XPC Gene

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Tang, P. XPC Gene. Encyclopedia. Available online: https://encyclopedia.pub/entry/4633 (accessed on 26 September 2026).

Tang P. XPC Gene. Encyclopedia. Available at: https://encyclopedia.pub/entry/4633. Accessed September 26, 2026.

Tang, Peter. "XPC Gene" Encyclopedia, https://encyclopedia.pub/entry/4633 (accessed September 26, 2026).

Tang, P. (2020, December 24). XPC Gene. In Encyclopedia. https://encyclopedia.pub/entry/4633

Tang, Peter. "XPC Gene." Encyclopedia. Web. 24 December, 2020.

XPC Gene

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This entry is adapted from the peer-reviewed paper https://medlineplus.gov/genetics/gene/xpc

XPC complex subunit, DNA damage recognition and repair factor: the XPC gene provides instructions for making a protein that is involved in repairing damaged DNA.

genes

References

Bernardes de Jesus BM, Bjørås M, Coin F, Egly JM. Dissection of the molecular defects caused by pathogenic mutations in the DNA repair factor XPC. Mol CellBiol. 2008 Dec;28(23):7225-35. doi: 10.1128/MCB.00781-08.
Chavanne F, Broughton BC, Pietra D, Nardo T, Browitt A, Lehmann AR, Stefanini M. Mutations in the XPC gene in families with xeroderma pigmentosum andconsequences at the cell, protein, and transcript levels. Cancer Res. 2000 Apr1;60(7):1974-82.
Cleaver JE, Thompson LH, Richardson AS, States JC. A summary of mutations inthe UV-sensitive disorders: xeroderma pigmentosum, Cockayne syndrome, andtrichothiodystrophy. Hum Mutat. 1999;14(1):9-22. Review.
D'Errico M, Parlanti E, Teson M, de Jesus BM, Degan P, Calcagnile A, Jaruga P,Bjørås M, Crescenzi M, Pedrini AM, Egly JM, Zambruno G, Stefanini M, DizdarogluM, Dogliotti E. New functions of XPC in the protection of human skin cells fromoxidative damage. EMBO J. 2006 Sep 20;25(18):4305-15.
Hoogstraten D, Bergink S, Ng JM, Verbiest VH, Luijsterburg MS, Geverts B,Raams A, Dinant C, Hoeijmakers JH, Vermeulen W, Houtsmuller AB. Versatile DNAdamage detection by the global genome nucleotide excision repair protein XPC. JCell Sci. 2008 Sep 1;121(Pt 17):2850-9. doi: 10.1242/jcs.031708.Erratum in: J Cell Sci. 2008 Dec 1;121(Pt 23):3991. Ng, Jessica M Y [added]. JCell Sci. 2008 Sep 1;121(Pt 17):2972.
Khan SG, Oh KS, Shahlavi T, Ueda T, Busch DB, Inui H, Emmert S, Imoto K,Muniz-Medina V, Baker CC, DiGiovanna JJ, Schmidt D, Khadavi A, Metin A, Gozukara E, Slor H, Sarasin A, Kraemer KH. Reduced XPC DNA repair gene mRNA levels inclinically normal parents of xeroderma pigmentosum patients. Carcinogenesis. 2006Jan;27(1):84-94.
Sugasawa K. UV-induced ubiquitylation of XPC complex, the UV-DDB-ubiquitinligase complex, and DNA repair. J Mol Histol. 2006 Sep;37(5-7):189-202.
Sugasawa K. XPC: its product and biological roles. Adv Exp Med Biol.2008;637:47-56. Review.

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Subjects: Genetics & Heredity

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Update Date: 24 Dec 2020

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