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Yang, C. Atypical Hemolytic-Uremic Syndrome. Encyclopedia. Available online: https://encyclopedia.pub/entry/4843 (accessed on 29 September 2026).
Yang C. Atypical Hemolytic-Uremic Syndrome. Encyclopedia. Available at: https://encyclopedia.pub/entry/4843. Accessed September 29, 2026.
Yang, Catherine. "Atypical Hemolytic-Uremic Syndrome" Encyclopedia, https://encyclopedia.pub/entry/4843 (accessed September 29, 2026).
Yang, C. (2020, December 24). Atypical Hemolytic-Uremic Syndrome. In Encyclopedia. https://encyclopedia.pub/entry/4843
Yang, Catherine. "Atypical Hemolytic-Uremic Syndrome." Encyclopedia. Web. 24 December, 2020.
Atypical Hemolytic-Uremic Syndrome
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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/atypical-hemolytic-uremic-syndrome

Atypical hemolytic-uremic syndrome is a disease that primarily affects kidney function. This condition, which can occur at any age, causes abnormal blood clots (thrombi) to form in small blood vessels in the kidneys. These clots can cause serious medical problems if they restrict or block blood flow. Atypical hemolytic-uremic syndrome is characterized by three major features related to abnormal clotting: hemolytic anemia, thrombocytopenia, and kidney failure.

genetic conditions

References

  1. Caprioli J, Noris M, Brioschi S, Pianetti G, Castelletti F, Bettinaglio P,Mele C, Bresin E, Cassis L, Gamba S, Porrati F, Bucchioni S, Monteferrante G,Fang CJ, Liszewski MK, Kavanagh D, Atkinson JP, Remuzzi G; International Registryof Recurrent and Familial HUS/TTP. Genetics of HUS: the impact of MCP, CFH, andIF mutations on clinical presentation, response to treatment, and outcome. Blood.2006 Aug 15;108(4):1267-79.
  2. Hirt-Minkowski P, Dickenmann M, Schifferli JA. Atypical hemolytic uremicsyndrome: update on the complement system and what is new. Nephron Clin Pract.2010;114(4):c219-35. doi: 10.1159/000276545.
  3. Jokiranta TS, Zipfel PF, Fremeaux-Bacchi V, Taylor CM, Goodship TJ, Noris M.Where next with atypical hemolytic uremic syndrome? Mol Immunol. 2007Sep;44(16):3889-900. Review.
  4. Loirat C, Noris M, Fremeaux-Bacchi V. Complement and the atypical hemolyticuremic syndrome in children. Pediatr Nephrol. 2008 Nov;23(11):1957-72. doi:10.1007/s00467-008-0872-4.
  5. Noris M, Bresin E, Mele C, Remuzzi G. Genetic Atypical Hemolytic-UremicSyndrome. 2007 Nov 16 [updated 2016 Jun 9]. In: Adam MP, Ardinger HH, Pagon RA,Wallace SE, Bean LJH, Stephens K, Amemiya A, editors. GeneReviews® [Internet].Seattle (WA): University of Washington, Seattle; 1993-2020. Available fromhttp://www.ncbi.nlm.nih.gov/books/NBK1367/
  6. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. N Engl J Med. 2009 Oct22;361(17):1676-87. doi: 10.1056/NEJMra0902814. Review.
  7. Noris M, Remuzzi G. Hemolytic uremic syndrome. J Am Soc Nephrol. 2005Apr;16(4):1035-50.
  8. Sellier-Leclerc AL, Fremeaux-Bacchi V, Dragon-Durey MA, Macher MA, Niaudet P, Guest G, Boudailliez B, Bouissou F, Deschenes G, Gie S, Tsimaratos M, FischbachM, Morin D, Nivet H, Alberti C, Loirat C; French Society of Pediatric Nephrology.Differential impact of complement mutations on clinical characteristics inatypical hemolytic uremic syndrome. J Am Soc Nephrol. 2007 Aug;18(8):2392-400.
  9. Sullivan M, Erlic Z, Hoffmann MM, Arbeiter K, Patzer L, Budde K, Hoppe B,Zeier M, Lhotta K, Rybicki LA, Bock A, Berisha G, Neumann HP. Epidemiologicalapproach to identifying genetic predispositions for atypical hemolytic uremicsyndrome. Ann Hum Genet. 2010 Jan;74(1):17-26. doi:10.1111/j.1469-1809.2009.00554.x.
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Subjects: Genetics & Heredity
Contributor MDPI registered users' name will be linked to their SciProfiles pages. To register with us, please refer to https://encyclopedia.pub/register : Catherine Yang
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Update Date: 24 Dec 2020
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