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Yang, C. Autoimmune Addison Disease. Encyclopedia. Available online: https://encyclopedia.pub/entry/4871 (accessed on 26 September 2026).
Yang C. Autoimmune Addison Disease. Encyclopedia. Available at: https://encyclopedia.pub/entry/4871. Accessed September 26, 2026.
Yang, Catherine. "Autoimmune Addison Disease" Encyclopedia, https://encyclopedia.pub/entry/4871 (accessed September 26, 2026).
Yang, C. (2020, December 24). Autoimmune Addison Disease. In Encyclopedia. https://encyclopedia.pub/entry/4871
Yang, Catherine. "Autoimmune Addison Disease." Encyclopedia. Web. 24 December, 2020.
Autoimmune Addison Disease
Edit
This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/autoimmune-addison-disease

Autoimmune Addison disease affects the function of the adrenal glands, which are small hormone-producing glands located on top of each kidney. It is classified as an autoimmune disorder because it results from a malfunctioning immune system that attacks the adrenal glands. As a result, the production of several hormones is disrupted, which affects many body systems.

genetic conditions

References

  1. Gombos Z, Hermann R, Kiviniemi M, Nejentsev S, Reimand K, Fadeyev V, Peterson P, Uibo R, Ilonen J. Analysis of extended human leukocyte antigen haplotypeassociation with Addison's disease in three populations. Eur J Endocrinol. 2007Dec;157(6):757-61.
  2. Husebye E, Løvås K. Pathogenesis of primary adrenal insufficiency. Best Pract Res Clin Endocrinol Metab. 2009 Apr;23(2):147-57. doi:10.1016/j.beem.2008.09.004. Review.
  3. Mitchell AL, Pearce SH. Autoimmune Addison disease: pathophysiology andgenetic complexity. Nat Rev Endocrinol. 2012 Jan 31;8(5):306-16. doi:10.1038/nrendo.2011.245. Review.
  4. Napier C, Pearce SH. Autoimmune Addison's disease. Presse Med. 2012 Dec;41(12 P 2):e626-35. doi: 10.1016/j.lpm.2012.09.010.
  5. Rottembourg D, Deal C, Lambert M, Mallone R, Carel JC, Lacroix A,Caillat-Zucman S, le Deist F. 21-Hydroxylase epitopes are targeted by CD8 T cellsin autoimmune Addison's disease. J Autoimmun. 2010 Dec;35(4):309-15. doi:10.1016/j.jaut.2010.07.001.
  6. Skinningsrud B, Lie BA, Lavant E, Carlson JA, Erlich H, Akselsen HE, Gervin K,Wolff AB, Erichsen MM, Løvås K, Husebye ES, Undlien DE. Multiple loci in the HLA complex are associated with Addison's disease. J Clin Endocrinol Metab. 2011Oct;96(10):E1703-8. doi: 10.1210/jc.2011-0645.
  7. Yu L, Brewer KW, Gates S, Wu A, Wang T, Babu SR, Gottlieb PA, Freed BM, Noble J, Erlich HA, Rewers MJ, Eisenbarth GS. DRB1*04 and DQ alleles: expression of21-hydroxylase autoantibodies and risk of progression to Addison's disease. JClin Endocrinol Metab. 1999 Jan;84(1):328-35.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Catherine Yang
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Entry Collection: MedlinePlus
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Update Date: 24 Dec 2020
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