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Xu, R. PDGFRA-Associated Chronic Eosinophilic Leukemia. Encyclopedia. Available online: https://encyclopedia.pub/entry/4859 (accessed on 29 September 2026).
Xu R. PDGFRA-Associated Chronic Eosinophilic Leukemia. Encyclopedia. Available at: https://encyclopedia.pub/entry/4859. Accessed September 29, 2026.
Xu, Rita. "PDGFRA-Associated Chronic Eosinophilic Leukemia" Encyclopedia, https://encyclopedia.pub/entry/4859 (accessed September 29, 2026).
Xu, R. (2020, December 24). PDGFRA-Associated Chronic Eosinophilic Leukemia. In Encyclopedia. https://encyclopedia.pub/entry/4859
Xu, Rita. "PDGFRA-Associated Chronic Eosinophilic Leukemia." Encyclopedia. Web. 24 December, 2020.
PDGFRA-Associated Chronic Eosinophilic Leukemia
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/pdgfra-associated-chronic-eosinophilic-leukemia

PDGFRA-associated chronic eosinophilic leukemia is a form of blood cell cancer characterized by an elevated number of cells called eosinophils in the blood. These cells help fight infections by certain parasites and are involved in the inflammation associated with allergic reactions. However, these circumstances do not account for the increased number of eosinophils in PDGFRA-associated chronic eosinophilic leukemia.

genetic conditions

References

  1. Buitenhuis M, Verhagen LP, Cools J, Coffer PJ. Molecular mechanisms underlyingFIP1L1-PDGFRA-mediated myeloproliferation. Cancer Res. 2007 Apr 15;67(8):3759-66.
  2. Cools J, DeAngelo DJ, Gotlib J, Stover EH, Legare RD, Cortes J, Kutok J, ClarkJ, Galinsky I, Griffin JD, Cross NC, Tefferi A, Malone J, Alam R, Schrier SL,Schmid J, Rose M, Vandenberghe P, Verhoef G, Boogaerts M, Wlodarska I, KantarjianH, Marynen P, Coutre SE, Stone R, Gilliland DG. A tyrosine kinase created byfusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib inidiopathic hypereosinophilic syndrome. N Engl J Med. 2003 Mar 27;348(13):1201-14.
  3. Elling C, Erben P, Walz C, Frickenhaus M, Schemionek M, Stehling M, Serve H,Cross NC, Hochhaus A, Hofmann WK, Berdel WE, Müller-Tidow C, Reiter A,Koschmieder S. Novel imatinib-sensitive PDGFRA-activating point mutations inhypereosinophilic syndrome induce growth factor independence and leukemia-likedisease. Blood. 2011 Mar 10;117(10):2935-43. doi: 10.1182/blood-2010-05-286757.
  4. Fukushima K, Matsumura I, Ezoe S, Tokunaga M, Yasumi M, Satoh Y, Shibayama H, Tanaka H, Iwama A, Kanakura Y. FIP1L1-PDGFRalpha imposes eosinophil lineagecommitment on hematopoietic stem/progenitor cells. J Biol Chem. 2009 Mar20;284(12):7719-32. doi: 10.1074/jbc.M807489200.
  5. Metzgeroth G, Walz C, Score J, Siebert R, Schnittger S, Haferlach C, Popp H,Haferlach T, Erben P, Mix J, Müller MC, Beneke H, Müller L, Del Valle F, AulitzkyWE, Wittkowsky G, Schmitz N, Schulte C, Müller-Hermelink K, Hodges E, WhittakerSJ, Diecker F, Döhner H, Schuld P, Hehlmann R, Hochhaus A, Cross NC, Reiter A.Recurrent finding of the FIP1L1-PDGFRA fusion gene in eosinophilia-associatedacute myeloid leukemia and lymphoblastic T-cell lymphoma. Leukemia. 2007Jun;21(6):1183-8.
  6. Roufosse FE, Goldman M, Cogan E. Hypereosinophilic syndromes. Orphanet J Rare Dis. 2007 Sep 11;2:37. Review.
  7. Vandenberghe P, Wlodarska I, Michaux L, Zachée P, Boogaerts M, Vanstraelen D, Herregods MC, Van Hoof A, Selleslag D, Roufosse F, Maerevoet M, Verhoef G, Cools J, Gilliland DG, Hagemeijer A, Marynen P. Clinical and molecular features ofFIP1L1-PDFGRA (+) chronic eosinophilic leukemias. Leukemia. 2004Apr;18(4):734-42.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Rita Xu
View Times: 709
Entry Collection: MedlinePlus
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Update Date: 24 Dec 2020
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