Acute Promyelocytic Leukemia

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Yang, C. Acute Promyelocytic Leukemia. Encyclopedia. Available online: https://encyclopedia.pub/entry/4640 (accessed on 22 September 2026).

Yang C. Acute Promyelocytic Leukemia. Encyclopedia. Available at: https://encyclopedia.pub/entry/4640. Accessed September 22, 2026.

Yang, Catherine. "Acute Promyelocytic Leukemia" Encyclopedia, https://encyclopedia.pub/entry/4640 (accessed September 22, 2026).

Yang, C. (2020, December 24). Acute Promyelocytic Leukemia. In Encyclopedia. https://encyclopedia.pub/entry/4640

Yang, Catherine. "Acute Promyelocytic Leukemia." Encyclopedia. Web. 24 December, 2020.

Acute Promyelocytic Leukemia

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/condition/acute-promyelocytic-leukemia

Acute promyelocytic leukemia is a form of acute myeloid leukemia, a cancer of the blood-forming tissue (bone marrow). In normal bone marrow, hematopoietic stem cells produce red blood cells (erythrocytes) that carry oxygen, white blood cells (leukocytes) that protect the body from infection, and platelets (thrombocytes) that are involved in blood clotting. In acute promyelocytic leukemia, immature white blood cells called promyelocytes accumulate in the bone marrow. The overgrowth of promyelocytes leads to a shortage of normal white and red blood cells and platelets in the body, which causes many of the signs and symptoms of the condition.

genetic conditions

References

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de Thé H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A. The PML-RARalpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR. Cell. 1991 Aug 23;66(4):675-84.
Pandolfi PP. Oncogenes and tumor suppressors in the molecular pathogenesis of acute promyelocytic leukemia. Hum Mol Genet. 2001 Apr;10(7):769-75. Review.
Parmar S, Tallman MS. Acute promyelocytic leukaemia:a review. Expert OpinPharmacother. 2003 Aug;4(8):1379-92. Review.
Salomoni P, Pandolfi PP. The role of PML in tumor suppression. Cell. 2002 Jan 25;108(2):165-70. Review.
Sanz MA, Montesinos P. Open issues on bleeding and thrombosis in acutepromyelocytic leukemia. Thromb Res. 2010 Apr;125 Suppl 2:S51-4. doi:10.1016/S0049-3848(10)70013-X. Review.
Yamamoto JF, Goodman MT. Patterns of leukemia incidence in the United Statesby subtype and demographic characteristics, 1997-2002. Cancer Causes Control.2008 May;19(4):379-90.
Zelent A, Guidez F, Melnick A, Waxman S, Licht JD. Translocations of theRARalpha gene in acute promyelocytic leukemia. Oncogene. 2001 Oct29;20(49):7186-203. Review.

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Subjects: Genetics & Heredity

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Entry Collection: MedlinePlus

Update Date: 24 Dec 2020

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