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Yang, C. Benign Recurrent Intrahepatic Cholestasis. Encyclopedia. Available online: https://encyclopedia.pub/entry/4950 (accessed on 27 September 2026).
Yang C. Benign Recurrent Intrahepatic Cholestasis. Encyclopedia. Available at: https://encyclopedia.pub/entry/4950. Accessed September 27, 2026.
Yang, Catherine. "Benign Recurrent Intrahepatic Cholestasis" Encyclopedia, https://encyclopedia.pub/entry/4950 (accessed September 27, 2026).
Yang, C. (2020, December 24). Benign Recurrent Intrahepatic Cholestasis. In Encyclopedia. https://encyclopedia.pub/entry/4950
Yang, Catherine. "Benign Recurrent Intrahepatic Cholestasis." Encyclopedia. Web. 24 December, 2020.
Benign Recurrent Intrahepatic Cholestasis
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/benign-recurrent-intrahepatic-cholestasis

Benign recurrent intrahepatic cholestasis (BRIC) is characterized by episodes of liver dysfunction called cholestasis. During these episodes, the liver cells have a reduced ability to release a digestive fluid called bile. Because the problems with bile release occur within the liver (intrahepatic), the condition is described as intrahepatic cholestasis. Episodes of cholestasis can last from weeks to months, and the time between episodes, during which there are usually no symptoms, can vary from weeks to years.

genetic conditions

References

  1. Folmer DE, van der Mark VA, Ho-Mok KS, Oude Elferink RP, Paulusma CC.Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicularlocalization of ATP8B1. Hepatology. 2009 Nov;50(5):1597-605. doi:10.1002/hep.23158.
  2. Kagawa T, Watanabe N, Mochizuki K, Numari A, Ikeno Y, Itoh J, Tanaka H, Arias IM, Mine T. Phenotypic differences in PFIC2 and BRIC2 correlate with proteinstability of mutant Bsep and impaired taurocholate secretion in MDCK II cells. AmJ Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G58-67.
  3. Klomp LW, Vargas JC, van Mil SW, Pawlikowska L, Strautnieks SS, van Eijk MJ,Juijn JA, Pabón-Peña C, Smith LB, DeYoung JA, Byrne JA, Gombert J, van der BruggeG, Berger R, Jankowska I, Pawlowska J, Villa E, Knisely AS, Thompson RJ, Freimer NB, Houwen RH, Bull LN. Characterization of mutations in ATP8B1 associated withhereditary cholestasis. Hepatology. 2004 Jul;40(1):27-38.
  4. Lam P, Pearson CL, Soroka CJ, Xu S, Mennone A, Boyer JL. Levels of plasmamembrane expression in progressive and benign mutations of the bile salt exportpump (Bsep/Abcb11) correlate with severity of cholestatic diseases. Am J Physiol Cell Physiol. 2007 Nov;293(5):C1709-16.
  5. Luketic VA, Shiffman ML. Benign recurrent intrahepatic cholestasis. Clin LiverDis. 2004 Feb;8(1):133-49, vii. Review.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Catherine Yang
View Times: 907
Entry Collection: MedlinePlus
Revision: 1 time (View History)
Update Date: 24 Dec 2020
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