DNMT3A Gene

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Li, V. DNMT3A Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4935 (accessed on 29 September 2026).

Li V. DNMT3A Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4935. Accessed September 29, 2026.

Li, Vivi. "DNMT3A Gene" Encyclopedia, https://encyclopedia.pub/entry/4935 (accessed September 29, 2026).

Li, V. (2020, December 24). DNMT3A Gene. In Encyclopedia. https://encyclopedia.pub/entry/4935

Li, Vivi. "DNMT3A Gene." Encyclopedia. Web. 24 December, 2020.

DNMT3A Gene

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/dnmt3a

DNA Methyltransferase 3 Alpha: The DNMT3A gene provides instructions for making an enzyme called DNA methyltransferase 3 alpha.

genes

References

Challen GA, Sun D, Jeong M, Luo M, Jelinek J, Berg JS, Bock C, VasanthakumarA, Gu H, Xi Y, Liang S, Lu Y, Darlington GJ, Meissner A, Issa JP, Godley LA, LiW, Goodell MA. Dnmt3a is essential for hematopoietic stem cell differentiation.Nat Genet. 2011 Dec 4;44(1):23-31. doi: 10.1038/ng.1009.
Chédin F. The DNMT3 family of mammalian de novo DNA methyltransferases. ProgMol Biol Transl Sci. 2011;101:255-85. doi: 10.1016/B978-0-12-387685-0.00007-X.Review.
Grossmann V, Haferlach C, Weissmann S, Roller A, Schindela S, Poetzinger F,Stadler K, Bellos F, Kern W, Haferlach T, Schnittger S, Kohlmann A. The molecularprofile of adult T-cell acute lymphoblastic leukemia: mutations in RUNX1 andDNMT3A are associated with poor prognosis in T-ALL. Genes Chromosomes Cancer.2013 Apr;52(4):410-22. doi: 10.1002/gcc.22039.Genes Chromosomes Cancer. 2015 Oct;54(10):653.
Holz-Schietinger C, Matje DM, Reich NO. Mutations in DNA methyltransferase(DNMT3A) observed in acute myeloid leukemia patients disrupt processivemethylation. J Biol Chem. 2012 Sep 7;287(37):30941-51. doi:10.1074/jbc.M112.366625.
Hsieh CL. The de novo methylation activity of Dnmt3a is distinctly differentthan that of Dnmt1. BMC Biochem. 2005 Mar 30;6:6.
Okamoto N, Toribe Y, Shimojima K, Yamamoto T. Tatton-Brown-Rahman syndrome dueto 2p23 microdeletion. Am J Med Genet A. 2016 May;170A(5):1339-42. doi:10.1002/ajmg.a.37588.
Okano M, Bell DW, Haber DA, Li E. DNA methyltransferases Dnmt3a and Dnmt3b areessential for de novo methylation and mammalian development. Cell. 1999 Oct29;99(3):247-57.
Tatton-Brown K, Seal S, Ruark E, Harmer J, Ramsay E, Del Vecchio Duarte S,Zachariou A, Hanks S, O'Brien E, Aksglaede L, Baralle D, Dabir T, Gener B, GoudieD, Homfray T, Kumar A, Pilz DT, Selicorni A, Temple IK, Van Maldergem L,Yachelevich N; Childhood Overgrowth Consortium, van Montfort R, Rahman N.Mutations in the DNA methyltransferase gene DNMT3A cause an overgrowth syndromewith intellectual disability. Nat Genet. 2014 Apr;46(4):385-8. doi:10.1038/ng.2917.
Xin B, Cruz Marino T, Szekely J, Leblanc J, Cechner K, Sency V, Wensel C,Barabas M, Therriault V, Wang H. Novel DNMT3A germline mutations are associatedwith inherited Tatton-Brown-Rahman syndrome. Clin Genet. 2017 Apr;91(4):623-628. doi: 10.1111/cge.12878.

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Subjects: Genetics & Heredity

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Entry Collection: MedlinePlus

Update Date: 24 Dec 2020

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