humans and animals, such as cats and dogs [4][5][6][7]. These species exhibit variations in virulence, transmission, and geographical distribution. Sporothrix is a true dimorphic fungus whose morphology depends on temperature, pH, and other factors, such as cyclic nucleotides [7][8]. At 25–28 °C and an acidic pH, it develops as mycelium, which is considered as the saprophytic phase whereas at higher temperatures (32–37 °C) and a pH of 7.0–7.5, it grows as yeast-like cells, which is the morphotype frequently isolated from infected tissues [7][8][9]. Hyphae form either primary or sympodial and secondary or sessile conidia [10][11][12][13][14]. Figure 1 shows the morphological stages of S. globosa, which are similar to other members of the genus.
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Figure 1. Morphological phases of S. globosa. Images show mycelia or filamentous cells (A), conidia (B), and yeast-like cells (C). Images produced in ELR laboratory.
Sporotrichosis is a cosmopolitan mycosis of humans and animals caused by members of the pathogenic clade of Sporothrix and is common mainly in intertropical areas. The pathogen is transmitted mainly in two ways: (a) the classical route, where soil- or decaying organic matter-borne fungal propagules (sapronosis) are inoculated through trauma and lacerations, and (b) an alternative route, in which the pathogen is inoculated via scratches or bites by infected animals. This route explains the horizontal transmission and zoonosis produced mainly by domestic cats [5][6][10]. On the other hand, infection by S. brasiliensis, an emerging fungal pathogen, can occur exclusively via bite, scratch, spore inhalation, direct contact with secretion, etc. [15].

2. Clinical Manifestations of Sporotrichosis

Sporotrichosis is a benign mycosis of humans. In general, it is limited to the epidermis where it forms lesions, the subcutaneous tissue, and the adjacent lymphatic vessels with occasional dissemination to bone tissue and internal organs. The severity and characteristics of the injuries depend on factors such as the depth of the lesion, the inoculum size, the inoculated morphology, virulence, comorbidities, and the immunological state of the host [16][17][18][19][20][21]. Sporotrichosis has been classified into four clinical categories: (a) fixed cutaneous, (b) lymphocutaneous, (c) multifocal, and (d) extracutaneous (systemic or visceral). It has a bad prognosis as it is associated with immunosuppression [18][19][20][22][23][24][25]. Figure 2 illustrates two of the most common clinical lesions of sporotrichosis.
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Figure 2. Clinical lesions of sporotrichosis. Fixed cutaneous (A) and classical lymphangitic or subcutaneous (B). Images were kindly provided by Dr. Alexandro Bonifaz, Mexico.

3. The Cell Wall

In most fungi, the cell wall (CW) plays a fundamental role in the pathogenicity and virulence of Sporothrix and other fungi, as it establishes the first contact with the host. It is formed by two layers: a relatively conserved internal layer containing β1,3- and β1,6-glucan, which is alkali-insoluble and linked to chitin by β1,4-linkages, forming a very dynamic exoskeleton that protects the cell from internal (cell membrane and cytoplasmic turgor) and external factors. The external layer is more heterogeneous and adaptable to physiological conditions. Apart from these components, the CW also contains galactomannans, glycoproteins, glycolipids, and melanin [26]. The fungal CW plays a vital role in host–pathogen interaction at most stages of infection, aiding in keeping cell integrity [27]. Various pathogen-associated molecular patterns (PAMPs) are present on the cell surface, which could be recognized by the host immune system’s pattern recognition receptors (PRRs), or they can function as virulence factors, contributing to the infection process and influencing the organism’s pathogenicity [28][29][30]. The proteins deriving from the Sporothrix CW remain insufficiently defined; however, multiple accounts exist regarding specific adhesins that attach to host extracellular matrix (ECM) proteins, including fibronectin, laminin, and type II collagen [31][32][33][34]. Pathogen adhesion to host cells plays a pivotal role in proper colonization and subsequent spread [34].
The β-glucan layer is joined to two classes of proteins: those containing internal repetitions (PIR) and those dependent on glycosil-phosphatidylinositol (GPI) that couple covalently to polysaccharides. Functions such as cell adhesion, masking, and immune blocking have been attributed to these extensions [35][36][37][38][39][40][41][42]. In S. schenckii and S. brasiliensis, the CW structure includes β-glucan microfibrils with β1,3, β1,4, and β1,6 linkages, as well as chitin and a peptidorhamnomannan (PRM), in addition to other homogeneous and heterogeneous polymers and manoproteins. Polysaccharides constitute approximately 80% of the dry weight of the CW, while glycoproteins constitute 20%. In some Sporothrix species, there may be variations, as some lack α-glucan. The absence of α-glucans in the CW of Sporothrix could have diverse consequences on the pathogen physiology, affecting its structural integrity, ability to withstand stress, interaction with the host immune system, colonization efficiency, and other aspects such as energy storage, virulence, and cell signaling [26][35][38][43][44][45][46][47][48][49][50]. Recently, the CW composition was analyzed in conidia, germlings, and yeast-like cells of S. globosa and compared with S. schenckii and S. brasiliensis. It was found that both conidia and yeast-like cells of S. globosa had a higher amount of chitin in their CWs, and all morphologies had more exposed β1,3-glucan on their surface compared to S. schenckii and S. brasiliensis [51]. The composition and structure of the fungal cell wall are influenced not only by environmental conditions but also by the cell cycle, changes in growth form, and other processes [52][53][54][55].

4. Pathogenicity and Virulence

Virulence factors have been recently reviewed in the hyphae, conidia, and yeast-like cells of S. schenckii [56]. Accordingly, while chitin and β1,3-glucans are associated with the virulence of conidia and hyphae, other components are responsible for the virulence of yeast-like cells. These include the antigenic PRM, CW proteins, melanin, secreted and intracellular proteases, extracellular vesicles, and some lipids. Many of the cell surface components are glycoproteins that allow Sporothrix to interact with the host and evade the immune response, thus allowing the pathogen to survive. Some of these virulence factors are discussed below.
Adhesion of the pathogen to target cells is a required condition for fungal infection to occur. Thus, blocking this primary step represents a potential target to prevent it. Some of the CW proteins, generically known as adhesins, bind to host extracellular matrix (ECM) proteins such as laminin, elastin, fibrinogen, fibrinonectin, and others. One of the best-known adhesins is Gp70, which is one of the major antigenic components of the CW and an important immunogenic factor against Sporothrix. Gp70 adhesin was purified, shown to contain 5.7% N-linked oligosaccharides, and shown to be involved in the adhesion of yeast cells to mouse tail dermis [57]. Its presence was further demonstrated in S. schenckii, S. brasiliensis, and S. globosa [58][59]. Later, recombinant Gp70 was expressed in E. coli, and its gene was predicted to encode for a 43 kDa protein. It was immunogenic and contrary to previous findings and contained a much higher amount of oligosaccharide [60]. Thus, Gp70 seems to play the dual role of an adhesin and antigen.
A major antigenic component of S. schenckii CW is PRM, a complex glycoconjugate that was purified from the yeast morphotype and shown to contain 57% mannose, 33.5% rhamnose, 14.2% proteins, and 1% galactose [47][61]. Whereas the sugar composition of RPM has been fully characterized, only a few of the constituent 325 proteins have been identified. Of these, recombinant GroEL/Hsp 60 and the uncharacterized protein Pap1 showed adhesion to ECM proteins and were more abundant in the yeast morphotype during interaction with HeLa cells [22].
A very important virulence factor is dimorphism, which is defined as the ability of certain fungi to switch between unicellular yeast and multicellular filamentous growth, depending on some environmental conditions. Seemingly, the change in the saprophyte to the parasitic form in pathogenic fungi obeys the need of the organism to adapt, grow, and disseminate in internal organs. The fungus enters the host in the form of conidia or short hyphae which, after some time, transforms into yeast-like cells. It is not clear whether this shift occurs extracellularly and then yeast cells are phagocyted or if conidia and hyphae are first internalized and the dimorphic transition occurs inside the cell. Some results suggest that the conversion of conidia to yeast and/or mycelium can occur inside macrophages [62].
In studies to investigate the compensatory cell responses to damage of the CW by perturbing agents, it was observed that 15 μM Congo red inhibits conidia germination of S. schenckii under conditions set for yeast development but not for mycelial growth, even at a 10-fold higher concentration. When the dye was added to yeast cells pre-grown in its absence, cells rapidly differentiated into mycelial cells, suggesting that this shift may be a strategy to evade the noxious effect of the dye [63]. Further studies confirmed the same behavior in S. globosa and showed that hypha returned to yeast-like cells as soon as the dye disappeared. Cell compensatory responses also included significant variations in the activity of glucosamine-6-phosphate synthase, a critical regulatory enzyme of UDP-GlcNAc levels [64][65].
Melanin is a factor of virulence present in the CW of Sporothrix and many other pathogenic fungi. For its importance in pathogenesis, this pigment has been studied from different aspects including its role in cutaneous sporotrichosis [66], synthesis and assembly in fungi [67], structure [68], biosynthesis in pathogenic species of Sporothrix [69], its relationship with the mammalian immune system [70], its synthesis pathway in fungi as a source for fungal toxins [71], and its role as a factor of virulence in S. schenckii [56]. Melanins are structurally complex dark pigment polymers present in all biological systems [72][73] and in fungi, they are synthesized by two pathways, either from 1,8-dihydronaphthalene (DHN) or L-3,4-dihydrophenylalanine (L-DOPA) [70]. The synthesis of pyomelanin in fungi involves oxidizing and polymerizing aromatic amino acids, like tyrosine, forming a three-dimensional melanin network. Pyomelanin provides protective and adaptive properties, helping the fungus resist environmental factors and antifungal agents. Precise synthesis details can vary by fungal species and environmental conditions [74]. In one study, nonpigmented S. schenckii was phagocyted more readily by human monocytes and murine macrophages than its melanized counterpart. It was also observed that the pigment protects the fungus against radiation [75]. In the same line, several characteristics of sporotrichosis induced in rats with wild type (MEL+) and mutant (MEL-) strains of S. schenckii were compared. Among other observed differences, the pigmented strain showed greater tissue invasion giving rise to multifocal granulomas, while the mutant cells restricted the fungus to the core of the granulomas [66]. Melanin also protects fungal cells from reactive oxygen species and nitric oxide released during phagocytosis [56]. Moreover, it has been observed in some fungi that melanin interferes with the immune system as it reduces the effectiveness of phagocytes, binds effector molecules and antifungals, and alters complement and antibody responses [70].
The most important factor of the virulence of Sporothix and many other organisms is the formation of biofilms. These are highly organized structures formed by sessile cells and a variable amount of extracellular polymeric substances (EPS), which function as an impermeable protecting coat that limits the diffusion of chemical substances, leading to recurring infections and resistance to antifungals [76][77][78]. Since the discovery of biofilms, it has been learned that about 90% of microorganisms possess this ability. The formation of biofilms is a complex process that occurs in four phases, namely adhesion, aggregation, maturation, and disaggregation. These colonies of sessile cells can form either on biotic or abiotic surfaces [79][80][81][82], such as medical devices, including catheters, prothesis, pacemakers, and others. A number of properties of biofilms have been studied in several pathogens, particularly Candida albicans and other pathogenic species of the genus [81][82][83][84][85] A biofilm formed by C. albicans is shown in Figure 3A. Recently, a review of materials used to prevent adhesion, growth, and biofilm formation of Candida species [86] was published. Information on biofilm formation by Sporothrix is rather limited. An image of a Sporothrix schenckii biofilm is depicted in Figure 3B. In one study, the ability of Sporothrix spp. to form biofilms in vitro was investigated, as well as the growth, morphology, and sensitivity of sessile cells to antifungals. Results corroborated previous findings observed in other organisms, i.e., that S. schenckii formed well-structured biofilms and the growth of sessile cells was less sensitive to antifungals than planktonic cells [87][88]. Later, it was demonstrated that biofilms formed in vitro by both mycelia and the yeast-like cells of the S. schenckii complex are inhibited by potassium iodide and miltefosine, an antiparasitary drug effective against helminthiasis [89]. Chitosan exhibits antimicrobial activity against many organisms, a function that largely depends on its molecular weight (MW) and deacetylation degree (DD) [90]. In one experiment, low, medium, and high MW chitosans with DD of 75–85% were tested in ten isolates of S. brasiliensis in the filamentous phase. Their effect was measured on planktonic cells, initial adhesion for biofilm formation, and mature biofilms. Low MW chitosan was more inhibitory of both planktonic cells and biofilm formation than the other chitosans, suggesting that low MW chitosan can penetrate and interact with the biofilm more easily than the high MW form, leading to the destruction of the biofilm structure more efficiently [91].
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Figure 3. Biofilm formed by C. albicans (A). Adapted with permission from [83], under an open access Creative Common License Deed (CC BY 3.0). Copyright 2015 Hindawi. S. schenckii (B) was produced in the JCVC laboratory.

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Subjects: Microbiology
Contributors MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register :
Jorge A. Ortiz-Ramírez
,
Mayra Cuéllar-Cruz
,
Julio C. Villagómez-Castro
,
Everardo López-Romero
View Times: 257
Revisions: 2 times (View History)
Update Date: 28 Sep 2023
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