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Li, V. DOCK8 Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4936 (accessed on 23 September 2026).
Li V. DOCK8 Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4936. Accessed September 23, 2026.
Li, Vivi. "DOCK8 Gene" Encyclopedia, https://encyclopedia.pub/entry/4936 (accessed September 23, 2026).
Li, V. (2020, December 24). DOCK8 Gene. In Encyclopedia. https://encyclopedia.pub/entry/4936
Li, Vivi. "DOCK8 Gene." Encyclopedia. Web. 24 December, 2020.
DOCK8 Gene
Edit

Dedicator of Cytokinesis 8

genes

References

  1. Crawford G, Enders A, Gileadi U, Stankovic S, Zhang Q, Lambe T, Crockford TL, Lockstone HE, Freeman A, Arkwright PD, Smart JM, Ma CS, Tangye SG, Goodnow CC,Cerundolo V, Godfrey DI, Su HC, Randall KL, Cornall RJ. DOCK8 is critical for thesurvival and function of NKT cells. Blood. 2013 Sep 19;122(12):2052-61. doi:10.1182/blood-2013-02-482331.
  2. Engelhardt KR, McGhee S, Winkler S, Sassi A, Woellner C, Lopez-Herrera G, ChenA, Kim HS, Lloret MG, Schulze I, Ehl S, Thiel J, Pfeifer D, Veelken H, Niehues T,Siepermann K, Weinspach S, Reisli I, Keles S, Genel F, Kutukculer N, Camcioğlu Y,Somer A, Karakoc-Aydiner E, Barlan I, Gennery A, Metin A, Degerliyurt A,Pietrogrande MC, Yeganeh M, Baz Z, Al-Tamemi S, Klein C, Puck JM, Holland SM,McCabe ER, Grimbacher B, Chatila TA. Large deletions and point mutationsinvolving the dedicator of cytokinesis 8 (DOCK8) in the autosomal-recessive form of hyper-IgE syndrome. J Allergy Clin Immunol. 2009 Dec;124(6):1289-302.e4. doi: 10.1016/j.jaci.2009.10.038. Erratum in: J Allergy Clin Immunol. 2010Mar;125(3):743. Kutuculer, Necil [corrected to Kutukculer, Necil].
  3. Harada Y, Tanaka Y, Terasawa M, Pieczyk M, Habiro K, Katakai T,Hanawa-Suetsugu K, Kukimoto-Niino M, Nishizaki T, Shirouzu M, Duan X, Uruno T,Nishikimi A, Sanematsu F, Yokoyama S, Stein JV, Kinashi T, Fukui Y. DOCK8 is aCdc42 activator critical for interstitial dendritic cell migration during immune responses. Blood. 2012 May 10;119(19):4451-61. doi: 10.1182/blood-2012-01-407098.
  4. Jabara HH, McDonald DR, Janssen E, Massaad MJ, Ramesh N, Borzutzky A, RauterI, Benson H, Schneider L, Baxi S, Recher M, Notarangelo LD, Wakim R, Dbaibo G,Dasouki M, Al-Herz W, Barlan I, Baris S, Kutukculer N, Ochs HD, Plebani A,Kanariou M, Lefranc G, Reisli I, Fitzgerald KA, Golenbock D, Manis J, Keles S,Ceja R, Chatila TA, Geha RS. DOCK8 functions as an adaptor that links TLR-MyD88signaling to B cell activation. Nat Immunol. 2012 May 13;13(6):612-20. doi:10.1038/ni.2305.
  5. Lambe T, Crawford G, Johnson AL, Crockford TL, Bouriez-Jones T, Smyth AM, PhamTH, Zhang Q, Freeman AF, Cyster JG, Su HC, Cornall RJ. DOCK8 is essential forT-cell survival and the maintenance of CD8+ T-cell memory. Eur J Immunol. 2011Dec;41(12):3423-35. doi: 10.1002/eji.201141759.
  6. Randall KL, Lambe T, Johnson AL, Treanor B, Kucharska E, Domaschenz H, WhittleB, Tze LE, Enders A, Crockford TL, Bouriez-Jones T, Alston D, Cyster JG, Lenardo MJ, Mackay F, Deenick EK, Tangye SG, Chan TD, Camidge T, Brink R, Vinuesa CG,Batista FD, Cornall RJ, Goodnow CC. Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol. 2009 Dec;10(12):1283-91. doi: 10.1038/ni.1820.Immunol. 2010 Jul;11(7):644. Johnson, Andy [corrected to Johnson, Andy L].
  7. Su HC, Jing H, Angelus P, Freeman AF. Insights into immunity from clinical andbasic science studies of DOCK8 immunodeficiency syndrome. Immunol Rev. 2019Jan;287(1):9-19. doi: 10.1111/imr.12723. Review.
  8. Zhang Q, Dove CG, Hor JL, Murdock HM, Strauss-Albee DM, Garcia JA, Mandl JN,Grodick RA, Jing H, Chandler-Brown DB, Lenardo TE, Crawford G, Matthews HF,Freeman AF, Cornall RJ, Germain RN, Mueller SN, Su HC. DOCK8 regulates lymphocyteshape integrity for skin antiviral immunity. J Exp Med. 2014 Dec15;211(13):2549-66. doi: 10.1084/jem.20141307.
  9. Zhang Q, Jing H, Su HC. Recent Advances in DOCK8 Immunodeficiency Syndrome. J Clin Immunol. 2016 Jul;36(5):441-9. doi: 10.1007/s10875-016-0296-z.
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